Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Indonesian Journal of Pharmaceutical Science and Technology

ijpst
Website

Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

Arjuna Subject : -

Articles 494 Documents

9 10 11 12 13

Quantification of Formaldehyde Residue in Wet Noodles Marketed in Indonesia using RP-HPLC Derivatization Method Mutakin Mutakin; Renyiska Yula; Ida Musfiroh; Nuraeni Nuraeni; Nurdjanah Azinar; Jutti Levita
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Illegal practices of formaldehyde as preservatives in wet noodles have been proven. These formaldehyde-preserved wet noodles are sold in West Java, Indonesia. This compound may be harmful to the body due to a decreasing of blood pressure, coma, acidosis, and acute renal failure. In this study we proposed a quantification method using high performance liquid chromatography (HPLC). A simulation was carried out as comparison. This simulation comprised of formaldehyde-spiked fish then the process was continued by washing, frying, and distilling the fish in a closed-system distillation. Similar condition was applied onto wet noodles purchased from traditional markets in Bandung. Method used was RP-HPLC derivatization method based on the reaction of formaldehyde carbonyl with two different reagents of DNPH (2,4-dinitrophenylhydrazine) and Nash (acetyl acetone, ammonium acetate and acetic acid) reagents. Result showed that formaldehyde residue was detected and quantified in all wet noodle samples with a range of 21-59 ppm. In conclusion, this method can be used for routine analysis to control illegal practices of formaldehyde in wet noodles. Moreover, washing and frying the formaldehyde-preserved food were proven could significantly help reducing formaldehyde level in food.Keywords: 2,4-dinitrophenylhidrazine, formaldehyde, RP-HPLC, wet noodles

Determination of Salbutamol and Guaifenesin in Mixture Using Zero- Crossing Wavelength Measurement Entris Sutisna; Farida Fauzia; Ida Musfiroh; Shelvy E Suherman
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

A mixture of salbutamol and guaifenesin in syrup was analyzed using zero-crossing wavelength method. NaOH 0.1 N was selected as the solvent. Zero-crossing wavelength of salbutamol is 246.2 nm and guaifenesin is 270.2 nm. Results showed that the recovery of salbutamol and guaifenesin are 95.96% and 93.94%, respectively, while the coefficient of variance is 0.995% for salbutamol and 0.2087% for guaifenesin. Limit of detection of salbutamol and guaifenesin are 0.05528 ppm and 9.443 ppm, respectively, while limit of quantification are 0.18427 ppm and 31.477 ppm. We concluded that this method could be applied to determine salbutamol and guaifenesin in mixture. Keywords: Derivative spectrophotometry, guaifenesin, salbutamol, zero-crossing

Tyrosinase Inhibitor Activity Measurement of Crude and Purified Extract of Moringa Leaves (Moringa oleifera L.) Zainal Abidin; Ummu Khaeriah; Zuhrina Zuhrina; Mamat Pratama; Muzakkir Baits
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Moringa leaves is one of the plants that have antioxidant activity. The compounds that have strong antioxidant activity also have strong antityrosinase activity. Moringa leaves contain flavonoid compounds that can inhibit tyrosinase activity in the melanin formation process. This study aimed to determine tyrosinase inhibitor activity of crude and purified extract of moringa leaves (Moringa oleifera L.). Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome from the oxidation of L-tyrosine in the mechanism of melanogenesis. The crude extract obtained by use maceration extraction method and ethanol solvent, whereas the purified extract obtained by use liquid-liquid extraction method and ethyl acetate solvent. The results showed that hydroquinone has IC50 value of 18,234 μg/mL while crude extract of moringa leaves shows IC50 value of 4405,24 μg/mL and purified extract of moringa leaves shows IC50 value of 401,6228 µg/mL. Purified extract of moringa leaves more active as tyrosinase inhibitor than its crude extract but less active than hydroquinone.Keywords: Moringa leaves, Purified extract, Tyrosinase Inhibitor, UV Rays

Antibacterial Activity of Extract and Fraction From Shitake Mushroom (Lentinula edodes) Against Acne Bacteria Ika Kurnia Sukmawati; Ari Yuniarto; Widhya Alighita; Ade Zam-zam J
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Acne is an inflammatory disease that occurs in the skin triggered by the bacteria acne treatment can be done by using natural materials that shiitake mushrooms (Lentinus edodes). This aims of this study were to determining the antibacterial activity of extracts and fractions shiitake mushrooms with broth microdilution method, determining the value of equality shiitake mushrooms with antibacterial comparison and determining the morphological changes of bacteria after exposure to the test sample with a Scanning Electron Microscope (SEM). Tests conducted antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at concentrations used is 1 ppm, 2 ppm, 4 ppm, 8 ppm, 16 ppm, 32 ppm, 64 ppm, 128 ppm, 256 ppm, 512 ppm. Best MIC value obtained in fraction of ethyl acetate and n-hexane fraction of the bacterium Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at a concentration of 256 ppm. KBM value of the n-hexane fraction against Staphylococus aureus bacteria at concentrations of 512 ppm and ethyl acetate fraction against bacteria Staphylococus aureus and epidermidis at a concentration of 512 ppm. Value equality is obtained 1 mg of ethyl acetate fraction of shiitake mushrooms equivalent to 5.346 x 10-2 mg of tetracycline. SEM test results showed the presence of antibacterial activity which is indicated by a change in cell morphology, their lumps and their cell wall frown on Propionibacterium acnes were exposed to ethyl acetate fraction.Key words: Acne, Lentinus edodes, antibacterials, microdilution, SEM

Diuretic Activity and Acute Toxicity of Combination Eurycoma longifolia Extract and Irbesartan Nurmeilis Nurmeilis; Dyah A Woro; Atiek Soemiati; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Biodistribution of 99mTc-HSA-nanoparticle in Lymphatic Node of Animal Model Induced by 7,12 Dimethylbenz(a)anthracene Rizky Juwita Sugiharti; Iim Halimah; Isa Mahendra; Witri Nuraeni; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Breast cancer is one of the most common malignant tumors found in women and hasbecome as the second cause of death in women after cervical cancer.We successfully synthesizedtechnetium-99m labeled Human Serum Albumin nanoparticle(99mTc-HSA nanoparticle); a radiopharmaceuticalwhich potentially used for application in lymphoscintigraphytechnique for tracing lymphatic system.This study was aims to obtain pre-clinical data from 99mTc-HSA nanocolloidin Sprague Dawleyfemale ratsgiven7, 12-dimethylbenzeneanthracene (DMBA) - induced cell proliferation in the breast tissues.The rats are divided into two groups, one groupsaregiven DMBA and observed for 5, 8 and 12 weeks and the other group is without any treatment as control.Biodistribution study of 99mTc-HSA nanoparticlewas conducted to identify the accumulation of this agent in the popliteal and lumbar lymph nodes and the other tissuecompare to normal rats. 99mTc-HSA nanoparticleshown good accumulation in popliteal lymph node 2.90+1.32 %ID; 0.81 + 0.47 %IDand 1.04+0.46 %ID at one hour post injectionin 5, 8 and 12 weeks respectively.The popliteal extraction (PE) was estimated with value 87.92 %, 74.07%, 71.79% in 5, 8 and 12 weeks respectively. This result showed that99mTc-HSA nanoparticleis very promising compound to be lymphoscintigraphyagentin detection of breast cancer.Key words: lymphoscintigraphy, 99mTc-HSA nanoparticle, breast cancer

Sintesis dan Karakterisasi Senyawa Antibakteri Kompleks Fe (III) dengan Derivat Schiff Base Lasmaryna Sirumapea; Asmiyanti Asmiyanti; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Reaksi antara amina primer dengan karbonil menghasilkan basa Schiff (Schiff base) yang secara teori memiliki sifat antibakteri. Sifat antibakteri ini dapat ditingkatkan dengan pembentukan kompleks Schiff base dengan logam tertentu. Telah dilakukan sintesis senyawa Schiff base dan kompleksnya dari 4,4-diamino difenil eter, ortohidroksi benzaldehid dan ion logam Fe (III). Senyawa Schiff base dan kompleks yang terbentuk dikarakterisasi gugus fungsinya dengan spektrometer FT-IR. Senyawa yang terbentuk kemudian diuji aktivitas antibakterinya terhadap bakteri Staphylococcus aureus menggunakan metode difusi agar. Spektra senyawa Schiff base mempunyai puncak pada bilangan gelombang 1620,21 cm-1 dan spektra senyawa kompleks mempunyai puncak pada bilangan gelombang 1612,49 cm-1. Puncak pada senyawa Schiff base mengindikasikan adanya ikatan CH=N, pergeseran puncak pada kompleks Schiff base menunjukkan adanya ikatan antara nitrogen dengan ion logam. Hasil pengujian senyawa Schiff base dan kompleks terhadap bakteri S. aureus menunjukkan positif sebagai antibakteri S. aureus. Kata kunci: Antibakteri, ortohidroksi benzaldehid, Schiff base, senyawa kompleks, 4,4 diaminodifenil eter

Formulasi dan Evaluasi Tablet Alprazolam 1 mg Yuti Mutiawati; Taofik Rusdiana; Fitrileni -; Anis Khorunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 1 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Alprazolam is benzodiazepines drug which used to manage short-term anxiety disorder, also used for the treatment of panic disorder, with or without agographobia. Many factors can affect drug dissolution rates from tablets, hence possibly drug bioavailability- including the crystal size of the drug, tablet disintegration mechanisms and rates, the method of granulation, type and amount of granulating agent employed, type, amount and method of incorporation of disintegrants and lubricants and other formulation and processing factors. The aim of the study was to prepare and evaluate alprazolam tablets with dosage strengths 1 mg, with wet granulation method, as an adjuvant used: corn starch and lactosa sebagai filler, sodium lauril sulfat as solubilizer, sodium starch glycolat as desintegrant, Erytrocin CI 45430 as colloring, polivinyl pirolidon K 30 as binder with variatrion concentration, ethanol 95% as wetting agent, talc, silicon dioksida coloidal and magnesium stearat as glidant and antiadherent, test for the granule are particle distribution, water content, angle of repose, bulk density, taped density, apparent density (compressibility), and test for the tablet dosage are description of tablet, wight uniformity, hardness, desintegration time, content uniformity, disolution, for the selected formula tested the comparison of disolution and bioequivalence to 1 mg Alprazolam tablet innovator, the results obtained, that the tablet alprazolam 1 mg, are meet the requirements. Keywords: Alprazolam, bioequivalence test, dissolution comparison test

Sedative Effect of Citronella (Cymbopogon nardus (L.) Rendle) towards Male Mice (Mus musculus) Yulianita Yulianita; E. Mulyati Effendi; Ekas Mara Firdayani
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Hypnotics are substances which in certain dose is meant for escalating psychological desire to sleep and reduse and causingsleep. The research was aimed to determining the influence and the effective dose of citronella grass as sedative substance applied on male mice. Animals used on the test were amounted to 25 male mice which were divided into 5 groups, each of them consisted of 5 mice. Whose given the citronella grass extract were Dose Group I (12mg/20gBW), Dose Group II (24mg/20gBW), and Dose Group III (48mg/20gBW), by means of Negative Control Group (-) 0,5mL of distilled water, and Positive Group Control (+) in terms of 0.013mL/20gBW Diazepam. The results of the research show that the conferral of citronella grass essence is positively potential as a sedative substance on the mice. Thus, Dose III (48mg/20gBW)becomes the most effective dose with the mice onset of falling recorded 46.7 seconds. The conferral duration of citronella grass essence towards sedative effect on male mice with the dose (III) of 48mg/20gBW is the most effective dose due to the relative similarity with diazepam as postive control, observed from the average duration being close to diazepam as positive control within the average onset amounted to 4.46 seconds, while diazepam itself is amounted to 1.38 seconds.Key words: Citronella Grass, Sedativum, Rotarod

Isolation and Activity Assay of Secondary Metabolites of Aspergillus niger in-Habiting in Termite’s Queen Nest Macrotermes gilvus Hagen., on Enriched Media Yohannes Alen; Evi Guslianti; Netty Suharti
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The Fungus is a group of the microorganisms that produce secondary metabolites. Secondary metabolites of fungus may be changed in different media. Secondary metabolites from Aspergillus niger in habiting in termite’s queen nest Macrotermes gilvus Hagen are disappeared gradually in artificial media. It was the reason to enrich the media with termite’s queen nest. The purpose of this research was to obtain the similar secondary metabolites of Aspergillus niger as it grows in their habitat. Enrichment was done with the experimental method. It used three concentrations of nest 0.25; 0.75 and 1 g/mL Sabouraud Dextrose Agar (SDA) media. Isolation was done use chromatography method. The antibiotic activities against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 were performed by the diffusion method. Results showed that enrichment of nest 1 g/mL media gave the best growth of fungus and it obtain the similar secondary metabolites as it grows in their habitat. Three pure compounds, EG-13-31-2, EG-13-34-9, and EG-13-44-2 were obtained. Based on physicochemical data, all compounds were terpenoid class and one of them (EG-13-34-9) contain the phenolic group. All compounds have activity against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 the bacteriostatic category.Key words: Aspergillus niger; Macrotermes gilvus Hagen; Sabouraud Dextrose Agar (SDA); Isolation; Enrich Media; Diffusion Method

Page 11 of 50 | Total Record : 494

9 10 11 12 13

Filter by Year

2014 2025

Filter By Issues

All Issue Vol 12 (2025): Vol. 12 Suppl. 2 (2025) 2025: Vol. 12 Suppl. 1 (2025) Vol 12, No 3 (2025) Vol 12, No 2 (2025) Vol 12, No 1 (2025) 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and Vol 11, No 3 (2024) Vol 11, No 2 (2024) Vol 11, No 1 (2024) 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference) 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference) Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B Vol 10, No 3 (2023) Vol 10, No 2 (2023) Vol 10, No 1 (2023) Suppl. 5, No. 1 (2023) Vol 9, No. 3, 2022 Vol 9, No. 2, 2022 Vol 9, No 1 (2022) Suppl. 4, No. 1 (2022) Vol 8, No 3 (2021) Vol 8, No 2 (2021) Vol 8, No 1 (2021) Suppl. 3, No. 1 (2021) Vol 7, No 3 (2020) Vol 7, No 2 (2020) Vol 7, No 1 (2020) Vol 6, No 3 (2019) Vol 6, No 2 (2019) Vol 6, No 1 (2019) Vol 6, No 1 (2019 In Press) Suppl. 2, No. 3 (2019) Suppl. 2, No. 2 (2019) Suppl. 2, No. 1 (2019) Vol 5, No 3 (2018) Vol 5, No 3 (2018) Vol 5, No 2 (2018) Vol 5, No 2 (2018) Vol 5, No 1 (2018) Vol 5, No 1 (2018) Suppl 1, No. 1 (2018) Suppl 1, No. 1 (2018) Vol 4, No 3 (2017) Vol 4, No 3 (2017) Vol 4, No 2 (2017) Vol 4, No 2 (2017) Vol 4, No 1 (2017) Vol 4, No 1 (2017) Supp 1, No 1 (2017) Supp 1, No 1 (2017) Vol 3, No 3 (2016) Vol 3, No 3 (2016) Vol 3, No 2 (2016) Vol 3, No 2 (2016) Vol 3, No 1 (2016) Vol 3, No 1 (2016) Vol 2, No 3 (2015) Vol 2, No 3 (2015) Vol 2, No 2 (2015) Vol 2, No 2 (2015) Vol 2, No 1 (2015) Vol 2, No 1 (2015) Vol 1, No 2 (2014) Vol 1, No 2 (2014) Vol 1, No 1 (2014) Vol 1, No 1 (2014) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muchtaridi

Contact Email
ijpsteditor@gmail.com

Phone
-

Journal Mail Official
ijpsteditor@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muchtaridi

Contact Email ijpsteditor@gmail.com

Phone -

Journal Mail Official ijpsteditor@gmail.com

Editorial Address -

Location Kota bandung, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muchtaridi

Contact Email
ijpsteditor@gmail.com

Phone
-

Journal Mail Official
ijpsteditor@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA