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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 5 Documents
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Search results for , issue "Vol 7, No 1 (2020)" : 5 Documents clear
Differences of Respiratory Rate Between Salbutamol and Aminofilin in Exacerbation Asthma Amelia Lorensia; Zullies Ikawati; Tri Murti Andayani; Daniel Maranatha
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.17034

Abstract

Exacerbation of asthma is a progressive step in progressive breathing, coughing, wheezing, breathing. In Indonesia salbutamol nebulation is used for the therapy of the first exacerbation attack. In addition, intravenous aminophylline is also recommended as a therapy, even if the use of aminophylline abroad is reduced due to its smaller effectiveness and often leads to greater unwanted reaction events. The effectiveness of asthma exacerbation therapy needs to be monitored and one of the monitoring parameters that is easily seen is the rate of breath.The aim of this study was to investigate the difference in respiratory rate values using salbutamol nebulisation and intravenous aminophylline in patients with asthma exacerbations in hospitals in Surabaya. The research was conducted by using quasi experimental method and data collection by purposive sampling. Analysis of the data to be used is a independent t-test. The results showed that the salbutamol group decreased respiratory rate by 50.00%, there were also patients who experienced an increase of breath rate of 13.64%. In the aminophylline group experienced a decrease in respiratory rate of 43.75% with an increase of breath rate of 18.75%. From the results of the study, it is necessary to monitor the effectiveness and the need to monitor the unwanted reactions of both treatments so that the therapies produced in the treatment of asthma exacerbations are more effective.Key words: Aminophylline, exacerbation asthma, respiratory rate, salbutamol 
Molecular Docking Studies of Compounds from Brucea javanica (L.) Merr. Towards The Discovery of Potential H5N1 Neuraminidase Inhibitors Rina Fajri Nuwarda; Zelika Mega Ramadhania; Imam Adi Wicaksono; Muhammad Yusuf; Ade Rizqi Ridwan Firdaus; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.25643

Abstract

The occurrences of a highly pathogenic avian influenza virus (HPAI) type A H5N1 has caused infections in millions of poultry as well as hundreds of human cases and even mortalities. Indonesia has become one of the world’s highest casualty rates of H5N1 human infections, with the number of deaths was 167 from a total of 199 cases. The development of viral resistance towards the available anti-influenza drugs neuraminidase (NA) inhibitors required the discovery of new inhibitors. In the recent advance of drug discovery, natural products have been considered as one of the essential sources of medicinal agents, and Brucea javanica has been found to possess antiviral activity against H5N1 NA. Thus, this research aimed to investigate the in silico activities of compounds from B. javanica using molecular docking methods against H5N1 NA. In this study, docking-based virtual screening of compounds from B. javanica to quickly select in silico hits to be potential NA inhibitors was performed. Subsequently, the intermolecular interactions of the inhibitor compounds with the H5N1 NA were analysed to examine the most preferred interactions. The results showed that brucein G and bruceoside C were found having the lowest binding energy and most preferred interactions with H5N1 NA and therefore, can be proposed for further study as potential NA inhibitors.Keyword: antiviral, Brucea javanica, H5N1, molecular docking, neuraminidase
Inhibition of Heme Polymerization Invitro Assay Of Extract of Sirih Leaf (Piper betle Linn.) and Sun Flower Leaves (Helianthus annuus L.) Ami Tjitraresmi; Moelyono Moektiwardoyo; Yasmiwar Susilawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.25319

Abstract

Malaria is a disease that occurs in tropical countries like Indonesia. The incidence of malaria in the world is still quite high and the occurrence of cases of Plasmodium resistance to antimalarial drugs and the widespread of resistance have prompted researchers to look for new antimalarial drugs, especially from natural materials. Betel leaf (Piper betle Linn.) And sunflower leaf (Helianthus annuus L.) have long been used by the people of Indonesia as an antimalarial drug. The purpose of this study was to determine antimalarial activity through inhibition of heme polymerization and determine secondary metabolite compounds by phytochemical screening from betel leaves and sunflower leaves. The heme polymerization inhibition activity assay was carried out by the in-vitro method using a microplate reader at 415 nm and 630 nm wavelengths. IC50 values of betel leaf extract and sunflower leaf were 178.67 μg/ml and 160.10 μg/ml, respectively. Phytochemical screening results from betel leaf showed the presence of flavonoids, polyphenols, tannins, quinones, saponins, and monoterpenoids-sesquiterpenoids, while sunflower leaves contain alkaloids, polyphenols, flavonoids, steroids and monoterpenoids-sesquiterpenoids.Keywords: Piper betle Linn., Helianthus annuus L., Malaria, Heme Polymerization
In Silico Study of Aglycon Curculigoside A and Its Derivatives as α-Amilase Inhibitors Nursamsiar Nursamsiar; Maya M. Mangande; Akbar Awaluddin; Syamsu Nur; Aiyi Asnawi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.23062

Abstract

α-amilase is an enzyme that catalyzes the hydrolysis of starch polysaccharides into oligosaccharides to then produce glucose. Inhibitions of the α-amylase enzyme is an effective strategy in modulating blood sugar levels in diabetics. The aglycon curculigoside A has similar structure to chalcon which is able to inhibit the α-amilase enzyme for the treatment of type 2 diabetes. The aim of this study was to determine the interaction of the curculigoside A aglycone compound and its derivatives with the α-amylase enzyme by using the docking simulation method. Docking simulations were carried out by using AutoDock 4.2 and α-amilase protein (PDB ID: 1B2Y) as macro molecule. The docking results showed that the aglycone curculigoside A and its derivatives able to interacted into the active site of the α-amylase enzyme. Three best ligands according to the simulation and prediction tests were compound 10, compound 23, and compound 41 has formed hydrogen bonding to Asp197, Glu233 and Asp300 residues with free bonding energy of -7.29, -7.22, dan -7.84 kcal/mol, respectively. In conclusion, Three best ligands has the same pattern of hydrogen bonds to the native ligand AC1 (6-methyl-5-(4,5,6-trihydroxy-3-hydroxymethyl-cyclohex-2-enylamino)-tetrahydro-pyran-2,3,4-triol) via amino acids redisues of α-amylase that play a role in the substrate by hydrolysis process.Keywords: aglycon curculigoside A, α-amylase, diabetes, docking 
Comparison Ability of Polymers Acrycoat S100 And HPMC K4M to Entrapment Efficiency Domperidone in Microspheres Pratiwi Apridamayanti; Nora Nurlina Sinaga; Rise Desnita
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.18461

Abstract

Domperidone is a prokinetic and antiemetic agent which has low bioavaibility. To increase the bioavaibility of drug, it can be modified into microsphere that can hold drug more longer in gastric to improve the bioavaibility. The microsphere preparation requires a polymer that can make matrix system to protect and deliver the drugs. Acrycoat S100 and HPMC K4M are the usual polymers that used for encapsulation and  have biodegradable characteristic. The aim of this research is to know the comparison ability of two different polymers to entrapment the drug in microsphere. Microsphere domperidone made by solvent evaporation method in 6 formula. F1, F2 and F3 using 50 mg, 100 mg and 150 mg Acrycoat S100 polymer, while F4, F5 and F6 using 50 mg, 100 mg and 150 mg HPMC K4m polymer. The tests were conducted by the determination of the percentage of entrapment efficiency using UV spectrophotometer and evaluation of organoleptic, particle measurement and surface microsphere morphology. The results showed that F3 with Acrycoat S100 polymer has a greater entrapment efficiency of 78,712% ± 4,260% compared to the highest percentage efficiency of HPMC K4M polymer of 4,734±0,390.Key words: Acrycoat S100, domperidone, entrapment efficiency, HPMC K4M, microsphere

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