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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 369 Documents
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Phytochemical Constituents and Pharmacological Activities of Houttuynia cordata Thunb. as a Phytopharmaceutical: A Narrative Review Asih Triastuti; Juldani Adytia; Uzulul Hikmah; Putri Ananditia
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15131

Abstract

Houttuynia cordata Thunb. is a promising medicinal plant recognized for its rich diversity of secondary metabolites, particularly flavonoids and essential oils, that are differentially distributed across its plant organs. This narrative review aimed to critically synthesizes the reported pharmacological activities, specific phytochemical constituents of each organ, molecular mechanisms of isolated bioactive compounds, and contributions of the metabolites produced by associated endophytic microorganisms. Relevant literature was identified through electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar using the keywords “Houttuynia cordata”, “phytochemical”, “pharmacological activity”, and “secondary metabolites”, from 2015-to 2025.  A broad body of literature published was examined to map the diversity of bioactive compounds, experimental models, and mechanisms of action. The findings reveal that the leaves of H. cordata are rich in flavonoids such as quercetin and rutin, which act as potent antioxidants and immunoprotective agents. The stems and rhizomes are dominated by monoterpenes and volatile ketones exhibiting marked antimicrobial and anti‑inflammatory properties. Preclinical evidence consistently demonstrates antitumor activity via apoptosis induction, multitarget antiviral effects, antidiabetic, and antihyperlipidemic activities as well as anti‑inflammatory actions mediated through the inhibition of TNF‑α and PGE₂ pathways. Antibacterial and anticancer properties are also notably attributable to the secondary metabolites produced by the endophytic microbiota associated with this plant. The phytochemical diversity of H. cordata and its symbiotic endophytes offer promising prospects for the discovery of novel bioactive compounds from Indonesian biological resources. Collectively, H. cordata holds substantial potential as antioxidant, antimicrobial, antivirus, anticancer, antidiabetic, antihyperlipidemic, anti-inflammatory, immunomodulatory, and antiasthma, warranting further investigation as an innovative phytopharmaceutical candidate.
Pattern and Appropriateness of Antiemetic Drug Utilization in Breast Cancer Patients at Sultan Agung Islamic Hospital, Semarang, Indonesia Sri Susilowati; Amelia Tivani Sari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15207

Abstract

Chemotherapy-induced nausea and vomiting (CINV) are common adverse effects experienced by patients undergoing chemotherapy. Antiemetic therapy is a key strategy for the prevention and management of CINV; therefore, appropriate antiemetic use is essential. This study aimed to determine the patterns of chemotherapy and antiemetic utilization and to evaluate the appropriateness of antiemetic therapy based on the emetogenic risk of chemotherapy agents and antiemetic dosing standards in breast cancer patients at Sultan Agung Islamic Hospital, Semarang, Indonesia, in accordance with the National Comprehensive Cancer Network (NCCN) Guidelines 2024. The study was conducted observationally using a cross-sectional design with retrospective data collection from patients’ medical records. A total of 84 breast cancer patients were included through purposive sampling, according to predefined inclusion and exclusion criteria. The most frequently used chemotherapy regimen was paclitaxel–cisplatin (26%). Antiemetics were administered both prophylactically and post-chemotherapy, with ondansetron combined with dexamethasone as the most commonly used regimen (99.4%), along with ranitidine and diphenhydramine as adjunctive therapy. Evaluation of antiemetic appropriateness showed that 98.8% of patients did not receive antiemetic therapy consistent with the emetogenic risk of the chemotherapy agents, particularly among those receiving high-emetogenic-risk regimens. In addition, dose evaluation revealed inappropriate dexamethasone dosing, primarily due to underdosing and non-standard dosing frequency compared with the NCCN Guidelines 2024. Overall, antiemetic use was largely inconsistent with NCCN Guidelines 2024 recommendations, potentially compromising optimal CINV prevention in highly emetogenic chemotherapy.
Medication Beliefs and Associated Factors Among Heart Failure Patients in Yemen and Role of Regimen Complexity: a Cross-Sectional Study Ramez Abdullah; Ulfa Filliana; I Dewa Agung Diva Candraningrat; Firda Ridhayani; Abdullah Mansoor; Sholikhah Rosvita Oktasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15222

Abstract

Beliefs about medication influence treatment engagement and outcomes in patients with heart failure, yet evidence from low-resource settings such as Yemen remains limited due to under-supported health care systems and low monitoring in health services. To assess medication beliefs among heart failure patients in Yemen and examine factors associated with necessity and concern beliefs, including medication regimen complexity. A hospital-based cross-sectional study was conducted between December 2023 and February 2024 among heart failure patients attending cardiology outpatient clinics in Sana’a, Yemen after ethical approval from the hospital. Data were collected using structured questionnaires, including the Beliefs About Medication Questionnaire (BMQ-Specific) and the Medication Regimen Complexity Index (MRCI). Multivariable linear regression analyses were performed to identify predictors of medication beliefs. A total of 250 patients were included, with a mean age of 51.08±11.47 years, and 65.2% were male. The median total BMQ score was 38.0 (IQR:35–42). Higher necessity beliefs were independently associated with older age (B=0.046, p=0.029), higher educational status (B=−1.240, p=0.030), and a greater number of prescribed medications (B=0.802, p=0.001), whereas greater medication regimen complexity was negatively associated with necessity beliefs (B=−0.276, p=0.003). Regarding concern beliefs, employment status (B=2.605, p<0.001) and longer duration since diagnosis (>3 years) (B=−1.155, p=0.029) were significant predictors, indicating a mild but significant impact. No significant associations were observed between concern beliefs and age, gender, education, income, number of medications, or regimen complexity. Medication beliefs among heart failure patients in Yemen are shaped by both patient and treatment-related factors. The findings have important implications in clinical practice, both clinical pharmacists and cardiologist can consider patients’ perspective to guide intervention design especially simplifying medication regimens and addressing patient-specific concerns.
Antibiotic Utilization and Patient with Sepsis Characteristics: A Multicenter Retrospective Study in Semarang Gilang Rizki Al Farizi; Tunik Saptawati; Yovita Dwi Arini; Rizky Budi Santoso; Suci Arsita Sari; Lutfi Defita Sari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14468

Abstract

Sepsis remains a critical global health challenge requiring prompt and appropriate antimicrobial intervention to reduce mortality. Despite established guidelines recommending early broad-spectrum antibiotic administration, empirical prescribing patterns and their alignment with clinical recommendations remain insufficiently documented in Indonesian multicenter settings, particularly in Central Java. This study addresses the knowledge gap by evaluating antibiotic utilization profiles and patient characteristics among hospitalized sepsis cases in Semarang, with emphasis on empirical therapy practices and stewardship implications. A multicenter retrospective observational study was conducted involving 200 sepsis patients meeting predefined inclusion criteria from two hospitals in Semarang during 2019–2023. Data were extracted from medical records and analyzed descriptively, considering inter-hospital variability in prescribing practices. Results demonstrated male predominance (51.5%), elderly population representation (42.5% aged >60 years), multiple comorbidity burden (50.5% with two comorbidities), and moderate hospitalization duration (36% for 3–7 days). Broad-spectrum agents active against both Gram-positive and Gram-negative organisms dominated prescribing patterns (89.4%), while time-dependent antibiotics represented 10.5% of prescriptions. Meropenem emerged as the most frequently prescribed agent (33.3%), administered exclusively via the intravenous route (100%). These findings underscore the importance of structured antimicrobial management and robust de-escalation strategies in local hospital settings to effectively balance necessary empirical coverage with the prevention of antimicrobial resistance
Correlation between Drug Information Services, Antibiotic Compliance, and Patient Satisfaction: A Cross-sectional Study at Osadha Clinic, Denpasar Ni Kadek Angellina; I Gusti Ayu Rai Widowati; I Gusti Made Aman; I Putu Riska Ardinata; Ida Ayu Manik Partha Sutema
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 2 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i2.14196

Abstract

Drug information services are an integral part of good pharmacy practice and play a vital role in promoting antibiotic compliance and ensuring treatment success. This study aimed to examine the correlation between drug information services, antibiotic compliance, and patient satisfaction at Osadha Clinic, Denpasar, Bali. A cross-sectional observational study was conducted involving 105 patients, using structured questionnaires and a pharmacist’s drug information checklist. Antibiotic compliance was assessed using a 16-item yes/no questionnaire, while patient satisfaction was measured through 22 Likert-scale statements. Validity and reliability were confirmed with an r-table value of r > 0.361 (p < 0.05), and Cronbach's alpha coefficients of 0.972 for compliance and  0.881 for satisfaction. Pearson correlation analysis demonstrated a significant relationship between drug information services and antibiotic compliance (r = 0.814, p < 0.001), as well as between drug information services and patient satisfaction (r = 0.905, p < 0.001). High-quality drug information services (characterized by clarity, accuracy, and comprehensibility) significantlyenhance patient compliance and satisfaction. These findings underscore the importance of strengthening pharmaceutical care to support rational antibiotic use and improve overall healthcare outcomes.
Analysis of Drug Related Problems (DRPs) Adult Patients with Type 2 Diabetes Mellitus at Dr. Moewardi Hospital Surakarta Faizal Ardiansyah; Rolando Rahardjoputro; Adhi Wardhana Amrullah; Eerzta Zusvita Widyastuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 2 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i2.14199

Abstract

Drug Related Problems are drug therapy–related issues that may negatively affect clinical and economic outcomes. Patients with type 2 diabetes mellitus are particularly at risk due to chronic disease management and frequent use of multiple medications. This study aimed to identify potential DRPs in adult outpatient type 2 diabetes mellitus patients at Dr. Moewardi Hospital, Surakarta. This observational descriptive study employed a cross-sectional design. Medical record data of adult outpatient type 2 diabetes mellitus patients treated during 2024 were retrospectively reviewed. Data extraction was conducted in February–March 2025. Patients were selected using purposive sampling based on inclusion and exclusion criteria. Potential DRPs were identified and classified according to the Pharmaceutical Care Network Europe Classification version 9.1. Among 100 medical records reviewed, 8 patients (8.0%) experienced potential DRPs, with a total of 28 cases consisting of 2 problem domains (P) and 6 cause domains (C). The most frequent problems were non-optimal drug treatment effects (P1.2) (21.4%) and possible adverse drug events (P2.1) (7.1%). The most common causes included inappropriate drug selection not in accordance with guidelines or formularies (C1.1) (25.0%) and subtherapeutic dosing (C3.1) (21.4%). Although the proportion of patients with potential drug related problems was relatively low, clinically relevant issues related to drug selection and dosing were identified. These findings highlight the important role of pharmacists in routine medication review and optimization of pharmacotherapy to prevent DRPs in outpatient type 2 diabetes mellitus management.
Retrospective Evaluation of Drug-Related Problems in Hospitalized Adult Patients with Type 2 Diabetes Mellitus at X General Hospital in 2024 Hafiidz Salam Arrosyiid Arrosyiid; Rolando Rahardjoputro; Agnes Prawistya Sari; Eersta Zusvita Widyastuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 2 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i2.14225

Abstract

Diabetes mellitus is a chronic disease characterized by high blood glucose levels due to metabolic disorders. Drug-Related Problems (DRPs) are treatment-related conditions that can lead to therapy failure, worsen glycaemic control, prolong hospitalization, and increase morbidity. This study aimed to identify DRPs in adult patients with type 2 diabetes mellitus hospitalized at General Hospital X during 2024. This retrospective descriptive study analysed medical records of 100 patients selected from 4,779 hospitalized diabetes patients in 2024. Data were analysed using Pharmaceutical Care Network Europe (PCNE) V.9.1 parameters focusing on problem and cause domains, then processed with SPSS. Most patients were female (61%) with the highest age group being 51-60 years (46%). The most common comorbidity was hypertension (42.26%). Treatment patterns were dominated by insulin aspart (NovoRapid) (29.12%) and metformin (25.82%). DRPs were identified in 33 patients (33%) with 49 total incidents. The most dominant category was treatment safety problems (P2) with 33 cases (67.34%), consisting of 1 adverse drug reaction and 32 potential drug interactions that could compromise patient safety and glycaemic stability. Other categories included drug selection problems (C1) in 11 cases (22.44%): 10 drugs without indication (C1.3) and 1 therapy duplication (C1.5); treatment effectiveness problems (P1) in 4 cases (8.16%) related to untreated indications (P3.1); and dose selection problems (C3) in 1 case (2.04%) involving insufficient dosage (C3.1). The predominance of treatment safety issues underscores the need for pharmaceutical care interventions in hospitalized diabetic patients.
The The Potency of Wax Apple Leaves (Syzygium samarangense) as Angiotensin-Converting Enzyme Inhibitors: Computational Approach Syifa Fitriyani; Alia Azka Permana; Nasywa Rahmatun Nissa; Fakhira Zahira Zahra; Dzava Prawinsyah Fairus Ismail; Bintang Satrio Mahardika; Dhania Novitasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 2 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i2.14264

Abstract

Hypertension is a chronic disease that significantly contributes to global mortality, often presenting without symptoms but potentially leading to serious complications. Angiotensin-converting enzyme (ACE) inhibitors are one of the first-line therapies for hypertension, working by reducing the formation of angiotensin II. Wax apple (Syzygium samarangense) leaves have been studied for their potential pharmacological activities, including in maintaining blood pressure. This study aims to evaluate the potential of secondary metabolites from wax apple leaves as ACE inhibitor candidates using an in silico approach, including Lipinski’s Rule of Five (Ro5) screening, ADMET prediction, pharmacophore modeling, and molecular docking. A total of 22 compounds were tested, with β-sitosteryl stearate showing the highest binding affinity to the ACE receptor, indicated by its low binding energy and strong interactions with key residues at the active site. Meanwhile, gallic acid was identified as a hit compound through pharmacophore modeling and demonstrated favorable ADMET properties. These findings support the potential of Syzygium samarangense as a natural source of antihypertensive compounds and provide a foundation for further research in the development of computational-based herbal medicines.
Impact of Emulsifier Balance on Physicochemical Stability and Antiinflammatory Efficacy of Calotropis gigantea Extract Emulgel Fauzi Rahman; Azimatul Mauna; Nur Hafifah; Ana Maria Ulfa; Luluk Latifah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 2 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i2.14409

Abstract

The long-term use of topical non-steroidal anti-inflammatory drugs (NSAIDs) is associated with local irritation and disruption of the skin barrier, highlighting the need for safer plant-based alternatives with adequate formulation stability. Calotropis gigantea leaves contain flavonoids with reported anti-inflammatory activity; however, their topical performance is limited by poor solubility and instability. This study aimed to evaluate the effect of emulsifier balance on the physical stability and anti-inflammatory efficacy of a Calotropis gigantea leaf extract emulgel. Three emulgel formulations were prepared using different ratios of nonionic surfactants Tween 80 and Span 80 (2:8, 5:5, and 8:2) based on hydrophilic–lipophilic balance (HLB) principles. The formulations were evaluated for physicochemical characteristics, accelerated physical stability using a cycling test, and in vivo anti-inflammatory activity using a carrageenan-induced paw edema model in rats. The formulation containing a balanced emulsifier ratio (5:5) exhibited the smallest deviations in viscosity, spreadability, and pH after cycling tests and demonstrated the highest edema inhibition (68.98 ± 1.64%). These results indicate that emulsifier balance plays a critical role in maintaining emulgel stability and directly influences its biological performance. Although chemical stability and dermal safety were not evaluated, this study provides evidence that rational emulsifier selection is essential for improving the effectiveness of herbal topical formulations.

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