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INDONESIA
STOMATOGNATIC- Jurnal Kedokteran Gigi
Published by Universitas Jember
ISSN : 16936485     EISSN : 24424935     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Terbit dua kali setahun pada bulan Maret dan Oktober. Berisi tulisan yang berupa hasil penelitian, hasil pemikiran (review article), laporan kasus (case report) dan obituary bidang Ilmu Kedokteran Gigi.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 10 No 2 (2013)" : 10 Documents clear
POKET PERIODONTAL PADA BURUH PEROKOK Kriswiharsi Kun Saptorini; Agus Perry Kusuma
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Background. Periodontal disease is a disease of the tissues supporting the teeth. Clinical signs of periodontitis is the presence of gingival inflammation, swelling interdental papillae, formation of pocket / gingival pocket and gingival recession. The increase of periodontal disease prevalence in smokers caused by poor oral hygiene and late diagnosis.Method. Reseach objective was to prove the factors that related to periodontal pocket. Study design was cross-sectional. The study population were 85 labours of loading and unloading at the Port of Tanjung Emas Semarang, the collection of data through interviews and clinical observations. Data were analyzed by chi-square test with 95 % Confidence Interval and Prevalence Ratio were calculated. Results. The results showed all respondents have periodontal pocket with an average depth of pocket were 1.4 mm. The proportion of periodontal pocket depth more than 1.4 mm (50.6%) and less than 1.4 mm (49.4%) were almost comparable. Factors significantly associated with periodontal pocket were the duration of smoking (p-value 0.04, 95% CI = 1.037 to 5.941; PR = 2.482), oral hygiene (p-value 0.023, 95% CI = 1.143 - 13.311; PR = 3.9), and saliva buffer capacity (p-value 0.011, 95% CI = 1.283 to 7.984; PR = 3.2). Conclusion. Smoke have a greater risk of periodontal pocket, therefore smokers should be given health education on dental and oral health maintenance in the form of brushing and regular dental plaque cleaning (scaling). Smokers need to reduce the number of cigarettes that smoked or quit smoking.
MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA Dian Agung Pangaribowo
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)- 1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.
SISTEM PENGHANTARAN OBAT TERTARGET, MACAM, JENIS-JENIS SISTEM PENGHANTARAN, DAN APLIKASINYA Lina Winarti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Development of methods to improve delivery of drugs for treating dangerous disease like cancer and viral infections are very important today. Selectivity in therapy is needed, hence capability to deliver drugs at specific site being studied in order to reduce toxicity and unwanted side effect at non target site. Many drugs delivery from passive targeting to active targeting delivery will be improved to reach that purpose. Because this system is very important for cancer therapy, many cytotoxic agent have been approved by clinical examination. Besides that targeting drug delivery is very useful for neurological diseases such as alzhemier, liver diseases, kidney, lung, and colon diseases.
PENGARUH NIKOTIN TERHADAP JUMLAH SEL LEYDIG PADA MENCIT (Musmusculus) Iis Rahmawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Nicotine which is one of toxic component in cigarette smoke had been reported to inhibit androgen biosynthesis and Leydig cell growth. Cigarette smoking alters plasma testosterone concentrations inmen. The effect of cigarette smoke can spoil sperm viability and spermatogenesis. It can cause hormonal condition and trigger the emergence of toxic substance on sperm that it can harm male fertility.The research design employed in this study was Post Test Only Control Group Design. The samples were adult male musmusculus. There were six groups of research subject chosen randomly after homogenization. Three groups were the control group and the other three were the experimental group. The subjects in the experimental group were injected with nicotine subcutaneously for one week, two weeks and three week with the same dosage namely 5 mg/kg bodyweight/day. The final observation was aimed at calculating the number of Leydig cell. The result of the one way Anova showed that the cell Leydig had a statistically significant difference on some experimental groups (p < 0.05). LSD test showed that there was significant difference between Leydig cells of P3 and K3; P2 and K3; P1 and K3. The conclusion of this research was that nicotine caused a decrease in the number of Leydig cell.
PEMBUATAN DENTAL RECORD YANG BAIK: IDENTIFIKASI IMIGRAN KORBAN KAPAL TENGGELAM DI TRENGGALEK 2011 Masniari Novita; Waloejo Noegroho
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

The main purpose of forensic identification is to match the Ante Mortem (AM) data to the Post Mortem (PM) data. In the DVI operation dental identification is one of the primer identifiers including finger prints and DNA. The most crucial problem is when the AM data is not sufficient enough to be compared with the PM data. Objectives. To compare the identification of immigrant victims in Trenggalek case and victims of Senopati case through the prosthetic aspect. Case Operation Procedure. From 103 victims of Trenggalek case only 49 victims were identified from medical, dental, property, fingerprint and DNA. Only 12 were identified by dental. There were 5 victims using porcelain bridge but none of them were identified by the prosthetic work. Compared with the Senopati case, 1 victim was identified from the partial denture worn. Conclusions. Forensic odontology identification depend on a good dental record made by a dentist as a AM data, and compared with the PM data from the victims. Prosthetic work is one of the good dental identifier because it has a spesific characteristic such as the cast, denture outline, material and number of teeth. There should be a good dental record from the prosthetic work that could be used as the AM data.
ANALISIS KESESUAIAN PENGGUNAAN ANTIINFEKSI PADA INFEKSI OPORTUNISTIK PASIEN HIV/AIDS RAWAT INAP DI RSUP DR. SARDJITO YOGYAKARTA Sinta Rachmawati
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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HIV / AIDS patients are prone to get opportunistic infections because of their low immunity level. The unappropriate treatment of opportunistic infections may result in morbidity and mortality. The research was carried out to analyze the use of anti-infective in the hospital. The study used a non-experimental and descriptive methods retrospectively from patient medical records. A total of 79 patients who met the inclusion criteria were analyzed descriptively. Suitability analysis based on the CDC and WHO guideline. Suitability analysis of drugs according to WHO and CDC in the case of TB / tuberculosis, candidiasis, pneumonia, PCP / Pneumocystis carinii pneumonia, (hepatitis C, toxoplasmosis, hepatitis B, meningitis, CMV infection / Cytomegalovirus consecutively were 95.2%, 96.8%, 64.3%, 81.8%. Suitability candidiasis dose and frequency according to the CDC : nystatin: underdose (81.8%), overdose (2.3%); fluconazole: appropriate dose (20.5%), underdose (4.5%), overdose (72.7%); itraconazole: underdose (100%), according to WHO: nystatin: appropriate dose (40.9%), overdose (43.2%); fluconazole: appropriate dose (50%), underdose (50%); ketoconazole: appropriate dose (100%). Suitability choice of drugs on pneumonia, according to the CDC: beta-lactams (78.6%), macrolides (100%), quinolones (50%). Suitability of doses and frequency of the PCP: cotrimoxazole, underdose (100%).
POTENSI PENGGUNAAN KITOSAN RANTAI PENDEK SEBAGAI PEMBAWA DALAM PENGHANTARAN GEN; EVALUASI IN VITRO Lina Winarti; Ronny Martien; S Sismindari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Gene therapy involves the introduction of DNA or ribonucleic acid (RNA) into the target cell either to express or suppress the biosynthesis of proteins. The success of gene therapy is highly dependent on a suitable carrier system that can efficiently deliver genes in to specific desired cell with minimum cytotoxicity on target cells. Chitosan is interesting to be used as a gene carrier because it has a high positive charge and low toxicity to cells. Positive charge chitosan can form complexes with the plasmid. DNA complexes provide protection against enzymes degradation and promote internalization of plasmids that have been condensed. In this study the complex formation of chitosan-pEFneo-GFP and chitosan / TPP-pEFneo-GFP is by complex coaservation method. The results of complex analysis with a 0.8% agarose gel electrophoresis for 30 minutes 100Volt showed that the complex was stayed in the well and the plasmids did not migrate like plasmids which were dissolved in the water and buffer solvent. Stability evaluation in storage at room temperature for 14 days showed that the complex with chitosan concentration 0.02%-0.04% were the most stable, so that transfection analysis performed for the complex with chitosan concentration of 0.02%-0.04%. Transfection results showed that chitosan is able to protect plasmid and promote the internalization of plasmid into the nucleus and then expressed as a green luminescence. From these results chitosan potentially be developed as a carrier system in gene delivery.
PENGARUH PENAMBAHAN ASAM LAKTAT SEBAGAI ENHANCER TERHADAP PENETRASI PERKUTAN KAFEIN DALAM BASIS GEL Lidya Ameliana; Lusia Oktora RKS; Devi Dwi N
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Caffeine is a drug which is effective as an anti-cellulite. Caffeine works by slowing down the lipogenesis process and accelerating the lipolysis process. In this research, caffeine was formulated in Sodium CMC gel base and lactic acid (0, 2, 4, and 6%) as enhancers. The aims of these research was to know the effects of lactic acid as enhancer on pH, viscosity, spreadibility, flowability properties, and percutaneous penetration study of caffeine gel. The results obtained that all formulas have fullfilled of all requirements and it can be concluded that lactic acid lowered the pH, increased viscosity, and lowered spreadibility. The highest flux was obtained the caffeine gel on concentration of 6% lactic acid is equal to 5.43 g/cm2 menit.
CELAH PALATUM (PALATOSCIZIS) Zainul Cholid
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Cleft palate is a congenital deformity that causes a multitude of problems and represents a special challenge to the medical community. Speech production, feeding, maxillofacial growth, and dentition are just a few important developmental stages that may be affected. Beside that, these children and their families often experience serious psychological problems. A broad spectrum of variations in clinical presentation exists. Several subtypes of cleft palate can be diagnosed based on severity. The correct diagnosis of a cleft anomaly is fundamental for treatment, for further genetic and etiopathological studies, and for preventive measures correctly targeting the category of preventable orofacial clefts. These article reviews the embriology, etiology, pathophysiology, and classification of the cleft palate
EFEKTIVITAS EKSTRAKDAUN BENALU NANGKA (Macrosolencochinchinensis (Lour.) van Tiegh) DALAM MENCEGAH PERTUMBUHAN TUMOR PARU MENCIT BETINA Dwi Nurahmanto; Edy Meiyanto
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Cancer was ranked first as the cause of death in all over the world. Chemopreventive sought from traditional preparations for example, various types of plant parasites. This study aims to determine the chemopreventive activity of aqueous extract of leaves of parasites jackfruit ( Macrosolen cochinchinensis ( Lour. ) van Tiegh ) on the growth of lung tumors of mice ( Mus musculus ) female strain Balb / c induced benzo [a ] pyrene . This research was conducted using the method Newborn Mice. Test animals used female mice (Mus musculus) strain BALB / c and benzo [ a] pyrene as carcinogenic compounds. Female mice were divided into 5 groups. Cancer control group were injected with B [ a] P were dissolved in dimethylsulfoxide ( DMSO ) . Solvent control group was given the same volume of DMSO in the control of cancer. The treatment group was divided into three dose groups are a dose of 250, 500, and 750 mg / kg . Extract made after female mice induced B [a] P. Chemopreventive intensity expressed as percentage inhibition of tumors in each group by counting the number of tumor nodules on average per lung in each mouse organs within each group. Statistical analysis used is the analysis of Test homogenity of variances and continued with Mann- Whitney Test. Parasite jackfruit leaf aqueous extract (Macrosolencochincinensis (Lour.) van Tiegh) dose of I, II, and III were able to inhibit development into lung of female mice with the percentage inhibition respectively 50 %, 36.87 %, and 84.57 % .

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