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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Formulation of emulsion of soybean (Glycinia soyae L.) tempeh and fermented spinach (Amaranthus sp.) using combination of gelatin and CMC as thickener Agustine Susilowati; Aspiyanto Aspiyanto; Puspa Dewi Lotulung; Yati Maryati
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.20204

Abstract

Mixture of soybean (Glycinia soyae L.) tempeh paste and spinach (Amaranthus sp.) fermented by Kombucha culture produces potential source of natural folic acid. The experiment activity aims to find out the best ratio of gelatin and CMC as thickener in emulsification to prepare supplement of natural folic acid. Emulsification process was conducted by adding gelatin and CMC at ratio of 0 : 0, 0.1 : 2, 0.2 : 4, 0.3 : 6, 0.4 : 8, and 0.5 : 10 (g/g) in mixture of fermented spinach concentration of 2.5, 5.0, 7.5, and 10.0% (w/w in soybean tempeh) and soybean tempeh. The best drying treatment was achieved at 50°C for 24 h. Result of experiment activity showed that based on the best folic acid, the optimum treatment to yield supplement paste was achieved at combination of gelatin-CMC ratio of 0.4 : 8 (g/100 g in mixture paste) and fermented spinach 2.5% (b/b in soybeans tempeh). Identification on folic acid in paste and supplement powder with mass spectra had been identified 6 folic acid monomer dominated by folic acid monomer with molecular weight (M+1) 442.87 and 442.66 Dalton (Da.) with relative intensity 100%. Paste and powder of supplement displayed distribution of particle size 1,745.1 and 984.1 nm with particle indexes of 1.124 and 1.121.Keywords : folic acid , gelatin, emulsification, tempeh, spinach, ratio.
Differences of Respiratory Rate Between Salbutamol and Aminofilin in Exacerbation Asthma Amelia Lorensia; Zullies Ikawati; Tri Murti Andayani; Daniel Maranatha
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.17034

Abstract

Exacerbation of asthma is a progressive step in progressive breathing, coughing, wheezing, breathing. In Indonesia salbutamol nebulation is used for the therapy of the first exacerbation attack. In addition, intravenous aminophylline is also recommended as a therapy, even if the use of aminophylline abroad is reduced due to its smaller effectiveness and often leads to greater unwanted reaction events. The effectiveness of asthma exacerbation therapy needs to be monitored and one of the monitoring parameters that is easily seen is the rate of breath.The aim of this study was to investigate the difference in respiratory rate values using salbutamol nebulisation and intravenous aminophylline in patients with asthma exacerbations in hospitals in Surabaya. The research was conducted by using quasi experimental method and data collection by purposive sampling. Analysis of the data to be used is a independent t-test. The results showed that the salbutamol group decreased respiratory rate by 50.00%, there were also patients who experienced an increase of breath rate of 13.64%. In the aminophylline group experienced a decrease in respiratory rate of 43.75% with an increase of breath rate of 18.75%. From the results of the study, it is necessary to monitor the effectiveness and the need to monitor the unwanted reactions of both treatments so that the therapies produced in the treatment of asthma exacerbations are more effective.Key words: Aminophylline, exacerbation asthma, respiratory rate, salbutamol 
Isolation of Secondary Metabolite A. niger “In-Habiting” Queen M. gilvus Hagen.’s Nest Yohannes Alen; Atika Melati; Gemmy Sarina; Akmal Djamaan
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.816 KB) | DOI: 10.24198/ijpst.v5i2.15364

Abstract

Aspergillus niger is pathogen fungi that can live in various locations and can live contiguous with many hosts, one of them is queen termite’s nest. The aims of the study were to isolated the secondary metabilite of A.niger. Extraction proccess of secondary metabolite compounds was carried out by maceration method using methanol solvent. Based on that proccess, methanol extract was be yield 4,32% sample weight. Fractination proccess was carried out in the separating funnel using ethyl acetate solvent, which ethyl acetate fraction was be yield 14.39% methanol extract. Separation of the compounds was carried out by column chromatography method using n-hexane and ethyl asetate eluents. Purification of the compounds were done by recrystallization method using n-hexane and ethyl asetate. Two secondary metabolite compounds were successfully isolated from ethyl acetate fraction of the methanolic extract of fungus A. niger “In-Habiting” queen termite’s nest M. gilvus Hagen. Based on organoleptic examination, the compound signed AM-12-22-01 is 35 mg, white needle crystals, melting point 151-153 oC. While, the AM-12-60-01* is 15 mg, white needle crystals, melting point 91-93 oC. Based on the chemical analysis, thin layer chromatography, ultraviolet and infrared spectra data it was identified that AM-12-22-01 and AM-12-60-01 were a phenolic compounds.Key words: isolation, A. niger, In-Habiting, M. gilvus Hagen.
Macronutrient Analysis Of Crab Meat Analogue Made From Non-Consumable Fish With Alginate Addition Ellya Sinurat; Singgih Wibowo; Dina Fransiska
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.044 KB) | DOI: 10.24198/ijpst.v1i1.10434

Abstract

The crab meat analogue products using alginates and proteins such as soybean. A mixture of sh added alginate croslinking with calcium chloride making gel and water retention. The purpose of this study to analysis macronutrient from the effects of alginate addition to the characteristics of the crab meat analogue. The formulation was made from the combination of alginate from Sargassum sp. The formulation was applied to the surimi from silver giddy (Gerres Kapas Blkr) to make crab meat analogue with different concentrations (0.25%, 0.5%, 0.75%, 1%). Parameters used to study the effects were moisture content, total ash, protein content, fat content, thiobarbituric acid value and sensory evaluation. The chemical analysis, moisture content, and ash content analysis showed a signi cant difference among the treatments, while the thiobarbituric acid value showed no difference among the samples. Based on sensory evaluation, the most preferred product was formula A (0.25% alginate) in terms of texture, taste, juiciness and overall acceptance with the characteristics of 2.47% ash content, 75.98% moisture content, 0.47% fat content, 12. 07% protein content, thiobarbituric acid value of 0.69 μmol/g. Keyword : crab meat analog, alginate, macronutrient, non consumable, Sargassum sp. 
Mulberry Leaves (Morus alba) for Diabetes Mellitus: Acute Toxicity Test in Male Wistar Rats Rena Nurita; Anisa Vitriana; Isni Maulina Sukmara; Nurul Utami; Maryam Maryam; Fathul Huda; Vycke Yunivita
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.754 KB) | DOI: 10.24198/ijpst.v1i1.16117

Abstract

Diabetes mellitus (DM) is a chronic disease which becoming health community problem in the world. DM patients can be treated by antidiabetic drugs throughout their lifetime. Therefore, to alleviate the concern for the side e ect, it is important to have an alternative therapy which has same e ect but less side e ect. One of alternative therapies which has been known for a long time ago is Mulberry leaves (Morus alba). For something to be clinically used as an alternative therapy, e ective and lethal dose should be known. Here we tried to discover the lethal dose (LD50) and the liver morphological changes, using the e ective dose that had been known from previous study. In our experiment, we used Morus alba leaves infusion and 25 male Wistar rats. These rats were divided into 1 control group and 4 groups treatment dosage, 0.3, 3, 30, and 300 grams/kg bodyweight. We observed the mortality in 7 days and examined the liver morphological changes. From this study, we conclude that 300 grams/ kg bodyweight or 48 grams/kg bodyweigtht in human was pseudolethal dose in male Wistar rats. We did not found any signi cant liver morphological changes. Therefore, we can categorize Morus alba as a harmless alternative therapy. Key words: Alternative therapy, diabetes mellitus, liver morphological changes, lethal dose, Morus alba.
Uji Aktivitas Antibakteri Pigmen Karotenoid Dari Bakteri Simbion Karang Lunak Sarcophyton sp. Terhadap Pertumbuhan Bakteri Patogen Staphylococcus aureus ATCC 25923 Awang Surya Wiguna; Lia Kusmita; Ocky Karna Radjasa
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 3 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4787.02 KB) | DOI: 10.15416/ijpst.v3i3.9176

Abstract

Mikroba penghasil antibiotik dapat berupa fungi maupun bakteri yang bersimbiosis pada organisme lain. Pigmen karotenoid dari bakteri simbion karang lunak merupakan mikroorganisme yang berpotensi sebagai antibakteri. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri ekstrak pigmen karotenoid dari bakteri simbion karang lunak Sarcophyton sp. terhadap pertumbuhan bakteri patogen Staphylococcus aureus ATCC 25923 serta mengetahui perbedaan aktivitas antibakteri ekstrak pigmen karotenoid pada konsentrasi 0,5 %, 0,75 %, dan 1 % dengan metode sumuran. Bakteri yang menghasilkan pigmen karotenoid dibiakkan dan diidentifikasi dengan mengisolasi DNA untuk dilakukan PCR dan mensequen hasilnya. Hasil penelitian aktivitas antibakteri dengan rata – rata diameter zona hambat pada konsentrasi 0,5 % sebesar 0,678 cm, konsentrasi 0,75 % sebesar 0,978 cm, konsentrasi 1 % sebesar 1,416 cm serta diameter zona hambat kontrol positif amoksisilin trihidrat sebesar 1,875 cm.
Analisis Farmakoekonomi Saintifikasi Jamu Antihipertensi, Antihiperglikemia, Antihiperkolesterolemia, dan Antihiperurisemia Supriyatna -; Hadiyana Sukandar; Imas Maesaroh; Firdha S. Maelaningsih
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 2 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.431 KB) | DOI: 10.15416/ijpst.v1i2.7512

Abstract

Saintifikasi jamu dikembangkan agar dapat dipromosikan oleh profesional medis dalam kesehatan formal, bertujuan untuk memberikan dasar ilmiah pemanfaatan jamu di pelayanan kesehatan, membangun jaringan, mendorong penyediaan jamu yang aman, efektif, dan berkualitas. Penelitian dirancang untuk mengetahui efektivitas penggunaan simplisia dalam formula jamu (antihipertensi, antihiperglikemia, antihiperkolesterolemia, dan antihiperurisemia), membandingkan biaya terapi menggunakan simplisia jamu dan obat generik. Penelitian farmakoekonomi menggunakan metode cross-sectional, analisis efektivitas biaya secara retrospektif. Penyediaan dan penggunaan simplisia saintifikasi jamu di puskesmas Gondomanan Yogyakarta dianalisis secara deskriptif. Dari hasil penelitian terdapat sebanyak 18 simplisia untuk formula jamu antihipertensi, antihiperglikemia, antihiperkolesterolemia, dan antihiperurisemia. Pengukuran terhadap tekanan darah sistolik dan diastolik pada kelompok jamu antihipertensi menunjukkan penurunan sebsesar 12,67% dan 2,33% setelah 7 hari penggunaan; kadar glukosa darah puasa 10,09% pada jamu antihiperglikemia, kadar kolesterol total 4,33% pada jamu antihiperkolesterolemia, dan kadar asam urat 32,91% pada jamu antihiperurisemia. Harga total jamu per hari setiap 1% penurunan lebih mahal daripada obat generik, yaitu Rp 1.290 untuk antihipertensi, Rp 750 antihiperglikemia, Rp 547,5 antihiperkolesterolemia, dan Rp 377,5 antihiperurisemia.
Optimasi Kondisi Pemisahan Glibenklamid Kombinasi Metformin dengan KCKT-SPE MIP Akrilamid Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 2 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.564 KB) | DOI: 10.24198/ijpst.v3i2.8527

Abstract

Telah dilakukan dan divalidasi metode analisis glibenklamid dalam plasma menggunakan kromatografi cair kinerja tinggi fase terbalik dengan pretreatment menggunakan SPE C-18 dan SPE-MIP monomer akrilamid. 1 mL metanol dan 1 mL akuabides digunakan sebagai conditioning agent, 1 mL metanol 5% dalam akuabides digunakan sebagai washing agent, dan 1 mL asetonitril digunakan sebagai eluting agent. Hasil ekstraksi dianalisis menggunakan kolom C18 (Shimadzu) 150 x 4,6 mm, ukuran partkel 5 µm, fase gerak 55:45  v/v asetonitril dan triflouro acid 0,1% dengan kecepatan alir 1 mL/menit, deteksi dilakukan pada 227 nm dengan standar internal gliklazid. Metode analisis divalidasi berdasarkan parameter linieritas, presisi, akurasi, selektivitas/spesifisitas, Limit of Detection (LOD), Limit of Quantification (LOQ) dan kesesuaian sistem. Dapat disimpulkan bahwa metode analisis yang digunakan memiliki validitas sesuai dengan yang dipersyaratkan dan SPE-MIP monomer akrilamid memberikan hasil ekstrasi yang lebih optimal dibandingkan dengan SPE C-18.
Stability of Eleutherine americana (L.) Merr. Extract as Lipstick Colorants as the Change of Temperature, Time, Storage Condition and the Presence of Oxidator Dewi Mayasari; Taofik Rusdiana; Yulien Ratu Kania; Marline Abdassah
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.047 KB) | DOI: 10.24198/ijpst.v5i1.12864

Abstract

Bawang Tiwai (Eleutherine americana (L.) Merr bulbus. is a typical plant from Kutai tribes which commonly used as an anti-bacterial and food coloring. The stability test is performed to determine the stability of the extract. Stability test was conducted in two solvents are distilled water and ethanol include the effects of temperature (25°C, 50°C, 80°C), pH (3, 5, 7), an oxidant for 6 hours, conditions of storage at room temperature and the temperature of the refrigerator for 24 hours and storage for 2 weeks. The absorbance of extract in ethanol and aquadest was decreasing due to the change of temperature, time, the presence of oxidator but due to pH changes, the absorbance of extract was increasing. Meanwhile, on the storage condition, showed the highest absorbance on dark, and room temperature storage compared to other condition.Key words: Eleutherine americana (L.) Merr bulbus, stability, color pigment
Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) from Garut West Java Diki Prayugo Wibowo; Yessi Febriana; Hesti Riasari; Diah Lia Auilifa
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.125 KB) | DOI: 10.24198/ijpst.v5i3.16030

Abstract

West Java is rich in essential oil-producing plants, essential oils known to be responsible for some pharmacological activities among its antioxidant and antimicrobial. This research aims to know antimicrobial, antioxidant activity and identify the components of a compound essential oil of nutmeg (Myristica fragrans Houtt.). Components chemistry identified with GC-MS (Gas Chromatography-Mass pectrometer). Antioxidant activity measured by using the DPPH method (2 2-diphenyl-1-picrylhydrazyl) at 516 λ wavelength absorbance. Antimicrobial activity determined Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) using microdilution method. The result of GC-MS showed the highest component on nutmeg containing 22.22% myristicin. The antioxidant test showed nutmeg had IC50 at 3,16%, essential oil showed antibacterial activity against Gram positive and Gram negative bacteria. Minimum inhibitory concentrations of essential oils range from 0.313% to 10%. The content of essential oils of nutmeg plants that grow in the area of West Java Garut can be used to overcome the problems of antioxidants and antimicrobial.Key words: Antioxidant, Antibacterial, Pala (Myristica fragrans Houtt), Chemical Composition.

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