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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 24 Documents

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Search results for , issue "Suppl 1, No. 1 (2018)" : 24 Documents clear

In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet, Yuliet; Sukandar, Elin Yulinah; Adnyana, I Ketut
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Hisbiscus surattensis L the local name âtamoenjuâ is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on Î±-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as Î±-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: Î±-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.

The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic Febriani, Yessi; Riasari, Hesti; Winingsih, Wiwin; Aulifa, Diah Lia; Permatasari, Ayu
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Red ginger (Zingiber officinale Roscoe) had been used as excipient in jamu for most people in Indo- nesia. Based on recent research, ethanol extract of red ginger had analgesics activity. The purpose of this research to determine analgesic activity content in water extract of the fresh and dry red ginger and ethanol extract of fresh and dry of red ginger dregs. Fresh and dry of red ginger extracted using decoc- tion method, and the dregs of fresh and dry red ginger extracted using soxhletation method in ethanol 96% at 400C. Red ginger water extract and red ginger dregs extract had been examined for analgesic by witkin method. The results showed, fresh and dry red ginger water extract had analgesic activity for 25 minutes but the activity reduced in 30 minutes. Fresh and dry red ginger dregs ethanol extract still had analgesic activity until 30 minutes. TLC chromatogram was sprayed with FeCl3 and formed two spots with grey colour for both extracts. After sprayed with vanillin sulfate, it formed violet and blue spots from both extracts. From the retention factor (Rf) , possibility shogaol and gingerol contained in extract that have analgesic activity. Key words: Analgesic, dregs, phenolic, red ginger (Zingiber o cinale Roscoe), Witkin method.

Cytotoxic Assay From Stem Bark Aglaia minahassae and Aglaia simplicifolia Against HeLa Cervical Cancer Cell Lines Kurniasih, Nunung; Milawati, Hersa; Fajar, Mohamad; Abdulah, Rizky; Putri Huspa, Desi Harneti; Supratman, Unang
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Cervical cancer ranks as the 2nd leading cause of female cancer in Indonesia. One of healing methods is chemotherapy, but this method still has many side e ects and also expensive treatment. Therefore, natural products discoveries need to be developed due to its important role as an alternative for anti- cancer drug. The aim of this research was to get IC50 value from methanol, n-hexane, ethyl acetate, and n-buthanol from stem bark of A. minahassae dan A. simplicifolia. Stem bark of A. minahassae (1.6 kg) and A. simplicifolia (1.1 kg) was grounded by methanol and its extract is successively extracted by n-hexane, ethyl acetate, and n-buthanol. Their extractâs cytotoxicity was then evaluated against HeLa cell lines. This research showed that A. minahassaeâs most cytotoxic extract against HeLa cell lines was n-hexane (IC50 = 27.4190 Î¼g/mL) and n-buthanol (IC50 = 4.3924 Î¼g/mL). Meanwhile, A. sim- plicifolia most cytotoxic extract extract against HeLa cell lines was n-hexane (IC50 = 23.3098 Î¼g/mL). Key words: A. minahassae, A. simplicifolia, cytotoxic assay, HeLa cell lines

Cytotoxic Activity and Phytochemical Analysis of Breynia cernua from Papua Dirgantara, Septriyanto; Tanjung, Rosye H.R.; Maury, Hendra K.; Meiyanto, Edy
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Breynia cernua (local name Katuk Hutan) is an Indonesian medicinal plant (family: Euphorbiace- ae) originated from Papua which have been used traditionally as alternative treatment for breast and cervical cancer. The objectives of this research were to investigate potential cytotoxic activity and phytochemical aspect test of B. cernua extract and its fractions. Extraction was performed by macera- tion using ethanol 96%, followed by successive fractionations. Phytochemical screening and in vitro cytotoxic activity test were obtained for extract and active fraction with Brine Shrimp Lethality Test (BSLT) method and MCF-7 tumor cell lines were assessed by 3-(4-5-dimethylthiazol-2yl)-2,5-diphe- nyl tetrazolium bromide (MTT) assay. The results from cytotoxic activity test of breast cancer MCF-7 cell line from ethanolic 96% extract and three fractions: n-hexane, ethylacetate and water fractions showed 246.841 ppm, 165.65 ppm, 562.57 ppm dan 713.78 ppm respectively meanwhile the IC50 value of doxorubicin as the positive control was 6 Î¼M. TLC and phytochemical screening showed the pres- ence of alkaloids, terpenoid, avonoids and tannins compounds in this active plant. Keywords: Antitumor, Breynia cernua, BSLT, MCF-7

Mulberry Leaves (Morus alba) for Diabetes Mellitus: Acute Toxicity Test in Male Wistar Rats Nurita, Rena; Vitriana, Anisa; Sukmara, Isni Maulina; Utami, Nurul; Maryam, Maryam; Huda, Fathul; Yunivita, Vycke
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Diabetes mellitus (DM) is a chronic disease which becoming health community problem in the world. DM patients can be treated by antidiabetic drugs throughout their lifetime. Therefore, to alleviate the concern for the side e ect, it is important to have an alternative therapy which has same e ect but less side e ect. One of alternative therapies which has been known for a long time ago is Mulberry leaves (Morus alba). For something to be clinically used as an alternative therapy, e ective and lethal dose should be known. Here we tried to discover the lethal dose (LD50) and the liver morphological changes, using the e ective dose that had been known from previous study. In our experiment, we used Morus alba leaves infusion and 25 male Wistar rats. These rats were divided into 1 control group and 4 groups treatment dosage, 0.3, 3, 30, and 300 grams/kg bodyweight. We observed the mortality in 7 days and examined the liver morphological changes. From this study, we conclude that 300 grams/ kg bodyweight or 48 grams/kg bodyweigtht in human was pseudolethal dose in male Wistar rats. We did not found any signi cant liver morphological changes. Therefore, we can categorize Morus alba as a harmless alternative therapy. Key words: Alternative therapy, diabetes mellitus, liver morphological changes, lethal dose, Morus alba.

Crystallization and Biological Studies of Nypa fruticans Wurmb Sap Hafizi, Sukairi A.; Razip, Asaruddin M.; Aliana, Wan S. W. M.; Tarmizi, Wan Y. S. A.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Nypa fruticans is a standout amongst the most broadly appropriated and helpful palm in the mangrove backwoods in the Southeast Asia. The sap of this plant is produced at the fruit stalks or called as ower stalks or in orescence. Nipa sap contains a lot of chemical constituents that can be used other alter- native to produce sugar that give a lot bene ts. The crystallization process of this sap was conducted in controlled temperature, pressure and humidity. As the crystal formed, remaining liquid was tested for biological studies which are antidiabetic, antioxidant and toxicity test. The antidiabetic properties were determined by inhibition of Î±-amylase and the result was compared to the synthetic drug which is acarbose. The sample showed that a high property of antidiabetic (50 mg/mL= 78.50% inhibition) compared to the acarbose (50 mg/mL= 80.90% inhibition). Meanwhile, the antioxidant properties of the sample were determined by2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. The sample also showed a positive result which is EC50 112.90 mg/mL. Lastly, the toxicity test was tested to brine shrimp (Artemia salina) to get the LC50. The result (LC50=271.7 mg/mL) showed low toxic- ity at different concentration of the sample. From this study, the sample had potential antioxidant and antidiabetic properties, with low toxicity. Key words: Î±-amylase, antioxidant, Artemia salina, Nypa fruticans, toxicity test

Effect Of Ethanol Extract Of Kenikir (Cosmos caudatus Kunth.) Leaves in Blood Glucose, Cholesterol and Histopathology Pancreas of Male White Rats (Rattus norvegicus) Tandi, Joni; Claresta, Jong A.; Ayu, Gusti; Irwan, Irwan
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The aim of this study was to investigate the effects extract of Kenikir in male rats parameters blood glucose, cholesterol and histopathological of the pancreas. Thirty rats were divided into six groups, and each group consists of five individuals with the details of groups I, II, and III as control groups and groups IV, V, and VI for the experiments. Group I: normal control was given NaCMC 0,5%; Group II: control negative was given Streptozotocin 30 mg/kgBW i.p, high feed fat 25 g/day, and the positive control was given met form in 45 mg/kgBW, and the experimental groups were each given extract of the kenikir leaves with dose 100 mg/kg BW, 200 mg/kgBW , and 400 mg/kg BW. The results showed that there were secondary metabolites contained in the extract of leaves of kenikir. Giving the extract of kenikir leaves at the dose of 200 mg/kg is effective in lowering the blood glucose levels, extract of leaves of kenikir with the dose of 400 mg/kg is effective to reduce the total cholesterol levels and regenerate pancreatic tissue, and extract of leaves of kenikir with the dose of 100 mg/kg BW did not give any maximum impacts to decrease the blood glucose. Keywords: Cholesterol, diabetic, histopathology, kenikir leaves ethanol extract

Cytotoxicity and Antimicrobial Activity of Propolis from Trigona itama Stingless Bees against Staphylococcus aureus and Escherichia coli Yusop, Syed A. T. W.; Asaruddin, Mohd R.; Sukairi, Ahmad H.; Sabri, Wan M. A. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Trigona itama is a stingless bees that produce honey which has been used widely as a traditional medicine. Due to limited research and knowledge on T. itama propolis, it becomes less popular in industrial production than honeybee propolis. The aim of this study was to identify the antibacterial activity and toxicity level in hexane, ethyl acetate and methanol extracts of T.itama propolis. T.itama propolis crude extract was tested for antibacterial activity by using disk di usion method. The antibacterial activities were assessed according to the inhibitory zone of agar medium with sample concentration of 1000 Î¼g/mL, 750 Î¼g/mL and 500 Î¼g/mL. The result from this study revealed that all T. itama propolis crude extract shows presence of inhibition zone against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The brine shrimp lethality test was used to monitor the toxicity level of T. itama propolis where methanol, ethyl acetate and hexane fraction showed low activity of toxicity where all crude extract LC50 showed above 250 Î¼g/mL. It could be concluded from this study that extract from T. itama propolis possessed antimicrobial activity and low level of toxicity. Key Words: Escherichia coli, propolis, stingless bees, Staphylococcus aureus, Trigona itama

Reversibility Time in Testicular Damage on Male Wistar Rat after Treatment of Averrhoa blimbi L. Fruits Extract as Antifertility Alipin, Kartiawati; Rochman, Indra A.; Malini, Desak M.; Madihah, Madihah
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Belimbing wuluh (Averrhoa blimbi) fruit is commonly used traditionally as antifertility. The bioactive compounds of A. blimbi have been known could inhibit spermatogenesis and development of testes, as well as decrease the quality and quantity of spermatozoa, thus, caused seminiferous tubular atro- phy. This study aimed to determine the reversibility time in testicular damage after the treatment of A. blimbi fruit extract on male Wistar rat. The method employed a completely randomized design (CRD) consists of nine treatments with three replications each. The treatment of the extract at a dose 1140 mg/ kg BW and control group was given the solvent. After 14 days of treatment, the reversibility time was examined in testis histological section by interval of seven days each until 49 days. The results showed that the treatment of A. blimbi fruit extract caused disruptions in seminiferous tubules, i.e. decreased the number of spermatogonium and spermatid, as well as the diameter of lumen and seminiferous tu- bules. The reversibility time was observing at 21 days after the end extract treatments, by increasing the number of of spermatogonium and spermatid, as well as the diameter of lumen and seminiferous tubules that signi cantly different with infertile rat (p<0.05). In conclusion, the reversibility time was 21 days after the treatment of A. blimbi fruit extract as antifertility. Key words: Averrhoa blimbi, rats, reversible time, tubulus seminiferous

Antioxidant and Cytotoxicity Studies of Nypa fruticans (Nypa Palm Sugar) Extract Sabri, Wan M. A. W.; Asaruddin, Mohd R. Asaruddin R.; Sukairi, Ahmad H.; Yusop, Syed A. T. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Nypa fruticans Wurmb which belongs to the family of Arecaceae is one of the most widely distributed and useful palm in the mangrove forests in the Southeast Asia. Nypa palm sugar or commonly known as âGula Apongâ was processed using nypa palm sap as raw material. The nypa palm sugar was expected to benefit wider community as source of alternative sweetener. In this study, 2, 2-diphenyl1-picryhydrazyl (DPPH) scavenging activity and cytotoxicity test of methanol extract of nypa palm sugar were conducted. The antioxidant activity was determined based on DPPH scavenging activity of extract. The cytotoxicity test was conducted against brine shrimp Artemia salina, and the LC50 value of the extract was calculated. The antioxidant activity showed that the EC50 of nypa palm sugar was 1304 mg/mL while the value of EC50 for ascorbic acid was 0.6112 mg/mL. The results of the cytotoxicity showed that the methanol extract of nypa palm sugar was interpreted as non-toxic as the value of LC50 was 184.0 mg/mL.Keywords: 2,2-diphenyl-1-picryhydrazyl, antioxidant, cytotoxicity, Nypa fruticans, nypa palm sugar

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