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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Degradation Study of Ketorolactromethamine by a Validated UPLC Method Mohammad Nasir Uddin; Md. Al-Amin; Md. Nazmul Haque Mijan; Suman Das
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.906 KB) | DOI: 10.24198/ijpst.v6i1.16508

Abstract

UPLC stability indicating method was developed for determining ketorolac tromethamine in its degradation study at different conditions. An isocratic mobile phase composition of 60:10:30 (v/v) containing CH3OH, CH3CN and 5mM NaH2PO4 and C18 column were used at a flow rate of 0.20 mL min-1. Satisfactory retention time was found 2.13±0.05 min at 320 nm when monitored by DAD detector. Forced degradation studies of ketorolac tromethamine was also performed at the following conditions: acid and basic hydrolysis, heat (50-70°C for 1 hr), photolytic (UV and sunlight for up to 3 hr), oxidation (3% hydrogen peroxide for 1 hr). Forced degradation study revealed that ketorolac degraded significantly under thermal conditions. In 1N acid and base hydrolysis, degradation was moderately significant and comparable. It was degraded marginally in 0.1N acid-base hydrolysis which was comparable to oxidative conditions. But in photolytic condition ketorolac shows insignificant degradation. Method was also applied to pharmaceutical formulation.Keywords: UPLC, Ketorolac tromethamine, pharmaceutical formulation, Forced degradation
Effect of Adding Granul Basil (Ocimum americanum) as Antioxidants in Fried Foods Deden I Dinata; Dadih Supriadi; Garnadi Djafar; Syerliana Syerliana; Wahyu Wijayanti; Shelvy E Suherman
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.482 KB) | DOI: 10.15416/ijpst.v2i1.7807

Abstract

Basil is one of medicinal plants in Indonesia that has been used empirically as antimicrobes, analgetic, antiinflammatory, antivirus, antitumor, and antioxidants that prevented ischemia. This research aimed to investigate the effect of adding granule ethanol extract of basil leaves (Ocimum americanum) as antioxidant to capture free radicals in fried foods. The antioxidant activity of ethanol extract of basil leaves with DPPH determinated by IC50, comparing the antioxidant activity of the granule and the control by determination of quality properties of oil and food after frying using Fourier Transfor Infra Red (FTIR) spectra, and quantitative parameters by determination percentage of free fatty acid (FFA). Results of maceration with ethanol 15.94% w/w, total ash content 9.85%, water soluble ash content 3.98%, acid insoluble ash content 3.98%, water soluble extract 25.89%, ethanol soluble extract 12.76%, water content 6.87%, drying shrinkage 11.19%. Testing the antioxidant activity of the ethanol extract of basil leaves with DPPH gave IC50 of 80.55 ppm. The result of antioxidant testing by determination percentage of FFA statistically with ANOVA (significance 0.00<5) and comparison of the concentration extract in basil granule with LSD test significantly different. The result indicates that adding ethanol extract of granules basil on fried foods gave antioxidant activity because it can inhibit the increasing of FFA percentage. Keywords: Antioxidant, basil leaves, DPPH, granule
Formulation and Optimization of Bisoprolol Fumarate Orally Fast Dissolving Film with Combination of HPMC E15 and Maltodextrin as Matrix Polymers Aristha Novyra Putri; Rahmayanti Fitriah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.48 KB) | DOI: 10.24198/ijpst.v1i1.19150

Abstract

Bisoprolol fumarate is a drug belonging β blockers group, and specifically is selective β1 adrenergic receptor blocker, a class medicines used primarily in cardiovascular diseases. The drug has 9-12 hrs half life (t1/2) and shows bioavailability of more than 80%1. An orally fast dissolving film dosage form with drug in mouth are absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism2. The study aimed to made of orally fast dissolving film bisoprolol fumarate by solvent casting method with combination of HPMC E15 and maltodextrin as matrix. Factorial design 23was applied to optimize the formula of orally fast dissolving film bisoprolol fumarate by varying level of polymer, it was HPMC E15 300 – 600 mg, maltodextrin 50 – 150 mg, and PEG400 50 – 90 mg. The optimum formula was determined by superimposed contour plot from various parameters: physical properties of orally fast dissolving film bisoprolol fumarate such as thickness, folding endurance, surface pH, in vitro disintegration, hidration study, and drug release for 300 second using Design Expert ® program. The study result showed that physical properties of 8 formulas such as organoleptic test were transparent, homogeny, and smooth in both of side; thickness 0.062 – 0.132 mm; weight variation 50.85 – 70.60 mg; folding endurance 987 – 2012; surface pH 6.69 – 6.99; disintegration (drop method) 18.33 – 20.76 sec; disintegration (petridish method) 27.63 – 30.41 sec; in vitro dissolution for 300 sec was 94.35 – 98.99%; and swelling index up to 30 second was 146.63 – 173.34%. Based on superimposed contour plot Design Expert® from factor response of folding endurance, surface pH, in vitro disintegration drop method, in vitro disintegration petridish method, swelling index, dan DE300with a statistically significant finding requires a P-value of 0.05 were obtained optimum formulas for the area in the range of HPMC E15 509.88 mg; Maltodextrin 108.63 mg; and PEG400 50 mg with the value of desirability 0.519.Key Words: bisoprolol fumarate, orally fast dissolving film, factorial design
Pengujian Efek Antikalkuli dari Herba Seledri (Apium graveolens L.) secara In Vitro Taofik Rusdiana; Sriwidodo Sriwidodo; Jajan Solahudin; Eli Halimah; Aep W Irwan; Suseno Amin; Sri A Sumiwi; Marline Abdassah
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.042 KB) | DOI: 10.15416/ijpst.v2i2.7812

Abstract

Tanaman seledri (Apium graveolens L.) mengandung berbagai senyawa metabolit sekunder antara lain flavonoid, polifenol, dan kuinon. Tanaman seledri selain untuk bumbu masakan dan sayuran, telah lama digunakan sebagai obat tradisonal untuk penurun tekanan darah tinggi (hipertensi), diuretik, dan hematuria. Penelitian ini bertujuan untuk mengungkap khasiat lain dari tanaman seledri sebagai antikalkuli atau peluruh batu ginjal. Pengujian efek antikalkuli (bagian dari uji preklinis) dilakukan secara in vitro yaitu dengan menguji tingkat kelarutan komponen batu ginjal (kalsium oksalat atau magnesium ammonium fosfat) sebagai solut (100 mg serbuk batu) dalam berbagai variasi konsentrasi sediaan cair seledri sebagai solven dibandingkan dengan solven air (volumen= 10 mL, suhu= 37 oC, waktu= 4 dan 24 jam). Hasil penelitian menunjukkan bahwa cairan infusa seledri pada konsentrasi 1,3; 3,3; dan 5,0% dapat melarutkan komponen kalsium dan magnesium batu ginjal dengan tingkat kelarutan yang secara signifikan lebih besar dibandingkan kelarutan dalam air sebagai kontrol negatif (konsentrasi 5%, Ca: 4,657 vs 199 ppm, Mg: 9,912 vs 9,37 ppm). Sementara fraksi air dari ekstrak metanol seledri juga menunjukkan daya larut yang signifikan terhadap baik kalsium maupun magnesium komponen batu ginjal pada konsentrasi pada 0,5% dibandingkan air (Ca: 3,7 vs 1,5 ppm dan Mg: 25,9 vs 14,5 ppm). Hasil tersebut dapat disimpulkan bahwa herba seledri memiliki potensi sebagai peluruh batu ginjal dengan mekanisme melarutkan kristal komponen batu ginjal. Kata kunci: Antikalkuli, Apium graveolens L., batu ginjal, seledri
Aktivitas Imunomodulator Ekstrak Etanol Daun Tempuyung (Sonchus arvensis Linn.) Asep Edi Sukmayadi; Sri Adi Sumuwi; Melisa Intan B; Anisa D. Aryanti
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 2 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.472 KB) | DOI: 10.15416/ijpst.v1i2.7515

Abstract

 Daun tempuyung (Sonchus arvensis Linn.) merupakan tanaman obat potensial di Indonesia yang secara empiris sering digunakan untuk mengobati asam urat, kencing batu, obat bengkak, batuk, asma, demam, peradangan, dan antibakteri. Penelitian ini bertujuan untuk mengetahui pengaruh aktivitas imunomodulator daun tempuyung terhadap peningkatan jumlah leukosit dan komponennya serta peningkatan IL-2 pada tikus jantan putih galur Wistar. Hewan coba diberi perlakuan ekstrak etanol daun tempuyung dengan dosis 100, 700, dan 1400 mg/KgBB serta Stimuno 50 mg/kgBB  yang disuspensikan dengan Na CMC 0,5%. Ekstrak diberikan setiap hari sekali selama 2 (dua) minggu dan 1 (satu) minggu setelah diberikan Shigella dysenteriae secara per oral. Darah tikus diambil dari jantung kemudian dilakukan perhitungan jumlah leukosit dan komponennya dengan flow cytometry, serta IL-2 dengan Sandwich ELISA. Hasil penelitian menunjukkan bahwa terdapat perbedaan bermakna antaraaktivitas imunomodulator ekstrak etanol daun tempuyung (Sonchus arvensis Linn.) pada dosis 100 mg/kgBB terhadap peningkatan jumlah leukosit, limfosit, monosit, dan IL-2 dibandingkan dengan kelompok kontrol negatif dengan nilai p≤0,05.Maka, hasil penelitian ini menunjukkan bahwa ekstrak etanol daun tempuyung dapat meningkatkan jumlah leukosit dan komponennya serta IL-2. Oleh karena itu, daun tempuyung yang merupakan obat tradisional asli Indonesia berpotensi memiliki aktivitas imunomodulator. Kata kunci:  IL-2, leukosit, limfosit, monosit, Shigella dysenteriae, Sonchus arvensis Linn.
Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum Meilia Suherman; Ike Susanti; Driyanti Rahayu; Rimadani Pratiwi; Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.992 KB) | DOI: 10.24198/ijpst.v6i1.18671

Abstract

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.
Formulasi dan Uji Stabilitas Tetes Mata Sulfasetamida Marline Abdassah; Tenri Noviardani; Jutti Levita; Shelvy E Suherman
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.024 KB) | DOI: 10.15416/ijpst.v2i1.7808

Abstract

 Tetes mata sulfasetamidayang mengandung natrium sulfasetamida 10%, 15%, dan 30% telah dibuat dan disterilkan. Metode sterilisasi yang digunakan adalah uap air mengalir 98-100 oC, penyaring bakteri, dan autoklaf 120-121 oC selama 15 menit. Tujuan penelitian ini adalah mendapatkan sediaan yang paling stabil selama penyimpanan 28 hari. Semua sediaan diamati kejernihan, pH dan konsentrasi natrium sulfasetamida.Semua sediaan mengalami kenaikan pH. Kekeruhan terjadi pada sediaan yang disterilkan dengan autoklaf. Sediaan paling stabil adalah tetes mata yang mengandung natrium sulfasetamid 10% yang disterilisasi dengan penyaring bakteri.
Virtual Screening Natural Compounds from Plants as Inhibitor of Estrogen Receptor Alpha I (ESR1) Andi Trihadi Kusuma; Daryono Hadi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1133.771 KB) | DOI: 10.24198/ijpst.v1i1.19149

Abstract

Flavanoid is one of the chemical compounds found in plants. Isoflavones (1.2-diarylpropane) are the largest group in the flavanoid that can be used to study the anticancer activity. 2IOK is one oftarget inhibitors which is obtainedfrom natural product compounds.The purpose of the research is to design new compounds have anti-cancer activity, especially for breast cancer based on the evaluation of the affinity of the compound against Estrogen Receptor Alpha (ESR1) usingthecomputational method. The parent compound is the test structure of isoflavones which has been reported to have anticancer activity, particularly for breast cancer. Based on the results of the validation method of docking with several combinations, the best method found was Triangle matcher-Affinity dG with anRMSDof 1.0452. Furthermore, this model providesROC graph value of  0.863. Therefore, the method was used  to screen compounds  in the UI database. Three compounds wereobtained from the process, which are potentially active against Estrogen Receptor Alpha (ESR1), namely C00010051, C00026048, C00025295. The MD simulations of protein-ligand complexes indicated exchanges process, namely the absence of  interaction between the ligand with the Phe404, insteadofthe ligand formed  hydrogen bonding with Glu353. Meanwhile, the C00025295 compound formed hydrogen bonding with the Leu346 residue.Keywords: virtual screening, molecular docking, molecular dynamic, ESR1
Uji Aktivitas Sediaan Gel Shampo Minyak Atsiri Buah Lemon (Citrus limon Burm.) Arif Budiman; Melina Faulina; Anna Yuliana; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.405 KB) | DOI: 10.15416/ijpst.v2i2.7813

Abstract

Ketombe merupakan gangguan yang terjadi di kulit kepala di mana salah satu penyebabnya adalah jamur. Salah satu bahan alam yang diketahui dapat digunakan sebagai antiketombe adalah buah lemon. Kandungan yang terdapat di dalam minyak atsiri buah lemon seperti flavanoid, monoterpen, dan seskuiterpen diketahui memiliki aktivitas sebagai antijamur. Tujuan penelitian ini adalah untuk menguji aktivitas minyak atsiri buah lemon dalam bentuk sediaan gel sampo terhadap jamur Malassezia sp. Penelitian ini diawali dengan penetapan Konsentrasi Hambat Minimum (KHM) dari minyak astsiri buah lemon secara mikrobiologi untuk mendapatkan konsentrasi bahan aktif dalam formulasi sediaan sampo gel. Orientasi formula meliputi variasi konsentrasi karbomer dan Hidroksi Propil Metil Selulosa (HPMC) sebagai basis gel. Evaluasi stabilitas sediaan gel meliputi pengamatan organoleptis, homogenitas, pH, dan viskositas. Dilakukan uji aktivitas antiketombe dari formula terbaik terhadap jamur Malassezia sp. Hasil menunjukkan bahwa Konsentrasi Hambat Minimum (KHM) minyak atsiri terhadap jamur Malassezia sp. adalah 0,5%. Formula yang menunjukkan hasil terbaik setelah evaluasi sediaan adalah formula yang mengandung basis HPMC sebanyak 6%. Sediaan sampo gel terbaik memiliki aktivitas sebagai antiketombe dengan memberika diameter hambat sebesar 29,4 mm terhadap jamur Malassezia sp. Kata kunci: Minyak atsiri, buah lemon, antiketombe, gel sampo, Malassezia sp.
Interaction of Andrographolide with Neuraminidase of H5N1 Virus and Nuclear Factor-kappaB Jutti Levita; Monika Novryanti; Masripah Masripah; Driyanti Rahayu; Shelvy E Suherman
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.767 KB) | DOI: 10.15416/ijpst.v2i1.7804

Abstract

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