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Treatment of PLGA Nanoparticles Ointment-Ethanol Extract of Archidendron pauciflorum in the Wound Healing in Diabetic Mice Desak Made Malini; Yasmi Purnamasari Kuntana; Madihah Madihah; Wildanul Furqon; Wawan Hermawan
Jurnal Biodjati Vol 5, No 2 (2020): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v5i2.9256

Abstract

Diabetic wounds lead to severe tissue damage and are diffi-cult to cure. Jengkol (Archidendron pauciflorum) is a plant commonly used by local Indonesian communities to treat diabetic wounds. The efficiency of herbal medicine still has a deficiency of its ability to reach the target organs, therefore nanotechnology is applied in the hope that all drug concentrations can reach the target organs successfully. This study aimed to evaluate the effectiveness of PLGA nanoparticle ointment-ethanol extract jengkol fruit peel (EEJFP) to accelerate the wound healing process in the skin of streptozotocin-induced diabetic mice. The research method used was experimental with a completely randomized design using six treatments and four replications. Diabe-tes was induced by intraperitoneal injection of streptozotocin 180 mg/ kg BW. Mice with a blood glucose level of ≥150 mg/dL were used for diabetic mice models. The incision wound created at the dorsolateral region of shaven skin at ±1 cm2 using sterile scissors. The treatments given were vaseline for Control Negative (CN) and Control Positive (CP), Betadine ointment (PB), 10% EEJFP ointment (P1), 5% PLGA nanoparticle ointment-EEJFP (P2), and 2.5% PLGA nanoparticle ointment-EEJFP (P3). The results showed that the administration of PLGA nanoparticles ointment-EEJFP with a concentration of 5% PLGA nanoparticle ointment-EEJFP (P2) resulted in the shortest wound length on day 3, 7 and 14; narrower granulation tissue; a larger number of blood capillaries; and denser collagen fibers (α <0.05) compared to CP and PB treatments. The administration of PLGA nanoparticle ointment-EEJFP with a concentration of 5% was the most effective concentration in accelerating wound healing in the skin of diabetic mice. 
Keanekaragaman Jenis Kupu-kupu Familia Nymphalidae dan Pieridae di Kawasan Cirengganis dan Padang Rumput Cikamal Cagar Alam Pananjung Pangandaran Virda Catur Lestari; Tatang S. Erawan; Melanie Melanie; Hikmat Kasmara; Wawan Hermawan
Agrikultura Vol 29, No 1 (2018): April, 2018
Publisher : Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.46 KB) | DOI: 10.24198/agrikultura.v29i1.16920

Abstract

ABSTRACTThe diversity of butterflies’ family of Nymphalidae and Pieridae at Cirengganis area and Cikamal Savannah area of Pananjung Sanctuary of PangandaranThe research reported the diversity o.f butterflies of Nymphalidae and Pieridae Families at Cirengganis area and Cikamal Savannah area which located at Pananjung Sanctuary, Pangandaran. The experiment was conducted using visual encounter survey method. The butterflies were caught using sweeping technique. The butterflies were collected and identified. Abiotic factors such light intensity and temperature were measured during observation. The result showed that 13 species of nymphalidae family were identified whilst only 2 species were identified belongs to the family of Pieridae. Butterfly diversity index at Cirengganis and Cikamal Savannah categorized as moderate with value of 2.285647. Vegetation that interacted with the butterflies were Tectona grandis), Psychotria aurantiaca, and Melastoma malabathricum. Furthermore, light intensity and temperature at Cirengganis were detected at 12473.33 lux and 28.6oC, respectively. While at Cikamal Savannah, the light intensity was measured at 26900 lux and temperature reached 33.6oC.Keywords: Visual encounter survey, Abiotic factor, VegetationABSTRAKPenelitian ini melaporkan mengenai keanekaragaman Jenis Kupu-Kupu Famili Nymphalidae dan Pieridae di kawasan Cirengganis dan Padang Rumput Cikamal Cagar Alam Pananjung Pangandaran. Metode yang digunakan adalah metode Visual Encounter Survey (VES). Penangkapan kupu-kupu dilakukan dengan teknik sweeping. Kupu-kupu yang diperoleh dikoleksi dan diidentifikasi. Faktor abiotik seperti intensitas cahaya dan suhu diukur selama pengamatan. Serta diamati pula vegetasi sekitar lokasi pengamatan yang berinteraksi dengan kupu-kupu. Hasil pengamatan diperoleh total kupu-kupu famili Nymphalidae sebanyak 13 spesies dan kupu-kupu famili Pieridae sebanyak 2 spesies. Nilai indeks keanekaragaman kupu-kupu di kawasan Cirengganis dan Padang Rumput Cikamal tergolong kategori sedang yaitu 2,285647. Hasil vegetasi yang diketahui berinteraksi dengan kupu-kupu yaitu jati (Tectona grandis), ki kores (Psychotria aurantiaca), dan harendong (Melastoma malabathricum). Sementara rata-rata intensitas cahaya dan suhu di Cirengganis sebesar 12473,33 lux dan 28,6oC dan di Padang Rumput Cikamal sebesar 26900 lux dan 33,6oC.Kata Kunci: Visual Encounter Survey, Faktor abiotik, Vegetasi
AKTIVITAS ANTIFIDAN EKSTRAK ETANOL DAUN TANAMAN Piper nigrum, Acorus calamus, DAN Dysoxylum alliaceum TERHADAP LARVA Spodoptera litura INSTAR III Hikmat Kasmara; Melanie Melanie; Vita Novianti; Madihah Madihah; Desak Made Malini; Rani Maharani; Tri Mayanti; Wawan Hermawan
BIOTIKA Jurnal Ilmiah Biologi Vol 16, No 1 (2018): BIOTIKA JUNI 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v16i1.17481

Abstract

BIOAKTIVITAS EKSTRAK DAUN SOSOR BEBEK (Kalanchoe daigremontiana Hammet & Perrier ) TERHADAP LARVA KUMBANG KOKSI (Epilachna vigintioctopunctata Fabricius , ,. Melanie; Wawan Hermawan; Unang Supratman
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 2 (2004): Biotika Desember 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i2.283

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AKTIVITAS ANTIFIDAN ANDROGRAFOLIDA PADA GANGLION SARAF LARVA Plutella xylostella Baum Suhendar; Erik S. Erawan; Wawan Hermawan
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 1 (2004): Biotika Juni 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i1.265

Abstract

EFEK ANTIFIDAN ANDROGRAFOLIDA TERHADAP HISTOKIMIA ENZIM PENCERNAAN LARVA Plutella xylostella Wawan Hermawan; Hikmat Kasmara; Yasmi P. Kuntana
BIOTIKA Jurnal Ilmiah Biologi Vol 3, No 1 (2004): Biotika Juni 2004
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v3i1.259

Abstract

Application of Common Greenbottle Fly (Lucilia sericata Meigen, 1826) Larvae Extract for Incision Wound Treatments in Rats Madihah Madihah; Lisda Mawarni Sihotang; Desak Made Malin; Wawan Hermawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.33 KB) | DOI: 10.24198/ijpst.v1i1.19144

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Common green-bottle fly (Lucilia sericata) larvae have been used in maggot debridement therapy to promote wound healing since the 19th century following the emergence of an antibiotic-resistant strain of bacteria. Whole body extracts and hemolymph of L. sericatalarvae shown antibacterial properties. This research aims to examine the ethanol extract from whole body of L. sericatalarvae to accelerate the wound healing on the skin of male Wistar rats (Rattus norvegicus). The method was a completely randomized design with six treatments and four replications each. The incision wound created at the dorsolateral region of shaven skin at ±1.5 cm using sterile scissors. The extract at concentration 5, 10 and 20% in olive oil were applied topically to wounded rats, as well as Betadine® for the reference group. For positive control only olive oil applied to wounded rats, as for negative control was non-treated wounded rats. The treatment was done twice a day for 14 days. At day 15th, the wounded site harvested, fixed in 10% NBF, embedded in paraffin, and sectioned at 5-7 µm, then stained with hematoxylin-eosin or trichrome Heidenhain’s Azan for histological examination. The results showed that topical application of the L. sericata larvae extract at concentration 10% was significantly recover the wounded skin by enhanced re-epithelialization, narrowed granulation tissue, as well as increased capillary number and collagen density than other treatments (p<0.05). Overall, our data support the L. sericatalarva extract as an agent to accelerate the wound healing process on skin.Key words: ethanol extract, green-bottle fly, incision wound, whole body larva, wound healing.
THE ANALYSIS OF DETERMINANT OF FOREIGN DIRECT INVESTMENT IN INDONESIA Etsuco Siomi; Wawan Hermawan
Quantitative Economics Journal Vol 8, No 1 (2019)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/qej.v8i1.23608

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The analysis results show that changes in macroeconomic conditions such as exchange rate, government expenditure and gross domestic product in Indonesia have a significant effect on foreign direct investment (FDI) Indonesia, while Inflation has a negative effect on foreign direct investment FDI and the monetary crisis has a negative effect on the development of FDI in Indonesia. So that the severe financial crisis in the American and European regions today, the impact on foreign direct investment (FDI) Indonesia is still within the limits of tolerance. Therefore, although there are still problems in the investment climate in Indonesia, the outlook for investment in Indonesia over the next period is still good, although perhaps with the growth of investment slows down.
PERAN SEKTOR PARIWISATA PADA PERTUMBUHAN EKONOMI KABUPATEN/KOTA DI JAWA BARAT Helmi Aliansyah; Wawan Hermawan
Bina Ekonomi Vol. 23 No. 1 (2019): Bina Ekonomi: Majalah Ilmiah Fakultas Ekonomi Universitas Katolik Parahyangan
Publisher : Center for Economic Studies Universitas Katolik Parahyangan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.953 KB) | DOI: 10.26593/be.v23i1.4654.39-55

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Sektor Pariwisata merupakan sektor yang sedang mengalami pertumbuhan pesat di Indonesia, demikian juga di Provinsi Jawa Barat. Penelitian ini bertujuan untuk melihat apakah terdapat pengaruh sektor pariwisata pada pertumbuhan ekonomi di Jawa Barat. Penelitian ini menggunakan data jumlah wisatawan, pengeluaran pemerintah sektor pariwisata, jumlah kamar hotel, dan jumlah restoran/rumah makan sebagai proyeksi sektor pariwisata, sedangkan rasio sektor pertanian pada PDRB sebagai variabel kontrol. Metode yang digunakan adalah Generalized Least Squuare (GLS) dengan data panel pada periode 2012-2017 dan 23 Kabupaten/Kota di Jawa Barat. Hasil penelitian menunjukkan bahwa jumlah kamar hotel, jumlah rumah makan/restoran, pengeluaran pemerintah sektor pariwisata, dan jumlah wisatawan berpengaruh positif terhadap pertumbuhan ekonomi.Kata kunci: pertumbuhan ekonomi; sektor pariwisata; belanja pemerintah; Generalized Least Squares (GLS); panel data; Jawa Barat
Analisis Dampak Ekonomi dan Sosial Pembangunan Infrastruktur di Indonesia Prita Amalia; Yogi Suprayogi; Yudi Azis; Wawan Hermawan; Eksa Pamungkas; Adi Nurzaman; Anhar Fauzan Priyono
Journal of Infrastructure Policy and Management (JIPM) Vol. 4 No. 1 (2021): Journal of Infrastructure Policy and Management (JIPM)
Publisher : PT Penjaminan Infrastruktur Indonesia (Persero)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Infrastructure projects are expected to deliver positive economic and social impact to the community. However, the model to analyze the economic and social impact is still limited. Therefore, this study aims to develop an economic and social impact model to be used for study the impact of infrastructure projects. The research focuses on several case studies of infrastructure projects which guaranteed by Indonesia Infrastructure Guarantee Fund (IIGF) both PPP (Public-Private-Partnership) Scheme and non-PPP Scheme on telco, water, tourism Sector. These sectors are believed to represented the major infrastructure development that cover both local, national, and international perspectives. The analytical method used to measure economic impacts from infrastructure development is a quantitative approach by using following attributes: Sectoral Economic Analysis, Potential Economic Analysis, Growth Accounting, Input-Output Table Analysis, and Statistical Forecasting. While, to analyse the social impact of infrastructure development, quantitative and qualitative approaches are used by In-depth Interview through questionnaire filling technique and Social Impact Assessment (SIA) method. In addition, this study also used legal approach method. The results show various economic impacts of project investment development, both in terms of potential and realization. Meanwhile, in terms of social impacts, there are various community responses to the realization of project development.