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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 305 Documents
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The Relation between Malondialdehyde (MDA) and Histopatological Appearance in male Wistar Rats Model Febrina Sylva Fridayanti; Erma Sulistyaningsih; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 1 No 1 (2015)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Fractures are a serious health problem in Indonesia due to increasing prevalence. The healing process of fracture is disturbed by the oxidative stress that caused by imbalance quantity of free radical and antioxidant. An antioxidant such as polyphenol, which can be found in cocoa, is needed to suppress oxidative stress. The study aimed to investigate the effect of the ethanolic extract of cacao on fracture healing process in a rat model through MDA concentration and histopatological appearance. This study is in vivo experimental study with post-test only controlled group design. 30 male Wistar rats were randomized and divided into 5 groups. 1 group was rats without fractured. The negative control and three treatment groups were rats with fractured manually on left tibia under anesthesia and immobilized by bandage. The treatment groups treated with cocoa ethanolic extract in a dose of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW orally for 21 days. The result showed that there was a significant different between the treatment groups and the negative control group on MDA concentration and histopatological appearance (p>0,05). The corelation between them were strong and had negative direction (R=-0,771). The study concluded that cocoa ethanolic extract had a positive effect to supress oxidation stress and increases the number of osteoblast on fracture healing process.   Key words: cocoa ethanolic extract, polyphenol, fracture healing process, oxidative stress
The Correlation between Service Quality of Maternal and Child Healthcare/Family Planning Clinic and Degree of Maternal and Child Health at Two Primary Health Care Centers in Jember Kunthi Kencana Makayasa Putri; Ida Srisurani Wiji Astuti; Sugiyanta Sugiyanta
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

The high Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) is still a major health problem in Indonesia. As an one of indicator to assess the quality of maternal and child healthcare is MMR and IMR. Service quality consists of five dimensions i.e., tangible, responsiveness, reliability, assurance, and empathy. The aim of this research was to determine the correlation between service quality of maternal and child healthcare/family planning polyclinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. This research used cross-sectional design with 144 respondents. Service quality was measured using ServQual questionnaire and degree of maternal and children health were measured using MMR and IMR. The results of statistical test with Spearman correlation test showed that the significance (p) = 0.000 and correlation coefficients (r) = 0.690. Thus, it can be concluded that there were a strong correlation between service quality of maternal and child healthcare/family planning clinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. Keywords: Maternal Mortality Rate, Infant Mortality Rate, ServQual. 
Immunoblotting Detection of Immunoglobulin G Post Subcutaneous Immunization Of Protein Hemaglutinin Pili Klebsiella pneumoniae 12,8 kDa on Mice BALB / C Dini Agustina
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5069

Abstract

Klebsiella pneumoniae is the second most common cause of community infection and nosocomial infections due to Gram-negative bacteria. These bacteria are able to induce the onset of immune response, especially humoral immune response.Humoral immunity acts through the activation of B cells that produce antibodies. Antibodies, especially IgG, will cause encapsulated bacteria such as Klebsiella pneumoniae to be better phagocytosed. The purpose of this study was to determine the IgG response to hemagglutinin protein pili K. pneumoniae 12.8 kDa. The method used in this research is Immunoblotting method with western blot and dot blot. The primary antibodies used for the western blot and dot blot tests were isolated from BALB / C mice serum induced with the subcutaneous pili K. pneumoniae 12.8 kDa protein. To get the standard in assessing the results of dot blot were used Corel Photo-paint X6. The semi-quantitative result of dot blot was obtained with the strongest reaction of the antibody dilution at 1/100 while the antigen dilution titer at 1 / 10.000. Results from western blotting showed a positive reaction of the pili protein subunit with a molecular weight of 128.1 kDa, 114.4 kDa, 64.9 kDa, 31.1 kDa, 27.7 kDa, 24.8 kDa, 20.9 kDa, 12.8 kDa, and 10 kDa. The conclusion of this study is the immunization of hemagglutinin pili K. pneumoniae 12.8 kDa subcutaneously capable of inducing the formationof Immunoglobulin G in BALB / C mice.
Syzygium Samarangense Leaves Ointment Enhances Wound Healing Process Of Skin Burn Based On Collagen Ain Yuanita Insani; Mega Citra Prameswari; Novail Alif Muharrom; Toyibatul Hidayati; Arista Prima Nugrahani; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6160

Abstract

Background: The World Health Organization (WHO) estimates the number of death in 2014 caused by burns is 265,000. Burns can caused skin damage as well as other complication problems such as dehydration, infection, and other multiple organ failures. Syzygium samarangense leaves contain flavonoids and saponins that can increase the activation of macrophages and TGF-B which is important to accelerate the process of collagen formation and wound healing process. Objective: Knowing the effect of Syzygium samarangense leaf extract on the healing process of burn based on collagen. Method: This in vivo study use true experimental design. We made burns by placing a coin that already heated in oven at 70ºC for 10 seconds. Rattus Wistar as experimental animals dividedinto 6 groups (n = 4) with details of Group A (normal), B (positive), C (negative). Groups D, E, and F were the groups that given ointment extract topically in doses of 15%, 30%, and 45% each day’s. Termination is done on day 7. Test statistics by using Anova and Kruskal Wallis. Results and discussion: From this research, Syzygium samarangense leaf extract can reduce the wound area (p <0,05) and increase the amount of collagen (p <0,05). Conclusion: Syzygium samarangense leaf extract ointment can accelerate the healing process of burns. Keywords : Burns, Syzygium samarangense Leaves ointment, Saponin, Flavonoid, Collagen
The Correlation between Nicotine Dependence Level and Negative Symptom in Schizophrenic Patients at Psychiatric Department of PTPN XI Djatiroto Lumajang Hospital Nafiys Hilmy; Alif Mardijana; Dwita Aryadina Rachmawati
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6330

Abstract

Smoking behavior is one problem in schizophrenic patients. The prevalence of smoking in schizophrenic patients is reported 2-4 times greater than the normal population. Nicotine can induce the dopamine release so it increase positive symptom and improve negative symptom also cognitive deficits. These effects are an attempt by schizophrenic patients to reduce the side effects of antipsychotic drugs. This causes the need of increased antipsychotic doses. This study aims to determine the correlation between nicotine dependence level andnegative symptom in Schizophrenic Patients at Psychiatric Department, PTPN XI Djatiroto Hospital Lumajang. This is an analytical observational study with cross sectional study design which uses 30 patients with schizophrenia at Psychiatric Department, PTPN XI Djatiroto Hospital Lumajang who met inclusion and exclusion criteria. Nicotine dependence level and negative symptom were obtained with guided interview based on Fagerström Nicotine Dependence (FTND) questionnaire and score of Positive and Negative Syndrome Scale (PANSS) negative subscale. Spearman correlation test result between these variables is p=0,019 and r=0,426 which means there is significant correlation with moderate strength between nicotine dependence level and negative symptom in Schizophrenic patients at Psychiatric Department, PTPN XI Djatiroto Hospital Lumajang. Keywords: Schizophrenia, Negative Symptom, Nicotine Dependence
Risk Factors of Perinatal Death Age 0-28 Days at RSD dr. Soebandi Jember Ainindya Pasca Rachmadiani; Muhammad Ali Shodikin; Cicih Komariah
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6737

Abstract

Abstract Perinatal deaths are babies who die at <28 days of birth. According to WHO, there are 2.7 million perinatal deaths worldwide in 2015. In 2016, the number of infant mortality at Jember is 50.19 per 1000 live births and become the second rank in Jawa Timur after Probolinggo. Infant mortality has been associated by maternal, gestational and neonatal factors. The aim of this study is to determine the risk factors of perinatal death age 0-28 days in RSD dr. Soebandi Kabupaten Jember. This research was analytic observasional with case control design doing in RSD dr. Soebandi Kabupaten Jember. The samples were 65 cases and 65 controls. Data analysis was done by Chi-square test and Fisher’s exact test with significance value < 0,05. The results showed APGAR Score (p <0.001, OR = 6.51), birth weight (p <0.001, OR = 9.66), body length (p <0.001 OR = 5.07), gestational age (p = 0.002; OR = 2.92), congenital anomalies (p = 0.013; OR = -) and maternal age (p = 0.001; OR = 4.51) were risk factors for perinatal death 0-28 days in RSD dr. Soebandi Kabupaten Jember. Keywords: perinatal deaths, neonatal factors, maternal factors, gestational factors.
The Correlation of Risk Factors to the incidence of Pediculosis capitis on Students in Pondok Pesantren Miftahul Ulum, Jember Nihayah Lukman; Yunita Armiyanti; Dini Agustina
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6488

Abstract

ABSTRACT Pediculosis capitis is a scalp disease caused by obligate ectoparasite (mite or lice) infection of Pediculus humanus var. capitis. This disease is a contagious disease that influenced by environment and behavior, so it becomes a dominant public health problem in densely populated environment like in boarding school. Some risk factors that cause Pediculosis capitis are; sex, educational level, hair wash frequency, use of comb or hair accessories together, use of bedding or bed together, hair length, and hair type. This study aims to determine the most dominant incidence, analyze the risk factors, and know the biggest risk factors to the incidence of Pediculosis capitis in santri at Pondok Pesantren Miftahul Ulum, Jember. The type of research that used was observational analytics with case control design conducted on 287 samples of SMP and SMA Miftahul Ulum students who fulfilled the inclusion and exclusion criterias. From this research, the proportion of Pediculosis capitis incidence was 214 respondents (74,6%), and then analyzed by Chi-Square test, it was found that the variables had significant relationship (p <0,05) to Pediculosis capitis occurrence, among others; sex, hair wash frequency, use of comb or hair accessories together, use of bedding or bed together, hair length and hair type. The result of logistic regression test shows that sex was the most biggest variable (p value = 0,000). Keywords: Pediculosis capitis, risk factors, boarding school
Comparison Profile of Nutrition Status in Stage V Chronic Kidney Disease Patients Hemodialyzing Using New and Reuse Dialyzer Yuli Hermansyah; Ika Aulia Kurniasari; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9613

Abstract

Burn wound healing process consists of three phases of inflammation, proliferation and remodelling. The number of fibroblasts has increased during the proliferation phase. Oxidative stress in burn may disrupt proliferation through TGF-β inhibition, result in decreased number of fibroblasts and poor burn wound healing. Genistein in edamame seeds has anti-inflammatory, antibacterial and antioxidant properties. Edamame contains vitamins A, C, and E which is also have antioxidant properties. Edamame has been suggested to protect burn wound healing from oxidative stress. This study aimed to understand the effectiveness of edamame seed (Glycine max L. Merril) ethanolic extract (ED) to fibroblast count in second degree burn wound healing. This is true experimental research with post test only control group design. The sample of this research was 24 rat models of second degree burn which was made by attaching hot metal (60 ° C) for 5 seconds on the shaved back of the rats. The sample was divided into 6 groups with topical treatment, among others: positive control group (silver sulfadiazine), negative control group (Na CMC 0.5%), group with ED 20%, ED 40%, ED 60%, and ED 80%. Treatment was given for 15 days and skin sample was taken on the 16th day. Observation of the number of fibroblasts was done by taking pictures of histhologic preparations in Hematoxylin and Eosin staining under 400x magnification of light microscope. In one way ANOVA test, significance value of 0.011 (p≤0,05) indicated that there was at least a significant difference between 2 groups. LSD’s post hoc analysis showed that there was a significant difference in the group ED 20, 40, and 60% compared with negative control. Keyword: burn wound healing, vegetable soybean, genistein, fibroblast count, silver sulfadiazine
Difference between Location of Soil with Risk of Contamination of Soil-transmitted Helmints Eggs and Larvae (Observational Study of Coffee Plantation Area in Silo District, Jember Regency) Rezza Putri Mahartika; Yunita Armiyanti; Cholis Abrori; Bagus Hermansyah; Yudha Nurdian
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.9468

Abstract

Soil-transmitted Helminths (STH) is a group of worms whose life cycle through the soil. The species of STH are roundworm (Ascaris lumbricoides), whipworm (Trichuris trichiura), hookworms (Necator americanus and Ancylostoma duodenale), and Strongyloides stercoralis. STH causes helminthiasis that infects more than 1.5 billion people or 24% of the world's population. Jember has many plantation areas. One of the plantations in Jember is Garahan Kidul plantation located in Sidomulyo village, Silo Sub-district, Jember. Soil on plantations tends to be moist and loose. This condition is ideal for the development of STH eggs and larvae. The general purpose of this study was to differentiate the numbers of soil contamination by STH eggs and larvae in soil samples in the garden area, riverside, and worker housing taken in the coffee plantation area in Silo District, Jember. This type of research is observational analytic with cross sectional research design. Soil samples are taken in the garden area, riverside, and worker housing that has a loose or not hard and moist soil texture. The results of the observation found that there were 4 eggs of Ascaris lumbricoides, 6 eggs and larvae of hookworm, and 2 eggs and larvae of Strongyloides stercoralis. There is the same amount of soil contamination at the location of the garden and riverside, which are 2 positive samples or 5.71% with a density of 0.02 eggs and larvae / gram of soil, while the number of soil contamination at the workers housing location is 8 positive samples or 25.71 % with a density of 0.11 eggs and larvae / gram of soil. Data were analyzed using Fisher's test. The results of data analysis showed a value of p = 0.0693 (p> 0.05) so that there were no differences in the number of soil contamination by STH eggs and larvae in the garden and river bank locations and p = 0.042 (p <0.05) so that there were differences the number of soil contamination by STH eggs and larvae at the location of worker housing with the location of garden and riverside. Keywords: STH, garden, riverside, wooker housing
Protective Effect of Cassava Leaf Extract on Gentamicin-Induced Hepatotoxity In Mice Rosita Dewi; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.13815

Abstract

Abstract Gentamicin usage can cause the damage of liver structure and function. The basic mechanism inducing liver damage from gentamicin is lipid peroxidation in cell membrane and the suppresion of antioxidant defence system in liver. Antioxidant in cassava leaf such as vitamin C, carotene, flavonoid, dan mineral can protect liver from drug toxicity effect. This research aimed to determine hepatoprotective effect of cassava leaf through microscopic observation of liver histopathology slide of mice induced by gentamicin. The research design was post test only control group design. Mice were divided into five groups, normal group, positive control (gentamicin 80 mg/kg b.w.); P1, P2, and P3 (gentamicin 80 mg/kg b.w. and cassava leaf extract 150 mg/kg b.w., 300 mg/kg b.w., 450 mg/kg b.w. respectively, for 14 days). The average score of liver cell damage was determined by microscopic observation of 200 liver cells undergoing parenchymal degeneration, hidrophic degeneration, and necrosis. One Way Anova analysis showed significant difference among the groups (p<0,05) and Post Hoc Tukey HSD test showed that cassava leaf extract at the dose level of 450 mg/kg b.w. resulted significant liver cell characteristic improvement in liver histophatology slide (p<0,05) compared to positive control group. It could be concluded that cassava leaf extract had protective effect on gentamicin-induced hepatotoxicity in mice. Keywords: cassava leaf extract, hepatotoxicity, gentamicin, liver histopathology

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