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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 494 Documents

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Effectiveness of Internal Chemical Indicator Strips for Class IV and V Insan S.K. Syah; Sohadi Warya; Vidhya Rohinee A/P Murugan@ Gopal; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Infections through contaminated medical equipments are a serious threat to any patient’s safety and could be dangerous this treatment or may lead to new illness. Sterilization process was a compulsory procedure to ensure sterility of medical equipments where chemical indicators were broadly used to monitor sterilization process. The purpose of this study is to determine the development of internal chemical indicators strips of class IV and V in the steam sterilization in order to obtain good and quality products. Internal chemical indicator strips were able to provide visual verification on products that had passed through the sterilization process, with colour change on the indicator. The stages in this research had also included microbial contamination test Laminar Air Flow (LAF), dosage formulations Sodium Chloride (NaCl) 0.9% infusion, application of internal chemical indicator strips in the moist heat sterilization process and evaluation of NaCl 0.9% infusion that includes sterility test. This study was carried comprising 7 variations of time with data that showed a positive reaction for both indicators with a change of colour after 121 °C of sterilization. Sterility test showed no microbial growth starting from the sterilization time of 10.5 minutes. This research had successfully concluded that internal chemical indicator strips class IV and V were effective on steam sterilization at 121 °C for 10.5 minutes and could be used to monitor the sterilization process. Keywords:Internal chemical indicators strips of class IV and V, NaCl 0.9% infusion, steam sterilization

Sunscreen Activity Testing of Robusta Coffee (Coffea cenephora ex froehner) Leave Extract and Fractions Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah; Riski Solehati; Aldi Elgiawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Coffee leaves are part of a plant that has not been optimally utilized. The purpose of this study was to explore the potential use of coffee leaves to help maintain skin health. Extraction method was carried out with maceration method using 70% ethanol solvent. Fractionation process was carried out by Liquid-Liquid Extraction method, using different solvents to accumulate the n-hexane, ethyl acetate [A1] and methanol fractions. Activity testing was carried out on all samples at concentrations of 50, 100 and 150 ppm including measurements of Sun Protecting Factor (SPF), Erythema and Pigmentation Transmittance Percentages (%Te [A2] and %Tp[A3] ) using UV-visible spectrophotometry at 290 and 400 nm wavelengths. The results showed that the ethyl acetate [A4] fraction at a concentration of 150 ppm had a higher potential as a sunscreen than other samples with SPF value of 19.82; %Te [A5] 10.96 and %Tp [A6] 18.14 and included in the category of fast tanning sunscreen.Keywords: coffee leaves, sunscreen, sun protecting factor, erythema, pigmentation

Molecular Docking Simulation of Cinchona Alkaloids Derivatives as Anti-cancer Agent Teni Ernawati
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

One of the triggers of breast cancer is the estrogen hormone. Estrogen α receptors play a role in breast development and growth. Estrogen receptors as molecular targets have been widely reported. Cinchona alkaloids have been known to function as anti-malarial, but recent studies have shown that cinchona alkaloids have other potentially such as anti-cancer, anti-tumor, anti-microbial, anti-HBV, anti-inflammatory, anti-oxidant, anti-obesity. Cinchona alkaloids have been developed as anti-cancer agent. They have comparable reactivity and selectivity of cinchona alkaloids functional to anti-cancer agent. In this study, molecular modeling has been performed on forty-four cinchona alkaloid derivatives. These cinchona alkaloids derived compounds have been evaluated as anti-cancer agent. Herein, we observed molecular interactions between selectivity of cinchona alkaloids with estrogen α receptors (ER-α). The docking simulation showed 3 cinchona alkaloids derivatives (cinchonine 2-chlorobenzoate, cinchonidine benzoate and cinchonine 2-(4-hydroxyphenyl) acetate) have lower free energy Gibs and and low kinetic inhibition compared to tamoxifen (as standard commercial) and there are 14 compounds that have relatively the same activity as tamoxifen from 44 alkaloid chincona derivatives.Keywords: cinchona alkaloids derivatives, quinine, quinidine, cinchonine, cinchonidine, anti-cancer, molecular docking

Synthesis, Characterization, Anticancer and In Silico ADME Properties of Caproic Acid Derivatives against P388 Cancer Cell Lines Galuh Widiyarti; Andini Sundowo; Megawati Megawati; Teni Ernawati
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The in-silico properties of absorption, distribution, metabolism, and excretion (ADME) and drugs likeness of caproic acid ester derivativeswere evaluated. The esterification of caproic acid from palm kernel oil with sitronelol and geraniol from citronella oil has been carried out using base (NaOH) catalyst. The cytotoxicity of ester compounds were also tested against P388 murine leukemia cancer cell lines using MTT method. Analysis of the ester productswere carried outusing spectroscopic (IR, MS and 1H-NMR) methods, which were confirmed that the desired compounds were successfully synthesized. Caproic acid ester derivatives showed higher anticancer activity compared to the parent caproic acid for P388 cancer cell lines. Citronellyl caproate with IC50 4.15x10-2µM has the strongeractivity than geranyl caproate with IC50 11x10-2 µM. ADME studies for the synthesized compounds revealed that the ester compounds have fulfill the Lipinski rule of five and has no carcinogenicity effect to rat or mouse.Key words: caproic acid, ester, P388, MTT, ADME

In Silico Study of Weight-selected Molecules of Sea Cucumber as Antimitotic through PyRx-Vina Approach Broto Santoso
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Active ligands usually have low molecular weights (MW). However, paclitaxel, a natural anticancer, has high MW. Some compounds (MW = 750-1000 dalton) in Sea cucumber from TCMSP database have anticancer activity. The objective of study is to obtain docking profile of selected compounds compared to taxol as native. Three of human kinesin-8, were collected from the RCSB database and regenerated by adding hydrogen atoms and charge using the Dock Prep in Chimera. These proteins and selected compounds were prepared to fulfil PyRx's requirement. Molecular docking was performed based on mass center value and grid-box volume from previous studies and resulted vina-score (kcal/mol). Docking data and their 3D conformation were analyzed using PyMOL, PoseView, and PLIP. The native alignment results between docked and original conformation showed that their RMSD value is less than one and only one that has the same three-dimensional conformation. Holothurinoside D, desholothurin B, and 2,4-dehydroechinoside B have a binding affinity of -9.7, -9.4, and -9.3 kcal/mol, respectively. Their value is better or at least the same as the native (-9.3 kcal/mol). Hydrophobic interactions between proteins and ligands occurred at residue of F272, V23, and P360. These results confirm that the anticancer mechanism of these compounds may be through inhibition of kinesin-8. Key words: in silico, sea cucumber, antimitotic, PyRx-vina

Exploration of Indonesian Plants as Skin Lightening against Tyrosinase: A Virtual Screening Pandu Hariyono; Jasson Rhinehard Karamoy; Maywan Hariono
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Aesthetic is nowadays becoming as one of the important things for people to increase self-confidence. Flawless skin could be one of the desired looks especially for females which is a valuable cosmetics market. Skin browning is often associated with dermatological problems which may lead to hyperpigmentation due to the increase of the melanin biosynthesis. Skin browning could be caused by the overproduction of melanin which is accelerated by the presence of human tyrosinase. Therefore, the inhibition of this kind of enzyme is associated with skin lightening. In this present study, we perform in silico virtual screening against human tyrosinase by utilizing a natural product database from Indonesia Herbal Database (http://herbaldb.farmasi.ui.ac.id/v3/) to select 20 hit compounds. The simulation was carried using AutoDock Vina via molecular docking. The result shows that from 200 compounds of the database, those hits have a free energy of binding range from -12.1 to -9.2 kcal/mol predicting the affinity of the corresponding compounds towards human tyrosinase associating with its potential as a skin whitening agent. The hits correspond to their presence in Indonesian local plant that could be potential as resources for skin whitening.Keywords: Indonesian plant, molecular docking, skin lightening, tyrosinase, virtual screening.

In Silico Study of Thioguanine Derivatives as Hemopexin Matrix Metalloproteinase9 (PEX-9) Inhibitors Kevin Cahaya Putra; Ervan Setyo Nugroho; Yohanes Krisna Wisnumurti; Sangga Putra Dewa; Benedictus Wisnu Putra Jati; Reynaldo Tiara; Dewi Setyaningsih; Maywan Hariono
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Matrix Metalloproteinase (MMP) was broadly studied as one of the protein targets in stopping angiogenesis. The most common target in MMP, i.e., the catalytic site, is reported as being the non-selective target for inhibition amongst all MMPs, but its inhibition is associated with adverse side effects. Hemopexin in MMP9 (PEX9) was found to be different to the other domains in the MMP family, which could be the next target for anticancer due to the availability of its crystal structure in the protein data bank (pdb). In this study, we design the analogues of a compound from the ZINC database bearing a pyrimidinone scaffold which previously showed activity as a PEX9 inhibitor using molecular docking. The docking is carried out using Autodock 4.0 with parameters such as 250 run and lammarckian genetic algorithm. The result shows that six designed compounds have a free energy of binding from -7.0 to -11.0 kcal/mol. The important amino acid residues which are involved in the hydrogen bond interaction are ARG106, GLU60, GLU14, and GLN154. In conclusion, the six design compounds could give an insight mechanism to inhibit the PEX-9 activity in silico.Keywords: Docking, Hemopexin, MMP9, PEX9, Thioguanine

Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch Wira Y. Rahman; Endang Sarmini; Herlina Herlina; Abidin Abidin; Triyanto Triyanto; Hambali Hambali; Sriyono Sriyono; Triani Widyaningrum
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumours. Currently, keloid is treated by a conventional method e.g.by applying the bulk of 32P radioisotope directly on keloid area. However, this method is considered inefficient and less secure. The purpose of this research is to obtain a technology for preparing of 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with particle size of <1 μm. These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily. Characterization of the prepared Cr32PO4colloids gave a yield of 97,8% with particle size of greater than > 1μm. Further study needs to be performed in due time in order to have Cr32PO4 colloids with a suitable particle size.Key words: keloid, chromic phosphate colloid, skin patch, condensation, oxidation-reduction reaction

99mTc-Human Serum Albumin-Nanoparticle for Sentinel Lymph Node Identification Rizky Juwita Sugiharti; Iim Halimah; Iswahyudi Iswahyudi; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The sentinel lymph node is the first lymph node in a lymph node basin to receive lymphatic drainage from a primary tumor. An accurate identification and characterization of sentinel lymph node is very important as it helps to decide the extension of surgery, the tumor staging, and establisment of the most adequate therapy. Technetium-99m labeled Human Serum Albumin nanoparticle (99mTc-HSA nanoparticle) was prepare as a radiopharmaceutical with particle size between 100 - 200 nmthat is used in lymphoscintigraphy technique for tracinglymphatic system and identifies the sentinel lymph node. Biodistribution study of 99mTc-HSA nanoparticle was conducted in mice to identify the accumulation of this agent in sentinel node and the other tissue. 99mTc-HSA nanoparticle showed good accumulation in sentinel node about1.29 +0.90 %ID with value of popliteal extraction 89.55 +8.52 at one hour post injection. This result was indicated that 99mTc-HSA nanoparticle is very promising compound to be further explored as sentinel lymph node imaging agent.Key words: Lymphoscintigraphy, 99mTc-HSA-nanoparticle, sentinel lymph node

Integrity Test for Hepa Filters in Cleanroom Preparation and Cleanroom Process of Labled Compound I Wayan Widiana; Hermanto Hermanto
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

One of some factors that take effect for the cleanroom sterilization is the integrity of HEPA filters. The value of HEPA filters integrity should be contained in the qualification document of air conditioning system (HVAC). HEPA filters integrity testing aims to ensure the performance of HEPA filters that installed in the air conditioning system, so that no leakage occurs in the installation of HEPA filters, that cause the cleanroom becomes unsterile. The methodology used is to supply aerosol concentration in the upper HEPA filter between 10 - 100 μg/L, and then perform a maximum aerosol penetration measurement on the downstream of HEPA filter. The results are compared with the standard provisions that is contained in the "Procedural Standards for Certified Testing of Cleanrooms", where the maximum permissible penetration is 0.01%. The maximum value of aerosol penetration below 0.01%, that states a HEPA filter has good integrity. While the maximum value of aerosol penetration percentage above 0.01%, states that a HEPA filter has poor integrity. Integrrity test of HEPA filters was performed on 8 units, there are in the cleanroom preparation and cleanroom process of labled compound. The result obtained from the test is that all HEPA filter units have excellent integrity with maximum penetration percentage below 0.01%. The maximum aerosol penetration rate obtained from the overall HEPA filter is 0.004825 % ± 0.000707.Keywords: Labled Compound, Cleanroom, HEPA filter integrity, aerosol penetration

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Muchtaridi

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