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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
ISSN : -     EISSN : -     DOI : -
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Articles 105 Documents
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LIMBAH KULIT GARCINIA MANGOSTANA L.: TEROBOSAN BARU UNTUK PERLINDUNGAN TERHADAP SIROSIS HEPATIS Rachman, Adelia Ulya; Wijaya, Marzuki Panji; Alvianita, Audesia; Hidayat, Putra Nur; Alamsjah, Jeffry
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Liver cirrhosis is caused by exposure of free radicals to the liver and can only be treated with a liver transplant. Previous studies mentioned that mangosteen (Garcinia Mangostana L.) pericarp contain antioxidant compounds. The aim of this study is to test the hepatoprotective ability of mangosteen pericarp to prevent liver cirrhosis’ progression.6 groups of mice will be given intervention and then the following parameters will be observed: serum ALT, AST, bilirubin and the histopathologic appearance of the mice’s liver. Of all four parameter that was observed, only the histopathologic appearance of the mice’s liver shows significant result.Keywords: mangosteen, cirrhosis, garcinia mangostana, herbal.
PENGEMBANGAN MARKA MOLEKULAR UNTUK KARAKTERISASI VARIETAS ANGGREK TANAH UNGGUL (SPATHOGLOTTIS) HASIL POLIPLOIDISASI DENGAN KOLKISIN Setiawan, Agus; Shochicha, Anahtadiya Nurfa; Cahya Pramana, Abrory Agus; Restiyanti, Restiyanti; Daryono, Budi Setiadi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Characterization of Spathoglottis has not been observed yet especially in determination of genetic relationship and identification of colchisine-induced polyploid orchid. The aim of this research was to study about characterization of fingerprinting molecular mark in DNA Barcode profiling of Polyploid Anggrek Tanah (Spatholgottis sp.) and fenetic relationship of polyploid orchid with superior hybrid soil orchid (Spatholgottis sp.). The method of this research is collecting the orchid, germinating orchid seed, colchisine-induced PLB orchid, making simply buffer DNA isolation, genome DNA isolation, quantitative test of genome DNA, qualitative test of genome DNA, liquidity DNA genom, liquidity RAPD primer, PCR Random Amplified Polimorphism DNA (RAPD) of Orchid DNA, electrophoresis of PCR-RAPD, polymorphism RAPD , Dendogram RAPD analysis, dan creating Orchid DNA barcode. Based on the result known that RAPD molecular method could be used in detection of polyploid Spathoglottis sp. with OPAW11 primer. Electroforegram could be made as DNA bar-coding for Spathoglottis sp. that also could be used to to trace the origin orchids from Indonesia.Keywords: Spathoglottis, RAPD, bar-code DNA, colchisine
GANYONG (CANNA EDULIS), YANG TERABAIKAN MENJADI BENTENG KANKER USUS BESAR Ismawardika, Alifiani; Larasandi, Deasy; Sadid, Ahmad; Fiolita, Redita Elva; Prayoga Griadhi, Nyoman Odiyana
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Background : Colorectal cancer is one of the most common cancer that can lead to mortality. Since  patients come in the late stage, mostly they have bad prognosis. Thus, prevention is the most effective way to decrease the mortality and morbidity. Ganyong (Canna edulis) is plant which the root contains of high fiber and calcium which are good to prevent colorectal cancer. Aim : This experiment is conducted to examine the preventive effect of ganyong solution to the development of colorectal cancer. Method : The research design is experimental with using of post test only with control group design method. 30 male Wistar rats weighing 100-120 gram (4 week of age) are used in this experiment. The rats are devided into 6 groups randomly and each group consists of 5 rats. Group 1 got AOM/DSS only While, AOM/DSS, coconut oil and ganyong solution are given to the group 2. Then group 3 got AOM/DSS and ganyong solution and group 4 got AOM/DSS and coconut oil. Group 5 got coconut oil and ganyong solution. And group 6 which is negative control group got aquadestIndependent t test is used to analyse the data. Result: Macroscopically, the amount of rats that have nodule in G2 (75%) is lesser than G4 (100%). Microscopically, there are 3 rats from G1 having adenokarsinoma while only 2 rats from G3 having same thing. Statistically this difference is significant (p>0,05). Conclusion : Ganyong can decrease the number of nodule in group which was given coconut oil. And  microscopically it can effective in preventing the tumor development in group without coconut oil.   Keyword : Canna edulis, colorectal cancer , prevention
TEKNOLOGI PEMANEN KABUT (FOG HARVESTING) SEBAGAI SOLUSI MENGATASI MASALAH KEKERINGAN PADA DATARAN TINGGI Taufani, Aditya Riski; Utomo, Puji; Maulana, Taufiq Ilham; Musofa, Musofa
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Drought occur in Ngoho Plateu, Semarang and always happened in dry season. However, the plateu has a big potential of fog, which always occur in wet and dry season. This research purposes to determine the potential of fog  harvesting, 4 models of standard fog collectors (SFC) were installed in two locations. Each location were installed 2 models with azimuth of 90o and 180o. Data collected for 4 months, on condition where foggy day only. Equipment that harvested largest amount of fog water was model 4 which were mounted on highest land of plateu azimuth of 90o. Model 4 was capable to harvest water 8 liter/m2 in fog duration of 8 hours. Keywords : water, fog, standard fog collector
SINTESIS POLIANILIN YANG DIPERKAYA γ-Fe2O3 DARI PASIR BESI LOKAL SULAWESI TENGGARA UNTUK APLIKASI Anton, Ardin; Nalis, M.; Taswito, C. C. N.; Agusu, La
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

This research is aimed to develop the radar absorbing material based on polyaniline enriched by γ-Fe2O3 synthetized from the sandstone. γ-Fe2O3 is, then, derived from calcination process of Fe3O4 powder at the temperature of 400-600oC. Fe3O4 powder itself is extracted from the local sandstone of South East Sulawesi area by using the co-precitipation method with both HCl and NH4OH act as the solvent and precitipation agent, respectively. The polyaniline is synthetized from its monomer, aniline, where both HCl and NH4OH are also used as a dopant and an oxydator agent, respectively. Effect of reaction pH on the crystal size of Fe3O4 is also investigated. The XRD spectrum shows that a rather high purity of Fe3O4 in nano size is being achieved at the pH value of 8 and 9. However, at a rather low pH value (6.5 and 7.5), the additional weak peaks in XRD spectrum shows the existence other metal compounds impurity. The crystal sizes is approximately ~8.01 and 11.07 nm for pH value of 8 and 9. The VSM measurement result shows that the saturated magnetization value of Fe3O4 is 24.45 emu/g. The Fe3O4 is calcined at temperature of 500oC for 3 hours to get γ-Fe2O3. Finally, the polyaniline-γ-Fe2O3 composites were synthetized using an insitu polymerization method where the weight contents of γ-Fe2O3 are 5, 10, 15, and 20 percent. Those materials will be useful as a prospective application in radar absorbing materials technology at frequency ranges of 9-17 GHz.           Keywords: polyaniline, γ-Fe2O3, co-precitipation, sandstone, radar absorbing materials
EKSTRAK CACING TANAH SEBAGAI INOVASI PENYEMBUHAN ULKUS DIABETIK BERBASIS INDUKSI DENSITAS AKSON Mardiati, Ni Putu Jeny; Yunitasari, Arinda Nur; Sari, Dwi Astika; Saraswasta, I Wayan Gede; Putra, Fetreo Negeo; Kristianto, Heri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Reduction of nerve growth factor expression in diabetic ulcer affects overall wound healing. Earthworm (Pheretima aspergillum) can stimulate schwann cell proliferation and migration to support axonal elongation. The objective of this study is to compare wound healing functions in diabetic ulcer of rats using earthworm extract, hydrogel, and conventional dressing. This study applied a true-experimental posttest only controlled group design. 21 days after treatment, the group receiving earthworm extract had a significantly higher percentage of wound contraction and axonal density compared to the control group (p<0.05). These results show that earthworm extract can promote wound healing in diabetic ulcer. Keywords: Diabetic Ulcer, Earthworm (Pheretima aspergillum), Wound Contraction, Peripheral Nerve Regeneration.
FORMULASI DAN FORTIFIKASI IKAN CAKALANG (Katsuwonus sp.) PADA BUBUR INSTAN SEBAGAI PANGAN FUNGSIONAL TINGGI PROTEIN DAN KARBOHIDRAT DALAM PENANGGULANGAN KASUS GIZI BURUK DI INDONESIA Yusida, Ayumi; Rahmawati, Rahmawati; Utami, Tri Nur; Fachrozan, Ryan
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Problems of malnutrition and malnutrition are found in Indonesia. Prevalence less severe in infants in Indonesia reached 17.9% in 2010 with 4.9% severe malnutrition and undernourishment by 13%. Malnutrition are found in areas such as eastern Indonesia Gorontalo, NTB, NTT and Papua. Total prevalence of malnutrition in the province of 33.6% or 463 370 infants. Combination rice and tuna can be used as a functional food. One of the proposed solution is to create an instant porridge based tuna to overcome the problem of poor nutrition. The advantages of instant porridge-based fish skipjack is easy to prepare, rich in protein, has a power longer lasting, and easier to distribute. The purpose of the study was to determine the nutrient content of tuna, rice, and instant porridge skipjack as a whole, determine the effect of processing on nutrient composition of tuna and rice, instant porridge determine formulations skipjack proper, and in an effort to diversify the fishery products increasing fish consumption Indonesian society.  Keywords:  carbohydrate,instant porridge, malnutrition, protein
PERANAN ZEOLIT NANOPORI TERMODIFIKASI SEBAGAI MATERIAL PENGONTROL PELEPASAN PUPUK UREA Hidayat, Rahmat; Fadillah, Ganjar; Chasanah, Uswatul; Wahyuningsih, Sayekti
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Effectiveness of catalyst zeolite nanoporous as a slow release fertilizer of nitrogen from urea has been researched. In this study, natural zeolite was activated by HF 1%  with a calsination temperature at 120oC and the surface of zeolite was modified by aminopropyltrimethoxysilane (APTMS) 5%. Zeolite activation was characterized by X-ray diffraction spectroscopy (XRD) and Surface Area Analyzer (SAA) while the modified zeolite was characterized by infrared spectroscopy (FTIR), Surface Area Analyzer (SAA) and UV-Vis spectroscopy. The results of the material characterization of zeolite-APTMS obtained size pore of 7,74 nm with a maximum adsorption capacity of urea was 3.668 mg/g. Slow release urea test  from zeolite-APTMS performed by observing the absorbance of the urea at a wavelength of 195 nm with a variation of time 0, 5,10,20,40,60,80,100 and 120 minutes The test of fertilizers in the soil is directly done by observing changes pH and release of NH4+ in the incubation time of 14 days. The results show that urea without zeolite will be released 100% in the 120 minute and zeolite-APTMS aqueous solution at minute 120 only released about 56,24%. While the application of fertilizers in the soil is directly obtained that urea with zeolite having a pH decrease slowly compared to urea without zeolite. It is addressed that the zeolite-APTMS potentially be developed as a release control material of nitrogen from urea is caused due to the ability of the zeolite to absorb urea-APTMS temporarily in the pore and hydrogen bonding interactions between the urea and N-H from APTMS. Keywords:  zeolite, zeolite-APTMS, urea, slow release fertilizer
O’MARK: INOVASI PEMANFAATAN PROSTAGLANDIN E2 DALAM SALIVA SEBAGAI EVALUASI TINGKAT KEPARAHAN PERIODONTITIS Amelia, Fitri; Pustaka, Tiana; Irsyadi, Fahmi Tsani; Fitriana, Ardian Ayu; Seputraningrum, Yuliana; Rachmawati, Ranny
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Periodontitis is an inflammatory disease affects teeth supporting tissues which causing loss of periodontal attachment and damaging alveolar bone. Periodontitis trigger host to produce monocytes, polymorphonuclears (PMN), macrophages and others to release inflammatory mediators such as IL-1, TNF-α, PGE2. In periodontal disease, PGE2 role in breakdown of alveolar bone. The biomarker used PGE2 that contained in human saliva. This research aims to prove that PGE2 in saliva could be a new method to measure severity and early diagnosis of periodontitis. This research used Post Test Only Controlled Group Design with human saliva as the samples. The samples collected from 20 patients divided into two groups which are: control group (patient without periodontitis) and experimental group (patient with periodontitis). Saliva collecting method which used was Passive Drool with 2 ml for each. Afterwards, the samples isolated with a kit to make sure the PGE2 in saliva active and then the ELISA test did. Data analysis used Independent T Test with p<0,05 to know comparison the level of PGE2 in both groups. Thereafter, a ROC curve analysis with p<0,05 used to find out sensitivity and specifity of PGE2 in saliva towards periodontitis. The amount of PGE2 in saliva were significantly increased in periodontitis patients compared with healthy patients, also PGE2 in saliva specific enough and sensitive to periodontitis so its could be used as a valid diagnostic tool in measuring the severity of periodontitis. Keywords:  Prostaglandin E2, saliva, periodontitis, early diagnose, severity
PERAKITAN VARIETAS UNGGUL ANGGREK TANAH (Spathoglottis Bintang Segunung) DOUBLE HAPLOID DENGAN KULTUR OVARIUM Setiawan, Agus
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

A rapid and efficient micropropagation method was esthablished for produced cloning of Orchid Hybrid Spathoglottis Bintang Segunung from Indonesia. The aim of this research was to optimize effects of 2,4-Dichlorophenoxyacetic acid (2,4-D), cold shock, and 6-Benzylaminopurine (BAP) to plantlet regeneration from ovarium culture and analyse the ploidy using flow cytometry. Ovarium explants from shut flower stalk were cultured on Vacin and Went (VW) medium supplemented with 2,4-D at 5 concentrations (0.01-1 ppm) and cold shock treatment after cultured at 3 variations 10oC (0, 2, and 4 h) and then incubate the explants in room with 24 photoperiodization (±25oC). After 10 days, while ovarium explants were subcultured on VW supplemented with 6-benzylaminopurin (BAP) (2.5 ppm) for 2 weeks. Further, ovarium explants were subcultured again on VW medium with filtered coconut water (150 ml/L). Regeneration of protocorm-like bodies (PLBs) and subsequent plantlet development were observed from on VW+ 1 ppm 2,4-D (Sig= 2%)+ 4h cold shock 10oC (Sig= 2%) dan 2,5 ppm BAP. The optimized procedure required about 2 months from cultured of the ovarium explant to plantlet formation. The peak from the histogram of flow cytometry showed that ovarium cultured of S. Bintang Segunung (CV= 4,35%) and leave of S. Bintang Segunung (CV= 5,19%) were the same triploid. The protocol of this experiment could produce the uniform plantlets and expected to initiate the regeneration of ovul cell which need more studying for the medium optimation.

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