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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

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Articles 493 Documents

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Kaposi’s Sarcoma-associated Herpesvirus Novia Indriyani Adisty; Sawitri Sawitri; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Kaposi’s sarcoma (KS) revealed by Moritz Kaposi first time in 1872. In the early 1980, the prevalence of SK began to increase dramatically. A new finding leads to growth, isolation, and characterization of a novel human herpes virus, now known as Kaposi’s sarcoma-associated herpes virus (KSHV) or Human herpes virus type 8 (HHV-8) from SK lesions. Puspose: To determine the role of herpes viruses in the pathogenesis of KS. Review: KS is a cancer that develops from cells lining the lymph vessels or blood vessels. A number of KSHV encoded protein is known to have the ability to oncogenic transformation, included are latent and lytic proteins. Latent proteins tend to increase survival and proliferation of infected cells, whereas lytic viral proteins are believed to support the growth factors and angiogenic paracrine secretion useful for tumor growth and progression. Conclusion: HHV-8 is necessary, but not sufficient to cause the KS, and other factors such as immunosuppression also play a role.Key words: Kaposi’s sarcoma, herpes viruses.

The Correlation between Interleukin-10 Serum with Bacterial Index in Multidrug Therapy-treated Leprosy Patients Eva Krishna Sutedja; Jono Hadi Agusni; Hartati Purbo Dharmadji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Immune respons disturbance oftenly found in leprosy patient, mainly in various T cell subset and cytokine immune system arranger. Interleukin-10 produced by Th 2 cell, Th3 cell, monocyte, dendritic cell, eosinophil, mast cell, and keratinocyte. Interleukin 10 (IL-10) works in active macrophage to end the respons to microbe and restore the system to the resting state after the microbes are destroyed. Purpose: To analyze correlation between IL-10 level with Bacterial Index (BI) in Multidrug Therapy (MDT)-treared leprosy patient. Methods: Cross sectional analytical observational study of 43 subjects, consisting of 38 males (88.4%) and 5 females (11.6%). The IL-10 examination used quantitative sandwich enzyme immunoassay, human IL-10 Quantikine® ELISA methods from R & D systems® Result: There was positive correlation between IL-10 and BI of MDT-treated leprosy patient (r = 0,504; p=0,001). Conclusion: The increasing of IL-0 correlated with high BI. Interleukin-10 level is higher in MB type than PB type of leprosy patients.Key words: Interleukin-10 (IL-10), bacterial index (BI).

A Retrospective Study: Erysipelas and Cellulitis Patients’ Profile Amalia Rositawati; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Erysipelas and cellulitis are acute infectious diseases caused by Streptococcus pyogenes/haemolytic and Staphylococcus aureus, which attack the subcutaneous tissue and superficial areas (dermis and epidermis). In the course of the disease, erysipelas and cellulitis often fall in a serious condition that requires proper handling. Purpose: To determine a general overview as well as predictive factors of the severity of erysipelas and cellulitis condition. Methods: Retrospective study by evaluating medical records of erysipelas and cellulitis patients in Medical Ward of Dermatology, Dr. Soetomo General Hospital Surabaya from the period of 2012-2014. Results: The incidence of new cellulitis patients during 2012-2014 were 29 cases (67.4%) while erysipelas 14 cases (32.6%). Most of chief complaint were the form of swelling, redness, and pain sensation. The most common of prodromal symptoms were febris, precipitating factors largely due to scratching and stab wounds. Most underlying disease of both erysipelas and cellulitis was anemia. Predilection was common in the lower extremities in erysipelas (92.8%) and cellulitis (93.1%). Normal count of leukocytes in patients with erysipelas was 52.9% and 56.25% in patients with cellulitis. Culture examination was perfomed in 33 (76.74%) of the total 43 cases. Ampicillin injection therapy was commonly used in 22 patients (51.1%). Conclusion: The correct management could increase the recovery rate, prevent complication and recurrency of erysipelas and cellulitis. Key words: cellulitis, erysipelas, Streptococcus pyogenes/haemoliticus, Staphylococcus aureus.

Open Oral Food Challenge in Adult with Food Allergy to Chicken Meat Yosi Charly; Cita Rosita SP; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Food allergy is a hypersensitivity of the body's response to food. Food allergies are divided into three groups: immunoglobulin E (IgE) mediated, non-IgE mediated, and mixed IgE mediated with non-IgE mediated. Food allergies can be life threatening, causing malnutrition, eating disorders, and psychosocial problems. The gold standard for the diagnosis of food allergy is double-blind placebo-controlled food challenge (DBPCFC), but time consuming, costly, and a resuming specialist to perform it. Open oral food challenge (OFC), commonly used as screening in the clinic, with food suspected of being in its true form, in particular to look for symptoms. Objective: To evaluate specific IgE and open OFC in adult patients with a history of food allergies to chicken. Methods: Descriptive cross-sectional study involving 28 adult patients with history of food allergies to chicken were diagnosed as urticaria, angioedema, and atopic dermatitis. Specific IgE chicken meat was performed and patients were asked to eliminate chicken for 1 week before open OFC. Results: Twenty eight samples, specific IgE within normal limit. Positive results of open OFC were found in 9 people and 19 negative result. Conclusion: The specific IgE chicken does not always correlate with clinical reactivity and open the OFC can be used for the diagnosis of food allergy to chicken meat. Key words: food allergies, spesific Ig E, open oral food challenge.

Allergic Contact Dermatitis due to Henna Tattoo with Secondary Infection Fransiska Rismauli Natallya; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Recently henna tattoo become popular. Incidence of allergic contact dermatitis due to henna tattoo is increasing. Para-phenylenediamine (PPD) is suspected as a contact sensitizer because it is often added to henna tattoo to make a darker color. Patch test is needed to determine the allergen. Case: A 18 year-old woman with chief complaint itchy redness patches, burning sensation, and blisters containing pus on her lower left arm after she applied henna tattoo on those site 3 days before. It was the second time applying henna and the reaction was appeared. The patient was treated with oral antibiotic for 5 days, oral antihistamine, and wet dressing with NaCL 0.9% for 3 days. Three days after wet dressing, topical corticosteroid was applied, and the lesion resolved. Patch test was performed 10 months later and showed positive reaction to PPD and toluenesulfonamide formaldehyde resin (TSFR). The previous history, patient had allergy to nail polish which TSFR was suspected as a contact sensitizer. Discussion: Allergic contact dermatitis is a hypersensitivity reaction caused by skin contact with an environmental allergen. Prior sensitization is required for allergy to develop. Patch test is the gold standard to determine the allergen. Based on history and physical examination, clinical relevance of patch test showed positive current relevance (possible) for PPD, and past relevance for TSFR. Conclusion: Avoiding the allergens are important in the management of contact dermatitis.Key words: Allergic contact dermatitis, henna tattoo, para-phenylenediamine (PPD), patch test.

A Retrospective Study: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Yuli Wahyu Rahmawati; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) is rare, but threaten the patient's life. Purpose: To evaluate management of SJS and TEN. Methods: A retrospective study to patient with SJS and TEN in 2011-2014, data regarding the prevalent of patients, history of patients, etiology, clinical manifestation, supporting of examination, therapy, complication, mortality, follow up, and duration of treatment patients recorded from medical report. Result: Total patient with SSJ and NET were 37 patients. Most patients were female (73%) with majority age range 25-44 years (48.6%), epilepsy is the most comorbidities (27%), the main etiology the use of drug (62.1%), the highest class of drugs is analgesic drugs (38.6%), 37 patients using corticosteroid for therapy (100%), skin is the most complication (50.9%), and death rate was zero (0%). Conclusion: Management of patients with SJS and TEN gives complete recovery. Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, management.

The Relation between Healing Time and Patient’s Characteristic in the Treatment of Common Warts with the Application of 80% Phenol Solution Dina Arwina Dalimunthe; Remenda Siregar; Chairiyah Tanjung
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Common warts are skin diseases which caused by human papilloma virus (HPV) infection. There are many modalities treatment for common warts, one of them is the application of 80% phenol solution that is classified as topical treatment. Purpose: To determine the healing time in treatment of common warts with the application of 80% phenol solution and it’s relation with age and sex of the patients. Methods: Open clinical trial was done at Dr. Pirngadi General Hospital Medan and H. Adam Malik General Hospital Medan from February to June 2013 on 17 patients with common warts. The application of 80% phenol solution was performed on patients and continued every week until complete regression, maximum of 6 weeks. Follow up was carried out every week for six weeks to observe healing time. Data were analyzed by Mann-Whitney test with α=0,05. Result: After six weeks, 11 patients (64,7%) were healed. Healing time was varied from 3 to 6 weeks, mostly 4 weeks (45,4%). Result of Mann-Whitney test showed statistically significant relationship between healing time and age (p=0,027) whereas the healing time were faster on patient 14 years and older, and no relation between healing time and sex (p=0,422). Conclusion: There was relation between healing time in application of 80% phenol solution with age in treatment of common warts and no relation with the sex of the patient.Key words: common warts, 80% phenol solution.

Profile of Serum Insulin-like Growth Factor-1 Levels in Patients with Acne Vulgaris I G.A. Kencana Wulan; Afif Nurul Hidayati; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne vulgaris (AV) is a skin disease that is commonly found in adolescence. In addition to causing physical disorders, acne vulgaris affects the quality of life of patients that cause social disorder, psychological, and emotional. Based on the observations of the experts, AV is rarely found in non-westernized populations, indicates an underlying environmental factors including diet. Excessive sebum production has an important role in the pathogenesis of AV. One of the factors which allegedly associated with the production of sebum and diet is IGF-1 in serum. Purpose: To evaluate the levels of IGF-1 serum in patients with AV with varying degrees of severity. Methods: This study is an observational cross-sectional study in 38 AV patients aged 15-24 years at the Outpatient Clinic of Dermatovenereology Department of Dr. Soetomo Hospital Surabaya as many as 38 people. The severity of AV are grouped according to the method of Combined Acne Severity Classification (CASC). Anamnesis of diet based on the table of load and glycemic index foods. Subjects has been collected through consecutive sampling. Results: Serum IGF-1 levels in the mild AV group was 155,000 (SD±23,381) µg/ml, in the moderate AV group was 211,052 (SD±85,498) µg/ml and in severe AV group was 150,000 (SD±45,826) µg/ml. Serum IGF-1 levels in male group was higher than female, was 199,230 (SD±85,582) µg/ml and in female group was 174,000 (SD±58,238) µg/ml. Serum IGF-1 levels in the aged group of 15-20 years was 192,270 (SD±80,766) µg/ml, higher than the aged group of 21-24 years, was 169,380 (SD±46,829) µg/ml. Conclusion: The mean levels of IGF-1 in patients with moderate degrees of AV was higher than mild or severe. IGF-1 levels can vary influenced by many factors. Key words: acne vulgaris, serum IGF-1, severity degrees of acne vulgaris.

Eosinophil and Eosinophil Cationic Protein Level Raising in Dermatitis Due to Food Patients Menul Ayu Umborowati; Sawitri Sawitri; Marsoedi Hoetomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Food allergy prevalence worldwide has been increase. Skin is secondary most often target organ in food allergy reaction. Food allergy affects 35% atopic dermatitis (AD) patients. Diagnosis of food allergy is still challenge because signs are not speciﬁc. Previous researches showed eosinophil and eosinophil cationic protein (ECP) role in food allergy reaction on gastrointestinal tract, but none on dermatitis due to food. Purpose: To evaluate eosinophil and serum ECP in dermatitis due to food. Method: This is a descriptive observational cross sectional study, with dermatitis due to food patients in Dermatovenereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya as subjects. Subjects has been collected trough consecutive sampling during 3 months, then data were analysized descriptively Results: Serum ECP level of dermatitis due to food patients were above normal range in all subjects, with mean level 108.5 µg/L, lowest level 33.011 µg/L and higher level 284.849 µg/L. Mean eosinophil of dermatitis due to food patients just arise above normal limit (0.413µg/L). AD patients were 48.4% among all subjects. Mean serum ECP level of AD patients was higher (121.703 µg/L) than non-AD (96.123 µg/L). Conclusions: Eosinophil and ECP seems have role in dermatitis due to food pathogenesis. Serum ECP examination can be beneﬁts to monitor dermatitis due to food severity.Key words: dermatitis due to food, eosinophil, serum eosinophil cationic protein.

Retrospective Study: Characteristic of Herpes Zoster Patients Lia Kinasih Ayuningati; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Herpes zoster (HZ) is a disease caused by the Varicella-zoster virus (VZV) that localized, primarily affects adults with characteristics of radicular pain, unilateral, and group of vesicles distributed according to dermatomes, innervated by a sensory nerve ganglion. Several risk factors for HZ is older populationand cellular immune dysfunction. Purpose: To evaluate general overview of HZ patients, hence better management can be provided. Methods: Retrospective study of newly diagnosed HZ patientsin Kemuning ward Dr. Soetomo General Hospital Surabaya during 2010-2013. Results: This study showed most commonly affected women (55.9%), themost common age was45-64 years old (40.7%)and the most common location was HZ thoracalis (31.4%). Conclusion: HZ is a common disease, which most commonly occured illness in elderlywith predisposing factors, that can determine the course of the disease, so we need proper management and education.Key words: herpes zoster, retrospective.

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