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<![CDATA[Oral Hairy Leukoplakia in Patient with HIV/AIDS ]]>
<![CDATA[Agustina Tri Pujiastuti]]>;
<![CDATA[Dwi Murtiastutik]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.71-77
<![CDATA[Background: Oral hairy leukoplakia (OHL) is an asymptomatic white plaque with vertical corrugations most commonly found on the lateral borders of the tongue. It is caused by local infection of Epstein- Barr Virus (EBV). OHL is usually associated with immunocompromised condition, and mainly described in patients with human immunodeficiency virus (HIV). Purpose: to report a case of oral hairy leukoplakia in an HIV patient that is often misdiagnosed as oral candidasis. Case: A 44-years old female came to the Dermato-Venereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya with complaint of persistent asymptomatic whitish color on both borders of her tongue. History taking revealed that at first the whitish color appeared spreading on the tongue, but after taking antifungal treatment, only the lesion on the borders still persisted, all attempts to scrub off the lesion failed. There were also history of diarrhea, fever and cough for almost 1 month. Further examination of HIV antibody 3 method tests revealed reactive result with CD4+ count of 1 cel/uL. Physical examination revealed bilateral painless white well demarcated plaque with “hairy” like corrugated appearance on the lateral borders of the tongue. Discussion: From history, clinical findings, and the reactive HIV antibody examination, the patient was diagnosed with AIDS with oral hairy leukoplakia. The patient was treated with acyclovir 200 mg, 5 times daily. After 2 weeks of treatment, clearance was achieved. Conclusion: The establishment of OHL which oftenly mistaken as oral candidiasis has a diagnostic value for HIV infection. Systemic antiviral institution and antiretroviral (ARV) medications as prevention for recurrence gave satisfying result. Key words: oral hairy leukoplakia, HIV, acyclovir.]]>
<![CDATA[Retrospective Study: Glycolic Acid Peel in Photoaging Patient ]]>
<![CDATA[Brama Rachmantyo]]>;
<![CDATA[Diah Mira Indramaya]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.27-33
<![CDATA[Background: Photoaging is premature skin aging that is caused by sun exposure in long periode. Glycolic acid peel is one of photoaging treatment that improve skin at epidermal layer. Improper patient selection and irregular follow-up may become factors of unsuccessful treatment. Purpose: To evaluate gycolic acid peel treatment for photoaging for improvement of medical service in the future. Methods: A retrospective study to photoaging patiens that were managed with glicolyc acid peel in Medical Cosmeutic Division Dermatology and Venereology Departement Dr. Soetomo General Hospital Surabaya on period from January 2011 to December 2013. The data were collected from medical record, Results: New patient of photoaging is 455 patients in Medical Cosmetic Division, 15.8% patients were treated with glycolic acid peel. Diagnosis classification were using Glogau classification. Thirty six point one percent of patient did not undergo follow up and 47.1% of patient’s interval of follow up were more than 4 weeks. Majority of patient (37.5%) have no improvement. Conclusion: Education to photoaging patient that undergo glycolic acid peel need to be improved. Clinical worsening and no improvement in some patients may be caused by irregular follow up. Key words: photoaging, retrospective study, glycolic acid peel.]]>
<![CDATA[Retrospective Study: Diagnosis and Management of Vulvovaginalis Candidiasis ]]>
<![CDATA[Ditta Harnindya]]>;
<![CDATA[Indropo Agusni]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.42-48
<![CDATA[Background: Vulvovaginalis candidiasis (VVC) is an infection of the vaginal mucosa and or vulva caused by Candida species. As many as 70-75% of women are infected by CVV at least once during their lifetime, which most often occurs in women of childbearing age. Purpose: To evaluate the general overview of new VVC patients at the Sexual Transmitted Infection Division Dermato-Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya from the period of 2010-2012. Methods: This is a retrospective study, and evaluating medical records of new CVV patients including basic information, history taking, physical and laboratory examination, management, follow up, and counseling. Result: There were 325 new CVV patients (11.5%) from the total 2.813 patients from the total of new patients at the STI Division Dermato-Venereology Outpatient Dr. Soetomo General Hospital Surabaya, range of age was mostly 25-44 years old (53.2%) and 257 (79.1%) patients were married. The most main complaint was vaginal discharge accompanied with itchy sensation in 213 (65.5%) patients. The most vaginal discharge appearance was white like cottage cheese in 245 (75.3%) patients. From the wet mount 220 (67.7%) patients showed either blastospore or pseudohyphae, while from the gram stain 220 (67.7%) patients showed 217 (66.8%) patients showed either blastospore or pseudohyphae. Therapy with ketoconasol is in 239 (73.2%) patients. Conclusion: Appropriate diagnosis, adequate therapy, also risk factors exploration and counseling are very important in the management of VVC.Key words: Vulvovaginalis candidiasis, fluor albus, itch, pseudohyphae, ketoconazole.]]>
<![CDATA[Profile of New Patients with Candida Infection in Skin and Nail ]]>
<![CDATA[Shinta Dewi Rahmadhani Soetojo]]>;
<![CDATA[Linda Astari]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.34-41
<![CDATA[Background: Candidiasis are different groups of infection which is caused by Candida albicans and other spesies in the genus Candida can invade hair, skin, nail, mucous membrane and systemic. Purpose: To evaluate profile, process of diagnosis, treatment and follow up of patient with candida infection on the skin and nails. Methods: This research was performed retrospectively to new patients with candida infection of skin and nails in period of 2011-2013. Result: There were 137 patients in period 2011-2013, which are 114 new patients with infection in skin and 23 patients with nails involvement. Most of them were women, respectively in 2011 (54.3%) 2012 (80%) and 2013 (56.6%). Most types of skin disorder is candida intertriginosa (62.2%) and candidiasis of skin and nails (91.3%). Conclusion: Overview of new cases of candida infections of skin and nails tend to decrease.Key words: Candidiasis spp, candida infection of skin and nails.]]>
<![CDATA[Expression of Transforming Growth Factor–Beta (TGF-β) on Regulatory T (Treg) Cell from Skin Lesion of Leprosy’s Patient ]]>
<![CDATA[Kristina Sihaloho]]>;
<![CDATA[Afif Nurul Hidayati]]>;
<![CDATA[Indropo Agusni]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.1-7
<![CDATA[Background: Clinical manifestations of leprosy depends on host’s immunity. Regulatory T (Treg) cells are known as CD4+CD25+FOXP3+ have roles in immune respons to maintain homeostasis. Transforming growth factor (TGF)-β are one of cytokine that is secreted by Treg cells. Treg cells are thought as unresponsiveness T cells (anergy) to Mycobacterium leprae and caused disease’s progression to lepromatosa. Purpose: To evaluate expression of TGF-β on Treg cells from patient leprosy’s skin lession. Methods: Design of study was cross-sectional, descriptive observation involving 18 leprosy patients who visited the Leprosy Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya. Biopsy from skin lession were performed then continued with histopathological examination. The type of leprosy was determined by clinical and histopathological examinations. Expression of TGF-β on Treg cell were performed by double staining immunohistochemistry in Biomoleculer and Pathology and Anatomy Laboratory at Brawijaya University, Malang. Result: Numbers of mid-borderline type (BB) leprosy’s patients were 2 (11,1%), 9 (50%) patients with borderline lepromatosa (BL) type, and 7 (38,5%) patients with Lepromatosa (LL) type. Mean expression of TGF-β on Treg cells from skin lession’s leprosy on BB type was 12 ± 2,12 cells/field of view, on BL type was 16 ± 3,64 cells/fields of view and on LL type was 22± 3,69 cells/field of view. Conclusion: Expression of TGF-β on Treg cells are increasing on skin lession’s leprosy patients might as prognostic indicator of severity of leprosy (lepromatosa type). Key words: immunohistochemistry, leprosy, Morbus Hansen, regulatory T cell, TGF-β.]]>
<![CDATA[Retrospective Study: Management of Atopic Dermatitis ]]>
<![CDATA[Nanny Herwanto]]>;
<![CDATA[Marsudi Hutomo]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.49-58
<![CDATA[Background: Atopic dermatitis (AD) is a chronic skin inflammatory disease, characterized with mild to severe itching, relapses, and mostly appears in infants and children. Although there has been current advances in the management of AD but satisfactory treatment has not been obtained. Purpose: To evaluate the treatment of patients with AD, hence better management can be provided. Methods: Retrospective study of newly diagnosed AD patients in Allergy Immunology Division of Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya during 2012-2014. Result: Antihistamine is the most widely prescribed medication, as many as 234 (36.3%) of all patients visits and cetirizine was the most given antihistamine in 142 (58%) of the patients. Emollients still used minimally, such as urea 10% cream in 71 (11%) patients, ambiphilic cream (biocream®) in 52 (8.1%) patients, and vaseline album in 11 (1.7%) patients. Conclusion: Emollients therapy is important in the management of AD and hence its usage should be adequate.Key words: atopic dermatitis, management, retrospective.]]>
<![CDATA[Higher Level Zinc Serum in Multibacillary Leprosy With Erythema Nodosum Leprosum compared to Patients Without Reaction ]]>
<![CDATA[Kinanti Prabawaningrum]]>;
<![CDATA[Linda Astari]]>;
<![CDATA[Indropo Agusni]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.8-15
<![CDATA[Background: Leprosy is an infectious disease that causes a redistribution of nutrients in the body, including zinc, and low food intake of zinc causes decreased serum zinc levels. The number of bacteria M. leprae in multibacillary (MB) type leprosy and acute inflammatory process in Erythema Nodosum Leprosum (ENL) reaction affect the levels of zinc. Purpose: To analyze differences in the results of serum zinc levels in MB patients without reactions and ENL. Methods: Cross sectional study was conducted on forty-eight patients with a diagnosis of MB leprosy in Dermato and venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya. Patient's blood had been taken to examine serum zinc levels. Result: The mean serum zinc levels of MB patients without reaction 78.49 g/dL, while ENL 175.83 g/dL. Conclusion: The mean serum zinc levels of MB patients with ENL is higher than without reaction.Key words: MB leprosy, ENL, cross sectional, serum zinc.]]>
<![CDATA[Kaposi’s Sarcoma-associated Herpesvirus ]]>
<![CDATA[Novia Indriyani Adisty]]>;
<![CDATA[Sawitri Sawitri]]>;
<![CDATA[Willy Sandhika]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.59-64
<![CDATA[Background: Kaposi’s sarcoma (KS) revealed by Moritz Kaposi first time in 1872. In the early 1980, the prevalence of SK began to increase dramatically. A new finding leads to growth, isolation, and characterization of a novel human herpes virus, now known as Kaposi’s sarcoma-associated herpes virus (KSHV) or Human herpes virus type 8 (HHV-8) from SK lesions. Puspose: To determine the role of herpes viruses in the pathogenesis of KS. Review: KS is a cancer that develops from cells lining the lymph vessels or blood vessels. A number of KSHV encoded protein is known to have the ability to oncogenic transformation, included are latent and lytic proteins. Latent proteins tend to increase survival and proliferation of infected cells, whereas lytic viral proteins are believed to support the growth factors and angiogenic paracrine secretion useful for tumor growth and progression. Conclusion: HHV-8 is necessary, but not sufficient to cause the KS, and other factors such as immunosuppression also play a role.Key words: Kaposi’s sarcoma, herpes viruses.]]>
<![CDATA[The Correlation between Interleukin-10 Serum with Bacterial Index in Multidrug Therapy-treated Leprosy Patients ]]>
<![CDATA[Eva Krishna Sutedja]]>;
<![CDATA[Jono Hadi Agusni]]>;
<![CDATA[Hartati Purbo Dharmadji]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.16-22
<![CDATA[Background: Immune respons disturbance oftenly found in leprosy patient, mainly in various T cell subset and cytokine immune system arranger. Interleukin-10 produced by Th 2 cell, Th3 cell, monocyte, dendritic cell, eosinophil, mast cell, and keratinocyte. Interleukin 10 (IL-10) works in active macrophage to end the respons to microbe and restore the system to the resting state after the microbes are destroyed. Purpose: To analyze correlation between IL-10 level with Bacterial Index (BI) in Multidrug Therapy (MDT)-treared leprosy patient. Methods: Cross sectional analytical observational study of 43 subjects, consisting of 38 males (88.4%) and 5 females (11.6%). The IL-10 examination used quantitative sandwich enzyme immunoassay, human IL-10 Quantikine® ELISA methods from R & D systems® Result: There was positive correlation between IL-10 and BI of MDT-treated leprosy patient (r = 0,504; p=0,001). Conclusion: The increasing of IL-0 correlated with high BI. Interleukin-10 level is higher in MB type than PB type of leprosy patients.Key words: Interleukin-10 (IL-10), bacterial index (BI).]]>
<![CDATA[Allergic Contact Dermatitis due to Henna Tattoo with Secondary Infection ]]>
<![CDATA[Fransiska Rismauli Natallya]]>;
<![CDATA[Marsudi Hutomo]]>
<![CDATA[ Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/bikk.V28.1.2016.65-70
<![CDATA[Background: Recently henna tattoo become popular. Incidence of allergic contact dermatitis due to henna tattoo is increasing. Para-phenylenediamine (PPD) is suspected as a contact sensitizer because it is often added to henna tattoo to make a darker color. Patch test is needed to determine the allergen. Case: A 18 year-old woman with chief complaint itchy redness patches, burning sensation, and blisters containing pus on her lower left arm after she applied henna tattoo on those site 3 days before. It was the second time applying henna and the reaction was appeared. The patient was treated with oral antibiotic for 5 days, oral antihistamine, and wet dressing with NaCL 0.9% for 3 days. Three days after wet dressing, topical corticosteroid was applied, and the lesion resolved. Patch test was performed 10 months later and showed positive reaction to PPD and toluenesulfonamide formaldehyde resin (TSFR). The previous history, patient had allergy to nail polish which TSFR was suspected as a contact sensitizer. Discussion: Allergic contact dermatitis is a hypersensitivity reaction caused by skin contact with an environmental allergen. Prior sensitization is required for allergy to develop. Patch test is the gold standard to determine the allergen. Based on history and physical examination, clinical relevance of patch test showed positive current relevance (possible) for PPD, and past relevance for TSFR. Conclusion: Avoiding the allergens are important in the management of contact dermatitis.Key words: Allergic contact dermatitis, henna tattoo, para-phenylenediamine (PPD), patch test.]]>
