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The Effect of Wear Particles from Joint Prostheses Materials to Bone Cells Number Suhartini, Suhartini
The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

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Background: The wear particles of joint prostheses can induce releasing of inflammatory mediators. Releasing of inflammatory mediators from activated inflammatory cells can lead bone cells respons. Methods: Wear particles generated by wear testing of both materials Ultra High Molecular Weight Polyethylene (UHMWPE) GUR 1120 and Stainless Steel 316 L with ion implantation by using pin on plate unidirectional motion machine and phosphate buffer saline (PBS) as lubricant. The velocity of running wear test is 116.5 mm/s and the sliding distance was 30 km. Furthermore, wear particles was inserted into knee joint synovium capsule of Rattus norvegicus sp. The animals were sacrificed to know the number bone cells on seventh day. Results: Statistical analysis by Kruskal Wallis showed that there was no significant differences in the number of osteoblast cells (p=0.094) and there were no significant differences in the number of osteoclast cells (p=0.143). Conclusion: There was no effect of wear particles from joint prosthesesto bone cells number

Chemical Effectiveness of Salvadora persica and Commercially Available Whitening Toothpaste on Preventing Tea and Chlorhexidine Stain (in vitro study) Erlina Sih Mahanani; Erry Mochamad Arief; Puteri Ezdiani Binti Mohamed Ismail
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Salvadora persica, a plant that contains a wide range of healthy components, has been used as chewing stick for ages to maintain good oral hygiene and currently has been approved to remove stains. However, its stain-preventing effect is still under investigation. This study aimed to investigate the effectiveness of Salvadora persica and commercially available whitening toothpastes on preventing tea and chlorhexidine stains. Sixty clear acrylic blocks were used and divided into 3 groups, 20 for each group. First group was treated with drinking water, second with commercially available whitening toothpaste and third with whitening toothpaste containing Salvadora persica extract. Baseline measurement by spectrophotometer was taken before starting the procedure. All specimens were immersed in artificial saliva for 2 minutes, rinsed in distilled water and exposed in 0.2% chlorhexidine and tea solution. These cycles were performed 8 times a day for 5 days. Intervention with whitening toothpaste was done for 2 minutes; twice a day. Eventually, all blocks were removed, washed and dried. Stain was assessed by spectrophotometer and visual assessment using Lobene stain index (1968). This study results showed significant differences among groups (Kruskal-Wallis test, p<0.001) and Salvadora persica extract was found to be more effective than commercially availablewhitening toothpaste on preventing stain formation

Effect of Allicin for Re-epithelialization During Healing in Oral Ulcer Model Renny Ayu Novianty; Bernadetta Esty Chrismawaty; Goeno Subagyo
The Indonesian Journal of Dental Research Vol 1, No 2 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Allicin (diallyl thiosulfinate) is the main component of fresh garlic with multi-bioactivities as therapeutic agent. Recently, allicin is being proposed as alternative therapy for aphthous ulcer. The purpose of this study was to determine the effect of topical allicin in aqueous garlic extract on re-epithelialization during healing of acetic acid induced oral ulcer model. Thirty males SD rats aged 2 months were equally divided into two groups as experimental and control groups. After sedated with 0.2 ml intramuscular Ketamine injection, ulcer model was made by applying 99.5% glacial acetic acid-moistened paper disc on rat buccal mucosa. This would gene- rate an immediate necrotic tissue, which produced a single crateriform ulcer in each of the experimental rats for the next two days. In the experimental group, one drop of allicin was applied twice daily onto the lesion. Three rats in each group were sacrificed on days 2, 3, 6, 9 and 12 after induction and were recorded as H0, H1, H4,H7 dan H10 groups, respectively. The tissue samples from buccal mucosa were processed for HematoxylinEosin (HE) staining, and then evaluated histologically. Re-epithelialization was assessed by measuring the thickness of the epithelium using an ocular micrometer under a light microscope. Data were analyzed statistically by Independent t-test with significant p-values of <0.05 (95%). Based on histological findings and trend graphs, it can be concluded that the topical application of allicin can accelerate re-epithelialization of ulcer healing process. This study suggests that allicin in aqueous garlic extract could be developed as therapeuticagent for aphthous ulcer

The Noteworthy Case: Atypical Palatal Ulcer Which is Progressivelly Develop to Oral Squamous Cell Carcinoma in Diabetic Elderly Prayudha, Satrya Ayu E.; Chrismawaty, B. Esti; Agustina, Dewi; Subagyo, Goeno
The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.124 KB)

Background: Oral ulcers are commonly painful lesions that are associated with numerous etiologies. Palatal ulcer could be referred as atypical oral ulcer due to unusual site predilection. The correct differential diagnosis is necessary to establish the appropriate treatment, with regards to all possible causes. Purposes: This report was intended to explain Oral Squamous Cell Carcinoma [OSCC] which is presented as atypical palatal ulcer resembling Necrotizing Sialometaplasia [NS]. Case and management: A 65 year old male, edentulous with history of uncontrolled type 2 Diabetes mellitus and experienced a gradually enlarging palatal ulcer. According to the patient, a fish bone pricked his hard palate just before the complaint. There was no lymphadenopathy, and intraoral examination revealed a solitary shallow ulcer on the right side of hard palate, covered by white pseudomembranous layer without erythematous halo. The margin of the ulcer was distinctive without induration. A month later, the lesion was progressively painful and interfere the oral function. The differential diagnoses were traumatic ulcer suspected to Eosinophilic Ulcer, Necrotizing Sialometaplasia [NS], and OSCC. Treatment plans included palliative measures and medical consultation regarding the need of biopsy. The biopsy was performed two months later. At that time, the ulcers were enlarged with indurated margin and necrotic center. A biopsy confirmed the diagnosis as OSCC with moderate differentiation. For proper treatment, the patient was referred to Oncology Department, Sardjito General Hospital. Conclusion: An atypical persistent solitary oral ulcer, especially in elderly, should prompt urgent investigation, since an oral malignancy must be foremost on the differential diagnoses list. This case report showed a progressively development of OSCC, even without preceding premalignant lesion. It is the dentists responsibility to identify any suspicion of oral premalignancy, so that proper referral can be performed earlier for reducing the mortality.

Address from Dean of The Faculty of Dentistry Universitas Gadjah Mada Iwa Sutardjo Rus Sudarso
The Indonesian Journal of Dental Research Vol 1, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

As mentioned in its Strategic Plans (2008-2012), Universitas Gadjah Mada (UGM) has its vision to be a World Class Research University which is excellent, independent, dignified, inspired by Pancasila, the five-point ideology, and dedicated to the needs and welfare of the nation and the world. The vision is done by UGM mission: To promote excellent teaching-learning opportunities and community service through research, with its special mission on research; To promote excellence in educational activities, research, and community service with the interest of the Indonesian society and to participate in Indonesian socioculturalbuilding.As a university unit, Faculty of Dentistry should play significant roles towards the vision. For this, research indeed is one of important factors towards the vision. To get better of research’s result application and social service, it is hoped that researcher possesses entrepreneurial ability while still maintaning his/her research quality. It can be said that, generally, research development in the Faculty of Dentistry is growing satisfactorily. But, still, it is not yet followed by strong publication. One of bestknown research publications is academic journal, nationally or internationally. This kind of publication is an effective form of communication among researchers and also a very considerable part in scientific and technological development.Considering the above driving forces and the uniqueness of the country in relation to researches in dental sciences, Faculty of Dentistry proudly publish “The Indonesian Journal of Dental Research” which is in turn to be a window for the international forum to learn on the progresses and achievements in dental research in Indonesia. In the future, it is also hoped that “The Indonesian Journal of Dental Research” be an information portal in terms of dental science and technology in Indonesia, and in the Asian region in general.Hopefully, this journal will be able to provide scientific media for sharing progresses and achievements in research on oral and dental sciences in Indonesia to the international forum. Moreover, this journal is expected to be an embrio for scientific portal in dental and oral sciences in Indonesia and Asia region.Iwa Sutardjo RSProfessor in Pediatrics DentistryDean of The Faculty of DentistryUniversitas Gadjah Mada

Analysis of Patients Visiting Niigata University Medical and Dental Hospital with Chief Complaints of Metal Allergy and/or Focal Infection in the Previous 8 Years Yosuke Akiba; Ken Tomizuka; Masaru Kaku; Maiko Kawasaki; Masako Nagasawa; Ryohei Takano; Katsumi Uoshima
The Indonesian Journal of Dental Research Vol 1, No 2 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Dental metal allergy and dental focal infection are possible causes of dermatological diseases, but have been the subjects of few reports to date. We have been treating such patients in our special clinic for more than 20 years.The purpose of the present study was to investigate the mouths of patients visiting our dental hospital over an 8-year period, with the aim of clarifying whether dental metal allergy and/or dental focal infection affects their dermatologic conditions.We surveyed all clinical records of the 185 patients who visited Niigata University Medical and Dental Hospital with chief complaints of dental metal allergy since 2002. Diagnostics of skin diseases, periodontal records, periapical lesions, dental caries, dental metal series patch test results and Electron Probed Micro-Analysis (EPMA) data were investigated. Ninety-two (49%) patients were suffering from pustulosis palmaris et plantaris and 20 (11%) patients had lichen planus. Eighty-two (49%) patients showed positive reactions on patch testing. Based on the result of patch tests, Ni showed the highest positivity rate (62%, 51 patients), but on EPMA, the number of patients with Ni as an allergen was 14 (27%). On the other hand, more than 98% of patients who showed positive reactions on patch test to Pd and Au had these metals in their dental prostheses. In addition, 112 (60%) patients showed the possibility of dental focal infections

Expression of MRP8/MRP14 mRNA in Monocytes of Periodontitis: Comparison between Diabetic and Non Diabetic Patients Ahmad Syaify; Sri Budi Barunawati; Suryono Suryono; Marsetyawan HNES
The Indonesian Journal of Dental Research Vol 1, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

The severity of periodontitis on patients with type 2 Diabetes Mellitus patients was strongly thought caused by decreasing of leukocytes function such as monoctyes and neutrophils. In our previous research it was found that calprotectin (MRP8/MRP14) level in leukocytes of periodontitis patients with type 2 DM was higher than periodontitis in non DM. The aim of this study was to determine calprotectin (MRP8/MRP14)mRNA expression in human monocytes of periodontitis patients with type 2 DM and without DM. Monocytes were isolated from the peripheral blood of periodontitis patients with uncontrolled type 2 DM, controlled type 2 DM, and non DM. The expression of total RNA calprotectin (MRP8 and MRP14) were detected by RTPCR using GAPDH as the innate control. It was observed that the value of MRP8/MRP14 mRNA expression DM patients were higher than non DM, and the highly significant increase expression (p<0.05) was on the uncontrolled type 2 DM. The basal level of MRP8/MRP14 expression increased in monocyte of periodontitis and type 2 DM patients compared with non diabetes subjects. It was suggested that high basal level MRP8/MRP14 has role in the regulation of severity periodontitis with diabetes mellitus.

The Effect of Anacardium Occidentale Leaves Extract with Various Concentrations Used as Denture Cleanser on Streptococcus Mutans Growth Kristiana, Dewi
The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.124 KB)

Introduction: Microbial adhesion on dentures surface can cause proliferation on bacteria colony, leads to formation of plaque which induce bad smell in mouth and denture stomatitis. There is evidence about denture stomatitis caused by another biofilm species, Streptococcus mutans (S. mutans). This study was aimed to observe efficacy differences on S. mutans growth inhibition of Anacardium occidentale leaves extract between various concentrations of 25%, 50%, and 75% as denture cleanser after 45 min immersing. Materials and methods: Samples were made from heat-cured resin acrylic plates with dimension of 10 x 10 x 1 mm. Heat-cured resin acrylic plates were immersed in Anacardium occidentale leaves extract with concentration of 25%, 50%, and 75% for 45 minutes. Each concentration contained of 8 samples. In control group, heat-cured resin acrylic plates were immersed in distilled water. To observe inhibiting effect of Anacardium occidentale leaves extract on S. mutans growth,spectrophotometer was used. Data were analyzed using one way ANOVA and LSD test. Results: Data analyses using one way ANOVA showed significant differences (p<0.05). In LSD test, significant differences on S. mutans growth inhibition effect of Anacardium occidentale leaves extract between concentration 25%, 50%, and 75% after immersing heat-cured resin acrylic plates for 45 minutes was found. Conclusion: In conclusion, Anacardium occidentale leaves extract in concentration of 75% used to immerse the acrylic plate for 45 minutes effectively inhibited the growth of S. mutans.

The Newly Bone Formation with Carbonate Apatite-Chitosan Bone Substitute in the Rat Tibia Anne Handrini Dewi; Andi Triawan
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Large bone defect still represent a major problem in orthopedics. A tissue engineering approach has been proposed where osteogenic cells, bioceramic scaffolds and growth factors can play in a role to the bone repair. Bone consist a mineral phase such as carbonate apatite and an organic phase such as collagen. Synthetic carbonate apatite ceramics are considered as promising alloplastic materials for bone substitute. Chitin is the organic matrix of the hard parts of exoskeleton of insect, crustacean and present in a small amounts in mushrooms. It is an insoluble, similar to cellulose and composed of N-acetylglucosamine unit. Partial deacetylation from chitin result in the formation of chitosan. Chitin’s properties as a flexible and strong material make it favourable as surgical thread. It has novel properties such as biocompatibility, biodegradability, anti bacterial, wound healing activity, tissue regeneration and hemostatic activitities. The composit from carbonate apatite and chitosan may have a great impact on human health care system as bioresorbable bone substitute. The aim of the study was to evaluate the newly bone formation on the bone healing of defect tibia treated with carbonate apatite-chitosan bone substitute. Eighteen Sprague Dawley rats, male, 3 months, weighing 250-300g used in this study. Bilateral defect were created in each tibia rat. The defects were filled with carbonate-apatite chitosan bone substitute. The rats were sacrificed after respectively 1, 2 and 3 weeks. The result of this study showed that carbonate apatite-chitosan significantly increased a number of osteoblast (p<0.05). Carbonate apatite-chitosan group showed that matrix deposition faster than the other groups and have a good interface with the old bone. These data indicate that carbonate apatite-chitosan are potential candidate for bone substitute

The Prevalence of Fibroma in Oral Mucosa Among Patient Attending USM Dental Clinic Year 2006-2010 Daddy Suradi Halim; Abdullah Pohchi; Pang EE Yi
The Indonesian Journal of Dental Research Vol 1, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

The purpose of this preliminary retrospective study was to determine the prevalence of fibroma in oral mucosa among patients attending USM dental clinic from 1/6/2006-1/6/2010. Fibroma of the oral mucosa is the most common benign tumor of the oral cavity. It is a reactive hyperplasia of fibrous connective tissue in response to local irritation or trauma. A lesion on any part of the oral mucosa have a broad differential diagnosisranging from traumatic lesions (mucocele), neurogenic lesions (neurofibromatosis), lipoma , epithelial tumors (squamous papilloma) and inflammatory/reactive hyperplasia of soft tissue (pulp polyp). A total number of 192 patients (82 male and 110 female) who are registered in the Oral Medicine and Oral Pathology Log Book were included in this study regardless of their age, 16 % of them were diagnosed to have fibroma and out of that, 29% of them were male and 79% female. The peak incidence of the lesion was in the 3rd decade of life. The lesions occurred in the tongue, lip mucosa, sulcus region and buccal mucosa were each to be 12.9%, 12.9% , 32.2 % and 41.9%. This study shows that fibroma is one of the common oral mucosal lesion and it occurred mostly in the 3rd decade of life where the prevalence is higher in female patients.

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA