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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
ISSN : -     EISSN : -     DOI : -
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Articles 105 Documents
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PENGARUH DISPERSANT TERHADAP NANOPARTIKEL TiO2 SEBAGAI OPTIMASI DIRT-FREE PAINT Adiati, Rima Fitria; Nurfadilah, Nurfadilah; Febiola, Cindy Claudia; Taufan, Ibnu; Fadhilah, Nur
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Research has been conducted to determine the effect of variations of dispersant on TiO2 nanoparticles as optimization of dirt-free paint. Dispersant used are Ethylene Glycol, Polyethylene Glycol, and Triton X-100 dissolved in white paint. Self-cleaning test with two kinds of stains shows that for mud stain, the best sample is the sample with Ethylene Glycol dispersant, by reduction of stain area reach 40.99 cm2. As for the food coloring stain, TiO2 samples with dispersant Triton X-100 with 24.57 cm2. SEM-EDX test results show that the TiO2 average particle size of paint without dispersant is 132.02 nm. By the addition of PEG, particle size becomes 104.98 nm. From the test results in this study can be shown that the dispersant material effect on the stability of a photocatalyst that can lead to self-cleaning properties, as well as agglomeration so it is able to disperse the TiO2 particles in the paint well. Keywords:  dirt-free paint, dispersant, TiO2
TEST KIT UNTUK ANALISIS SIANIDA DALAM KETELA POHON BERDASARKAN PEMBENTUKAN HIDRINDANTIN Sulistyarti, Hermin; Kusumawardhani, Nury; Zulfah, Novy Lailatuz; Cahyani, Yulia Dwi; Fahriyani, Hilda Emilia; Milda, Balqis
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cyanide is a highly toxic substance, which causes high number of poisoning by cyanide in a variety of foodstuffs; therefore the availability of test kits as fast and easy tool for analyzing cyanide is extremely demanded. The proposed cyanide test kit is developed based on the reaction of cyanide and nynhidrine to form a blue hydrindantin under strong basic solution. Cyanide test kit was optimized toward the λ maximum, pH, stability time of complex and concentration of nynhidrine. Optimization of maximum λ was done by measuring absorbance using visible spectrophotometer at range λ 560-620 nm. Optimization of pH was done by conditioning hydrindantine complex using NaOH solution to obtain pH of  9-14. Optimization of stability time of complex was done by monitoring complex under time range 0-120 minutes. The optimization of ninhydrin concentration was performed by varying the concentration of ninhydrin in range 0.5 to 3.5%. The results showed that the optimum conditions were: λ 590 nm, pH 12, the stability time of complex  of 30 minutes, and  concentration of ninhydrin of 1%. Test kit can determine cyanide at the range 1-10 ppm. test kit has been validated and applied for measuring cyanide in cassava with reliable results. Keywords:  nynhidrin, hidrindantin, cyanide, test kit, cassava
PEMANFAATAN POTENSI GANGGANG HIJAU (Ulva lactuca) SEBAGAI ANTIOKSIDAN ALAMI PADA PENCEGAHAN INFARK MIOKARD AKUT Mahmud, Iwan; Pertiwi, Reza; Azis, Nofa Risma; Reviana, Desi Novita
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Acute myocardial infarction is a myocardial necrosis due to blood flow to the heart muscle is disrupted. The occurrence of acute myocardial infarction is usually due to atherosclerosis of coronary arteries. Acute myocardial necrosis caused by total blockage of a coronary artery by a thrombus formed on an unstable atherosclerotic plaque. Radical compounds can cause auto-oxidation reaction that can cause lipid peroxidation which resulted in the accumulation of lipids in the artery walls and cause atherosclerosis are at great risk. Antioxidant compounds capable of capturing free radicals caused by auto-oxidation reaction that can cause lipid peroxidation which resulted in the accumulation of lipids in the artery walls and cause atherosclerosis are at great risk. Melatonin and sulfate content of polysaccharides present in Ulva lactuca.L have antioxidant activity according to several studies that have been done. This research method is done in 2 ways, namely in vitro and in vivo. This in vitro test using qualitative and quantitative tests using DPPH reagent. As for the in vivo test is used to measure the levels of MDA (malonaldehyde). Extracts of green algae (Ulva lactuca L.) has the ability of antioxidants seen from in vitro assays and in vivo. Data percent DPPH radical scavenging (ES50) on average positive control gallic acid and ethanol extracts of green algae (Ulva lactuca L.) respectively, are 0.912 ug / ml and 1426.616 pg / ml. The analysis showed that  200 mg / kg is an ideal dosage to prevent acute myocardial infarction.Keywords:  Green algae, myocardial infarction, heart, aterosclerosis
PENENTUAN NILAI SPF (SUN PROTECTING FACTOR) EKSTRAK N-HEKSAN ETANOL (1:1) DARI RICE BRAN (Oryza sativa) SECARA IN VITRO DENGAN METODE SPEKTROFOTOMETRI UV-VIS Mulyani, Mulyani; Putri, Pramita; Wahidatullail, Nurul
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Sunlight is an energy source for the survival of living on earth, but the overexposure on the skin provides the degree of damage depends on the frequency and duration of sunlight exposure on the skin. The ability to withstand ultraviolet rays of a sunscreen is rated as Sun Protecting Factor / SPF. This study aims to determine the SPF (Sun Protection Factor) n-Hexane ethanol extract (1:1) of rice bran (Oryza sativa), using spectrophotometry UV-Vis method. Rice bran was extracted by soxhletasi using mixed solution of n-Hexane ethanol (1: 1), then prepared sample solution using absolute ethanol with the concentration series of 100 ppm, 150 ppm, 200 ppm, 250 ppm, and 300 ppm. The absorbance of solutions were then measured by UV-Vis spectrophotometer with a wavelength of 280-400 nm. Result showed that n-Heksan ethanol ekstract (1:1) of rice bran can effectively block the UV-B ray. The SPF values acquired are starting from a concentration of 200 ppm, where the SPF value is 2,355 and then at concentration of 250 ppm is 2,884 and at concentration of 300 ppm is 3.483.Keywords:  Rice bran, Oryza sativa, sunscreen, spectrophotometry.
IDENTIFIKASI 16S RRNA DAN UJI ZIMOGRAFI BAKTERI ASAL PANTAI PAPUMA PENGHASIL ENZIM FIBRINOLITIK SEBAGAI ANTI ATHEROTHROMBOSIS A.S, Pananjung; I, Novanda asri; Nuryady, M Mirza; Ulfa, Evi Umayah
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Atherotrombosis is a disease caused by a blood clot (thrombus) in a blood vessel, and it can be the leading cause of death in the world. Atherotrombosis disease can be overcome with thrombolytic agents, one of which is a fibrinolytic enzyme but it has a expensive price, so we needto looking for a new fibrinolytic agent in this case the bacteria, from Papuma coastal. This research is a follow-up from past research, to identify the bacteria from papuma by using 16S rRNA, and to know the Enzyme activated by using Zymografi.The result of this research is, the bacteria identification by 16S rRNA is similar with Microbacterium testaceum with similarity percentage is about 97%. This bacteria is positive fibrinolityc bacteria it can showed by the result of Zymografi test, there is a one white band on zymografi gel, and because the protein marker on zymografi gel is unseen, so we just used the  qualitative observation. Keywords:Atherotrombosis, fibrinolitic, 16s rRNA, Bacteria  Identification, Zimografi. 
GELAS KAYU BIDARA LAUT (GEYU BILUT) SEBAGAI ANTIMALARIA Najiyyah, Siti Ulfatun; Ardiansyah, Ardiansyah; Prayitno, Oktavianus; Safitri, Rinitha Dinda; Megantari Ekaputri, Ni Putu Galuh
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Malaria until now still remain one of the main problem of world health. About 40% or 2.4 billion people in the world live in malaria endemic areas. Therefore, malaria cases in Indonesia on 2008 is about 1.624.930 cases. More than 25% province in Indonesia shows resistence to sulfadoksin-pirimetamin, cloroquin and kina in the last decade. People of  NTB believes that stewed water of geyu bilut works as antimalaria. The purpose of this research is to know the effectivity of stewed water of geyu bilut as antimalaria. The research that had been done is an experimental research using post test only control group design. The research sample are 30 Balb/c mice that have fullfiled inclusion criteria and have been selected by using simple random sampling. Every sample was infected with 200µL P.berghei intraper-itoneally on day 0. Treatment start given with sondage 2-4 hours after infection, the treatment are 0.3ml aquades to negative control group, 0.3ml cloroquin with dose 5 mg/kgBW to positive control group and 0.3ml of stewed water of geyu bilut with concentration 0,0003% to the treatment group, the dose start given with orally once per day, from day 0 to day 7. The thin blood smear was made on day 1 to 8 and was checked by using light microscope with total magnify 1000x, percentage of parasitemia was counted per 1000 erythrocytes. Primary data that has been collected then processed using Kruskal Wallis Test. The result that was collected from stewed water of geyu bilut with dose based on empiric fact has parasitemia percentage that don’t have significant difference with negative control and positive control group (p>0,05). Therefore, from this research we can conclude that 0,3ml stewed water of geyu bilut with concentraion 0.0003% is not effective as antimalaria. Keywords: malaria, parasitemia percentage, geyu  bilut, Strychnos ligustrina BI.
PEMANFAATAN TEKNOLOGI DIMPLE PADA LAMBUNG KAPAL UNTUK MENGURANGI TAHANAN KAPAL Firmanullah, Dhani Mishbah; Firmansyah, M Wahyu; Santoso, Fandhika Putera
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Research in fluid mechanics are developed to decrease the resistance of the ships by the flow on the surface of wet surace area. Fluid on the wet surface area will be create a friction. One of solution to decrease the force of friction is modification itself. The applications of marine, resistance of the ship will be effect to the require power to move the ship on the service velocity. Decrease of the total resistance will be decrease the require power of the engine that affect to the oil consumption of the ship. Dimples is the basines that can modification the fluid flow on the wet surface area of the ships. It can reduce the total resistance. The purpose of this research are to know the information about best horizontal distance between each dimple, to know the value the friction coefficient, and the total resistance between dimple installation and non dimple or normal hull construction. The method on this research is the simulation using Computational Fluid Dynamics (CFD). Dimple using 0,5 m for diameter, 0,15 m for the depth, and 1,5 m for the vertical distance. The principle dimension for the length between perpendicular is 117 m, breadth 20 m, height 9,2 m, and draught 6,9 m. The variables is the horizontal distance with the value 3, 4, 5 m, velocity 8, 10, 12, 14, 16, 18 knots. The results of this research are the best distance is 4 m and can reduce the total resistance 16,48 %.Keywords: Friction Force, Dimple, Computational Fluid Dynamics
POTENSI VAKSIN ATEROSKLEROSIS VIA INDUKSI PROTEIN LECTIN-LIKE OXIDIZED LDL RECEPTOR 1 (LOX-1) TERHADAP AKTIVASI NF-κB, EKSPRESI eNOS DAN KADAR CRP PADA TIKUS DENGAN DIET ATEROGENIK Albaar, Thoha Muhajir; Tamara, Fredo; A, Oktavia Rahayu; Putri, Ardina Pramesti; Nurkhairina, Angi; Yurina, Valentina
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Atherosclerosis is a chronic inflammation condition as a response to the lipoproteins deposition in the artery wall.Oxidized low density lipoprotein (OxLDL) the major of atherosclerosis development. Lectin- like oxidized lo density lipoprotein 1 (LOX-1) is primary  receptor for OxLDL in endothelial cells. Recent studies have shown that LOX-1 might be potential for the atherosclerosis drugs development. This study was designed to investigate the response of LOX-1 vaccination with alum as adjuvant for atherogenesis to prevent increasing of NF-kB , CRP, and decrease of eNOS. This study was experimental laboratory with post test only control group design for 56 days using 28 male Wistar rats. Rats were divided into 7 groups which were negative control with normal diet AIN 93 M, positive control with atherogenic diet AIN 93 M, atherogenic diet AIN 93 M and LOX-1 protein treatment with dosage 1 ng + alum (P1), 10 ng + alum (P2), 100 ng + alum (P3), 1μg + alum (P4) and alum only (P5). On the 57th day, the rats were sacrificed and taken its serum spesimen to measure CRP level with enzyme immunoassay method and aorta tissues to measure NF-kB activation and expression eNOS with immunohistochemical method. Statistical analysis showed that the administration of LOX-1 protein in the treatment groups is significant to prevent NF-kB activation (p=0,00) and prevent decreased expression of eNOS (p=0,00), but not significant to prevent increased CRP level (p=0,83). The conclusion of this study is that the LOX-1 protein vaccination  have potency to prevent atherosclerosis with decreasing NF-kB activation and prevent decreasing eNOS expression. Keywords:  Atherosclerosis vaccine, LOX-1, NF-kB, eNOS, CRP
POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
ANALISIS JERAMI PADI UNTUK PEMBUATAN MIKROMEMBRAN SEBAGAI PENDAUR AIR LIMBAH RUMAH TANGGA Febriyana, Nur Aini; Mirfada, Zakiyatul; Jamila, Nurul; Wijayanto, Ach. Afif; Pradana, Novan
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

The increase of population in Indonesia led to increased domestic waste. In addition, agricultural waste in Indonesia is very potential, such as rice straw. Rice straw ash contains silica which reached 94.5% silica is the main content of the base material micromembrane to absorb pollutants. Membrane separation is a medium that is selectively permeable to withstand certain components and skip the other components. Experimental procedures in this study includes the synthesis of silica, the manufacture of the membrane, and the membrane analysis. The results showed that the pore size of the membrane meets the standards mikromembran size from 0.3 to 10 lm. Rice straw silica functional groups located at the wave number of 3503.45 cm-1. Silica clusters seen at the peak of 1097.42 cm-1, which showed a group siloksa Si-O-Si. Optimal mass of silica used for the manufacture of silica membrane is 5 grams. The silica membrane was tested lowering the pH value from 7.2 to 6.9 caused a lot of impurities are retained and bind to the membrane. Micromembrane also lower turbidity values with 92% rejection and filter bacteria from 66000 into a 5500 colony. Keywords:  straw, waste, membrane

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