MEDISAINS
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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<![CDATA[Psychoeducation reduces anxiety and cortisol hormones in high-risk pregnant women ]]>
<![CDATA[Sahupala, Sapiah]]>;
<![CDATA[Suharsono, Suharsono]]>;
<![CDATA[Wijayanti, Krisdiana]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.23398
<![CDATA[Background: High-risk pregnancy poses significant challenges to both maternal and fetal health, increasing the risk of complications, anxiety, and elevated cortisol levels. Anxiety in high-risk pregnancies has been widely studied, but most interventions focus on pharmacological treatments or psychological support without integrating physiological stress markers such as cortisol levels. Psychoeducation is a nonpharmacological intervention designed to enhance understanding, equip women with stress management skills, and promote confidence in facing pregnancy. However, limited studies have examined its direct impact on both anxiety and cortisol levels in high-risk pregnant women.Purpose: This study aims to evaluate the effectiveness of psychoeducation in reducing anxiety and cortisol levels among high-risk pregnant women.Methods: This study employed a pre-experimental one-group pretest-posttest design without a control group. The intervention consisted of four structured psychoeducation sessions, each lasting 120 minutes over two weeks. A total of 23 high-risk pregnant women participated in the study. Anxiety levels were measured using the DASS-21, and cortisol levels were assessed through saliva samples collected before and after the intervention. Data were analyzed using the Wilcoxon signed-rank test.Results: The findings revealed a significant reduction in anxiety scores from 15.60 ± 2.99 to 8.52 ± 1.88 (p < 0.001) and cortisol levels from 15.72 ± 9.10 to 10.40 ± 6.97 (p < 0.001), indicating the effectiveness of psychoeducation in reducing both psychological and physiological stress in high-risk pregnancies.Conclusion: Psychoeducation, delivered through four sessions over two weeks, is effective in reducing anxiety and cortisol levels in high-risk pregnant women. This intervention should be integrated into prenatal care to support maternal well-being and stress management.]]>
<![CDATA[Potential of turmeric cream (curcuma caesia roxb.) extract in incision wounds ]]>
<![CDATA[Udayani, Ni Nyoman Wahyu]]>;
<![CDATA[Adrianta, I Ketut Agus]]>;
<![CDATA[Wiguna, I Putu Bagus Artha]]>;
<![CDATA[Yowani, Anak Agung Sagung Iswarani]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.23731
<![CDATA[Background: Incisional wounds are the most common wounds in the community. Improper handling of incision wounds can worsen wounds and cause infection. The content of secondary metabolites in black turmeric rhizomes can act as anti-inflammatory and antimicrobial in the healing process of incision wounds. However, its effectiveness in healing incision wounds has not been widely studied, so further research is needed.Purpose: This study was conducted to determine the potential of black turmeric cream as an herbal medicine to heal incision wounds.Methods: This study was an invivo experimental research study with a randomized post-test control group design. The samples used were 20 male rats that were made to have a 2 cm incision wound on the back area, consisting of a negative control, a positive control, and three black turmeric extract groups (5%, 10%, and 15%). The data obtained were analyzed by an ANOVA (Analysis of Variance) parametric statistical test.Result: The results showed that the highest decrease in incision wound length was found in the black turmeric rhizome cream Formula III group and the lowest in the negative control group. On day 14, the incision wound area of the Formula III black turmeric rhizome cream group had closed or healed (0.00 cm), while the negative control group had the slowest incision wound closure (0.39 cm).Conclusion: Black turmeric rhizome cream can heal and prevent infection of the incision wound. This shows the potential of black turmeric rhizome as an anti-inflammatory and antimicrobial.]]>
<![CDATA[Patient adherence and diabetes distress on glycemic outcomes: a cross-sectional study ]]>
<![CDATA[Rahmatulloh, Wahyu]]>;
<![CDATA[Ristiyorini, Iin]]>;
<![CDATA[Kusumaningsih, Wiji Sri]]>;
<![CDATA[Ainni, Ayu Nissa]]>;
<![CDATA[Zakhroh, Siti Aminatun]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.23773
<![CDATA[Background: Diabetes Mellitus (DM) is a chronic disease that requires high compliance with therapy and lifestyle changes. However, compliance often causes emotional stress that can affect the effectiveness of treatment. This study is important to understand the impact of medication compliance and diabetes distress on glycemic control in DM patients.Purpose: This study aims to determine the impact of adherence and distress on glycemic control.Methods: This cross-sectional study was conducted at the Kebumen II Health Center from April to July 2024 with a sample of 87 respondents. The Diabetes Distress Scale (DDS) was used to measure patient stress levels, and the Medication Adherence Report Scale (MARS-5) was used to assess patient compliance levels. while glycemic control was evaluated with random blood glucose (RBG) and fasting blood glucose (FBG). Data were analyzed using the Pearson correlation test.Results: His study was dominated by female participants (75%) and those over 60 years of age (51%). A total of 64% of patients showed low adherence to antidiabetic medication, and 78% had uncontrolled random blood glucose (RBG) levels. Moderate diabetes distress was observed in 36% of patients, while 46% experienced low distress. There was a significant relationship between medication adherence and RBG levels (r =-0.283; p<0.05), but no significant relationship with FBG. There was no significant relationship between diabetes distress and blood glucose levels (RBG and FBG).Conclusion: Low adherence levels will significantly increase RBG levels but not significantly increase FBG levels. Likewise, high stress has the potential to increase blood glucose levels, although not statistically significant.]]>
<![CDATA[In vitro study: thymoquinone inhibits the proliferation and migration of keloid fibroblasts and increases their apoptosis ]]>
<![CDATA[Hadi, Restu Syamsul]]>;
<![CDATA[Juniarti, Juniarti]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.23975
<![CDATA[Background: No treatment can eliminate keloids. Thymoquinone (TQ) is hypothesized to play a pivotal role in treating keloids by modulating cellular processes such as proliferation, migration, and apoptosis. However, the existing studies investigating its effects on these mechanisms in keloid fibroblasts are limited and require further exploration.Objective: This study aims to investigate the effects of TQ on the proliferation, migration, and apoptosis of keloid fibroblasts in vitro.Methods: This experimental study was conducted using keloid fibroblast cultured in vitro. Cells were seeded in a 96-well plate at a density of about 5x103 cells per well with 100 μl of culture medium, and cells were cultured for 24, 48, and 72 hr for each concentration of TQ. Cell proliferation was assessed using a CCK-8 Kit, measuring optical density with a microplate reader. Apoptosis was measured using the TUNEL assay. Cell migration following TQ treatment was evaluated using the Scratch assay. The statistical test used a one-way analysis of variance (ANOVA) followed by the least significant difference (LSD) test. Results: TQ inhibited the proliferation of keloid fibroblasts at a dose of 5 µM after 48 hours of incubation and 10 µM after 24 hours of incubation. The inhibitory effect of TQ on fibroblast proliferation increased in a dose- and time-dependent manner. Treatment at 5 and 10 µM doses increased apoptosis in keloid fibroblast cultures. The TQ5 µM group achieved 60% closure, while the 10 µM group showed 55% closure. Migration was significantly inhibited in the 25 µM and 50 µM groups, with only 30% and 10% closure, respectively, at 72 hours.Conclusion: Thymoquinone inhibits the proliferation and migration of keloid fibroblast cells while promoting apoptosis. These properties suggest that TQ could be developed as a potential treatment for keloid-related skin issues.]]>
<![CDATA[Effectiveness of the personal hygiene module in increasing the knowledge of pregnant women with anemia on the dangers of worm infection ]]>
<![CDATA[Saraswati, Endah]]>;
<![CDATA[Wahida, Wahida]]>;
<![CDATA[Nurdjaya, Malahayati]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.24067
<![CDATA[Background: Worm infections are a common cause of anemia in pregnant women, particularly in areas with poor sanitation. While many studies have examined anemia in pregnancy, few have specifically explored the effectiveness of personal hygiene education in increasing pregnant women's knowledge of the dangers of worm infection.Purpose: Â This study aimed to evaluate the effectiveness of a personal hygiene module in increasing the knowledge of pregnant women with anemia about the dangers of worm infection. Methods: This quasi-experimental study, which involved 30 pregnant women with anemia, was conducted in the coastal area of North Konawe Regency, Southeast Sulawesi Province. A purposive sampling technique was used, and data were analyzed using the paired t-test.Result: The average knowledge score before education was 29.27, significantly increasing to 52.40 after implementing the personal hygiene module (p = 0.000).Conclusions: The personal hygiene module effectively improves the knowledge of pregnant women with anemia regarding the dangers of worm infection.]]>
<![CDATA[The effect of consuming rosella flower-infused water on control blood pressure in pregnant women with hypertension ]]>
<![CDATA[amin, dewita rahmatul]]>;
<![CDATA[Sugiarti, Rosi Kurnia]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.24075
<![CDATA[Background: Hypertension during pregnancy is one of the leading causes of maternal morbidity and mortality. Rosella flower infused-water, rich in bioactive compounds such as flavonoids and polyphenols, have been shown to lower blood pressure safely. Although previous studies have highlighted the antihypertensive effects of rosella in the general population, research specifically focusing on its use in pregnant women with hypertension is still limited.Objective: This study aims to investigate the effect of rosella flower-infused water on control blood pressure reduction in pregnant women with hypertension.Method: The research design used is quasi-experimental with a pre-test and post-test approach involving 100 pregnant women with hypertension in Desa Karangraharja. The intervention group received 200 ml of rosella flower-infused water for 14 days in conjunction with nifedipine 10 mg, while the control group only received nifedipine 10 mg. The blood pressure of the control and intervention groups was measured using the Mann-Whitney Test.Results: The rosella flower-infused water effectively reduced systolic blood pressure in the intervention group by 24.92 mmHg compared to the control group by 18.78 mmHg (p=0.000). Diastolic blood pressure in the intervention group decreased by three mmHg, although this was not statistically significant compared to the control group's decrease of 3.6 mmHg (p=0.715).Conclusion: The 200 ml rosella flower-infused water for 14 consecutive days reduced systolic blood pressure in pregnant women with hypertension.]]>
<![CDATA[Accelerating perineal wound healing using binahong leaf extract sanitary pads ]]>
<![CDATA[Asmaidar, Asmaidar]]>;
<![CDATA[Runjati, Runjati]]>;
<![CDATA[Santjaka, Aris]]>;
<![CDATA[Cicilia, Fitri]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.24284
<![CDATA[Background: Sanitary pads are essential for postpartum mothers to accommodate lochia and prevent infection in perineal wounds. Binahong leaves (Anredera cordifolia) contain flavonoids with antiseptic, antioxidant, and analgesic properties that promote wound healing by inhibiting microbial growth and reducing inflammation. However, research on the use of sanitary pads infused with Binahong leaf extract for perineal wound healing remains limited.Objective: This study investigates the effectiveness of Binahong leaf extract sanitary pads in accelerating postpartum perineal wound healing. Methods: A quasi-experimental study with a post-test-only randomized control group design was conducted at the Poasia Health Center, Kendari City. The study included postpartum mothers meeting specific inclusion and exclusion criteria, with a total sample of 34 participants (17 intervention, 17 control). The intervention group used Binahong leaf extract sanitary pads four times daily, while the control group relied on standard dry wound care. The intervention lasted seven days, and wound healing was assessed using the REEDA scale on days three, five, and seven.Results: The findings demonstrated a significant effect of Binahong leaf extract sanitary pads on perineal wound healing. The intervention group (2.52 ± 0.87) experienced faster wound recovery than the control group (5.23 ± 1.67) (p< 0.001).Conclusion: Binahong leaf extract sanitary pads effectively accelerate perineal wound healing in postpartum mothers and may serve as an alternative wound care approach.]]>
<![CDATA[In vivo study of Centella asiatica leaf extract cream for Matrix Metalloproteinase-1 inhibition and collagen enhancement to prevent photoaging ]]>
<![CDATA[Purmawanti, Sri]]>;
<![CDATA[W, Joko Wahyu]]>;
<![CDATA[Sumarawati, Titiek]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.24719
<![CDATA[Background: Ultraviolet B (UVB) exposure accelerates skin aging, causing wrinkles and increasing matrix metalloproteinase-1 (MMP-1) activity, which degrades collagen. Centella asiatica (CA) has well-documented anti-inflammatory and antioxidant properties that may counteract UVB-induced photoaging. However, studies on its topical formulation for MMP-1 inhibition and collagen enhancement remain limited.Purpose: This study aims to determine the effect of CA leaf extract cream on inhibiting MMP-1 and increasing collagen in skin tissue exposed to UVB rays.Methods: This experimental study used a post-test only control group design. The sample population of BALB/c mice was 24, divided into four groups: healthy control group (KN), negative control group (K-), Treatment 1 (P1): 10% CA extract cream dosage, and Treatment 2 (P2): 20% CA extract cream dosage. Skin tissue samples were measured for MMP-1 expression using immunohistochemistry (IHC) staining, and collagen density using Sirius Red staining. Data analysis on MMP-1 expression using One-way ANOVA test and collagen density using Kruskal Wallis test.Results: MMP-1 expression was highest in the K2 group (UVB exposure + cream base) and decreased in the P1 and P2 groups (10% CA cream), with the lowest expression in the K1 group (healthy control). However, One-Way ANOVA showed no significant differences among groups (p=0.053). Collagen density analysis using the Kruskal-Wallis test showed significant differences (p = 0.04), with a decrease in the K2 group and an increase in the K3 and K4 groups.Conclusion: Application of CA extract cream affects MMP-1 expression and collagen density in skin tissue exposed to UVB rays.]]>
<![CDATA[Sociodemographic and psychological factors associated with depression among nursing home elders ]]>
<![CDATA[Widyasari, Eka]]>;
<![CDATA[Ariani, Tutu April]]>;
<![CDATA[Aini, Nur]]>;
<![CDATA[Marta, Ollyvia Freeska Dwi]]>;
<![CDATA[Mashfufa, Erma Wahyu]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v0i0.25830
<![CDATA[Introduction: Depression in the elderly is shaped by sociodemographic and psychological factors. Depression generally affects older adults and is associated with a poor life, with sociodemographic and psychological factors such as social support and loneliness playing a role in the onset of depression. However, the relationship between these factors and depression in the elderly is still rarely explored.Purpose: This study aims to explore the relationship between psychological and sociodemographic factors on the level of depression in the elderly living in nursing homes, with a focus on social support, level of loneliness, and cognitive impairment.Methods: This study used a descriptive cross-sectional design and involved 72 older adults living in four East Java, Indonesia nursing homes. Data were collected through questionnaires using the Multidimensional Scale of Perceived Social Support (MSPSS), UCLA Loneliness Scale, Mini-Mental State Examination (MMSE), and Beck Depression Inventory-II (BDI-II), which were translated into Bahasa Indonesia. Multiple logistic regression was used to understand the relationship between sociodemographic and psychological factors and the level of depression in the elderly.Results: Marital status (AOR 0.177, p = 0.030) and social support (AOR 0.950, p = 0.040) are significantly associated with depression in the elderly.Conclusion: Marital status and level of social support have the potential to cause depression in the elderly living in nursing homes.]]>
