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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 494 Documents

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Evaluation of 99mTc-Ethambutol Radiopharmaceutical Using High Performance Liquid Chromatography with Radioactive Detector (Radio-HPLC) Maula Eka Sriyani; Rizky Juwita Sugiharti; Eva Maria Widyasari; Iim Halimah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

99mTc-ethambutol is a radiopharmaceuticals used to determine the location of Mycobacterium tuberculosisthat causes TB disease. To prepare this radiopharmaceuticals, several supporting compounds are required in addition to ethambutol and radionuclide compounds. These are mannitol as filler, SnCl2as a reducing agent and sodium pyrophosphate as co-ligand. The radiopharmaceuticals is made in the form of a lyophilized kit without 99mTc radionuclides. The aim of this study was to determined the effect of reducing agents on 99mTc-ethambutol preparation using the High Performance liquid chromatography (HPLC) equiped with radiodetector (radio-HPLC) to the quality of radiopharmaceuticals. In the previous study, the determination of radiochemical purity only used TLC by determining the amount of impurities TcO2and TcO4. This study was carried out more profoundly by using radio-HPLC to ensure the quality of radiopharmaceutical products that were made is actually 99mTc-ethambutol. The Test were performed using paper chromatography, electrophoresis, radio-HPLC, and stability test of 99mTc-ethambutol radiopharmaceuticals. The results showed that the radiopharmaceuticalkit of ethambutol is performing good physical characterictics and high radiochemical purity of 99mTc-ethambutol both in analysis using paper chromatography, electrophoresis and radio-HPLC. The 99mTc-ethambutol shown the peak at retention time (tr) 7,97 minutes using UV and radioactive detector, C18 column, isocratic system using phosphate buffer 0,2 M pH 7,4 and Acetonitrile (90 :10), flow rate 0,8 mL/min. The radiochemical purity of 99mTc-ethambutol is still remain high (91.44 ± 0.92%) after 27 days of kit were made.Key words: 99mTc-ethambutol, radio-HPLC, TB disease, Mycobacterium tuberculosis, radiopharmaceuticals.

Labeling of Piperine with Iodine-131 as Radiotracer in the Development of Cancer Drugs from Indonesia’s Natural Products Isti Daruwati; Yulia Anggraini; Aang Hanafiah Wangsaatmadja
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Piperine, as one of the secondary metabolites of pepper, shows many pharmacological activities in various studies, including as antiinflammatory, antimicrobial, hepatoprotective, antioxidant, and potentially anticancer agents. Cancer is still one of the leading causes of death in the world due to the absence of specific symptoms in early-stage of cancer. The development of drugs for early diagnosis and selective treatment of cancer cells is considered one of the best solutions to reduce mortality. The activity of piperine that could induce apoptosis of 4T1 breast cancer cells and HT-29 colon cancer cells at in vivo trials prove it as a potential compound that can carry radioactive atoms (as labeled-compound) to cancer cells. This study was conducted to determine the optimal conditions of labeling of piperine with iodine-131 in order to obtain a 131I-piperinewhich can later be used as a radiotracer in the development of cancer drugs. The labeling of piperine was performed by Chloramine-T iodination method and followed by purification with ion exchange chromatography. The optimal labeling results of piperine with 43.99% ± 1,23 radiochemical purity were obtained with piperine 3mg/300μL, chloramine-T 50 μg as an oxidizer, incubation time 30 min at room temperature, and 100 μg sodium metabisulphite as a reductor. To improve the purity of the preparation, purification by ion exchange chromatography method with Dowex 1x8 mesh 100-200 as resin was used until obtained 93,26% ± 0,94 of radiochemical purity. Further research is necessary before 131I-piperinecan be used as a radiotracer for cancer diagnosis in nuclear medicine.Keywords:cancer, iodine-131, 131I-piperine,labeled-compound, radiotracer

Molecular Dynamics Simulation Estrogen Receptor Alpha againts Andrographolide as Anti Breast Cancer Doni Dermawan; Riyadi Sumirtanurdin; Deti Dewantisari
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Breast cancer is the most common cancer suffered by women with 1.67 million new cases in the world by 2012 with a mortality rate of 12.9%. Tamoxifen is a standard therapy for breast cancer but can cause endometrial and thromboembolic cancer. Andrografolid is an active compound from Andrographis paniculata which has antiproliferation activity of MCF-7 breast cancer cells with IC50 was 61.11 μM. The purpose of this study was to design andrographolide modification structures as human estrogen receptor alpha (hER-α) antagonists. Molecular docking simulation results showed that the andrographolide and AND5 (best andrographolide derivative) have free binding energy (ΔG) values were -9.65 kcal/mol and -12.43 kcal/mol, respectively, and hydrogen bonds were formed with Gly521, Asp351, and Met343. The ΔG value of ANDS was lower than tamoxifen (-11.40 kcal/mol). Pharmacophore modeling results showed that andrographolide and AND5 had a high pharmacophore-fit value of 46.39% and 63.47%, respectively. Molecular dynamics simulation using MM-PBSA calculation method, showed that the hERα-AND5 system has a value of ΔGTOTAL = -50.52 kcal/mol compared to the hERα-estradiol system as an agonist with a value of ∆GTOTAL = -40.86 kcal/mol . These results suggested that AND5 has better affinity for hERα compared to estradiol so that AND5 is a very promising anti breast cancer agent.Keywords: Andrographolide, molecular dynamics, breast cancer, molecular docking, estrogen receptor alpha

Optimization of Sample Preparation Methods on Formaldehyde Analysis in Meatball with Schryver’s Method Febrina Amelia Saputri; Nur S.B. Rosli; Wiwiek Indriyati
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Meatball is one of Indonesian’s favorite food. However, the fraudulent traders often add carcinogen compounds, formaldehyde to ensure the meatball is not easily rotten. The purpose of this study was to find out the best sample preparation method for formaldehyde analysis in the meatball. The preparation methods were the distillation, hot immersion, and cold immersion. Formaldehyde was then analyzed by Schryver’s method. UV-Vis spectrophotometer was used for quantitative analysis. The distillation method yielded the highest recovery (100.64%) compared to hot immersion (98.11%) and cold immersion (94.17%). The best method was used to test the meatball samples that have been collected around Jatinangor, Indonesia. The results of the qualitative analysis for five samples of meatball showed that two samples containing formaldehyde with the highest concentration of formaldehyde in the sample B2 (14.72ppm) and followed by B5 (8.77ppm).Keywords : Cold immersion, distillation, formaldehyde, hot immersion, meatball, Schryver.

Comparative Study of Antioxidant Phycocyanin Extracts Activity between S. platensis with S. fusiformis Using DPPH Method Dwi Margiati; Danni Ramdani; Asri Peni Wulandari
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Phycocyanin is Spirulina’s content which has antioxidant activity to inhibit oxidation process or formation of free radicals that play a role in the initiation high-degenerative diseases. This research is aim to determine the best antioxidant activity of S. platensis with S. fusiformis through the best extraction methods of Spirulina cell between distilled water and PBS (Phosphate Buffer Solution). This research method existed Spirulina cell extraction used distilled water and PBS, and then followed by fractionation and dialysis phycocyanin extract, afterward tested the antioxidant activity used DPPH method. The result of extraction used PBS with a salt concentration of ammonium sulfate 30% produced the best purity value of phycocyanin extract of both types of Spirulina. Results of tested the antioxidant activity, S. fusiformis has the best antioxidant activity compared with S .platensis with a value of 311.43 ppm and 387.36 ppm, respectively.Keywords: Antioxidant, DPPH, Phycocyanin extracts, S. fusiformis, S. Platensis

Antihyperlipidemia and Antihyperglycemic Studies of Arcangelisiaflava(L.)Merr. Phenolic Compound: Incorporation of In Vivo and In Silico Study at Molecular Level Wahyuning Setyani; Hanny Setyowati; Dwi Hadi Setya Palupi; Hanievia Rahayunnissa; Maywan Hariono
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Yellow root had been extensively studied its potential as herbal medicines in many pharmacologic activities due to its alkaloid content namely berberine. To date, there is no study of the yellow root as the source of flavonoid to have anti-hyperglycemia and anti-hyperlipidemia effect. This present study focuses on flavonoid fraction being investigated its in vivo potential to reduce blood glucose level (165mg/dL at 28mg/kg of a fraction, peroxidase inhibition and catalase activation. The extract was obtained from the fresh yellow root, using the re-maceration method. These extracts were calculated as yield (%), then followed by a preliminary phytochemical investigation. The evaluation of anti-hyperglycemic and anti-hyperlipidemia activity was done using the fraction form of yellow root. The isolation of phenolic compounds was carried out by radial chromatography (chromatotron). The isolated compound was then structurally and computationally characterized using NMR and molecular docking, respectively. The fraction reduced the activity of peroxidase (6.33%) at 14 mg/kg and increase catalase activity (15.74%) at 28 mg/kg of body weight of fraction, respectively. An effort to isolate the flavonoid in the fraction reveals a rutin-like structure, a flavonoid glycoside. This result, therefore, guides the utilization of rutin and its aglycon as the model of lipid peroxidase inhibitor and catalase activator upon in silico molecular docking.Keywords: anti-hyperglycemia, anti-hyperlipidemia, molecular docking, a phenolic compound, yellow root

Evaluation Patch of Rhizoma Extract Kencur (Kaempferia galanga L.) as Anti-Inflammatory with Enhancer Hesti Riasari; Revika Rachmaniar; Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Kencur (Kaempferia galanga L.) is a family of Zingiberaceae. Several studies have shown that kencur can help reduce inflammation because kencur is known to contain anti-inflammatory compounds, namely marker compounds from flavonoids, kaempferol. For the development of pharmaceutical preparations, research on anti-inflammatory plasters containing 96% ethanol extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from ginger rhizome with the addition of penetration enhancer (enhancer), namely propylene glycol. This anti-inflammatory plaster was tested for its activity in 5 groups of Wistar strain rat feet which had been induced 1% carrageenan (negative control); positive control (diclofenac sodium), ethanol96% extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from kencur rhizome and compared with plaster of kencur rhizome ethanol extract without enhancer. The results showed the effect of adding enhancers 30 minutes after administration. 96% ethanol extract and ethyl acetate extract had reduced inflammation by 79.99% in rat test animals compared to plaster ethanol extract of rhizome kencur without the addition of enhancers. Keywords : Kaempferia galanga. L., patch, anti-inflammatory, enhancer, propylene glycol

Software Development to Calculate Absorbed Dose Rate Distribution Using TG-43 Formula Ismet Isnaini; Wahyuni Z Imrana
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Radioisotope applications have become widespread in many fields, such as medical. For the optimal treatment using radioisotope, an accurate absorbed dose rate distribution calculation is required to provide the optimal dose for each patient. A software has been designed to calculate this absorbed dose rate distribution so that paramedics would know whether the absorbed dose rate distribution emitted from that particular source is sufficient or not. Using the TG-43 formula derived by American Association of Physicist in Medicine (AAPM), the calculation were performed using manufacturing data of the Ir-192 source and the function which involve the geometric position between the source and a calculation point. The results of this calculation which were viewed using the imageJ software, have shown that the absorbed dose rate for a source located in the center of a volume was getting larger near the source location but has decreased drastically at the source location.This is due to the unavailability of manufacturing data for radius less than 2.5 mm. As for absorbed dose rate distribution emitted from several sources, the dose rate accumulated and reached the maximum in the middle. It has also formed some sort of shape depending on the location of the source, which form an isodose line or curves.Keywords: TG-43 Formula, absorbed dose rate distribution

Profile of Occupational Dose at TRIGA 2000 Nuclear Facility Rini Heroe Oetami; Afida Ikawati; Dadang Supriatna
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Occupational dose is one of the safety parameters that must be verify to meet the safety objectives. Monitoring of occupational dose at TRIGA 2000 nuclear facility in 2015-2017 was performed using TLDs. The objectives of the monitoring were to evaluate and assess the occupational dose not to exceed the dose limit. In Technical and Health and Safety Division showed the maximum occupational dose for individual of 2.16 mSv and the highest collective dose of 0.029 man-Sv. The maximum occupational dose for individual in Reactor Division was of 1.48 mSv and the highest collective dose of 0.019 man-Sv. The maximum occupational dose for individual in Technophysic Division of 1.4 mSv and the highest collective dose of 0.017 man-Sv. In the Labeled Compound Division, the maximum occupational dose for individual of 2.59 mSv and the highest collective dose of 0.035 man-Sv . From the total of 82 radiation workers, the highest percentage of radiation workers received the occupational doses in the dose range of (1.01-1.50) mSv were: 50% (41 persons, in 2015), 85.36% (70 persons, in 2016) and 70.73% (58 persons, in 2017). 4 persons dose record were within of (2.01-2.50) mSv and 2 persons within of (2.51-3.00) mSv. No radiation worker received doses exceeded the annual dose limit of 20 mSv. Keywords: Occupational dose, Equivalent dose, Dose limit, Radiation worker

Binding Mode, Absorption, And Distribution Profile, Mutagenicity and Carcinogenicity of Asam Gelugur (Garcinia atroviridis Griff.) Fruit Phytoconstituents as Influenza H7N9 Neuraminidase Inhibitor Mohamad Taufik Ismullah; Sri Adi Sumiwi; Tiana Milanda; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The purpose of this study was to predict the bond mode, absorption and distribution profile as well as the mutagenicity and carcinogenicity of the asam gelugur fruit compounds which have the best inhibitory activity in neuraminidase influenza subtype H7N9 active pocket by in silico. Pharmacophore modeling and molecular docking using Ligandscout software. Absorption and distribution profiles using PreADMET software. Mutagenicity and carcinogenicity using Toxtree software. The results showed that 10 of the 13 compounds of asam gelugur fruit formed hydrogen bonds with important amino acid residues in the active sac neuraminidase H7N9. Organic acid group compounds have good absorption and distribution profiles. All acid gelugur fruit compounds are predicted not to be mutagenic and carcinogenic. Hydroxycitric acid is a compound that is predicted to have the best inhibition with the lowest Ki value of 1.09 µM. Hydroxycitric acid is a compound that is predicted to have the best inhibition with the lowest Ki value of 1.09 µM.Keywords: Neuraminidase Inhibitor, Influenza, H7N9, Hydroxycitric Acid

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Muchtaridi

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