cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rizky Abdulah
Contact Email
r.abdulah@unpad.ac.id
Phone
-
Journal Mail Official
editorial@ijcp.or.id
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
Core Subject :
Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol 10, No 3 (2021)" : 8 Documents clear
Respon Terapi Community Acquired Pneumonia pada Geriatri: Tinjauan Kasus di Intensive Care Unit Widyati Widyati; I Wayan Suryajaya; Arroyani A. Dilaga; Nidaul Hasanah; Renni Simorangkir; Rizky Hidayaturahmah
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.209

Abstract

Pneumonia komunitas adalah salah satu masalah yang semakin meningkat di populasi lanjut usia. Berbagai faktor yang terkait dengan penuaan, seperti komorbiditas, status gizi dan disfungsi menelan telah terlibat dalam peningkatan Community Acquired Pneumonia (CAP) pada populasi yang lebih tua. Streptococcus pneumoniae masih merupakan patogen yang paling umum di antara geriatri, meskipun patogen multiple drug resistance (MDR) juga seringkali menginfeksi geriatri, khususnya pada pneumonia berat. Strategi terapi antibiotik empirik pada pasien CAP berat adalah antibiotik spektrum luas atau kombinasi β-laktam dan fluorokuinolon, atau β-laktam dan makrolida. Laporan kasus ini memaparkan dua kasus CAP pada geriatri yang mewakili dua golongan terapi yang berbeda dengan hasil yang sangat berbeda pula. Kombinasi cefoperazon sulbaktam-makrolida tidak memberikan respon terapi yang baik hingga hari ke-7, sehingga makrolida diganti dengan amikacin dan diteruskan selama 3 hari. Di lain pihak, kombinasi cefoperazon sulbaktam-levofloksasin memberikan hasil yang baik dengan durasi terapi 9 hari. Pemilihan antibiotik dengan penetrasi yang baik ke paru sangat penting untuk mendapatkan efektivitas terapi. Resistensi azitromisin dapat menjadi salah satu penyebab utama terapi tidak efektif, namun karena efek pleiotropic yang dimiliki azitromisin, azitromisin direkomendasikan untuk tetap diberikan. Pemberian kombinasi cefoperazon/sulbaktam-levofloksasin dan cefoperazon/sulbaktam-amikasin pada kedua kasus ini efektif. Manfaat dari laporan kasus ini adalah terapi CAP pada lansia memerlukan kombinasi antibiotik baik dengan fluorokuinolon maupun aminoglikosida. Azitromisin pada kedua kasus di atas menunjukkan resistensi dan tidak dapat difungsikan sebagai antibiotik kedua pada kombinasi. Kata kunci: Antibiotik, CAP, geriatri, pneumonia  Therapeutic Response of Community Acquired Pneumonia in Geriatrics: A Case Series from Intensive Care UnitAbstractCommunity acquired pneumonia (CAP) is a common major growing challenge to elderly populations. Several aging factors, including comorbidities, nutritional status and digestive dysfunctions have been associated with increasing CAP among older persons. Furthermore, Streptococcus pneumoniae remains the most predominant pathogen in geriatrics, although multiple drug resistance (MDR) species regularly occur, particularly in severe pneumonia. Broad-spectrum antibiotics or a combination of β-lactam and fluorokuinolones, or β-lactams and macrolides serve as a promising therapy mainly in critical CAP patients. This study describes two geriatric CAP cases representing two separate treatments with widely varied results. The combination of cefoperazone sulbactam-azithromycin did not generate suitable clinical response until 7 days. As a consequence, the macrolides were replaced with amikacin and continued for 3 days. Meanwhile, the cefoperazone sulbactam-levofloxacin samples significantly improved the clinical conditions under 9 days. The selection of antibiotics with sufficient lung penetration is important in providing the effective therapy. Conversely, azithromycin resistance potentially instigates ineffectiveness, but is also recommended due to its pleiotropic effects. The benefit of this case study shows that CAP treatment among older population requires a blend of antibiotics with either a fluorokuinolone or an aminoglycoside. In both instances, azitromisin is believed to demonstrate high resistance, therefore, it is incapable in functioning as a second antibiotic component.Keywords: Antibiotic, CAP, geriatric, pneumonia
Pharmacy staffing and workload in RSGM Unpad using Workload Indicators of Staffing Needs (WISN) method Faisal Kuswandani; Dwintha Lestari; Felisha F. Balafif
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.198

Abstract

Introduction : One of the challenges in the health facility is the balance between the number of staff and workloads to achieve quality, effectiveness and efficiency. Developing countries that have limited resources and budgets finds out difficult to achieve it. This study aims to analyze the workload at Pharmacy RSGM Unpad using the Workload Indicators of Staffing Needs (WISN) from the World Health Organization (WHO). Methodology: The study employed descriptive cross-sectional design and the Workload Indicator of Staffing Needs (WISN) methodology. Conducted in May 2020. We utilized observations, discussion and interviews to obtain information from staff; document review from hospital's records in 2019. Results :  Available work time in a year were 97440 minutes. As a result, the staffing needed  the Inpatient-outpatient department in Pharmacy RSGM Unpad were 4 people and in the logistic-purchasing department in Pharmacy RSGM Unpad were 2 people. The WISN ratio was obtained at 1.17 (> 1) which means the workload and number of staff at Pharmacy RSGM Unpad were not appropriate (overstaff). Conclusion : Based on the analysis using the WISN method, the number of staff in the Pharmacy RSGM Unpad is overstaff the existing workload. The Pharmacy RSGM Unpad can redistribute staff and develop pharmaceutical satellites to increase effectiveness and efficiency.
Peran Gen TNFRSF11B sebagai Pemicu Osteoporosis Sekunder pada Pasien Artritis Reumatoid Nur A. Ali; Dika P. Destiani; Riezki Amalia
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.234

Abstract

Artritis reumatoid (AR) adalah kelainan autoimun sistemik yang menyebabkan peradangan luas dan persisten pada lapisan sendi sinovial. Pasien dengan AR memiliki risiko lebih besar terkena osteoporosis sekunder. Osteoporosis (OP) sekunder adalah komplikasi umum dari radang sendi seperti AR. Prevalensi OP sekunder pada pasien AR di berbagai belahan dunia dilaporkan antara 22% hingga 36%. Beberapa polimorfisme genetik dapat memengaruhi timbulnya penyakit osteoporosis. Proses remodeling tulang erat kaitannya dengan receptor activator nuclear factor-κB ligand (RANKL)/RANK dan osteoprotegerin (OPG). RANK/ RANKL/OPG adalah memiliki peran penting dalam osteoklastogenesis, karena OPG mampu menghambat diferensiasi dan aktivasi osteoklas. Kajian pustaka ini membahas mengenai hubungan polimorfisme gen TNFRSF11B yang mengkode protein OPG dengan risiko osteoporosis sekunder pada penderita AR. Metode yang digunakan pada kajian pustaka ini adalah dengan penelusuran artikel penelitian dan artikel review dari Pubmed, Cochrane Library, dan Medline dengan kata kunci “TNFRSF11B polymorphism”, “osteoprotegerin polymorphism”, “rheumatoid arthritis”, dan “secondary osteoporosis”. Sebagai hasil kajian pustaka, didapatkan beberapa simpulan berbeda dari studi pengaruh polimorfisme gen TNFRSF11B terhadap OP sekunder pada AR. Gen TNFRSF11B memiliki beberapa polimorfisme yang erat kaitannya dengan remodeling tulang, di antaranya adalah C950T, G1181C, A163G, T245G dan rs4876869.Kata kunci: Artritis reumatoid, osteoporosis sekunder, polimorfisme, TNFRSF11B The Roles of TNFRSF11B Genes as a Trigger for Secondary Osteoporosis in Rheumatoid Arthritis CasesAbstractRheumatoid arthritis (RA) is an autoimmune disorder responsible for widespread and persistent inflammation of the synovial joint lining. Hence, victims are prone to greater risk of developing secondary osteoporosis (OP), a common complication of arthritis. The global prevalence of secondary OP among RA patients is estimated between 22-36%, although certain genetic polymorphisms pose a possible influence. Also, bone remodeling is closely related to the receptor activator nuclear factor-κB ligand (RANKL)/RANK and osteoprotegerin (OPG). The variables play a significant role in osteoclastogenesis, due to the ability of OPG to inhibit osteoclast differentiation and activation. This literature review discusses the relationship of TNFRSF11B gene polymorphisms that encode OPG protein with the risk of developing secondary osteoporosis in RA patients. The research method encompassed exploring similar articles from Pubmed, Cochrane Library, and Medline, using particular keywords, such as “TNFRSF11B polymorphism”, “osteoprotegerin polymorphism”, “rheumatoid arthritis” and “secondary osteoporosis”. Several distinct conclusions were obtained after analyzing the effects of TNFRSF11B gene polymorphisms on secondary OP in RA cases. Furthermore, the TNFRSF11B gene showed various polymorphisms closely related to bone remodeling, including C950T, G1181C, A163G, T245G and rs4876869.Keywords: Polymorphism, rheumatoid arthritis, secondary osteoporosis, TNFRSF11B
The Beyond-Use Date Perception of Drugs in North Jakarta, Indonesia Fonny Cokro; Sherly T. Arrang; Jonathan A. N. Solang; Pangestuning Sekarsari
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.172

Abstract

Beyond-Use Date (BUD) refers to the unsafe period of drug consumption and is calculated from the moment of opening the primary package. Meanwhile, Indonesia has no current related data, in terms of public awareness. Therefore, this research aims to assess the BUD perception of North Jakarta communities and pharmacists’ roles in providing the relevant information. The data collection process employed a semi-structural interview across 6 districts in the research location between September-November 2019, followed by data transcription and thematic development. Based on 60 informants recruited by purposive sampling, three themes were obtained, including residual drug storage, pharmacists’ contributions, and BUD awareness. Furthermore, about 97% of the respondents were completely unaware of the subject matter, while 100% denied having any form of sensitization from pharmacists. The perception of 50% were based on the expiration date labelled on the medications. In summary, North Jakarta community’s views were possibly influenced by very poor BUD knowledge. Therefore, the role of pharmacists in educating patients and communities appears very essential.Keywords: Drug-compounding, drug-stabilities, perception, pharmacists Persepsi mengenai Beyond-Use Date Obat pada Masyarakat Jakarta Utara, IndonesiaAbstrakBeyond-Use Date (BUD) merupakan waktu ketika sediaan obat tidak dapat digunakan lagi dan dihitung berdasarkan waktu pembukaan kemasan primer sediaan. Sampai dengan saat ini, tidak terdapat data tentang pemahaman masyarakat Indonesia mengenai BUD. Penelitian ini bertujuan untuk melihat persepsi masyarakat Jakarta Utara mengenai BUD, serta mengetahui peran apoteker dalam menyediakan informasi BUD. Data mengenai persepsi BUD diperoleh dari wawancara semi terstruktur yang dilakukan di 6 kecamatan yang terletak di Jakarta Utara pada September–November 2019, dan diikuti oleh proses transkripsi dan pengembangan tema. Dari 60 informan yang direkrut secara purposive sampling, didapatkan tiga tema yaitu penyimpanan sisa obat racikan, kontribusi apoteker terkait BUD, dan pengenalan terhadap BUD. Mayoritas informan (97%) tidak mengetahui tentang BUD, dan semua informan (100%) tidak pernah menerima informasi BUD dari apoteker. Sebagian dari informan memiliki persepsi bahwa BUD sama dengan masa kadaluarsa yang ada di kemasan pabrik. Kami menyimpulkan bahwa persepsi masyakat Jakarta Utara mengenai BUD dapat disebabkan oleh pengetahuan tentang BUD yang rendah, dan peran apoteker dalam menginformasikan dan mengedukasi pasien dan masyarakat mengenai BUD sangat diperlukan. Kata kunci: Apoteker, obat racikan, persepsi, stabilitas obat
Implikasi Polimorfisme Gen CYP2A6 terhadap Penyakit Kardiovaskular Preiffer A. Prasojo; Christine Patramurti
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.217

Abstract

Gen CYP2A6 merupakan penyandi enzim CYP2A6. Gen CYP2A6 diketahui memiliki tingkat polimorfisme yang tinggi sehingga menyebabkan terdapatnya variasi bentuk alel baik dalam bentuk aktif maupun alel inaktif. Adanya variasi bentuk alel ini selanjutnya dapat berakibat pada penurunan, peningkatan atau penghilangan aktivitas enzim CYP2A6 yang disandi oleh gen ini. Salah satu substrat spesifik enzim CYP2A6 adalah nikotin, suatu senyawa aktif terdapat dalam rokok. Nikotin diketahui merupakan salah satu faktor risiko penyakit kardiovasakuler, sehingga kehadiran alel inaktif gen CYP2A6 akan menyebabkan penurunan aktivitas enzim CYP2A6 dalam metabolisme nikotin dan lebih lanjut akan meningkatkan risiko penyakit kardiovaskuler. Tujuan dari artikel review ini yaitu untuk mengevaluasi implikasi polimorfisme gen CYP2A6 terhadap penyakit kardiovaskular. Database yang digunakan pada artikel review ini berasal dari PubMed dan Google Scholar yang kemudian dilakukan seleksi dengan menggunakan kriteria inklusi dan eksklusi. Hasil yang diperoleh yaitu terdapat pengaruh polimorfisme gen CYP2A6 terhadap kandungan nikotin dalam darah terutama pada individu dengan gen CYP2A6 yang memiliki aktivitas metabolisme yang lambat atau buruk yang mengakibatkan kadar nikotin dalam darah yang tinggi, yang kemudian mengakibatkan peningkatan pengaktifan sistem saraf simpatis, lipolisis, dan resistensi insulin yang menyebabkan peningkatan kejadian anterosklerosis. Disimpulkan bahwa polimorfisme gen CYP2A6 akan meningkatkan penyakit kardiovaskuler terutama pada perokok, baik aktif maupun pasif.Kata kunci: Atherosklerosis, CYP2A6, penyakit kardiovasuler, polimorfisme The Effects of CYP2A6 Gene Polymorphism on Cardiovascular DiseasesAbstractThe CYP2A6 gene encodes its enzymes and is highly polymorphic, leading to variations in allele forms, both in the active and inactive states. These changes result in a decrease, increase or deletion of enzyme activities. One of the specific substrates is nicotine, an active compound in cigarettes. Nicotine is a major risk factor for cardiovascular diseases, and the inactive alleles tends to decrease its metabolism and expands the threat to infections. Therefore, this study aims to evaluate the effects of CYP2A6gene polymorphism on cardiovascular diseases. Relevant literatures were obtained using PubMed and Google Scholar, while the eventual selection followed the inclusion and exclusion criteria. Based on this review, the CYP2A6 gene polymorphism, both in increased, decreased or deleted alleles, was known to significantly influence nicotine metabolism and its blood levels. Species categorized as slow or poor metabolizers, tend to decrease the nicotine metabolism, but result in greater nicotine blood levels. This outcome subsequently accelerated the activation of the sympathetic nervous system, lipolysis, and insulin resistance, to trigger atherosclerosis. In summary, CYP2A6 gene polymorphism is known to increase cardiovascular diseases, particularly among active or passive smokers.  Keywords: Atherosclerosis, cardiovascular disease, CYP2A6, polymorphism
Penggunaan dan Resistensi Antibiotik di Instalasi Rawat Intensif Rumah Sakit Umum Daerah di Bali: Studi Ekologikal selama 3 Tahun Herleeyana Meriyani; Dwi A. Sanjaya; Ni Wayan Sutariani; RR. Asih Juanita; Nyoman B. Siada
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.180

Abstract

Resistensi bakteri yang terjadi di Intensive Care Unit (ICU) disebabkan oleh banyak faktor, salah satunya adalah penggunaan dan pemilihan antibiotik yang tinggi dan selektif. Perlu dilakukan studi tentang tingkat penggunaan antibiotik dan resistensi bakteri terhadap antibiotik di ICU yang dapat menjadi dasar evidence untuk merencanakan program guna mengontrol tingkat penggunaan antibiotik yang berdampak terhadap resistensi bakteri di ICU. Penelitian ini merupakan penelitian ekologikal yang dilakukan di rumah sakit umum daerah di Bali dengan menggunakan data retrospektif selama tahun 2017–2019. Data yang digunakan yaitu data penggunaan antibiotik sistemik (dinyatakan dalam defined daily doses (DDD) per 100 hari rawat), dan data persentase sensitivitas bakteri di ICU. Analisis statistik dilakukan dengan menggunakan korelasi rank Spearman. Segmen penggunaan antibiotik terbanyak ditetapkan menggunakan drug utilization 90% (DU90%) dan kategori fenotipik bakteri ditetapkan berdasarkan Centers for Disease Control and Prevention (CDC). Hasil penelitian menunjukkan terdapat tujuh antibiotik yang masuk dalam segmen DU90%, yaitu levofloksasin, seftriakson, ampisilin, sefotaksim, siprofloksasin, ampisilin-sulbaktam, dan gentamisin. Enam bakteri Gram-negatif terbanyak di ICU yaitu: Acinetobacter baumannii, Enterobacter cloacae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia dan Pseudomonas aeruginosa. Terdapat lima bakteri dengan kategori multi drug resistant (MDR) yaitu A. baumannii, E. cloacae, E. coli, K. pneumonia dan P. aeruginosa. Terdapat dua spesies bakteri yang termasuk dalam kategori carbapenem resistant (CR) dan extended-spectrum cephalosporin-resistant (ESCR) yaitu A. Baumannii dan E. cloacae. Hanya bakteri E. coli yang menunjukkan korelasi yang signifikan dengan arah negatif antara penggunaan antibiotik dan persentase sensitivitas bakteri di ICU (r=–0,543; p=0,024). Dapat disimpulkan bahwa semakin tinggi penggunaan antibiotik menyebabkan penurunan sensitivitas bakteri terhadap antibiotik. Kata kunci: Carbapenem resistant, DDD, extended-spectrum cephalosporin-resistant, MDR, resistensi bakteri, studi ekologikal Antibiotic Use and Resistance at Intensive Care Unit of a Regional Public Hospital in Bali: A 3-Year Ecological StudyAbstractAntibiotic resistance at Intensive Care Unit (ICU) has been impacted by several factors, including high utilization and selectivity. The consumption rate and its selective pressure appear very extensive, with regular opportunities for cross-transmissions. In addition, ICU patients are susceptible to carriage acquisition and subsequent infections with high resistant bacteria. Therefore, this study investigates the relationship between the use and resistance of antibiotics in the ICU of a regional public hospital. The results potentially serve as confirmations for planning programs necessary to control ICU-related antibiotic consumption levels. This ecological analysis was also based on inpatient retrospective data from a regional public hospital in Bali from 2017–2019. Subsequently, the amount of intake expressed as daily doses (DDDs) per 100 patient days, and percentage of resistant bacterial isolates were examined using Spearman rank correlation. The largest segment of the antibiotics was determined by drug utilization 90% (DU90%) and the phenotypic class was defined by Centers for Disease Control and Prevention (CDC). Similarly, the most predominantly applied antibiotics were levofloxcacin, ceftriaxone, ampicillin, cefotaxime, ciprofloxacin, ampicillin-sulbactam and gentamycin. Meanwhile, the major gram-negative bacteria were Acinetobacter baumannii, Enterobacter cloacae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa. Furthermore, 5 multi drug resistant (MDR) bacteria were observed, including A. baumannii, E. cloacae, E. coli, K. pneumonia and P. aeruginosa, while A. baumannii and E. cloacae occurred as carbapenem resistant (CR) and extended-spectrum cephalosporin-resistant (ESCR), respectively. However, only E. coli showed a negative significant correlation between antibiotic utilization and the percentage of ICU bacterial sensitivity (r=–0,543; p=0,024). Therefore, higher consumption of antibiotics decreases its percentage susceptibility. Keywords: Antibiotic resistance, carbapenem resistant, DDD, ecological study, extended-spectrum cephalosporin-resistant, MDR
Efektivitas dan Keamanan Terapi Benzodiazepin pada Pasien Gangguan Ansietas dengan Riwayat Penyalahgunaan Obat Ni Nyoman Y. Mendra; Zullies Ikawati; Cecep S. Kristanto
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.190

Abstract

Gangguan ansietas merupakan salah satu gangguan mental yang paling banyak dijumpai. Beberapa faktor dapat memicu terjadinya gangguan ansietas, salah satunya adalah riwayat penyalahgunaan obat. Tatalaksana terapi pada pasien ansietas dengan riwayat penyalahgunaan obat membutuhkan berbagai pertimbangan, pasalnya penggunaan benzodiazepin pada kondisi ini dapat memicu terjadinya ketergantungan. Penelitian ini bertujuan untuk mengetahui hubungan riwayat penyalahgunaan obat terhadap efektivitas dan keamanan terapi benzodiazepin pada pasien gangguan ansietas. Penelitian ini merupakan jenis penelitian observasional analitik dengan rancangan cohort retrospektif pada pasien rawat jalan dengan gangguan ansietas periode Januari 2018–Oktober 2020 di RS Bethesda Yogyakarta. Efektivitas terapi benzodiazepin dinilai dari respon terapi berupa perbaikan gejala dan kondisi pasien, sementara keamanan terapi dinilai dari adanya gejala yang mengarah ke ketergantungan terhadap benzodiazepin selama 6 bulan masa pengamatan. Jumlah sampel penelitian yakni 91 pasien, yang terbagi atas 2 kelompok yakni 52 pasien dengan riwayat penyalahgunaan obat, sementara 39 lainnya tanpa riwayat. Berdasarkan hasil uji chi-square diketahui bahwa riwayat penyalahgunaan obat memiliki hubungan signifikan dengan efektivitas benzodiazepin (p=0,031), namun tidak berlaku pada kejadian ketergantungan (p=0,45). Pasien dengan riwayat penyalahgunaan obat memiliki kecenderungan untuk tidak mengalami perbaikan dalam 6 bulan penggunaan benzodiazepin (RR 1,65; 95%CI 1,055–2,581). Sementara itu riwayat penyalahgunaan obat tidak berhubungan dengan keamanan terapi benzodiazepin.Kata kunci: Benzodiazepin, gangguan ansietas, ketergantungan, respon terapi, riwayat penyalahgunaan obat  The Efficacy and Safety of Benzodiazepine in Anxiety Disorder Patient with Drug Abuse HistoryAbstractAnxiety disorder is generally perceived as one of the predominant mental health conditions. Particular factors are known to induce the occurrence, including drug abuse history. The effective management of anxiety requires several considerations, due to the high dependence risk of benzodiazepine. Therefore, this study aimed at determining the relationship between the efficacy and safety of benzodiazepine in anxiety disorder with drug abuse history. The analysis employed an observational approach using cohort retrospective design in outpatients at Bethesda Yogyakarta hospital between January 2018-October 2020. Subsequently, benzodiazepine efficacy was assessed by therapeutic response, such as symptom improvement, while the safety was determined using symptoms that led to the condition. Based on 91 outpatients data, 52 showed previous drug abuse experiences, while 39 had no history. Chi-square analysis further reported a significant relationship between drug abuse history and benzodiazepine efficacy (p=0.031), but not applicable to the dependency (p=0.45). Therefore, patients with records of drug abuse appeared unresponsive during the 6 months of benzodiazepine therapy (RR 1.65; 95%CI 1.055–2.581), but these were not associated with safety. Keywords: Anxiety disorder, benzodiazepine, dependency, history of drug abuse, therapeutic response 
Adverse Event Sindroma Metabolik Kombinasi Terapi Risperidon dan Klozapin pada Pasien Skizofrenia di Rumah Sakit Jiwa Magelan Gilang R. Al Farizi; Dyah A. Perwitasari; Haafizah Dania; Melisa I. Barliana; Santi Yuliani
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.159

Abstract

Kombinasi risperidon dan klozapin pada pasien skizofrenia dapat menyebabkan adverse drug event peningkatan body mass index (BMI), tekanan darah sistolik, dan tekanan darah diastolik seiring lamanya terapi. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara durasi kombinasi terapi risperidon dan klozapin dengan peningkatan BMI, tekanan darah sistolik, dan tekanan darah diastolik pada pasien skizofrenia. Metode yang digunakan adalah studi kohort retrospektif periode Februari–Mei 2019 pada 59 pasien skizofrenia rawat inap di Rumah Sakit Jiwa Magelang. Subjek dibagi ke dalam 2 kelompok durasi terapi <8 minggu (48 pasien) dan ≥8 minggu (11 pasien). Pengukuran BMI, tekanan darah sistolik, dan tekanan darah diastolik dilakukan pada hari pertama rawat inap dan saat konsultasi rawat jalan yang disesuaikan dengan cut-off point NCEP-ATP III modifikasi BMI populasi Asia Tenggara. Kuesioner terstruktur digunakan untuk mengukur kalori intake dan aktivitas fisik yang diperoleh dari catatan medis pasien. Hasil uji bivariat menunjukkan hubungan bermakna secara klinik antara BMI saat pertama rawat inap dan saat rawat jalan pada kelompok durasi terapi ≥8 minggu, 22,41±2,98 kg/m2 vs 25,2±6,80 kg/m2 (p=0,023, –2,75 (–5,12–(–0,39)), namun tidak ada hubungan bermakna pada tekanan darah sistolik 117±11,73 mmHg vs 118±15,42 mmHg (p=0,797, 95%CI –1,07 (–9,41–7,26) dan tekanan darah diastolik 76±7,86 mmHg vs 73±8,48 mmHg (p=0,192, 95%CI 3,52 (–1,81–8,86) antara kedua kelompok. Faktor usia, jenis kelamin, status merokok, dosis, komedikasi, intake kalori, dan aktivitas fisik tidak menunjukkan hubungan bermakna dengan peningkatan BMI, tekanan darah sistolik, dan tekanan darah diastolik.Kata kunci: Kombinasi terapi risperidon dan klozapin, metabolik, skizofrenia Adverse Events of Risperidone and Clozapine Combination Therapy on Schizophrenic Patients at Magelang Mental HospitalAbstractThe adverse drug effect of risperidone and clozapine combination therapy possibly increases the BMI, systolic and diastolic blood pressures of mental victims. This study aimed at determining the relationship between the duration of risperidone and clozapine combination therapy and increase in body mass index (BMI), systolic and diastolic blood pressures of schizophrenic patients. The correlation was obtained using the cohort retrospective method on 59 schizophrenic inpatients at Magelang Mental Hospital from February–May 2019. Participants were grouped into 2 categories, termed <8 and ≥8 weeks with 48 and 11 persons, respectively. Subsequently, patients’ BMI, systolic and diastolic blood pressures were measured during the first day of hospitalization and outpatient consultations, based on NCEP-ATP III cut off-point with the modification of Southeast Asian population’s BMI. Structured questionnaires were used to evaluate calory intake and physical activity as well as generate respondents’ medical records. The bivariate analysis results showed a significant relationship between BMI increase at initial hospitalization and during outpatient consultation on group  ≥8 weeks therapy, 22.41±2.98 kg/m2 vs 25.2±6.80 kg/m2 (p=0.023, –2.75 (–5.12–(–0.39)). However, there is no major correlation occurred in systolic 117±11.73 mmHg vs 118±15.42 mmHg (p=0.797, 95%CI –1.07 (–9.41–7.26)) and diastolic blood pressures 76±7.86 mmHg vs 73±8.48 mmHg (p=0.192, 95% CI 3.52 (–1.81–8.86)) for both groups. Furthermore, age, gender, smoking status, dosage, co-medication, calory intake and physical activity indicated no substantial variations, in terms of the increase in BMI, systolic and diastolic blood pressures among two categories.  Keywords: Metabolic syndrome, risperidone and clozapine combination therapy, schizophrenia

Page 1 of 1 | Total Record : 8

 1 

Filter by Year

2021 2021


Reset
Filter By Issues
All Issue Vol 14, No 3 (2025) Vol 14, No 2 (2025) Vol 14, No 1 (2025) Vol 13, No 3 (2024) Vol 13, No 2 (2024) Vol 13, No 1 (2024) Vol 12, No 3 (2023) Vol 12, No 2 (2023) Vol 12, No 1 (2023) Vol 11, No 4 (2022) Vol 11, No 3 (2022) Vol 11, No 2 (2022) Vol 11, No 1 (2022) Vol 10, No 4 (2021) Vol 10, No 3 (2021) Vol 10, No 2 (2021) Vol 10, No 1 (2021) Vol 9, No 4 (2020) Vol 9, No 3 (2020) Vol 9, No 2 (2020) Vol 9, No 1 (2020) Vol 8, No 4 (2019) Vol 8, No 3 (2019) Vol 8, No 2 (2019) Vol 8, No 1 (2019) Vol 7, No 4 (2018) Vol 7, No 3 (2018) Vol 7, No 3 (2018) Vol 7, No 2 (2018) Vol 7, No 2 (2018) Vol 7, No 1 (2018) Vol 7, No 1 (2018) Vol 6, No 4 (2017) Vol 6, No 4 (2017) Vol 6, No 3 (2017) Vol 6, No 3 (2017) Vol 6, No 2 (2017) Vol 6, No 2 (2017) Vol 6, No 1 (2017) Vol 6, No 1 (2017) Vol 5, No 4 (2016) Vol 5, No 4 (2016) Vol 5, No 3 (2016) Vol 5, No 3 (2016) Vol 5, No 2 (2016) Vol 5, No 2 (2016) Vol 5, No 1 (2016) Vol 5, No 1 (2016) Vol 4, No 4 (2015) Vol 4, No 4 (2015) Vol 4, No 3 (2015) Vol 4, No 3 (2015) Vol 4, No 2 (2015) Vol 4, No 2 (2015) Vol 4, No 1 (2015) Vol 4, No 1 (2015) Vol 3, No 4 (2014) Vol 3, No 4 (2014) Vol 3, No 3 (2014) Vol 3, No 3 (2014) Vol 3, No 2 (2014) Vol 3, No 2 (2014) Vol 3, No 1 (2014) Vol 3, No 1 (2014) Vol 2, No 4 (2013) Vol 2, No 4 (2013) Vol 2, No 3 (2013) Vol 2, No 3 (2013) Vol 2, No 2 (2013) Vol 2, No 2 (2013) Vol 2, No 1 (2013) Vol 2, No 1 (2013) Vol 1, No 4 (2012) Vol 1, No 4 (2012) Vol 1, No 3 (2012) Vol 1, No 3 (2012) Vol 1, No 2 (2012) Vol 1, No 2 (2012) Vol 1, No 1 (2012) Vol 1, No 1 (2012) More Issue