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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian STOMATOGNATIC- Jurnal Kedokteran Gigi JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Kartika : Jurnal Ilmiah Farmasi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Dwi Nurahmanto
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS EKSTRAKDAUN BENALU NANGKA (Macrosolencochinchinensis (Lour.) van Tiegh) DALAM MENCEGAH PERTUMBUHAN TUMOR PARU MENCIT BETINA Nurahmanto, Dwi; Meiyanto, Edy
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Cancer was ranked first as the cause of death in all over the world. Chemopreventive sought from traditional preparations for example, various types of plant parasites. This study aims to determine the chemopreventive activity of aqueous extract of leaves of parasites jackfruit ( Macrosolen cochinchinensis ( Lour. ) van Tiegh ) on the growth of lung tumors of mice ( Mus musculus ) female strain Balb / c induced benzo [a ] pyrene . This research was conducted using the method Newborn Mice. Test animals used female mice (Mus musculus) strain BALB / c and benzo [ a] pyrene as carcinogenic compounds. Female mice were divided into 5 groups. Cancer control group were injected with B [ a] P were dissolved in dimethylsulfoxide ( DMSO ) . Solvent control group was given the same volume of DMSO in the control of cancer. The treatment group was divided into three dose groups are a dose of 250, 500, and 750 mg / kg . Extract made after female mice induced B [a] P. Chemopreventive intensity expressed as percentage inhibition of tumors in each group by counting the number of tumor nodules on average per lung in each mouse organs within each group. Statistical analysis used is the analysis of Test homogenity of variances and continued with Mann- Whitney Test. Parasite jackfruit leaf aqueous extract (Macrosolencochincinensis (Lour.) van Tiegh) dose of I, II, and III were able to inhibit development into lung of female mice with the percentage inhibition respectively 50 %, 36.87 %, and 84.57 % .
Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro (Optimization of Hydroxypropyl Methylcellulose and Carbopol for Moisture Content and Release Rate of Ibuprofen Patch In Vitro) Kristine Dwi Puspitasari; Dwi Nurahmanto; Lidya Ameliana
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Ibuprofen is non steroidal antiinflammatory drug (NSAID) of the propionic acid class which is widely used for the treatment of rheumatoid arthritis. Ibuprofen patch is an effective approach evading ibuprofen's adverse effect in the GI tract and first pass effect. The function of polymer is to control the drug release from the patch. The aims of this study were to determine the effect of hydroxypropyl methylcellulose (HPMC) K4M and carbopol 934 combination on the moisture content (MC), in-vitro drug release, and to obtain the optimum formula of those polymers. Ibuprofen patch were prepared into three formulas based on simplex lattice design with the ratio of HPMC K4M : carbopol 934, that were 1 : 0, 0.5 : 0.5, and 0 : 1. Design expert software was used to obtain the optimum formula of both polymers. The results of this study showed that patch with HPMC K4M : carbopol 934 (0.5 : 0.5) gave the best MC and the in-vitro drug release. The optimum formula was HPMC K4M and carbopol 934 with the ratio of 0.5 : 0.5. Keywords: ibuprofen, patch, HPMC, carbopol
Optimasi Komposisi Polietilen Glikol dan Lesitin sebagai Kombinasi Surfaktan pada Sediaan Nanoemulsi Kafein (Optimization of Polyethylene Glycol and Lecithin Composition as Surfactant Combination in the Caffeine Nanoemulsion) Dessy Dwi Risky Ayuningtias; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i2.5864

Abstract

Caffeine is one of alkaloids that have the potential to skin cancer treatment. Caffeine is hydrophilic with log-P value of 0.07 that makes difficult to penetrate to the stratum corneum. Nanoemulsion is one of system which made to increase drug penetration. Oneof the important component in the nanoemulsion is a surfactant that acts as a unifier between the oil and water phases to form one phase that isotropic and thermodynamically stable. The presence of lipophilic component in the surfactant can affect the skin barrierdisturb, thus increasing penetration. The aims of this study was to find the best composition of the PEG-400 and lecithin as surfactant combination to obtain a nanoemulsion that is safe, stable, and increasing penetration of caffeine. The experiment was conducted using a factorial design method which observed responses of flux value and viscosity deviation. The viscosity deviation and flux were analyzed using Design Expert 10.0 trial to determine the optimal formula of caffeine nanoemulsion. The results obtained optimal formula of nanoemulsion that has composition of PEG-400 as 32% and lecithin as 7% . Prediction of viscosity deviation and flux value of optimal formula was 0,034 cP and 0.514 μg cm-2min-1.Keywords: caffeine, nanoemulsion, PEG-400, lecithin
Optimasi Tween dan Propilen Glikol dalam Self-Nanoemulsifying Drug Delivery System VCO-Minyak Daun Kemangi Feny Dhea Camelia; Dwi Nurahmanto; Budipratiwi Wisudiyaningsih
Pustaka Kesehatan Vol 9 No 3 (2021): Volume 9 No.3, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i3.22582

Abstract

Basil (Ocimum basilica) contains active compounds of essential oils that have volatile properties, so it will affect its antibacterial activity. SNEDDS was chosen as a delivery system to increase essential oil stability. The purpose of this study was to determine the effect of tween 80 concentration, propylene glycol, and their interactions in VCO on SNEDDS of basil leaf oil on response and to determine the antibacterial activity with optimum characteristics. Optimization of tween 80 and propylene glycol was conducted using the VCO oil phase with a factorial design method using design expert software 11 with the response used, namely% transmittance and emulsification time. Verification and characterization were carried out including organoleptic, pH, particle size, particle distribution, then tested for antibacterial activity. The results showed that an increase of tween 80 concentration and a decrease of propylene glycol would increase the transmittance value and decrease the emulsification time. There was no interaction effect between the two. Prediction software design expert 11 showed optimum formula with a clear yellow color appearance, the distinctive odor of basil oil, has an average pH of 6.81 ± 0.03, an average particle size of 19.7 ± 0.16 nm, a particle distribution with an average PDI average of 0.163 ± 0.05. The optimum formula with a concentration of 30 μl has activity against S. thypi with an average inhibition zone diameter of 17.21 ± 1.01 mm.
Optimasi Hidroksipropil Metilselulosa dan Mentol pada Sediaan Gel Dispersi Padat Ibuprofen–Polietilenglikol dengan Metode Desain Faktorial (Optimization of Hydroxypropyl Methyl Cellulose and Menthol in Ibuprofen Gel Solid Dispersion-Polyethyleneglycol usi Maharani Dwi Pratiwi; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5895

Abstract

Ibuprofen is included in non-steroidal anti-inflammatory drug (NSAID) which is used for the treatments of arthritis and inflammation. Ibuprofen gel is an effective approach evading ibuprofen's side effect in GI tract and first pass effect. The aims of this study was to determine the effect of HPMC and menthol combination on viscosity, penetration flux and to obtain the optimum formula.The gel evaluations were organoleptic testing, pH, viscosity, spreadibility test, assay of ibuprofen gel, and in vitro penetration rate. In vitro penetration testing used the paddle type dissolution tester. Furthermore ibuprofen which penetrated through rat skin were analyzed by UV-Vis spectrophotometer. Ibuprofen gel were prepared into four formulas based on factorial design and the data were analyzed using design expert trial 9.0.3. The viscosity testing of F1, Fa, Fb, and Fab were 183.30 ± 14.433,261.67 ± 16.07, 158.33 ± 7.637, and 310.0 ± 13.23 dPa.s. The in vitro penetration rate of F1, Fa, Fb, and Fab were 0.7225, 0.6716, 1.5587 And 1.0702 µg/cm2.minutes. It can be concluded that Fb has the optimum formula. Keyword: optimization, HPMC, menthol, factorial design
Optimasi Komposisi Polietilen Glikol dan Lesitin sebagai Kombinasi Surfaktan pada Sediaan Nanoemulsi Kafein (Optimization of Polyethylene Glycol and Lecithin Composition as Surfactant Combination in the Caffeine Nanoemulsion) Dessy Dwi Risky Ayuningtias; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.5386

Abstract

Caffeine is one of alkaloids that have the potential to skin cancer treatment. Caffeine is hydrophilic with log-P value of 0.07 that makes difficult to penetrate to the stratum corneum. Nanoemulsion is one of system which made to increase drug penetration. One of the important component in the nanoemulsion is a surfactant that acts as a unifier between the oil and water phases to form one phase that isotropic and thermodynamically stable. The presence of lipophilic component in the surfactant can affect the skin barrier disturb, thus increasing penetration. The aims of this study was to find the best composition of the PEG-400 and lecithin as surfactant combination to obtain a nanoemulsion that is safe, stable, and increasing penetration of caffeine. The experiment was conducted using a factorial design method which observed responses of flux value and viscosity deviation. The viscosity deviation and flux were analyzed using Design Expert 10.0 trial to determine the optimal formula of caffeine nanoemulsion. The results obtained optimal formula of nanoemulsion that has composition of PEG-400 as 32% and lecithin as 7% . Prediction of viscosity deviation and flux value of optimal formula was 0,034 cP and 0.514 µg cm-2min-1. Keywords: caffeine, nanoemulsion, PEG-400, lecithin
Optimasi Propilen Glikol dan Etanol sebagai Peningkat Penetrasi Ibuprofen dalam Sediaan Gel dengan Metode Simplex Lattice Design (Propylene Glycol and Ethanol Optimization as Ibuprofen Penetration Enhancer in Gel Dosage using Simplex Lattice Design Metho Baiq Wahyudyati Karnia Qisti; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6611

Abstract

Ibuprofen is a non-steroid anti inflammatory drug (NSAID) used for rheumatoid arthritis treatment. In this study, formulation, evaluation, and optimization of ibuprofen gel formula were conducted in order to determine the best ibuprofen penetration rate through the rats skin using propylene glycol and ethanol as penetration enhancers and to find out the optimum formula to get the best penetration rate with simplex lattice design method. Evaluations included organoleptic, pH, viscosity, gel dispersive, assay of gel formulations, and ibuprofen penetration rate assay. Penetration rate was determined by paddle type dissolution and the samples were analyzed by spectrophotometry UV-Vis. The results of ibuprofen penetration rate assay were analyzed and optimized using design expert trial version 10. The results of ibuprofen penetration rate were F1 1.524 ± 0.121 µg/cm2.minute; F2 1.945 ± 0.0104 µg/cm2.minute; and F3 1.173 ± 0.216 µg/cm2.minute. Penetration rate optimization resulted in one optimum solution formula which was 18.000% propylene glycol and 12.000% ethanol with a maximum flux of 1.957 ug/cm2.minute and desirability 1. It can be concluded that the best ibuprofen penetration rate was F2 with flux 1.945 ± 0.0104 µg/cm2.minute with 15% propylene glycol and 15% ethanol. Keywords: gel, ibuprofen, propylene glycol, ethanol, simplex lattice design
Optimasi Tween 80 dan Propilen Glikol dalam Self-Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Atsiri Daun Kemangi (Ocimum basilicum) Nofia Elisa Putri; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.22628

Abstract

Basil (Ocimum basilicum) is a plant from Lamiaceae family that has the potential for typhoid fever treatment. Basil essential oil is a hydrophobic compound being difficult to dissolve in the gastrointestinal tract. SNEDDS is one system that can solve this problem. The vital components of SNEDDS are surfactants and cosurfactants to increase the stability of the SNEDDS system by forming small droplets. This research determines the best composition of Tween 80 and Propylene glycol (PG), which can form nanoemulsion spontaneously in the gastrointestinal tract with a droplet size of nanometers. This research used a factorial design method to observed responses transmittance and emulsification time. Response transmittance and emulsification time then analyzed using Design Expert 11.0 to determine the optimum formula of SNEDDS basil essential oil. The optimum formula of SNEDDS basil essential oil obtained was a formula with a composition of 2.05 mL of Tween 80 and 1.35 mL of Propylene glycol. The optimum formula characterization test results showed a pH value of 7.01 ± 0.007; particle size 46.1 ± 0.61 nm; polydispersity index 0.46 ± 0.016. The antibacterial activity test optimum formula showed the ability to inhibit the growth of Salmonella typhi bacteria with an inhibition zone diameter of 20.50 ± 0.59 mm.
Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating (Optimization Temperature and Heating Time Formation of Inclusion Complexes Glibenclamide-β-Cyclodextrin by Sealed-Heating Metho Aslyni Putri Suranina Barus; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Glibenclamide is a second-generation sulfonylurea that used for type II diabetes mellitus. Glibenclamide is included in the biopharmaceutical classification system (BCS) class II, which has a low solubility and high permeability. One effort that can be done to improve the solubility of drug is inclusion complexation. The aims of the study was to determine temperature and heating time on inclusion complexation of glibenclamide-β-cyclodextrin using sealed-heating method. Optimization done using a factorial design for two factors with 22 number of experiments. Inclusion complexes were determined its miosture content, solubility and in vitro dissolution. Moisture content study showed that F1> FB > FA > FAB. The results of solubility study were analyzed statistically using One-Way ANOVA and least significantly different (LSD). Statistical analysis showed that each formula had a significant difference solubility with FAB > FB > FA > F1>Control. Optimization on in vitro dissolution showed that FAB was an optimum formula with drug release of 87.24% within 180 min. This formula was characterized by DSC to observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. DSC analysis was indicated that inclusion complexation between glibenclamide and β-cyclodextrin was formed. Keywords: glibenclamide, β-cyclodextrin, inclusion complexe, sealed-heating
Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate desy diana sari; Lidya Ameliana; Dwi Nurahmanto
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.12266

Abstract

Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.
Co-Authors A., Mohammad Zulfikhar Ali Djamhuri Ameliana, Lidya Andriyani, Novia Arafika, Whendy Waliya Aslyni Putri Suranina Barus Azis, Rani Firda Nur Imaniah Azis, Rani Firda Nur Imaniah Baiq Wahyudyati Karnia Qisti Budipratiwi Wisudiyaningsih Dessy Dwi Risky Ayuningtias desy diana sari Edy Meiyanto Edy Meiyanto Eka Deddy Irawan Eliyatiningsih, Eliyatiningsih Evi Umayah Ulfa Feny Dhea Camelia Friska Wira Sabrina Gazzali, Amirah Mohd Haris Raudhatuzakinah Dwiputri Ifa Rosi Mahrifah Ika Puspitasari Kristine Dwi Puspitasari Kumala Sari, Lusia Oktora Ruma Lina Winarti Lusia Oktora Ruma Kumala Sari Maharani Dwi Pratiwi Mahrifah, Ifa Rosi Mahrifah, Ifa Rosi Nofia Elisa Putri Nuri Nuri Nursatriya, Agne Yuliana Nurul Shalikha Paramayuda, Farukh R.K.S., Lusia Oktora Rani Firda Nur Imaniah Azis Sabrina, Friska Wira Sabrina, Friska Wira Shalikha, Nurul Taffana Windy Hananta Vega Kartika Sari Viddy Agustian Rosyidi