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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 349 Documents

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PENGARUH EKSTRAK ETANOLIK BUAH PARIJOTO (Medinilla speciosa Blume) TERHADAP KADAR GULA DARAH DAN FUNGSI SEKSUAL TIKUS JANTAN GALUR WISTAR MODEL DIABETES MELLITUS KRONIK Rina Wijayanti; Asih Puji Lestari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTChronic diabetes mellitus is a disease of increased blood glucose levels in a long time so that it can affect sexual function such as damage spermatogenesis and aphrodisiac function. Parijoto has flavonoid content. This study aimed to determine the effect of ethanolic extract of parijoto (Medinilla speciosa Blume) fruit in blood glucose level and the sexual function in alloxan-induced diabetic male rats. The design of the study was post test only control group design, 25 male wistar rats aged 2 months with BB 100-200 gram divided into 5 groups. Group 1 (normal control), group 2 (negative control) induced alloxan 100mg / kgBB, groups 3, 4, and 5 were alloxan induced and administered EEBP at doses of 100 mg / kgBW, 250 mg / kgBW, and 500 mg / kgBW. Alloxan-induced rats were left for 4 weeks to achieve chronic DM. Data analysis of blood glucose level and spermatozoa quality using one way anova followed by LSD post hoc. While aphrodisiac of introducing and climbing using one way anova continued by LSD and coitus using kruskal wallis. The results showed that there were significant differences between negative control with normal group, III, IV, and V. The effect of ethanolic extract of parijoto fruit on blood glucose level and sexual function in alloxan-induced diabetic male rats showed no difference between treatment group of 100 mg / kgBW with negative group, and there were significant differences between treatment group of 250 mg / kgBW and 500 mg / kgBW with negative group. Ethanolic extract of parijoto fruit at dose 250 mg / kgBB and 500 mg / kgBB decrease blood glucose level, improve and increase sexual function in alloxan-induced diabetic male rats.

FORMULASI DAN KARAKTERISASI FISIK MASKER GEL PEELOFF EKSTRAK LENGKUAS (Alpinia galanga, (L.) Sw) Mar’atus Sholikhah; Rahayu Apriyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Alpinia galanga (L.) Sw or galangal is widely used by Indonesian people as a spice in cooking. The content of catechins and 1-acetoxicavicol acetate in the extract is known to have antioxidant activity. The ability of these antioxidants needs to be applied to pharmaceutical dosage forms to improve aesthetics and ease of use. One of the topical drug delivery systems that is in accordance with the needs of the community today is the preparation of peel-off gel mask. The purpose of this study was to determine the effect of variations in PVA gelling agent concentration as a mask base on the physical characteristics of galangal extract peel-off gel masks. Three mask formulations were made based on variations in the concentration of PVA in the range of 5% -15%. The physical characterization of the preparations included organoleptic tests, homogeneity, pH, viscosity, adhesion, dispersion, and drying time. Homogeneity and organoleptic parameters were analyzed descriptively. The parameters of viscosity, drying time, pH, spreadability, and adhesion were analyzed statistically using Anova Single Factor with a confidence level of 95%. The results showed that the F1 and F2 formulas with PVA concentrations of 10% and 12.5% were the optimum formulas as a mask base. Based on statistical tests, variations in the concentration of PVA significantly influence the parameters of mask adhesion with a p-value of 0.0001 (

AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT PISANG KEPOK, PISANG MAS DAN PISANG NANGKA MENGGUNAKAN METODE DPPH Azimatur Rahmi; Nadya Hardi; Linda Hevira
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Banana is one of the most common crops in Indonesia. Banana peel contains phenolic antioxidant compounds. This study used extraction, DPPH, and spectrophotometry to determine the potential antioxidant activity of three types of banana peels, namely kepok banana peel, trout banana peel, and jackfruit banana peel. Banana peel simplisia powder was extracted by maceration using 96% ethanol as solvent. The resulting banana peel extract was then phytochemical screening for flavonoid compounds, tannins, alkaloids, steroids, and terpenoids. This antioxidant activity test used a qualitative method using TLC and quantitative method with reagent of 0.2 N DPPH by UVVis spectrophotometry. The results showed that the three banana peels tested had antioxidant activity and it is classified as active. The IC50 values for the ethanolic extracts of kepok banana peel, trout banana peel, and jackfruit banana peel were 9,702 ppm, 13,322 ppm and 10,747 ppm respectively. Ascorbic acid as a comparison obtained an IC50 value of 9,613 ppm. From the data obtained, kepok banana peel extract has the highest antioxidant than extract of trout banana peel, and jackfruit banana peel.

KARAKTERISASI DAN AKTIVITAS REPELEN MINYAK ATSIRI SEREH WANGI (Cymbopogon nardus L), AKAR WANGI (Vetiveria zizanoides L.), NILAM (Pogestemon Cablin), CENGKEH (Syzgium aromaticum) ASAL KABUPATEN GARUT TERHADAP NYAMUK Aedes aegypti BETINA Diki Prayugo Wibowo; Ardi Rustamsyah; Yunan Kurniawan
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 13 No 2 Desember 2016
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Demam berdarah dengue (DBD) merupakan penyakit menular yang hingga kini masih menjadi masalah, karena bisa menyebabkan kematian. Vektor utama penularan penyakit DBD adalah nyamuk Aedes aegypti.Salah satu cara menghindari nyamuk adalah dengan menggunakan repelen yang berasal dari minyak atsiri. Tujuan penelitian ini adalah untuk mengkarakterisasi dan mengetahui aktivitasrepelen minyak atsiri akar wangi (Vetiveria zizanoides L.), cengkeh (Syzygium aromaticum (L.) Merr. & L.M.Perry), sereh wangi (Cymbopogon nardus L), dan nilam (Pogostemon cablin(Blanco) Benth.) dari kabupaten Garut terhadap nyamuk Aedes aegypti betina. Karakterisasi minyak atsiri meliputi penentuan warna, berat jenis, indek bias, kelarutan dalam etanol dan bilangan asam. Pengujian aktivitas repelen dilakukan menggunakan lengan sukarelawan. Kontrol negatif menggunakan virgin coconut oil (VCO), sedangkan kontrol positif menggunakan N,N,-dietil-m-toluamida (DEET). Konsentrasi minyak atsiri yang digunakan dalam penelitian ini adalah 2,5%, 5%, dan 10%. Pengamatan daya repelen dilakukan setiap 5menit sampai 15 menit dilakukan berulang selama 3 kali. Sampel dinyatakan memiliki potensi repelen bila potensi repelen ≥95% . Hasil penelitian menunjukkan bahwa minyak atsiri sereh wangi memiliki aktivitas repelen pada konsentrasi 10% dengan daya repelen 96.26%. Kata kunci : repelen, Aedes aegypti, minyak atsiri ABSTRACT Dengue hemorrhagic fever (DHF) is an infectious disease that there are still be a problem, because it can cause death.Vector transmission of dengue fever is Aedes aegypti. One way to avoid mosquito is by using repellent derived from the volatile oil. The purpose of this research is to characterized and investigated of repellent activity of volatile oil akar wangiVetiveria zizanoides L.), cengkeh (Syzygium aromaticum (L.) Merr. & L.M.Perry), sereh wangi (Cymbopogon nardus L), and nilam (Pogostemon cablin (Blanco) Benth.) from Garut district against Aedes aegypti female. Characterization of volatile oils contain of determinations of colours, spesific gravity, refracty index, ethanol solubility and acid number. The repellent activity test was carried out using arms volunteers.Virgin coconut oil ( VCO) was used as negative control, while control positive was using n, n,-dietil-m-toluamida ( DEET ). Concentrations of volatile oil used in this study were 2.5 %, 5 %, and 10 %.Observation of repellentheld every 5 minutes to 15 minutes with 3 times repeated. The sample has potent repellent activity if it has ≥ 95% potential repellent. The result showed that the volatile oil of sereh wangi has repellent activity with 96.26 % potential repellent in 10 % concentration. Keywords: repellent, Aedes aegypti, volatile oil

Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy cover cover
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Redaktur Ahli Dr. Sumantri, M.S., Apt Prof. Dr. SuwijiyoPramono, Apt Prof. Dr. Mustofa, M.Kes, Apt Dr. Mimiek Murukmihadi, SU., Apt Redaktur Pelaksana Devi Nisa Hidayati, S.Farm, M.Sc. Staf Redaksi : Ellya Zulfa, S.Farm., M.Sc., Apt. Dewi Andini Kunti, S.Farm., M.Farm. Danang Novianto, S.Farm. Sekretaris Redaksi Ririn Lispita Wulandari., S.Farm., M.Si.Med., Apt Distributor Imam Asrofi Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail :jurnalfarmasiuwh@yahoo.co.id Terbit 2 kali setahun sejak September 2004

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SELADA ROMAINE (Lactuca sativa var. Longifolia) DAN DAUN SELADA KERITING (Lactuca sativa var. Crispa) BESERTA IDENTIFIKASI BEBERAPA SENYAWA ANTIOKSIDAN Maria Ulfah; Ady Laksono Putro; Efa Erfiana Safitri
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTFree radicals are suspected as triggers of various degenerative diseases. Antioxidants are compounds that can counteract free radicals. This study aims to determine the antioxidant activity by DPPH method and analyze the active compounds contained in romaine lettuce extract (Lactuca sativa var Longifolia) and lactuca sativa var Crishpa lettuce extract (Lactuca sativa var Crishpa). Romaine lettuce and and lactuca sativa var Crishpa was done extraction with a maceration method using 70% as ethanol solvent. The concentration of extract used was 12.5; 25; 50; 100; 200 and 400 ppm and vitamin C concentrations as comparison was 0.5; 1; 1.5; 2; 2,5 and 3 ppm tested its antioxidant activity by DPPH method by spectrophotometry visible, until IC50 value was obtained. The identification of the active compound was performed by phytochemical screening and Thin Layer Chromatography (TLC). The results showed that romaine lettuce has IC50 value of 151,1515 ppm and lactuca sativa var Crishpa has IC50 value of 183,7560 ppm and vitamin C value was 1,7005 ppm. The chemical compounds contained in romaine ethanol extract and lactuca sativa var Crishpa lettuce extract are alkaloids, phenols and flavonoids.Keywords: Antioxidant, DPPH, IC50, TLC, Romaine, Lactuca sativa var Crishpa

HUBUNGAN GENOTIPE rs 1042713 (Arg16Gly) DENGAN EFEKTIVITAS 2-AGONIS PADA PENDERITA ASMA Sri Haryanti; Zullies Ikawati; Mustofa Mustofa; Tri Murti Andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 01 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT To produce an effect, the agonist drug 2 will bind to the ADRB2 receptor. The effect of agonist 2 shows variation between individuals due to the presence of encoding gene polymorphisms. There are 80 ADRB2 polymorphisms, including Arg16Gly in amino acids 16. The innate ADRB2 genotype is called wildtype, whereas mutated ones is called mutant. The purpose of this study was to determine whether there was a relationship between genotype rs 1042713 (Arg16Gly) and the effectiveness of β2-agonist drugs in asthma sufferers. This study was an observational study with a cross sectional design and prospective data collection. Examination of the presence of gene polymorphisms and assessment of effe A total of 101 asthma patients who met the inclusion criteria were sorted by genome type by pharmacogenomic examination uses the Asthma Control Test (ACT) questionnaire. The results of the statistical test with chi square to determine the relationship of genome type and asthma control obtained p value 0.131. The comparison of the effectiveness of the wildtype genome is more effective than the mutant of 1.887x, and heterozygote is more effective 1,667x greater than the mutant. There is no significant relation between genotypes rs 1042713 (Arg16Gly) with effectiveness, but the possibility of clinical effectiveness is different. Keywords: Asthma, β2-agonist, ADRB2, genotype, effectiveness.

PENETAPAN KADAR STEVIOSIDA PADA SIMPLISIA DAN EKSTRAK DAUN Stevia rebaudiana DARI TIGA DAERAH BERBEDA Dian Kartikasari; Nurkhasanah Nurkhasanah; Suwijiyo Pramono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPharmaceutical raw materials from agriculture or collection of wild plant chemical content can not be guaranteed always constant due to variable seed, the body, the climate, the conditions (age and how to harvest). The content of the chemical compounds responsible for the biological response must have chemical specifications, namely the composition information (type and concentration). The efficacy of traditional medicine based on the chemical compound. Therefore, the assay of the active substance a crude drugs and extracts needs to be done to ensure that a traditional medicinal products can be assured of quality and usefulness. The assay performed on botanicals and 50% ethanol extract of leaves of Stevia rebaudiana. The assay of the crude drugs and extracts from the stevia leaf area of Malang, Tawangmangu, and Bogor using High Performance Liquid Chromatograph method. Results of the assay stevioside on simplicia and stevia leaf extract obtained stevioside levels in simplicia stevia leaves from Malang, Bogor, Tawangmangu consecutive namely 5.65%; 3.89%; 1.59%. Stevioside levels in the stevia leaf extract of Malang, Bogor, Tawangmangu respectively, are 14.14%; 22.40%; 66.65%.Key word: Stevia rebaudiana leaf, stevioside content, High Performance Liquid Chromatograph

Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy cover cover
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

DAFTAR ISI

Volume 13 No. 1 Juni 2016 farmasi farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

Jurnal IlmuFarmasi& FarmasiKlinik Journal of Pharmaceutical Science & Clinical Pharmacy

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