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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
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Articles 244 Documents
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Search results for , issue "JURNAL ILMU FARMASI " : 244 Documents clear
The Potential of Avocado Oil for Topical Use: A Narrative Review Ratna Hapsari Tri Mustika Dewi; Niswatus Sholihah; Rima Nofitasari; Dhimas Adhityasmara; Ayu Shabrina
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.11218

Abstract

Skin aging is a multifaceted biological process that is impacted by both internal (genetics, hormones, cellular metabolism, and metabolic processes) and external (long-term exposure to UV light, pollution, ionizing radiation, chemicals, and toxins) aspects. Monounsaturated fatty acids, especially oleic acid, found in avocado oil are beneficial for wound healing, moisturizing, and anti-aging. Finding avocado oil's role as an active ingredient in cosmeceuticals was the aim of this investigation. The study's article review technique entails a thorough search of the Pubmed, Google Scholar, Proquest, Springer Link, and Science Direct databases for articles published between 2018 and 2024. The sample utilized in this study consisted of research publications that satisfied the inclusion criteria, resulting in a total of 12 articles. The result of this study showed that avocado oil is mostly formulated in emulgel and cream preparation.  Avocado oil can be used as sunscreen due to the presence of the unsaturated fatty acid such as oleic acid and linoleic acid. All of the topical application of avocado oil showed the potential of this oil as antioxidant, anti-aging and sunscreen. Avocado oil is potential as cosmeceutical at the concentration of 3% to 20%.
Studi In-Silico Senyawa Flavonoid Herba Kumis Kucing (Orthosiphon Stamineus B.) Sebagai Penghambat Enzim Siklooksigenase-2 Dandy Rifaldy Rifaldy; Rosario Trijuliamos Manalu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8299

Abstract

Inflamasi adalah respons tubuh terhadap rangsangan yang dianggap berbahaya, namun inflamasi yang tidak tertangani akan menyebabkan inflamasi semakin memburuk. Penghambatan enzim siklooksigenase-2 (COX-2) oleh Non Steroidal Antiinflammatory Drug (NSAID) dapat mengurangi proses inflamasi, namun NSAID memiliki banyak efek samping negatif. Penelitian ini bertujuan menguji senyawa flavonoid herba kumis kucing (Orthosiphon stamineus B.) sebagai kandidat alternatif obat antiinflamasi, dengan melakukan studi in silico yang meliputi identifikasi sifat mirip obat, molecular docking, dan prediksi sifat farmakokinetik. Dari hasil analisis didapatkan dua senyawa flavonoid herba kumis kucing (Orthosiphon stamineus B.) yang memiliki afinitas lebih kuat dan stabil dalam pengikatan enzim siklooksigenase-2, yakni cirsimaritin dan pilloin dengan skor molecular docking -79,64 dan -80,61, dibandingkan ligan alami IMN skor -78,46 dan ligan pembanding ibuprofen skor -78,05, dengan memiliki pengikatan situs aktif yang mirip yakni pada residu asam amino Ser 530. Senyawa tersebut juga memenuhi kriteria sifat mirip obat dan diprediksi >90% molekulnya dapat diabsorpsi di usus, dimetabolisme oleh CYP3A4 di hati, dan tidak menyebabkan hepatotoxic, sehingga cirsimaritin dan pilloin berpotensi dikembangkan lebih lanjut untuk dijadikan kandidat obat antiinflamasi.
Quality of Life and Compliance Based On Hypertension Patient Characteristics At Krobokan Primary Health Center West Semarang District Gilang Rizki Al Farizi; Rissa Maharani Dewi; Fransica Gloria; Hartika Widiya
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9455

Abstract

Hypertension is the chronic diseases that is a health problem in Indonesia. According to the Basic Health Research 2018 the hypertension population in Indonesia is around 34.1% at the age of ≥18 years. Every year hypertension sufferers are increasing, around 29% of adults suffer from hypertension worldwide. Patients with hypertension require long therapy even for life which certainly makes patients continuously consume antihypertensive drugs which can ultimately affect patient compliance and quality of life. The purpose of the study was to determine description of quality of life and  adherence based on hypertention patient at Krobokan Primary Health Center, West Semarang district. This study used a quantitative design with observational research and a cross-sectional approach conducted in the period March-May 2023. The instruments used were MMAS-8 and HRQOL SF-36 as many as 53 samples who met the inclusion criteria. The results showed that the highest respondent characteristics were female 36 (68%), age 56 - 65 years 26 (49%), high school 18 (34%), housewives 31 (58%), length of hypertension ≥ 2 years 27 (51%), one of hypertention drug taken 50 (94%), suffering from other illnesses 23 (43%) and moderate adherance 36 (68%). In the domains of energy, emotional role, physical role, physical function and general health had a low quality of life in most patients with moderate adherence
Comparative Dissolution Study Between Resveratrol Nanocream Formula and Conventional Resveratrol Cream with Dimethylsulfoxide Addition Dewi Fitriani Puspitasari; Rahmawati Salsa Dinurrosifa
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9660

Abstract

Resveratrol has potential activity as an antioxidant. Several studies have formulated resveratrol into topical preparations, but the low solubility of resveratrol causes low release of the active substance. Dimethylsulfoxide is a widely used ingredient in topical preparations, which can be used to increase the solubility of poorly soluble substances Nanocream is a nanoparticle-based topical drug delivery. The globule size is nanoscale, which can help improve drug solubility. The aim of the research was to conduct a comparative dissolution study between resveratrol nanocream formula and resveratrol conventional cream preparation with the addition of dimethylsulfoxide at various concentrations of 3%, 5% and 7%. The research method began with formulating resveratrol nanocream preparation. The preparation consisted of lipid components dispersed into a cream base. The lipids consisted of VCO, tween 80 and propylenglycol. Loading drug of resveratrol lipid was 300 mg, then tested for transimtance value and globule size. Conventional resveratrol cream formula was made into FI, FII and FIII, where each formula used different concentration of DMSO. Physical characteristics testing was conducted on nanocream and conventional resveratrol cream.Analysis of dissolution test results was observed among FI, FII and FIII in conventional cream formulas. The dissolution test results of these three formulas were also compared with the resveratrol nanocream preparation. Observation of dissolution results was assessed from the percentage of active substance released at minutes 5, 10, 15, 30, 45, 60.The dissolution test results showed that there was no significant difference in the percentage of active substance released between the conventional resveratrol cream preparation formulas, but there was a significant difference between the three conventional resveratrol cream preparation formulas and the resveratrol nanocream preparation. 
Computation Design: Nanostructured Lipid Carrier Formula of Pinostrobin Anita Puspa Widiyana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8378

Abstract

Nano lipid carriers (NLC) function by increasing the solubility and oral bioavailability of hydrophobic drugs. This study was conducted to estimate the solubility of pinostrobin in various types of solid and liquid lipid carriers through computational design and to select the optimal NLC formula with the best candidate lipid carriers. Pinostrobin and all lipid carriers were determined for their interactions with the AutoDockTools program. The values of the free energy binding (ΔG), the inhibition constant (Ki), and the type of interaction visibility were recorded as a result of the molecular docking. The interaction type of visualization was determined by the BIOVIA Discovery Studio program. The results showed that apocarotenal was the best liquid lipid carrier with a ΔG value of -3.57 kcal/mol and a Ki value of 2.40 mM. Cetosteryl alcohol was the best carrier for solid lipids, with a ΔG value of -2.18 kcal/mol and a Ki value of 25.35 mM. Apocarotenal and cetostearyl alcohol as lipid carrier candidates for the NLC formula of pinostrobin.
Analisis Kualitatif Bahan Kimia Obat dalam Jamu Pegal Linu di Wilayah Gunung Kidul dan Grobogan Diva Laila Ramadhani; Perdana Priya Haresmita; Tesia Aisyah Rahmania
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9319

Abstract

Jamu pegal linu merupakan jamu yang paling populer di masyarakat. Akan tetapi, masih banyak bahan kimia obat yang ditemukan dalam jamu pegal linu. Oleh karena itu, peneliti akan melakukan analisis kualitatif sampel jamu pegal linu dengan tujuan untuk mengetahui apakah produk yang mengandung bahan kimia obat (BKO) dengan standar pembanding parasetamol, prednison, dan ibuprofen. Sampel 1, 2, 3, 4, 5, dan 6 merupakan sampel jamu pegal linu yang diperoleh dari toko jamu di wilayah Gunung Kidul dan Grobogan. Analisis kualitatif BKO dilakukan dengan Kromatografi Lapis Tipis (KLT) menggunakan fase diam silika gel 60 GF254, fase gerak kloroform:etanol (9:1), etil asetat:kloroform (4:1), kloroform:etanol (4,5:0,5) dan dideteksi sinar UV 254 nm. Berdasarkan uji organoleptis diperoleh data yang bervariasi. Setiap sampel jamu memiliki bau, rasa, warna, bentuk, dan sediaan yang beragam. Berdasarkan uji KLT sampel 1 mengandung bahan kimia obat yaitu parasetamol dan ibuprofen. Sampel 2, 3, 4, dan 5 mengandung bahan kimia obat prednisone. Sampel 6 mengandung bahan kimia obat parasetamol.
Pengembangan Sistem Dispersi Padat Ezetimibe dengan Matriks PEG 8000 menggunakan Metode Peleburan Annisa Maulidia Rahayyu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8351

Abstract

Ezetimibe termasuk pada Biopharmaceutics Classification Sistem (BCS) kelas II yang memiliki kelarutan yang rendah, sehingga laju disolusi dan bioavailabilitas oralnya rendah. Suatu sistem disperse padat dapat meningkatkan luas permukaan obat dan kontak antara obat dan media disolusi, sehingga laju disolusi ezetimibe akan meningkat. PEG 8000 telah banyak digunakan sebagai suatu pembawa hidrofilik dan laktosa monohidrat serta avicel PH 101 sebagai adsorben.            Penelitian ini bertujuan untuk menimgkatkan laju disolusi dari obat ezetimibe yang tidak larut air dengan membentuk sistem dispersi padat ezetimibe_PEG 8000 dengan rasio 1:1; 1:2; dan 1:3. Sistem dispersi padat dibuat dengan metode peleburan. Evaluasi laju disolusi, difraksi X-ray (XRD), dan analisis  pada sistem dispersi padat dengan rasio 1:1; 1:2; 1:3, dan ezetimibe murni dilakukan.            Hasil dari evaluasi tersebut menunjukkan sistem dispersi padat meningkatkan laju disolusi dari ezetimibe. Selain itu, karakterisasi DTA menunjukkan hilangnya puncak endotermik dari ezetimibe pada dispersi padat dan hasil karakterisasi sinar-X menunjukkan penurunan intensitas relatif dari puncak ezetimibe yang memperlihatkan adanya perubahan bentuk kristal menjadi amorf. Kesimpulan dari penelitian ini adalah sistem dispersi padat ezetimibe-PEG 8000 dapat meningkatkan laju disolusi  dan karakteristik fisik dari ezetimibe. 
Pengaruh Informasi Kemanfaatan Penggunaan Obat Tradisional dan Suplemen Terhadap Willingness to Pay Dalam Pencegahan NCDs di Kota Yogyakarta Arisa Mardiani; Eliza Dwinta; Raden Jaka Sarwadhamana; Imram Radne Rimba Putri
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8388

Abstract

The current incidence of NCDs can not only attack the elderly but can start at a younger age. Must carry out prevention efforts as early as possible by consuming traditional medicines (OT) and supplements. Can obtain information on the benefits of the two products through packaging labels. However, many people still need to pay more attention to them, so they need to understand the proper and correct use of OT and supplements. Willingness to pay (WTP) goes hand in hand with the benefit information obtained. Because if it follows the benefits and prices, the community's WTP is expected to increase. This study aimed to determine the effect of information on the benefits of using OT and supplements on WTP in preventing NCDs in Yogyakarta with a cross-sectional study design. They conducted this research for one month in 5 sub-districts of Yogyakarta City, namely Danurejan, Gondomanan, Mantrijeron, Umbulharjo, and Wirobrajan sub-districts with 107 respondents. The sampling technique uses accidental sampling, and the research instrument is a WTP questionnaire. The results of the research on statistical tests using Kendall Tau found that the significance values were 0.225 (OT) and 0.094 (supplements) > 0.05, so it concluded that information on the benefits of using OT and supplements from packaging labels did not affect WTP in preventing NCDs in the City of Yogyakarta.
Asthma Control and Quality of Life of Asthma Patients At St General Hospital Jatmiko susilo; Soleha Kurniawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8599

Abstract

Asthma is a chronic condition characterized by chronic airway inflammation that causes various respiratory symptoms that can severely impact a patient's daily life. Suboptimal control of asthma is associated with increased costs of care and treatment and decreased quality of life (QoL). This study aims to examine asthma control status and its relationship with the QoL of asthma patients at ST. General Hospital. This cross-sectional study involved 50 asthmatics aged 18-65 who attended ST. General Hospital. Two questionnaires were used: an asthma control test (ACT) and an adult asthma quality-of-life questionnaire (Mini-AQLQ). By using SPSS, the Spearman Rank test was employed to identify associations with a 95% confidence level. Of the 50 respondents studied, asthma status was categorized as partially controlled (50%), totally controlled (14%), and uncontrolled (36%). A significantly worse QoL was observed in respondents with uncontrolled asthma, whereas a good QoL (minimal or no impairment) was observed in partially controlled respondents (p = <0.001). There was a relationship between asthma control and the respondent's QoL (rho = 0.832). Appropriate treatment will increase asthma control and improve the QoL of patients treated at ST. General Hospital. Further research is needed to evaluate risk factors, psychological effects, and behavioral screening in poorly controlled asthma patients.
Profil Pasien Sindrom Koroner Akut dan Pengobatannya Pada Rumah Sakit di Kota Tasikmalaya Sahrul Hikam; Ilham Alifiar; Yedy Purwandi Sukmawan
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8242

Abstract

Sindrom koroner akut (SKA) merupakan penyebab kematian nomor 1 di dunia dan nomor 2 di Indonesia setelah strok. Pengobatan yang tepat dapat menurunkan resiko terjadinya kematian akibat SKA. Antiplatelet, antikoagulan atau fibrinolitik merupakan obat yang digunakan untuk penatalaksanaan SKA. Akan tetapi, sampai saat ini gambaran penggunaan obat pada pasien SKA di Indonesia yang meliputi SKA-NSTEMI dan SKA-STEMI masih terbatas. Selain itu, profil dan penggunaan obat SKA di kota Tasikmalaya masih belum diketahui. Tujuan penelitian ini adalah untuk mengetahui gambaran pasien SKA dan pengobatannya. Penelitian ini merupakan penelitian observasional retrospektif terhadap data rekam medis pasien pada Januari 2020- Desember 2020. Pasien yang masuk kedalam kriteria penelitian berjumlah 78 pasien. Hasil studi menunjukkan bahwa kejadian SKA-STEMI lebih banyak dibandingkan SKA-NSTEMI (RR 4,0986, CI 95% 2.2296-7.5345, p 0,0001), dan banyak terjadi pada usia 40-60 tahun dengan jenis kelamin laki-laki. Gastroesophageal reflux disease (GERD), diabetes melitus dan hipertensi merupakan komorbid terbanyak pada pasien SKA-STEMI, sedangkan hipertensi dan dispepsia merupakan komorbid terbanyak pasien SKA-NSTEMI. Hasil uji hubungan chi square menunjukkan tidak terdapat perbedaan antara jenis SKA dengan usia, jenis kelamin dan komorbid (p>0,05). Pada profil penggunaan obat, antiplatelet meliputi aspirin dan clopidogrel digunakan pada seluruh pasien SKA, sedangkan antikoagulan fondaparinux lebih banyak digunakan dibandingkan dengan enoxaparin (55 vs 23). SKA-STEMI mendominasi dibandingkan SKA-NSTEMI dengan pengobatan yang digunakan adalah aspirin, clopidogrel, fondaparinux, atau enoxaparin, selain itu usia, jenis kelamin dan komorbid tidak berhubungan dengan jenis SKA.

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