Claim Missing Document
Check
Articles

Found 13 Documents
Search

Treatment of PLGA Nanoparticles Ointment-Ethanol Extract of Archidendron pauciflorum in the Wound Healing in Diabetic Mice Desak Made Malini; Yasmi Purnamasari Kuntana; Madihah Madihah; Wildanul Furqon; Wawan Hermawan
Jurnal Biodjati Vol 5, No 2 (2020): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v5i2.9256

Abstract

Diabetic wounds lead to severe tissue damage and are diffi-cult to cure. Jengkol (Archidendron pauciflorum) is a plant commonly used by local Indonesian communities to treat diabetic wounds. The efficiency of herbal medicine still has a deficiency of its ability to reach the target organs, therefore nanotechnology is applied in the hope that all drug concentrations can reach the target organs successfully. This study aimed to evaluate the effectiveness of PLGA nanoparticle ointment-ethanol extract jengkol fruit peel (EEJFP) to accelerate the wound healing process in the skin of streptozotocin-induced diabetic mice. The research method used was experimental with a completely randomized design using six treatments and four replications. Diabe-tes was induced by intraperitoneal injection of streptozotocin 180 mg/ kg BW. Mice with a blood glucose level of ≥150 mg/dL were used for diabetic mice models. The incision wound created at the dorsolateral region of shaven skin at ±1 cm2 using sterile scissors. The treatments given were vaseline for Control Negative (CN) and Control Positive (CP), Betadine ointment (PB), 10% EEJFP ointment (P1), 5% PLGA nanoparticle ointment-EEJFP (P2), and 2.5% PLGA nanoparticle ointment-EEJFP (P3). The results showed that the administration of PLGA nanoparticles ointment-EEJFP with a concentration of 5% PLGA nanoparticle ointment-EEJFP (P2) resulted in the shortest wound length on day 3, 7 and 14; narrower granulation tissue; a larger number of blood capillaries; and denser collagen fibers (α <0.05) compared to CP and PB treatments. The administration of PLGA nanoparticle ointment-EEJFP with a concentration of 5% was the most effective concentration in accelerating wound healing in the skin of diabetic mice. 
Keanekaragaman Jenis Kupu-kupu Familia Nymphalidae dan Pieridae di Kawasan Cirengganis dan Padang Rumput Cikamal Cagar Alam Pananjung Pangandaran Virda Catur Lestari; Tatang S. Erawan; Melanie Melanie; Hikmat Kasmara; Wawan Hermawan
Agrikultura Vol 29, No 1 (2018): April, 2018
Publisher : Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.46 KB) | DOI: 10.24198/agrikultura.v29i1.16920

Abstract

ABSTRACTThe diversity of butterflies’ family of Nymphalidae and Pieridae at Cirengganis area and Cikamal Savannah area of Pananjung Sanctuary of PangandaranThe research reported the diversity o.f butterflies of Nymphalidae and Pieridae Families at Cirengganis area and Cikamal Savannah area which located at Pananjung Sanctuary, Pangandaran. The experiment was conducted using visual encounter survey method. The butterflies were caught using sweeping technique. The butterflies were collected and identified. Abiotic factors such light intensity and temperature were measured during observation. The result showed that 13 species of nymphalidae family were identified whilst only 2 species were identified belongs to the family of Pieridae. Butterfly diversity index at Cirengganis and Cikamal Savannah categorized as moderate with value of 2.285647. Vegetation that interacted with the butterflies were Tectona grandis), Psychotria aurantiaca, and Melastoma malabathricum. Furthermore, light intensity and temperature at Cirengganis were detected at 12473.33 lux and 28.6oC, respectively. While at Cikamal Savannah, the light intensity was measured at 26900 lux and temperature reached 33.6oC.Keywords: Visual encounter survey, Abiotic factor, VegetationABSTRAKPenelitian ini melaporkan mengenai keanekaragaman Jenis Kupu-Kupu Famili Nymphalidae dan Pieridae di kawasan Cirengganis dan Padang Rumput Cikamal Cagar Alam Pananjung Pangandaran. Metode yang digunakan adalah metode Visual Encounter Survey (VES). Penangkapan kupu-kupu dilakukan dengan teknik sweeping. Kupu-kupu yang diperoleh dikoleksi dan diidentifikasi. Faktor abiotik seperti intensitas cahaya dan suhu diukur selama pengamatan. Serta diamati pula vegetasi sekitar lokasi pengamatan yang berinteraksi dengan kupu-kupu. Hasil pengamatan diperoleh total kupu-kupu famili Nymphalidae sebanyak 13 spesies dan kupu-kupu famili Pieridae sebanyak 2 spesies. Nilai indeks keanekaragaman kupu-kupu di kawasan Cirengganis dan Padang Rumput Cikamal tergolong kategori sedang yaitu 2,285647. Hasil vegetasi yang diketahui berinteraksi dengan kupu-kupu yaitu jati (Tectona grandis), ki kores (Psychotria aurantiaca), dan harendong (Melastoma malabathricum). Sementara rata-rata intensitas cahaya dan suhu di Cirengganis sebesar 12473,33 lux dan 28,6oC dan di Padang Rumput Cikamal sebesar 26900 lux dan 33,6oC.Kata Kunci: Visual Encounter Survey, Faktor abiotik, Vegetasi
AKTIVITAS ANTIFIDAN EKSTRAK ETANOL DAUN TANAMAN Piper nigrum, Acorus calamus, DAN Dysoxylum alliaceum TERHADAP LARVA Spodoptera litura INSTAR III Hikmat Kasmara; Melanie Melanie; Vita Novianti; Madihah Madihah; Desak Made Malini; Rani Maharani; Tri Mayanti; Wawan Hermawan
BIOTIKA Jurnal Ilmiah Biologi Vol 16, No 1 (2018): BIOTIKA JUNI 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v16i1.17481

Abstract

BIOAKTIVITAS EKSTRAK DAUN SOSOR BEBEK (Kalanchoe daigremontiana Hammet & Perrier ) TERHADAP LARVA KUMBANG KOKSI (Epilachna vigintioctopunctata Fabricius , ,. Melanie; Wawan Hermawan; Unang Supratman
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 2 (2004): Biotika Desember 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i2.283

Abstract

AKTIVITAS ANTIFIDAN ANDROGRAFOLIDA PADA GANGLION SARAF LARVA Plutella xylostella Baum Suhendar; Erik S. Erawan; Wawan Hermawan
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 1 (2004): Biotika Juni 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i1.265

Abstract

EFEK ANTIFIDAN ANDROGRAFOLIDA TERHADAP HISTOKIMIA ENZIM PENCERNAAN LARVA Plutella xylostella Wawan Hermawan; Hikmat Kasmara; Yasmi P. Kuntana
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 1 (2004): Biotika Juni 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i1.259

Abstract

Application of Common Greenbottle Fly (Lucilia sericata Meigen, 1826) Larvae Extract for Incision Wound Treatments in Rats Madihah Madihah; Lisda Mawarni Sihotang; Desak Made Malin; Wawan Hermawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.33 KB) | DOI: 10.24198/ijpst.v1i1.19144

Abstract

Common green-bottle fly (Lucilia sericata) larvae have been used in maggot debridement therapy to promote wound healing since the 19th century following the emergence of an antibiotic-resistant strain of bacteria. Whole body extracts and hemolymph of L. sericatalarvae shown antibacterial properties. This research aims to examine the ethanol extract from whole body of L. sericatalarvae to accelerate the wound healing on the skin of male Wistar rats (Rattus norvegicus). The method was a completely randomized design with six treatments and four replications each. The incision wound created at the dorsolateral region of shaven skin at ±1.5 cm using sterile scissors. The extract at concentration 5, 10 and 20% in olive oil were applied topically to wounded rats, as well as Betadine® for the reference group. For positive control only olive oil applied to wounded rats, as for negative control was non-treated wounded rats. The treatment was done twice a day for 14 days. At day 15th, the wounded site harvested, fixed in 10% NBF, embedded in paraffin, and sectioned at 5-7 µm, then stained with hematoxylin-eosin or trichrome Heidenhain’s Azan for histological examination. The results showed that topical application of the L. sericata larvae extract at concentration 10% was significantly recover the wounded skin by enhanced re-epithelialization, narrowed granulation tissue, as well as increased capillary number and collagen density than other treatments (p<0.05). Overall, our data support the L. sericatalarva extract as an agent to accelerate the wound healing process on skin.Key words: ethanol extract, green-bottle fly, incision wound, whole body larva, wound healing.
Ekstrak Etanol Kulit Buah Jengkol Menurunkan Kadar Glukosa dan Meningkatkan Hormon Insulin Tikus Diabetes Yang Diinduksi Streptozotocin Desak Made Malini; Madihah Madihah; Dita Aprila Khoirunnisa; Indriani Sasmita; Nining Ratningsih; Kartiawati Alipin; Wawan Hermawan
Jurnal Veteriner Vol 20 No 1 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.755 KB) | DOI: 10.19087/jveteriner.2019.20.1.65

Abstract

Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of jengkol’s fruit peel is an alternative treatment for DM. This study aims to determine the effect of ethanol extract of jengkol’s fruit peel to decrease glucose and increase insulin level of Wistar female rats which induced by streptozotocin (STZ). This research used the experimental method of Completely Randomized Design (RAL). Rat were first induced by single intravenous injection of STZ except Negative Control. Furthermore, rats were divided into six groups, namely Negative Control (NC), Positive Control (PC), Reference Group (RG) glibenclamide 10 mg/kg BW, and ethanol extract of jengkol’s fruit peel (EEOJFP) treatment at dose of 385 (P1), 770 (P2), and 1540 (P3) mg/kg BW with four replications each. Treatment was administered orally for 14 days. Data were analyzed by analysis of variance (ANAVA) with 95% confidence level and Duncan Multiple Range Test. The result showed that treatment of EEOJFP with dose of 385, 770 and 1540 mg/ kgBW decreased blood glucose 28.6%;65.4% and 59.1% successively, increased insulin as 54%; 230% and 206%. There was a protective effect of EEOJEF to level of blood glucose and insulin secretion of rat-STZ induced. The conclusion from this research is Ethanol extract of Jengkol’s fruit peel at dose 770 mg/kg BW is an effective dose in decreasing the level of glucose and increasing the level of insulin hormone in STZinduced diabetic rats.
THE ANALYSIS OF DETERMINANT OF FOREIGN DIRECT INVESTMENT IN INDONESIA Etsuco Siomi; Wawan Hermawan
Quantitative Economics Journal Vol 8, No 1 (2019)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/qej.v8i1.23608

Abstract

The analysis results show that changes in macroeconomic conditions such as exchange rate, government expenditure and gross domestic product in Indonesia have a significant effect on foreign direct investment (FDI) Indonesia, while Inflation has a negative effect on foreign direct investment FDI and the monetary crisis has a negative effect on the development of FDI in Indonesia. So that the severe financial crisis in the American and European regions today, the impact on foreign direct investment (FDI) Indonesia is still within the limits of tolerance. Therefore, although there are still problems in the investment climate in Indonesia, the outlook for investment in Indonesia over the next period is still good, although perhaps with the growth of investment slows down.
DETERMINAN ANGKA PARTISIPASI MURNI: STUDI PADA PENDUDUK MISKIN TINGKAT PROVINSI DI INDONESIA Wawan Hermawan; Indra Maipita; Setyo Tri Wahyudi
Jurnal Ilmu Ekonomi dan Pembangunan Vol 20, No 1 (2020): Jurnal Ilmu Ekonomi dan Pembangunan
Publisher : EP FEB UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.913 KB) | DOI: 10.20961/jiep.v20i1.34273

Abstract

One of the success of education can be seen in the development of the Pure Participation Rate (APM). Positive economic growth and a reduction in poverty levels raise questions on what factors affect the APM at the elementary, junior high and high school levels for the poor in Indonesia. The panel data model for 29 provinces and the 2011-2015 timeframe forms the basis of research data. The estimation results of the model show the coefficient of income per capita is very elastic and affects the APM for each level of education in Indonesia. Government spending on education still has the effect of increasing the APM for primary school, junior and senior high school education but has an impact that actually reduces the APM. Inequality increases the APM in Indonesia at the elementary and high school levels, whereas at the junior high level it actually lowers the APM. Finally, age at each level has an influence on middle and high school levels, but is different for elementary school levels. Keyword: Pure Participation Rate, Per capita income, government expenditure and Equality