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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Media Kesehatan Politeknik Kesehatan Makassar JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Pharmaceutical and Medicinal Sciences Jurnal Ilmiah Farmasi Farmasyifa Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Pengabdian Kefarmasian Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan

Syamsu Nur

Sekolah Tinggi Ilmu Farmasi Makassar

Author-ID : 3511797

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Pengaruh Tempat Tumbuh dan Lama Penyulingan secara Hidrodestilasi terhadap Rendemen dan Profil Kandungan Kimia Minyak Atsiri Daun Kemangi (Ocimum canum Sims L.) Syamsu Nur; Junaedy Aryanto Baitanu; Sahibuddin A Gani
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Kemangi (Ocimum canum Sims L.) is one of the plants producing essential oils. Kemangi essential oil is taken from the stem and leaves. This study aims to determine the precentage of the yield of kemangi leaf oil and to identify the content of the chemical compounds of essential oils found in kemangi leaves based on the comparison of the place of growth and duration of distillation. Kemangi leaf samples were obtained from the Bontoala sub-district and from Tinggimoncong sub-district of South Sulawesi. The extraction method of essential oils of kemangi leaves is done by the method of distilation/hydrodestilation using three variations of distillation time, namely 6 hours, 12 hours and 18 hours. Based on the results of the study, it can be concluded that the kemangi leaf essential oil which has the highest yield is from Tinggimoncong sub-district of South Sulawesi, which is 3.325 % with distilation time for 18 hours, GC-MS identification results also show that kemangi leaves essential oil from Tinggimoncong sub-district of South Sulawesi has 93 components of chemical compounds with 5 main components, namely: 5-heptene-2-one, 6-methyl, 1,6-octadien-3-ol, 3,7-dimethyl, α-Terpeniol, 2,6-octadienal, 3,7-dimethy (E), eugenoland also has a component of minor compounds, namely: citral, lynalil acetate, eucalyptol, geraniol, verbenol, carveol, and trans-isoeugenol.

UJI AKTIVITAS ANTIOKSIDAN DAUN KERSEN (Muntingia calabura L.) DENGAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) DAN FRAP (Ferric Reducing Antioxidan Power) Fitriyanti Jumaetri Sami; Syamsu Nur; Naimah Ramli; Budi Sutrisno
As-Syifaa Jurnal Farmasi Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Has conducted research of antioxidant activity from kersen leaves (Muntingia calabura Linn) using DPPH (1,1-diphenyl-1-picrilhydrazil) and FRAP (Ferric Reducing Antioxidant Power). Kersen leaves extracted by maceration using ethanol 70%. Phytochemical identification of kersen leaves contain phenolic, flavonoids and saponins compounds. The test results of antioxidant activity using DPPH method with series concentrations of 2, 4, 6, 8, and 10 ppm obtain IC50 value 6.8249 ug / ml. Testing of the ethanol extract of antioxidants obtained by FRAP method IC50 83,149 µM. Based on these data the ethanol extract of kersen leaves has good antioxidant activity.

In Silico Study of Aglycon Curculigoside A and Its Derivatives as α-Amilase Inhibitors Nursamsiar Nursamsiar; Maya M. Mangande; Akbar Awaluddin; Syamsu Nur; Aiyi Asnawi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.23062

α-amilase is an enzyme that catalyzes the hydrolysis of starch polysaccharides into oligosaccharides to then produce glucose. Inhibitions of the α-amylase enzyme is an effective strategy in modulating blood sugar levels in diabetics. The aglycon curculigoside A has similar structure to chalcon which is able to inhibit the α-amilase enzyme for the treatment of type 2 diabetes. The aim of this study was to determine the interaction of the curculigoside A aglycone compound and its derivatives with the α-amylase enzyme by using the docking simulation method. Docking simulations were carried out by using AutoDock 4.2 and α-amilase protein (PDB ID: 1B2Y) as macro molecule. The docking results showed that the aglycone curculigoside A and its derivatives able to interacted into the active site of the α-amylase enzyme. Three best ligands according to the simulation and prediction tests were compound 10, compound 23, and compound 41 has formed hydrogen bonding to Asp197, Glu233 and Asp300 residues with free bonding energy of -7.29, -7.22, dan -7.84 kcal/mol, respectively. In conclusion, Three best ligands has the same pattern of hydrogen bonds to the native ligand AC1 (6-methyl-5-(4,5,6-trihydroxy-3-hydroxymethyl-cyclohex-2-enylamino)-tetrahydro-pyran-2,3,4-triol) via amino acids redisues of α-amylase that play a role in the substrate by hydrolysis process.Keywords: aglycon curculigoside A, α-amylase, diabetes, docking

Antioxidant Activity and Cytotoxicity Against WiDR Cell and Vero Cell of The Karamunting (Rhonomyrtus tomentosa L.) Leaves Ethanol Extract Marwati Marwati; Andi Anggriani; Asril Burhan; Akbar Awaluddin; Syamsu Nur; Rizky Dharmayanti; Ega Lilingan; Melkisedek D. Tiboyong
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.26769

Karamunting (Rhodomyrtus tomentosa L.), a plant used as a traditional medicine, is widely distributed throughout Indonesia. Karamuting has the potential as an antioxidant and anticancer agents because of its phenolic and flavonoid components. This study aimed to determine total phenolic level, antioxidant activity and cytotoxic of karamunting leaves extract. The simplisia of karamunting leaves were extracted by maceration method using 96% ethanol, tested for its antioxidant activity using DPPH and its citotoxic by MTT method (3- (4,5-dimethyltiazol-2-il) -2,5-diphenyl tetrazolium bromide) on WiDr cells and Vero cells. The results of this study showed that the yield of karamunting extract were 15.635% with a total phenolic level of 0.76%, antioxidant activity (IC50 values) of 15,330 μg / mL and cytotoxicity (IC50 values) of 205.7069 μg / mL for WiDr cells and 44.87703 μg / mL for Vero cells. Ethanol extract of karamunting leaves possessed a very strong antioxidant activity while it showed a weak cytotoxic effect on WiDr cells and toxic effect on Vero cells.Keywords: Antioxidant, Anticancer, Karamunting

SKRINING AKTIVITAS ANTIOKSIDAN, ANTIAGING DAN PENGHAMBATAN TYROSINASE DARI EKSTRAK ETANOLIK DAN ETIL ASETAT DAGING BUAH DAN KULIT BUAH LANGSAT (Lansium domesticum Corr) SECARA IN VITRO Syamsu Nur; Rumiyati Rumiyati; Endang Lukitaningsih
Majalah Obat Tradisional Vol 22, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

This study aims to determine the bioactivity of L.domesticum as cosmetic ingredient. The extraction was prepared by maceration with ethanol 96 % and ethyl acetate to obtain ethanolic extract of fruit flesh (BLE), ethanolic extract of fruit peel (KLE), ethyl acetate extract of fruit flesh (KLE) and fruit peel (KLEA). Then, determination of compounds was conducted by thin layer chromatography (TLC) and analysed of total phenolic and flavonoid content with colorimetric method. The antioxidant capacity was measured using radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH), β-carotene bleaching assay (BCB) and ferric reducing antioxidant power assay (FRAP). The inhibitory effect of skin degradation enzymes (anti-aging) was carried out using elastase and collagenase assay. The tyrosinase inhibitory effect was determined using mushroom tyrosinase. Based on TLC result, extract of L.domesticum containing phenolic, flavonoids, terpenoids and steroids compounds. The largest of total flavonoid content was obtained in KLE (4,76±0,26 %b/b EQ) and phenolic total content in BLEA (6,4±0,15 %b/b EG). Sequence of antioxidant activity measured using DPPH method was BLEA> KLE> BLE> KLEA; while using BCB method and FRAP method were respectively KLEA>BLEA> KLE> BLE; and BLEA> KLE> BLE> KLEA. KLE and KLEA extracts showed the most potent to remaining activity of the enzyme elastase and collagenase. In addition, BLE extract has the higest tyrosinase inhibition than others. Based on these results it can be concluded that the extracts of the fruit flesh and fruit peel of L. domesticum can be used as a cosmetic active ingredient for anti-aging and anti-tyrosinase.

PENENTUAN KADAR FLAVONOID DARI EKSTRAK ETANOL DAN ETIL ASETAT DAUN KESAMBI (Schleichera oleosa. L) Syamsu Nur; Nursamsiar Nursamsiar; Khairuddin Khairuddin; Megawati Megawati; Alfat Fadri
Acta Pharmaceutica Indonesia Vol. 46 No. 2 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v46i2.15772

Daun kesambi (Schleichera oleosa L.) merupakan tanaman yang mengandung senyawa saponin, tanin, alkaloida, steroid, fenolik, dan flavonoid. Penelitian ini bertujuan untuk mengetahui kadar flavonoid total yang terkandung dalam ekstrak etanol dan etil asetat daun kesambi (S. oleosa L.) dengan atau tanpa hidrolisis. Ekstraksi dilakukan dengan metode refluks menggunakan pelarut etanol 70% dan etil asetat dengan atau tanpa penambahan asam asetat sebagai penghidrolisis sehingga diperoleh ekstrak etanol 70% dan etil asetat dengan atau tanpa hidrolisis. Penentuan kadar flavonoid total dari masing-masing sampel dilakukan secara kolorimetri menggunakan pereaksi AlCl3 dan serapan masing-masing sampel diukur dengan menggunakan spektrofotometer UV-Visible. Hasil penelitian menunjukkan kadar total falvonoid untuk sampel ekstrak etanol tanpa hidrolisis sebesar 62,1±0,98 (mgEQ/g) sedangkan sampel yang dihidrolisis asam asetat sebesar 57±0,23 (mgEQ/g). Kadar total flavonoid untuk sampel ekstrak etil asetat tanpa hidrolisis sebesar 40,7±0,77 (mgEK/g) sedangkan sampel yang dihidrolisis asam asetat sebesar 39,8±0,18 (mgEK/g). Hasil tersebut menunjukkan adanya perbedaan kadar flavonoid total dari masing-masing sampel dengan atau tanpa proses hidrolisis.

Penetapan Kadar Fenolik Dan Flavonoid Total Ekstrak Daun Mangkokan (Polyscias scutellaria) Syamsu Nur; Suwahyuni Mus; Marwati Marwati; Nursamsiar Nursamsiar; Fitriyanti Jumaetri Sami; Alfat Fadri
Jurnal Farmasi dan Ilmu Pengobatan Vol 5 No 1 (2020)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v5i1.116

Daun segar tanaman mangkokan memiliki beberapa khasiat dan mengandung beberapa bahan kimia yang memiliki bioaktivitas. Penelitian ini bertujuan untuk mengetahui kandungan kimia dan kadar fenolik serta flavonoid total dari ekstrak etanol daun mangkokan (Polyscias scutellaria). Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Identifikasi fenolik dilakukan dengan pereaksi FeCl3. Warna hijau kehitaman yang terbentuk menandakan adanya senyawa fenol. Identifikasi flavonoid dilakukan dengan pereaksi antara serbuk magnesium dan HCl pekat, warna jingga yang terbentuk menandakan adanya flavonoid. Penetapan kadar fenolik dan flavonoid dari ekstrak daun mangkokan dilakukan secara kolorimetri menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan kadar fenolik total ekstrak etanol daun mangkokan adalah 14,67 mgEAG/g dan kadar flavonoid total sebesar 1,83 mgEQ/g.

Uji Aktivitas dan Formulasi Krim Antioksidan dari Kombinasi Beberapa Ekstrak Etanol Kulit Buah Jeruk (Citrus sp.) Radhia Riski; Syamsu Nur; Elisabeth Pabontong
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 1 (2021)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i1.126

Kulit buah jeruk nipis (Citrus aurantifolia Swingle.), jeruk purut (Citrus hystrix D.C.), jeruk manis (Citrus sinensis L.) mengandung senyawa flavonoid dan vitamin C yang dapat menangkal radikal bebas sehingga mencegah penuaan dini. Penelitian ini bertujuan untuk menentukan aktivitas penghambatan radikal bebas dari ekstrak etanol kulit buah jeruk nipis, jeruk purut, jeruk manis, dan memformulasinya dalam bentuk sediaan krim. Pada penelitian ini ekstrak kulit jeruk nipis, jeruk purut, jeruk manis diuji aktivitas penghambatan radikal bebas dan diformulasi menjadi sediaan krim dengan variasi konsentrasi (tween 80- span 80) sebanyak (1%, 2%, 3%). Hasil penelitian menunjukkan bahwa ekstrak kulit buah jeruk nipis, dapat menghambat radikal bebas pada konsentrasi (IC50) 240 bpj, ekstrak kulit jeruk purut (IC50) 210 bpj, ekstrak kulit jeruk manis (IC50) 133 bpj, dan kombinasi ekstrak (IC50) 67 bpj. Ekstrak kombinasi selanjutnya diformulasi dalam bentuk krim dan diperoleh hasil bahwa semua formula krim memenuhi persyaratan kestabilan dan formula optimum adalah formula I.

UJI AKTIVITAS ANTIOKSIDAN DARI BEBERAPA EKSTRAK KULIT BATANG JAMBLANG (Syzygium cumini) MENGGUNAKAN METODE PEREDAMAN RADIKAL 2,2-DIPHENYL-1-PICRYLHYDRAZYL (DPPH) Fitriyanti Jumaetri Sami; Syamsu Nur; Sukriani Kursia; Sahibuddin A Gani; Trito Reski Sidupa
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 4 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i4.2249

Jamblang (Syzygium cumini) merupakan salah satu buah lokal Indonesia. Semua bagian tanaman ini dapat digunakan untuk pengobatan salah satunya sebagai antioksidan. Tujuan dari penelitian ini adalah untuk menentukan potensi antioksidan dari beberapa ekstrak kulit batang jamblang dengan menggunakan kuarcetin sebagai pembanding. Kulit batang jamblang diekstraksi secara refluks dengan menggunakan pelarut etanol, etil asetat, dan n-heksan kemudian di uji potensi antioksidannya. Hasil penelitian diperoleh nilai IC50 ekstrak etanol kulit batang jamblang sebesar 164,3 ppm, ekstrak etil asetat kulit batang jamblang sebesar 237,7 ppm, ekstrak n-heksan kulit batang jamblang sebesar 5235,6 ppm. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak etanol kulit batang jamblang memberikan aktivitas antioksidan yang lebih kuat jika dibandingkan dengan ekstrak lainnya. Namun hasil tersebut masih lebih kecil jika dibandingkan dengan kuarcetin dengan nilai IC50 4,57 ppm.

UJI AKTIVITAS TABIR SURYA PADA BEBERAPA SPESIES DARI FAMILY ZINGIBERACEAE DENGAN METODE SPEKTROFOTOMETRI Fitriyanti Jumaetri Sami; Syamsu Nur; Megawati M. Martani
As-Syifaa Jurnal Farmasi Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Testing activity sun screen of several species from family Zingiberaceae with a spectrophotometric method have been. Study purpose is to obtain data on the sunscreen activity of ginger extract Z. officinale var. Officinale, Z. officinale var. Rubrum and Zingiber zerumbet SM and their combination with the parameters of % transmission of erythema, % transmission of pigmentation and SPF. The method used an experimental laboratory. Evaluation of the activity of ethanol extract of Z. officinale var. Officinale, Z. officinale var. Rubrum and Zingiber zerumbet SM made by maceration method using 70% ethanol. The test is based on the ability of the absorb the rays ultraviolet. Research carried out by the respective concentrations of ethanol extract of Z. officinale var. Officinale, Z. officinale var. Rubrum and Zingiber zerumbet SM of 200 ppm , 400 ppm , 600 ppm, 800 ppm and 1000 ppm. Based on percent transmission of erythema and percent transmission of pigmentation at a concentration of 1000 ppm, respectively ethanol extract Z. officinale var. Officinale, Z. officinale var . Rubrum and Zingiber zerumbet SM could be used as a sunscreen but still weak to be used as sunscreen ingredients. The result showed that combined Z. officinale var. Officinale, Z. officinale var. Rubrum and Zingiber zerumbet SM at a concentration of 500 ppm obtained percentage value of 1% transmission of erythema and 3,9% of pigmentatied transmission and categories as sunblock with SPF value is 50 protection.

Co-Authors Aiyi Asnawi Akbar Awaluddin Alfat Fadri Alfat Fadri Alfat Fadri Alfat Fadri Alfrida Tandilolo Ali Djamhuri Amriani Sapra Andi Anggriani Andi Nur Aisyah Andi puanguce Paluseri Asril Burhan Asril Burhan Astuti Amin Budi Sutrisno Burhanuddin Taebe Ega Lilingan Elisabeth Pabontong Endang Lukitaningsih Endang Lukitaningsih Fhahri Mubarak Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami Fitriyanti Sami Imrawati Imrawati Imrawati Imrawati Junaedy Aryanto Baitanu Khairi, Nur Khairuddin Khairuddin Khairuddin Khairuddin Libertin Libertin Marwati Marwati Marwati Marwati Maya M. Mangande Megawati Megawati Melkisedek D. Tiboyong Mirnawati Salampe Muhammad Aswad Naimah Ramli Noer Rahman Nursamsiar Nursamsiar Radhia Riski Rifah Yulianty Rizky Dharmayanti Rumiyati Rumiyati Rumiyati Rumiyati Sahibuddin A Gani Sukamto Salang Mamada Sukriani Kursia Suwahyuni Mus Trito Reski Sidupa William Johanes Dian Patabang Zulfaidah Rahma

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