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Berkala Ilmu Kesehatan Kulit dan Kelamin

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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 493 Documents

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Topical Therapy in Atopic Dermatitis Patient Wahyunita Desi Ratnaningtyas; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is an inflammation skin disorder characterized by itchy, chronic, residif, can occur in infant, child, and adult. The therapy for AD are divided into systemic and topical therapy. Topical therapy is the first line therapy for mild and moderate AD which are the most common type AD. Purpose: To evaluate the pattern of topical therapy in new AD patients. Methods: Retrospective study methods was performed by evaluating medical records of new AD patients who received topical therapy in Allergy Immunology Division, Department of Dermatology and Venereology, Dr. Soetomo General Hospital from 2013 until 2015. The evaluated data included the patient's visitation, age, gender, time visit, patient's complaint, periode of illness, history of atopy, physical examination, management, and follow up. Results: There were 272 patients (83.2%) of 327 new AD patients who received topical therapy. Topical therapies were provided in form of corticosteroid topical for 187 patients (23.6%), emolient for 183 patients (23.1%), and topical antibiotic for 40 patients (5.1%). Patients who did not return to the hospital after first visitation were 174 patients (53.2%). Conclusion: Corticosteroid topical is the first line therapy for atopic dermatitis, but emolient is important to improve skin barrier.

Sensitivity Difussion Test of Cefixime against Neisseria gonorrhoeae from Female Sex Worker with Cervicitis Gonorrhea without Complication who Follow Periodic Presumptive Treatment (PPT) Trisniartami Setyaningrum; Astindari Astindari; Hans Lumintang
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Neisseria gonorrhoeae as etiology of gonorrhoeae infection is considered to be most concerned because of emerging antibiotic resistant strains that compromise the effectiveness of treatment. The emergence of antibiotic resistance has remained a challenge for a few decades. The third generation cephalosporins such as cefixime and ceftriaxone are now the first-line therapy in many region, however, the reduction of the susceptibility to cephalosporins is likely to emerge and spread. Purpose: To evaluate susceptibility of cefixime to Neisseria gonorrhoeae with diffusion test in uncomplicated cervicitis gonorrheae of female sex worker who following Periodic Presumptive Treatment’s program. Methods: The study design was descriptive observational cross sectional for 3.5 months from November 2012-February 2013 in Putat Jaya Public Health Center Surabaya. Results: There were 21 isolates of N. gonorrhoeae from 86 cervical secretions which were performed cefixime diffusion susceptibility test. Based on in vitro cefixime diffusion susceptibility test against N. gonorrhoeae isolates obtained 7 isolates (33.3%) were resistant to cefixime and 14 isolates (66.7%) sensitive to cefixime. From sensitive isolates, 5 of 14 isolates (35.7%) had inhibition zone with a diameter of 31 mm which is the minimum limit of cefixime ability to inhibit the growth rate of N. gonorrhoeae. Conclusions: There were found N. gonorrhoeae isolates that resistant to cefixime and some isolates with near of concentration maximal inhibition of cefixime with diffusion test. Thus it’s necessary to perform sentivity test of cefixime to N. gonorrhoeae using dilution test to obtain the resistance of N. gonorrhoeae to cefixime.

Sindrom Dermatofitosis Kronis Esthy Yuliana; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Latar belakang: Infeksi kulit oleh Tricophyton rubrum merupakan infeksi jamur superfisial terbanyak. Organisme ini dapat menyebabkan suatu sindrom spesifik yang mengenai pasien yang rentan dengan manifestasi yang berbeda-beda, sehingga seringkali tidak disadari oleh klinisi sebagai bagian dari suatu sindrom. Meskipun sudah dilaporkan di berbagai literatur, namun masih belum ada nomenklatur yang jelas mengenai sindrom ini. Tujuan: Membantu dalam menegakkan diagnosis dan memberikan pengobatan yang tepat, karena kasus seringkali luput dari perhatian. Telaah kepustakaan: Bohmer dan kawan-kawan memberikan definisi sindrom dermatofitosis kronis dengan kriteria, yaitu (A) adanya lesi kulit di empat lokasi: (1) kaki, seringkali mengenai telapak kaki, (2) tangan, biasanya telapak tangan, (3) kuku, dan (4) sekurang-kurangnya satu lesi di lokasi lain dari tubuh, kecuali lipat paha; (B) hasil pemeriksaan KOH positif dari kerokan kulit di keempat lokasi; (C) identifikasi T. rubrum dari kultur sel di setidaknya tiga dari empat lokasi. Diagnosis ditegakkan bila memenuhi kriteria (A) and (B) and (C). Sindrom ini seringkali gagal dengan pengobatan konvensional dan kambuh kembali setelah pengobatan dihentikan. Obat antijamur pilihan yang paling tepat adalah itraconazole dan terbinafine. Simpulan: Dalam menegakkan diagnosis, manifestasi klinis harus dikonfirmasi oleh pemeriksaan mikroskopik (KOH) dan kultur, untuk menentukan ada tidaknya jamur spesies tertentu.

Manifestation of Skin Disorders in HIV & AIDS Patients Indah Sari Listiana Dewi; Aﬁf Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Human immunodeﬁciency virus (HIV) can causes deﬁciency of cellular immunity resulting in decreased +lymphocyte T helper (CD4 T cell). Most common infections and neoplastic process of skin in HIV patients were facilitated by loss of CD4 in immune system. Skin disorders are often found in patients with HIV/AIDS, so that the necessary understanding and evaluation are needed for better management. Methods: Descriptive retrospective study using medical records of patients diagnosed with HIV & AIDS related skin disorders in Intermediate Unit Care of Infection Disease Ward, Dr. Soetomo General Hospital, Surabaya in 2013. The type of skin disorder, aged, supporting examination, transmission factors, CD4 counts, and therapy were recorded. Results: HIV & AIDS patients in 2013were about 649 patients, 301 patients (46.3%) among of them suffered from skin disorders. Most of them were in 25-44 years of age (70.8%). The most common skin disorders were oral candidiasis (81.1%). Examinations were performed (52.8%) to conﬁrm the diagnose. Most of transmission factors were well3 known (66.1%). CD4 count cell were clearly noted only 17.3% in medical record, and 12.2% in CD4 1-100 sel/mm. There were 31.6% of patients received ARV. Conclusions: Skin disorders are most common disorders in HIV & AIDS patients and are determined by CD4 count. Oral candidiasis is most common skin and mucocal disorder in HIV & AIDS patient. Key words: HIV-AIDS, skin disorders, CD4+ T cells, oral candidiasis,retrospective study.

The Effects of Platelet Rich Plasma Topical Gel on Chronic Plantar Ulcer Healing in Leprosy Patient Diana Kartika Sari; M. Yulianto Listiawan; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Plantar ulcer is a physical disability that most often occurs in approximately 10-20% of leprosy patient. Conventional therapies such as dressings, surgical debridement, and skin graft can not provide satisfactory improvement. Platelet rich plasma (PRP) has a variety of growth factors required in ulcer wound healing. Purpose: To prove the effect of PRP topical gel to the size of wound, macrophage activation, neovascularization, fibrosis, and formation of granulation tissue on chronic plantar ulcer healing in leprosy patients. Methods: The analytic cohort study of 20 leprosy patients with chronic plantar ulcer in Morbus Hansen Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Biopsies were performed before and after PRP topical gel treatment on leprosy patient with chronic plantar ulcers. Results: After two doses of PRP topical gel, wound size of 9 patients (45%) was reduced <0.5 cm. Statistycal analysis showed significant differences in size of lesions (p = <0.05), the number of macrophages (p = <0.001), number of capillaries (p = 0.003), and the amount of granulation (p = 0.032) before and after PRP topical gel treatment. While the results of the analysis of the number of fibroblasts showed no significant difference (p = <0.05). Conclusion: PRP topical gel treatment gives good results, in terms of improvement in wound size, an increase in macrophages, neovascularization and granulation tissue.

A Retrospective Study: Clinical Manifestation of Genital Herpes Infection Laissa Bonita; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Genital herpes infection was sexual transmitted disease, caused by Herpes simplex virus (HSV) especially type 2. The characteristic of clinical sign is group of vesicles, based on eritematous macule, and often recurrent. Purpose: To evaluate the pattern of genital herpes patients at Sexual Transmitted Infection (STI) Division, Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya, since January 2011 until December 2015. Methods: A retrospective study took, data were obtained medical record of herpes simplex genitalis patients at STI Division, Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya, since January 2011 until December 2015. Results: The number of genital herpes infection cases decreased, 1.8% of patients who came to STI division Outpatient Clinic. Mostly women who were 25–34 years of age. Most common main complaints were pain. Erosion was the most clinical manifestation. The patients mostly got oral acyclovir and analgesic as the treatment. The majority of patient had counseling for about 55.9%. They came to be followed up at least once. Conclusion: The number of genital herpes cases decreased. The most of age affected were sexually active group.

A Diagnostic Test of Tinea Cruris Using Polymerase Chain Reaction Restriction Fragmented Length Polymorphism Cut Putri Hazlianda; Kamaliah Muis; Isma Aprita Lubis
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea cruris is the second most common dermatophytosis in the world and the most common in Indonesia. The conventional diagnostic method fungal culture is slow and less specific, therefore requiring a more rapid and exact diagnostic methods. Polymerase chain reaction (PCR) is a very sensitive and specific test to diagnose various microorganisms including pathogenic fungi. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) is a PCR method with the addition of enzyme after amplification, therefore enabling for more specific results. Purpose: To determine the diagnostic value of PCR-RFLP in the diagnosis of tinea cruris. Methods: This study is a diagnostic test tinea cruris with PCR-RFLP by using culture as the gold standard. The specimens were skin scrapings from thirty-one patients suspected of having tinea cruris from history taking and dermatological examination. The tools and materials that were used in this study were Sabaroud’s dextrose agar media, Internal Transcribe Sequences (ITS) 1 and ITS 4 primer, and MvaI. Results: The values of the diagnostic test yielded in this study are: the sensitivity value was 75%, the specificity was 66.7%, the positive predictive value was 70.6%, the negative predictive value was 71.4%, the positive likelihood ratio was 2.25, the negative likelihood ratio was 0.38, the accuracy value was 70.9%. Conclusion: PCR-RFLP can be used as an alternative tool for the diagnosis of tinea cruris.

Metal Patch Testing with Nickel, Chromium, and Cobalt in Atopic Dermatitis Patients Yuri Widia; Evy Ervianti; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a cutaneous inflammation characterized by skin hyperreactivity due to complex interplay between genetic susceptibility and environmental allergens. In AD, recurrences are frequent and cause problems. Although elevation of total immunoglobulin E (IgE) level; and positive specific IgE to environmental allergens and food are found in most cases, some AD patients with normal IgE level still recurred and raised the possibility of other factors as a trigger. Datas from some studies showed high frequency of positive results in metal patch testing and improvement in AD after allergen elimination and low metals diet. Based on these studies, metal is considered as a trigger of reccurrences in AD. Nickel, chromium and cobalt are the primary metals that gives high frequency of positive patch test results in patients with intrinsic AD. Purpose: To evaluate metal patch testing results with nickel, chromium and cobalt in atopic dermatitis patients at Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya. Methods: This study was observational cross-sectional descriptive study of patch testing to nickel, chromium, and cobalt at 23 AD patients who met the inclusion and exclusion criteria. Results: Patch testing to nickel sulphate metal gave positive result in 17.39% patients, potassium dichromate 8.7%, and cobalt chloride 4.35%. Four people (17.39%) showed positive patch test results; 3 people (13.04%) showed the value of the normal serum total IgE and 1 (4.35%) showed an increasing total serum IgE level. Conclusions: Metal patch testing against AD can be considered in AD patients with normal IgE values.

PEREMAJAAN TANGAN (Hand Rejuvenation) Lodika Handayani; Nelva Karmila Jusuf
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

ABSTRAKLatar belakang: Setelah wajah, tangan merupakan bagian yang mencolok dari tubuh manusia. Penuaan tangan ditandai dengan atrofi kutaneus dan dermal, dengan ruang intermetakarpal yang dalam, tulang dan tendon yang menonjol dan vena retikular yang menggembung. Perubahan epidermal termasuk lentigen solaris, keratosis seboroik, aktinik keratosis, skin laxity, rhytides, tactile roughness, dan teleangiektasis. Peremajaan tangan telah menjadi kebutuhan pasien yang mendatangi praktek dermatologis, kosmetik dan bedah plastik. Tujuan: Membahas mengenai penuaan tangan dan berbagai teknik peremajaan tangan. Telaah kepustakaan: Peremajaan tangan merupakan prosedur medik yang membuat tangan tampak lebih muda tampilannya. Kulit dan jaringan subkutan merupakan target bertahap pada protokol peremajaan tangan. Berbagai teknik peremajaan tangan meliputi teknik revolumesasi dan filler (asam hialuronat, poly-l-lactic acid (PLLA), kalsium hidroksiapatit, dan transfer lemak), pengobatan terhadap vena (skleroterapi dan endovenous laser ablation) dan peremajaan epidermis dan dermis (peeling kimiawi, terapi laser, sinar dan energi). Simpulan: Banyak pilihan yang tersedia untuk peremajaan dan restorasi penuaan tangan, hal ini tergantung pada keluhan dan tanda klinis yang dijumpai pada pasien.Kata kunci: penuaan, penuaan tangan, teknik peremajaan tangan.

Characteristic of Subcutan Mycosis: A Retrospective study Netty Sukmawati; Evy Ervianty
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Subcutaneous mycosis is a rare cases. Incidence of subcutaneous mycosis in Indonesia is unknown. Limited experiences, problems in diagnosis and management may cause difficulties in treating subcutaneous mycosis. Objective: To know the characteristic of subcutaneous mycosis cases in Indonesia and to improve the quality of medical service. Methods: Retrospective study of cases were treated in Departement of Dermatology and Venereology Dr. Soetomo General Hospital within 2010–2014 (5 years). The data include number of cases, age, sex, domicile, complained, risk factors, duration of illness, location of skin lesion, symptoms, laboratory examination, and treatment. Results: a number of cases ranged between 1-8 patients per year. There was 1 case in 2010, 2 cases in 2011, 2 cases in 2012, 2 cases in 2013, and 8 cases in 2014. The diagnosis included eumycetoma, actinomycetoma, chromoblastomycosis, basidiobolomycosis, and phaeohyphomycosis. No cases of sporotrichosis, lobomycosis, and rhinosporodiosis. Majority of patients showed specific characteristic history, clinical manifestation, and histopathology examination, but most culture results were negative. Treatment was given based on diagnosis. Conclusions: Number of subcutaneous mycosis cases per year is 1-8 patients. Diagnosis based on characteristic history, clinical manifestations and histopathology examination.Key words: mycosis subcutan, characteristic, retrospective study.

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