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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 505 Documents

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Melanocyte Function and Count of Leukotrichia in Vitiligo Using S100 Immunohistochemistry and Microphtalmia Associated Transcription Factor (MITF) M. Yulianto Listiawan; Marina Rimadhani; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Melanocyte of the hair follicle is one of the major sources of repigmentation in vitiligo. Leukotrichia is complete depigmentation with significant bleaching hair. Leukotrichia in nonsegmental vitiligo may contribute to the lack of response to medical treatment. Leukotrichia is often associated with absent of melanocyte, showing poor prognosis for vitiligo treatment. Purpose: To evaluate melanocyte count and function of leukotrichia’s melanocyte in vitiligo and comparing with other feature. Method: Melanocyte count in each feature of lesional skin in 18 segmental vitiligo patients were evaluated based on vitiligo extent tensity index (VETI). Melanocyte count has been evaluated using immunohistochemistry S100 and microphtalmia associated transcription factor (MITF). Results: Eighteen patients were nonsegmental vitiligo, and five of them had leukotrichia. Two of five leukotrichia patients did not express MITF nor melanocyte. There were no differences of melanocyte and MITF expression between patient with or without leukotrichia. Conclusion: Leukotrichia is a poor indicator for treatment response in vitiligo, but this research showed that leucotrichia may not contribute to the lack of response upon medical treatment.

Significant Different Level of Malondialdehyde (MDA) as Oxydative Stress Marker in Severity Groups of Acne Vulgaris Sylvia Anggraeni; Trisniartami Setyaningrum; M Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne vulgaris (AV) is a common chronic inflammatory disease of sebaceous gland that may decrease patient’s quality of life. Oxidative stress is suggested to play role in the pathogenesis of AV. Purpose: To evaluate the differences of malondialdehyde (MDA) level as oxidative stress marker in AV severity. Method: This is an analytic observational cross sectional research of AV patients in Cosmetic Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo hospital Surabaya. Subjects were collected through consecutive sampling since May-August 2015. Total samples were 42 patients, classified into 3 severity groups (mild, moderate, severe). Samples were taken from blood vein, examined with Enzyme-linked immunosorbent assay (ELISA) then analyzed statistically. Results: There were differences of MDA mean level among AV severity groups: mild 58.371 ng/ml (SD±25.2141); moderate 99.121 ng/ml (SD±8.5172); and severe 171.779 ng/ml (SD±49.9694). Post hoc analytic revealed that there were statistically differences of MDA level in all stages (mild-moderate p=0.002; mild-severe p=0.000; moderate-severe p=0.000). Conclusions: This research revealed that oxidative stress plays a role in AV pathogenesis. Lipid peroxidation process in sebum produced lipid oxidant that could induce inflammatory process in sebaseous gland via Peroxisome Proliferator-Activated Receptor (PPAR).

The Pathogenesis of Atopic Dermatitis: The Role of Filaggrin Tamarachiara Kuntjoro; Erna Harijati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a multifactorial skin disease with waxing and waning inflammatory process. In recent years, genetic mutations namely the null mutations of the filaggrin gene (FLG) has been the focus in AD risk factors investigations. Purpose: To highlight the emerging topic on the role of filaggrin as an important element in the pathogenesis of AD. Reviews: Filaggrin binds to cytoskeleton keratin to bring the physical strength to corneocytes. Filaggrin will be degraded to amino acids that conserve acidic pH and condensation of the skin. Patients with FLG null mutations are more likely to experience early-onset, severe and persistent AD. AD patients with FLG R501X null mutations are reported to be the least responsive to therapy. Conclusion: A filaggrin deficit is the main culprit in AD development that eventually leads to the defective skin barriers, reduction in natural moisturizing factors (NMF), infections and inflammation. FLG mutations associates with the phenotypes and course of AD which could be examined using Raman-determined NMF.

The Role of Human Papillomavirus in Bowenoid Papulosis Yuli Wahyu Rahmawati; Dwi Murtiastutik; Sjahjenny Mustokoweni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Human Papillomavirus (HPV) infection can be associated with a variety of cutaneous as well as mucosal manifestations. Some types of HPV are associated with increased risk of epithelial malignancies; these have been divided into low-risk and high-risk types based on their oncogenic potential. Bowenoid papulosis (BP) strongly associated with high risk type. Purpose: To provide information to health workers, in order to be more concern about BP.Review: The term BP refers to multifocal papular lesions on the genitalia with histological features similar to squamous cell carcinoma (SCC) in situ or Bowen’s Disease (BD). Its clinical manifestation is characterized by multiple brownish or erythematous papules located in the anogenital region, affecting mostly young adults with an active sex life. Clinically, it must be differentiated from seborrheic keratosis, and melanocytic nevus. Bowenoid papulosis is strongly associated with HPV 16.Conclusion: The natural course of BP is unpredictable, the lesions may increase, decrease, and even disappear spontaneously. Progression to an invasive SCC has been estimated in 2.6% of cases, HPV type 16 is the most frequent causative agent of BP.

TINEA KAPITIS PADA REMAJA Nurina Dhani Rahmayanti; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Tinea kapitis adalah infeksi dermatofita pada kulit kepala, alis dan bulu mata yang cenderung menyerang rambut dan folikel, umumnya pada anak. Pada remaja dapat diberikan terapi sesuai terapi standar tinea kapitis. Kasus: Remaja wanita, 16 tahun, berat badan 33kg dengan amenore primer, datang ke Poli Kulit dan Kelamin RS Dr. Soetomo Surabaya karena kebotakan di kepalanya sejak 3 minggu sebelumnya. Awalnya berupa bercak kemerahan, gatal, tertutup sisik tipis. Rambut berubah menjadi abu-abu, kusam, mudah rontok sehingga menyebabkan kebotakan. Pemeriksaan fisik dan laboratorium dalam batas normal. Pemeriksaan dermatologis menunjukkan adanya alopesia diameter 10 cm x 10 cm dengan plak eritematosa ringan tertutup skuama tipis di daerah parieto-occipitalis. Rambut keabu-abuan, kusam, mudah dicabut. Pemeriksaan wood lamp menunjukkan fluoresensi hijau terang. Pemeriksaan KOH menunjukkan adanya spora ektotrik. Hasil kultur Sabouraud Dextrose Agar (SDA) positif dan diidentifikasi sebagai Microsporum audouinii. Penderita didiagnosis dengan tinea kapitis tipe greypatch, diberikan griseofulvin 125mg tablet mikron 2x3 per hari dan sampo ketoconazole 2% sehari sekali. Pada follow-up minggu ke-6, lesi membaik, gatal berkurang, pemeriksaan wood lamp dan KOH memberikan hasil negatif. Diskusi: Pada pasien ini, terdapat amenore primer, dimana kadar hormon progesteron rendah menyebabkan berkurangnya produksi sebum sehingga komponen free fatty acid yang berfungsi fungistatik dan fungisidal juga rendah dan meningkatkan resiko tinea kapitis. Griseofulvin merupakan terapi pilihan untuk kasus tinea kapitis yang disebabkan oleh spesies Microsporum audouinii

Retrospective Study: Oral Therapy in Children with Atopic Dermatitis Asmahani Thohiroh; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is an inflammation skin characterized by itchy, chronic, residif; can occur in infant, child, and adult. The therapy for AD are divided into systemic and topical therapy. Systemic therapy includes antihistamine and corticosteroid. Purpose: To evaluate pattern of oral therapy in new child AD patient. Methods: Retrospective study methode was performed by evaluating medical records of new child AD patient who received oral therapy in Pediatric Division, Departement of Dermato-veneorology Dr. Soetomo General Hospital 2010 until 2012. The evaluated data include the patient's visitation, age, gender, time visit, patient's complain, periode of illness, history of atopy, physical examination, management, and follow up. Results: There were 558 patients (88.9%) of 628 new child AD patients who received oral therapy. Oral therapies were provided in form of antihistamine for 518 patients (92.8%), oral antibiotic for 129 patients (23.1%), and corticosteroid for 40 patients (7.2%). Patients who did not return to the hospital after first visitation were 461 patients (82.6%). Conclusions: Most of the child AD patient got an oral therapy. Most of the oral therapy was antihistamine.Key words: atopic dermatitis, child, oral therapy, retrospective.

Formulation Cream of Extract Moringa oleifera Leave as Antiaging Nining Sugihartini; Evi Nuryanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Moringa oleifera leaf as natural material has the activity to protect skin because it contains antioxidants. Therefore, the development of dosage forms in the form of a antiaging cream is required to be used by the human. Purpose: To determine the concentration of extract moringa oleifera leaf which will provide the ability as antiaging. Methods: Extract of moringa oleifera leaf was obtained by maceration methods by ethanol 70% as solvent. Then extract was formulated in dosage forms an antiaging cream with concentration of variations are formula I (0%), formula II (3%), formula III (6%) and the formula IV (9%). After that cream was evaluated with parameters moisture, evenness, pore, spot and wringkle on human probandus whom have used the cream for 14 days. Results: Increasing the concentration of Moringa oleifera leaf extract led to a decreasing evenness (p<0.05) which efective on concentration 3%. Conclusion: The concentration of Moringa oleifera leaf extract that can be used as antiaging which decreasing evenness was 3%.

Evidence Based Treatment of Alopecia Areata Eva Hariani; Nelva K. Jusuf
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Alopecia areata is a chronic autoimmune disease, involving non-scarring hair loss, which affects hair follicles and sometimes nails. Hair loss pattern presents as patchy alopecia, ophiasis, ophiasis inversa (sisapho), reticularis or diffuse. Alopecia areata is common disorder and can impact on patient’s quality of life. Purpose: To review commonly used evidence based treatments of alopecia areata. Review: A number of treatments for alopecia areata have been showed to stimulate hair growth but there is no universally proven therapy that sustains remission. There is high rate of spontaneous remission in alopecia areata makes difficult to assess effectiveness of treatment (spontaneous remission occurs in up to 80% of patients). Numerous of topical and systemic treatment for alopecia areata have been assessed by randomized controlled trials. However management of patients with alopecia areata is still challenging. Conclusion: A number of treatments were found to be effective for alopecia areata. Based on randomized controlled trials, contact immunotherapy has the highest therapeutic evidence based level. Potent topical corticosteroid and intralessional corticosteroids are recommended for limited patchy hair loss and contact immunotherapy for extensive patchy hair loss and alopecia areata totalis/universalis.

Profile of Serum Interferon Gamma Induced Protein 10 in Borderline Leprosy Patients with and without Type 1 Leprosy Reaction Agustina Tri Pujiastuti; Indropo Agusni; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred. Purpose: To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction. Methods: This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria. Results: Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123 ± 327,628 pg/mL and 331,648 ± 101,819 pg/mL in groups without reaction. Conclusions: Serum IP10 levels in borderline leprosy patient with type 1 reaction is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Further studies are needed to reveal the role of IP`10 in type 1 leprosy reaction.

Pengaruh Pemberian Topikal Campuran Produk Metabolit Amniotic Membrane Stem Cell (AMSC) pada Penyembuhan Ulkus Plantar Kronis Morbus Hansen Asmahani Thohiroh; Cita Rosita SP; Sawitri Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Ulkus plantar kronis pada Morbus Hansen (MH) masih menjadi permasalahan dalam hal medis maupun sosial pasien. Produk metabolit amniotic membrane stem cell (AMSC) mengandung growth factor dan sitokin yang dibutuhkan pada penyembuhan ulkus kronis. Vitamin C sebagai antioksidan, antiinflamasi, dan sintesa kolagen bermanfaat pada penyembuhan luka. Campuran keduanya diharapkan dapat membantu penyembuhan ulkus kronis MH. Tujuan: Untuk membuktikan pengaruh pemberian topikal campuran produk metabolit AMSC dengan vitamin C pada prosentase penyembuhan ulkus plantar kronis Morbus Hansen yang lebih cepat dibandingkan perawatan standar dengan framycetin gauze dressing (FGD). Metode: Penelitian merupakan penelitian eksperimental analitik dengan menggunakan metode uji klinis terkontrol, pemilihan pasangan serasi, dan desain paralel yang membandingkan terapi topikal gel campuran produk metabolit AMSC dengan vitamin C (PM-AMSC-VC) (perlakuan) dan FGD (kontrol) pada pasien ulkus plantar kronis MH. Hasil: Rerata prosentase penyembuhan ulkus setiap minggu dan diakhir studi didapatkan rerata prosentase yang lebih besar pada kelompok perlakuan yang mendapatkan gel campuran produk metabolit AMSC dengan vitamin C dibandingkan dengan kelompok kontrol yang mendapatkan FGD. Didapatkan perbedaan bermakna sebelum dan sesudah pengobatan pada selisih luas dan dalam ulkus antara kelompok campuran produk metabolit AMSC dengan vitamin C dan FGD, yaitu pada selisih luas ulkus didapatkan hasil p=0,012 dan selisih dalam ulkus p=0,015. Simpulan: Pemberian topikal campuran produk metabolit AMSC dengan vitamin C memberikan hasil yang baik pada penyembuhan ulkus plantar kronis MH.

Page 13 of 51 | Total Record : 505

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