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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 7 Documents

Search results for , issue "Suppl. 2, No. 1 (2019)" : 7 Documents clear

Application of Common Greenbottle Fly (Lucilia sericata Meigen, 1826) Larvae Extract for Incision Wound Treatments in Rats Madihah Madihah; Lisda Mawarni Sihotang; Desak Made Malin; Wawan Hermawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Common green-bottle fly (Lucilia sericata) larvae have been used in maggot debridement therapy to promote wound healing since the 19th century following the emergence of an antibiotic-resistant strain of bacteria. Whole body extracts and hemolymph of L. sericatalarvae shown antibacterial properties. This research aims to examine the ethanol extract from whole body of L. sericatalarvae to accelerate the wound healing on the skin of male Wistar rats (Rattus norvegicus). The method was a completely randomized design with six treatments and four replications each. The incision wound created at the dorsolateral region of shaven skin at ±1.5 cm using sterile scissors. The extract at concentration 5, 10 and 20% in olive oil were applied topically to wounded rats, as well as Betadine® for the reference group. For positive control only olive oil applied to wounded rats, as for negative control was non-treated wounded rats. The treatment was done twice a day for 14 days. At day 15th, the wounded site harvested, fixed in 10% NBF, embedded in paraffin, and sectioned at 5-7 µm, then stained with hematoxylin-eosin or trichrome Heidenhain’s Azan for histological examination. The results showed that topical application of the L. sericata larvae extract at concentration 10% was significantly recover the wounded skin by enhanced re-epithelialization, narrowed granulation tissue, as well as increased capillary number and collagen density than other treatments (p<0.05). Overall, our data support the L. sericatalarva extract as an agent to accelerate the wound healing process on skin.Key words: ethanol extract, green-bottle fly, incision wound, whole body larva, wound healing.

Formulation and Optimization of Bisoprolol Fumarate Orally Fast Dissolving Film with Combination of HPMC E15 and Maltodextrin as Matrix Polymers Aristha Novyra Putri; Rahmayanti Fitriah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Bisoprolol fumarate is a drug belonging β blockers group, and specifically is selective β1 adrenergic receptor blocker, a class medicines used primarily in cardiovascular diseases. The drug has 9-12 hrs half life (t1/2) and shows bioavailability of more than 80%1. An orally fast dissolving film dosage form with drug in mouth are absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism2. The study aimed to made of orally fast dissolving film bisoprolol fumarate by solvent casting method with combination of HPMC E15 and maltodextrin as matrix. Factorial design 23was applied to optimize the formula of orally fast dissolving film bisoprolol fumarate by varying level of polymer, it was HPMC E15 300 – 600 mg, maltodextrin 50 – 150 mg, and PEG400 50 – 90 mg. The optimum formula was determined by superimposed contour plot from various parameters: physical properties of orally fast dissolving film bisoprolol fumarate such as thickness, folding endurance, surface pH, in vitro disintegration, hidration study, and drug release for 300 second using Design Expert ® program. The study result showed that physical properties of 8 formulas such as organoleptic test were transparent, homogeny, and smooth in both of side; thickness 0.062 – 0.132 mm; weight variation 50.85 – 70.60 mg; folding endurance 987 – 2012; surface pH 6.69 – 6.99; disintegration (drop method) 18.33 – 20.76 sec; disintegration (petridish method) 27.63 – 30.41 sec; in vitro dissolution for 300 sec was 94.35 – 98.99%; and swelling index up to 30 second was 146.63 – 173.34%. Based on superimposed contour plot Design Expert® from factor response of folding endurance, surface pH, in vitro disintegration drop method, in vitro disintegration petridish method, swelling index, dan DE300with a statistically significant finding requires a P-value of 0.05 were obtained optimum formulas for the area in the range of HPMC E15 509.88 mg; Maltodextrin 108.63 mg; and PEG400 50 mg with the value of desirability 0.519.Key Words: bisoprolol fumarate, orally fast dissolving film, factorial design

Virtual Screening Natural Compounds from Plants as Inhibitor of Estrogen Receptor Alpha I (ESR1) Andi Trihadi Kusuma; Daryono Hadi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Flavanoid is one of the chemical compounds found in plants. Isoflavones (1.2-diarylpropane) are the largest group in the flavanoid that can be used to study the anticancer activity. 2IOK is one oftarget inhibitors which is obtainedfrom natural product compounds.The purpose of the research is to design new compounds have anti-cancer activity, especially for breast cancer based on the evaluation of the affinity of the compound against Estrogen Receptor Alpha (ESR1) usingthecomputational method. The parent compound is the test structure of isoflavones which has been reported to have anticancer activity, particularly for breast cancer. Based on the results of the validation method of docking with several combinations, the best method found was Triangle matcher-Affinity dG with anRMSDof 1.0452. Furthermore, this model providesROC graph value of 0.863. Therefore, the method was used to screen compounds in the UI database. Three compounds wereobtained from the process, which are potentially active against Estrogen Receptor Alpha (ESR1), namely C00010051, C00026048, C00025295. The MD simulations of protein-ligand complexes indicated exchanges process, namely the absence of interaction between the ligand with the Phe404, insteadofthe ligand formed hydrogen bonding with Glu353. Meanwhile, the C00025295 compound formed hydrogen bonding with the Leu346 residue.Keywords: virtual screening, molecular docking, molecular dynamic, ESR1

Tyrosinase Inhibitor Activity Measurement of Crude and Purified Extract of Moringa Leaves (Moringa oleifera L.) Zainal Abidin; Ummu Khaeriah; Zuhrina Zuhrina; Mamat Pratama; Muzakkir Baits
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Moringa leaves is one of the plants that have antioxidant activity. The compounds that have strong antioxidant activity also have strong antityrosinase activity. Moringa leaves contain flavonoid compounds that can inhibit tyrosinase activity in the melanin formation process. This study aimed to determine tyrosinase inhibitor activity of crude and purified extract of moringa leaves (Moringa oleifera L.). Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome from the oxidation of L-tyrosine in the mechanism of melanogenesis. The crude extract obtained by use maceration extraction method and ethanol solvent, whereas the purified extract obtained by use liquid-liquid extraction method and ethyl acetate solvent. The results showed that hydroquinone has IC50 value of 18,234 μg/mL while crude extract of moringa leaves shows IC50 value of 4405,24 μg/mL and purified extract of moringa leaves shows IC50 value of 401,6228 µg/mL. Purified extract of moringa leaves more active as tyrosinase inhibitor than its crude extract but less active than hydroquinone.Keywords: Moringa leaves, Purified extract, Tyrosinase Inhibitor, UV Rays

Biodistribution of 99mTc-HSA-nanoparticle in Lymphatic Node of Animal Model Induced by 7,12 Dimethylbenz(a)anthracene Rizky Juwita Sugiharti; Iim Halimah; Isa Mahendra; Witri Nuraeni; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Breast cancer is one of the most common malignant tumors found in women and hasbecome as the second cause of death in women after cervical cancer.We successfully synthesizedtechnetium-99m labeled Human Serum Albumin nanoparticle(99mTc-HSA nanoparticle); a radiopharmaceuticalwhich potentially used for application in lymphoscintigraphytechnique for tracing lymphatic system.This study was aims to obtain pre-clinical data from 99mTc-HSA nanocolloidin Sprague Dawleyfemale ratsgiven7, 12-dimethylbenzeneanthracene (DMBA) - induced cell proliferation in the breast tissues.The rats are divided into two groups, one groupsaregiven DMBA and observed for 5, 8 and 12 weeks and the other group is without any treatment as control.Biodistribution study of 99mTc-HSA nanoparticlewas conducted to identify the accumulation of this agent in the popliteal and lumbar lymph nodes and the other tissuecompare to normal rats. 99mTc-HSA nanoparticleshown good accumulation in popliteal lymph node 2.90+1.32 %ID; 0.81 + 0.47 %IDand 1.04+0.46 %ID at one hour post injectionin 5, 8 and 12 weeks respectively.The popliteal extraction (PE) was estimated with value 87.92 %, 74.07%, 71.79% in 5, 8 and 12 weeks respectively. This result showed that99mTc-HSA nanoparticleis very promising compound to be lymphoscintigraphyagentin detection of breast cancer.Key words: lymphoscintigraphy, 99mTc-HSA nanoparticle, breast cancer

Sedative Effect of Citronella (Cymbopogon nardus (L.) Rendle) towards Male Mice (Mus musculus) Yulianita Yulianita; E. Mulyati Effendi; Ekas Mara Firdayani
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Hypnotics are substances which in certain dose is meant for escalating psychological desire to sleep and reduse and causingsleep. The research was aimed to determining the influence and the effective dose of citronella grass as sedative substance applied on male mice. Animals used on the test were amounted to 25 male mice which were divided into 5 groups, each of them consisted of 5 mice. Whose given the citronella grass extract were Dose Group I (12mg/20gBW), Dose Group II (24mg/20gBW), and Dose Group III (48mg/20gBW), by means of Negative Control Group (-) 0,5mL of distilled water, and Positive Group Control (+) in terms of 0.013mL/20gBW Diazepam. The results of the research show that the conferral of citronella grass essence is positively potential as a sedative substance on the mice. Thus, Dose III (48mg/20gBW)becomes the most effective dose with the mice onset of falling recorded 46.7 seconds. The conferral duration of citronella grass essence towards sedative effect on male mice with the dose (III) of 48mg/20gBW is the most effective dose due to the relative similarity with diazepam as postive control, observed from the average duration being close to diazepam as positive control within the average onset amounted to 4.46 seconds, while diazepam itself is amounted to 1.38 seconds.Key words: Citronella Grass, Sedativum, Rotarod

Sunscreen Activity Testing of Robusta Coffee (Coffea cenephora ex froehner) Leave Extract and Fractions Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah; Riski Solehati; Aldi Elgiawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Coffee leaves are part of a plant that has not been optimally utilized. The purpose of this study was to explore the potential use of coffee leaves to help maintain skin health. Extraction method was carried out with maceration method using 70% ethanol solvent. Fractionation process was carried out by Liquid-Liquid Extraction method, using different solvents to accumulate the n-hexane, ethyl acetate [A1] and methanol fractions. Activity testing was carried out on all samples at concentrations of 50, 100 and 150 ppm including measurements of Sun Protecting Factor (SPF), Erythema and Pigmentation Transmittance Percentages (%Te [A2] and %Tp[A3] ) using UV-visible spectrophotometry at 290 and 400 nm wavelengths. The results showed that the ethyl acetate [A4] fraction at a concentration of 150 ppm had a higher potential as a sunscreen than other samples with SPF value of 19.82; %Te [A5] 10.96 and %Tp [A6] 18.14 and included in the category of fast tanning sunscreen.Keywords: coffee leaves, sunscreen, sun protecting factor, erythema, pigmentation

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