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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 349 Documents

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PENGARUH METODE EKSTRAKSI TERHADAP KADAR TOTAL FENOLIK, KADAR TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN MENGKUDU (Morinda citrifolia L.) Septiana Laksmi Ramayani; Eka Amalia Permatasari; Indah Novitasari; Maryana Maryana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 01 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Excessive Reactive Oxygen Species (ROS) can cause hypertension. Prevention of the risk of hypertension is consume an antioxidant. Noni (Morinda citrifolia L). is a plant that empirically proven to lower blood pressure and has antioxidant activity. Antihypertensive activity of noni leaves is influenced by phenolic and flavonoid compounds. The extraction method affects the levels of compound in extracts. The aims of study is determine the effect of the extraction method on the total phenolic level, total flavonoid level and antioxidant activity of noni leaf extract. The extraction methods are maceration, Microwave Assisted Extraction and Soxhlet. The results showed that the different extraction methods affected the total phenol level, total flavonoid level and antioxidant activity of the noni leaf extract. The Soxlet method provides the highest total phenolic level, total flavonoid level and antioxidant activity than other extraction methods. Keywords: Noni leaf extract, extraction method, total phenolic level, total flavonoid level and antioxidant activity

AKTIVITAS ANTIOKSIDAN DAN UJI IRITASI SEDIAAN MASKER GELL PEEL-OFF EKSTRAK METANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum L.) Reni Widaya Murti; Nabila Annisa Praditia; Hanuriza Umi Hadifa; Ratna Kurniasih; Fahmi Naqi; Rina Wijayanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 13 No 2 Desember 2016
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Antioksidan merupakan salah satu penangkal radikal bebas. Ekstrak metanol kulit buah rambutan yang mengandung senyawa fenolik seperti asam ellagat, corilagin dan geraniin berpotensi sebagai antioksidan. Kosmetika wajah tersedia dalam berbagai bentuk sediaan, salah satunya berbentuk masker gel peel-off. Tujuan penelitian ini untuk mengetahui aktivitas antioksidan dan uji iritasi sediaan masker gel ekstrak metanol kulit buah rambutan. Tahapan penelitian diawali dengan pencarian bahan, pembuatan ekstrak kulit buah rambutan, uji DPPH ekstrak, pembuatan sediaan masker gell peel-off, uji DPPH sediaan, dan uji iritasi. Hasil penelitian menunjukkan IC50 ekstrak sebesar 6,6771 μg/mL, IC50 sediaan masker gel peel-off pada F0, F1, F2, F3 yang dimana F0 tidak mengandung ekstrak, F1 mengandung 50 mg ekstrak, F2= 150 mg ekstrak, F3= 250 mg ektrask didapat hasil IC50 berturut-turut 8,867; 6,655; 6,786; 6,598 μg/mL. Uji iritasi sediaan masker kulit buah rambutan untuk F0 terdapat eritema pada kelinci 1 dan 2 di jam ke-24 dan 48 sedangkan pada kelinci 3 pada jam ke-24. Untuk F1 dan F2 eritema terjadi pada jam ke-24 dan 48 untuk kelinci 1, semua jam pada kelinci 2 dan jam ke-24 pada kelinci 3. Eritema yang terjadi pada F3 terdapat pada kelinci 2 di jam ke-24, 48 dan 72. Edema tidak terjadi pada setiap formula di semua kelinci. Kata Kunci: Kulit Buah Rambutan, Antioksidan, Masker Gel ABSTRACT Antioxidants are one of the free-radical scavengers. Methanol extract of rambutan peel containing phenolic compounds such as acids ellagat, corilagin and geraniin potential as antioxidants. Facial cosmetics are available in a variety of dosage forms, one of which shaped peel-off mask gel. The purpose of this study to determine the antioxidant activity and irritation test preparation gel mask methanol extract of rambutan peel. Research stage begins with the search for materials, manufacturing of rambutan peel extracts, extracts DPPH test, preparation of a peel-off mask gell, DPPH test preparation, and irritation test. The results showed the extract inhibition concentration is 6.6771 µg / mL; inhibition concentration of gel peel-off mask at F0, F1, F2, F3 where F0 does not contain extracts, F1containing 50 mg of extract, F2 = 150 mg extract; F3 = 250 results inhibition concentration obtained mg ektrask respectively 8.867; 6.655; 6.786; 6.598 µg / mL. Skin irritation test preparation rambutan mask to F0 are erythema in rabbits 1 and 2 at the 24th hour and 48 while in rabbits 3 at the 24th hour. For F1 and F2 erythema occurred at the 24th hour and 48 for rabbits 1, all hours of the rabbit 2 and the 24th hour in rabbits 3. Eritema happened in F3 found in rabbits 2 at the 24th hour, 48 and 72. edema does not occur in any formula at all rabbits. Keywords: Rambutan peel, Antioxidants, Gel Mask

EFEKTIVITAS ANTIBAKTERI MINYAK ATSIRI DAUN EUKALIPTUS (Eucalyptus globulus) DALAM SEDIAAN KRIM SEBAGAI ANTIBAKTERI Staphylococcus aureusATCC 29213 Intan Martha Cahyani; Miftakhul Khoeriyah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Staphylococcus aureus is one of the acne-causing bacteria. 1,8 cineole is the content of eucalyptus leaves oil which has antibacterial activity Staphylococcus aureus. This research aimed to examine the effective consentration of eucalyptus leaves oil as an Staphylococcus aureus ATCC 29213 antibacterial. Eucalyptus leaves oil made in series a concentration of 5%, 7,5% and 10% for antibacterial activity test using the pitting diffusion method. Based on the test result of antibacterial activity gained an average diameter of inhibition zone eucalyptus leaves oil successively 1,286 cm; 1,424 cm; 1,574 cm. The statistically test results showed significant difference in the antibacterial activity of eucalyptus leaves oil in concentrations 5%, 7,5% and 10% to the growth of Staphylococcus aureus ATCC 29213. Eucalyptus leaves oil has an effective concentration of 10% as an antibacterial stapgylocuccus aureus and made cream formula. Test of antibacterial activity obtained resistibility zone diameter 1,136 cm. The result of t-test indicated that cream formula has significant effect on antibacterial activity. Keywords: Eucalyptus leaves oil, antibacterial effectivity, cream.

UJI AKTIVITAS ANTIDEPRESAN PERASAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza, Roxb) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) Dian Kartikasari; Hairunisa Hairunisa; Emy Nadya Natasha
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPrevention and treatment with synthetic antidepressants has many side effects that affect the central nervous system and usage must be under the supervision of a doctor. Whereas prevention and traditional medicine relatively do not cause side effects, are inexpensive, and easy to obtain. One example of traditional medicine from natural ingredients, which can provide an antidepressant effect is ginger rhizome. This research aims to determine whether ginger rhizome have antidepressant effects on male white mice. Antidepressant effect testing was carried out on male white mice (Mus musculus) using the forced swim test method. The part of the plant used is the rhizome of the ginger plant. Curcuma rhizome is made with juice and given orally with a concentration of 20%, 40%, and 60%. The negative control used is Na CMC 0.5%, while the positive control used, namely amitriptilyn. The parameters observed were the duration of immobility time, swimming time and climibing time (in seconds) which were calculated from minutes 3-6 for 6 minutes, and statistical tests were carried out with a confidence level of 95%. The results showed that at a concentration of 40% the curcuma rhizome juice had a significant value (p> 0.05) which means that there was no significant difference in antidepressant effect (%) from the juice of temulawak 56.31% and amitriptylin 78.78%Keywords: ginger rhizome, antidepressants, the forced swim test

EVALUASI PENGGUNAAN ANTIBIOTIKA PADA PASIEN LEUKEMIA LIMFOBLASTIK AKUT DENGAN DEMAM NEUTROPENIA DI RUMAH SAKIT UMUM DAERAH ABDUL WAHAB SJAHRANIE SAMARINDA Octaviana Maria Simbolon; Liniati Geograf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The use of antibiotics is one of the management of neutropenic fever in patients with acute lymphoblastic leukemia (ALL). Irrational and excessive antibiotics can promote resistance to certain bacteria. The aim of this study was to evaluate the use of antibiotics given to ALL patients with neutropenic fever qualitatively and quantitatively. This type of observational research was conducted with a descriptive method using a cross-sectional design. Retrospective data collection from medical records of ALL patients who received antibiotics during 2017-2018. The quality of antibiotic use was analyzed using the Gyssens method, while the quantity of antibiotic use was analyzed using the DDD method per 100 bed days. Based on the results of the study of 7 ALL patients with neutropenic fever, the rational (category 0) use of antibiotics was 50% and the irrational (category I-IV) use of antibiotics was 50%. The use of inappropriate antibiotic dose (category IIA) was 25%, the use of the antibiotic inaccurate interval of use (category IIB) was 10%, and there was no indication that antibiotic use (category V) was 15%. Quantitative evaluation of the use of antibiotics using the DDD method per 100 bed days showed that the total use of antibiotics was 7 types with a DDD value of 100 patient days of 19.15. The most widely used antibiotic is the cephalosporin class, namely cefotaxime with a DDD value of 6.51. Keywords: antibiotics, leukemia, quality, quantity

PENGARUH VARIASI KONSENTRASI CMC Na SEBAGAI PENGIKAT DALAM PASTA GIGI EKSTRAK ETANOLIK DAUN JAMBU BIJI (Psidium guajava L.) DAN EKSTRAK ETANOLIK DAUN SIRIH MERAH (Piper crocatum Ruiz dan Pav) TERHADAP KARAKTERISTIK FISIKNYA Dewi Andini K.M.; Mimiek Murrukmihadi; Nur Laili; Diana Cholida
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Sodium Carboxymethyl Cellulose (CMC Na) commonly used as binder on toothpaste becauseits has good viscosity. The active ingredient of two type of toothpaste is ethanol extract of guava leaves (EEDJB) and ethanol extract of red betel leaf (EEDSM), respectively which has the potential for antiplaque on teeth. The purpose of this study to determine the effect of variations concentration of CMC Naagainst physical characteristics from toothpaste EEDJB and EEDSM. EEDJB and EEDSM had made by maceration method using ethanol 70% as a solvent. Three different concentrations of CMC Naof toothpaste formulation EEDJB are FI (0.5%); FII (0.75%); FIII (1.00%) and EEDSM are FI (0.45%); FII (0.67%); FIII (0.90%). Toothpaste of EEDSM and EEDJB had tested against its physical characteristics. Based on theexperimental results of toothpaste formulations EEDJB and EEDSM states that the higher concentration of CMC Na hadn’t affect the organoleptic and foaming test, but the viscosity becomes higher and the potency dispersive of becomes decreases. Value of viscosity (dPas) toothpaste EEDJB for FI (123,33 ± 5,77); FII (256,67 ± 20,81); FIII (283,33 ± 10,40), while toothpaste EEDSM for FI (125±5); FII (250±25); FIII (316,6± 28,87. The average of the potency dispersive (cm2) of toothpaste EEDJB with a load of 150 grams for F1 (1,75); F2 (1,21); F3 (0,89), while toothpaste EEDSM with a load of 150 grams for F1 (1,64); F2 (1,26); F3 (0,73). Keywords : CMC Na, ethanolic extract of guajava leaves, ethanolic extract of red betle leaves, toothpaste

TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C Risha Fillah Fithria; Ririn Lispita Wulandari; Devi Nisa Hidayati; Lilis Rejeki
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell

EFEK ANTIDIARE EKSTRAK ETANOL UMBI RUMPUT TEKI (Cyperus rotundus L.) TERHADAP MENCIT PUTIH Rifda Naufa Lina; Monik Dewi Astutik
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Diarrhea is a disease characterized by stimulation of bowel movements continuously and feces that are not formed or liquid that has a frequency of more than 3 times in 24 hours. The incidence of diarrhea can occur throughout the world and causes 4% of all deaths and 5% of health losses to cause disability. Cyperus rotundus L. can be used as an antidiarrheal drug because it contains a compound such as tannins and flavonoids. This research is an experimental study with a Post-test only Control Group Design. The subjects using white male mice (Mus muscullus) 25 mice and divided into 5 groups: positive control, negative control, ethanol extracts of rubers Cyperus rotundus L. with a dose of 250 mg/kgBB, 500 mg/kgBB and 1000 mg/kgBB. Before the treatment, mice fasted and induced diarrhea (oleum ricini). Obsevations was made by observing the parameters of diarrhea: duration of diarrhea, frequency of diarrhea and feces consistency every 30 minutes for 4 hours. The numerical data was then processed using SPSS with one way ANOVA test. The results obtained showed that the administration of extract with a dose of 250 mg/kgBB, 500 mg/kgBB and 1000 mg/kgBB had an antidarrheal with effective dose is 500 mg/kgBB. Keywords: antidiarrheal, ethanol extract of tubers Cyperus rotundus L., oleum ricini, Cyperus rotundus

AKTIVITAS BAWANG PUTIH (Allium sativum L.) SEBAGAI AGEN ANTIBAKTERI Debi Kristiananda; Juvita Lisu Allo; Veronica Arien Widyarahma; Lusiana Lusiana; Jeanne Magistra Noverita; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Garlic (Allium sativum L.) has various potentials in overcoming diseases, one of which is as an antibacterial. The purpose of this study was to explore, analyze and review the activity of garlic (Allium sativum L.) as an antibacterial agent. This study uses a literature search method using search sites such as Google Scholar, Pubmed, ScienceDirect, AYU, NCBI, Elsevier, PlosOne, and Google Scholar. by entering keywords such as antibacterial, Garlic, and Allium sativum L. Garlic contains secondary metabolites that function as antibacterial agents such as alkaloids, tannins, saponins, flavonoids, allicin. Garlic has been shown to inhibit the growth of gram-positive and negative bacteria species Escherichia, Salmonella, Staphylococcus, Streptococcus, Klebsiella, Proteus, Bacillus, Clostridium, P. aeruginosa, K. pneumoniae and, Bifidobacterium lactis predominantly using the paper disk and well diffusion method.

PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70% DAUN BINAHONG (Anredera cordifolia, (Ten.) Steenis) SEGAR DAN DAUN BINAHONG (Anredera cordifolia, (Ten.) Steenis) KERING DENGAN METODE DPPH (2,2-DIPHENIL-1-PICRYL-HYDRAZYL) Ariyanti Ariyanti; Tsani Imada; Ida Rifkasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 1 juni 2017
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Kerusakan pada sel dan jaringan yang merupakan akar dari sebagian besar penyakit disebabkan oleh spesies kimia yang sangat aktif dan berbahaya yang disebut radikal bebas.Tujuan penelitian ini adalah untuk mengkaji nilai pKa dan pengaruh pembentukan senyawa kompleks ibuprofen dengan β-siklodekstrin terhadap peningkatan kelarutan ibuprofen. Metode penelitian yang digunakan untuk menentukan nilai pKa adalah dengan pengukuran absorbansi pada panjang gelombang 266 nm. Pengujian kelarutan dan optimasi kompleks antara ibuprofen dengan β-siklodekstrin menggunakan spektrofotometri ultraviolet dengan metode factorial design. Kompleks ibuprofen dengan β-siklodekstrin dievaluasi menggunakan spektrofotometri inframerah, dan dioptimasi dengan metode simplex lattice designmenggunakan software design expert versi 7.1.3. Hasil penelitian ini menunjukan bahwa pKa ibuprofen adalah 4,37 ± 0,07 dan 5,24 ± 0,07. Kompleks ibuprofen dengan β-siklodekstrin yang terbentuk dievaluasi secara spektrofotometri inframerah menunjukan hilangnya puncak gugus -C=O- dari ibuprofen pada bilangan gelombang 1721 cm-1dan transmisi baru dengan transmisi 12,77% pada bilangan gelombang 1908 cm-1 dan 9,785 pada bilangan gelombang 1698 cm-1. Peningkatan kelarutan ibuprofen dikompleks dengan β-siklodekstrin adalah 2,30 kali ± 0,12 pada pH 2,39; 1,30 kali ± 0,16 pada pH 6,39; 1,74 kali ± 0,06 pada pH 3,2 dan 0,99 kali ± 0,02 pada pH 7,2. Komposisi kelarutan optimum pada pH 2,39 dan 6,39 adalah pada pH 2,39, suhu 30°C, ibuprofen 100 mg, dan β-siklodekstrin 200 mg, sedangkan pada pH 3,2 dan 7,2 adalah pada pH 3,2, suhu 45°C, ibuprofen 100 mg, dan β-siklodekstrin 200 mg. Kata kunci: kelarutan, β-siklodekstrin, ibuprofen, pKa. ABSTRACT Ibuprofen is a nonsteroid anti-inflammatory drug (NSAID) that can inhibit activities of siklooksigenase-1 and siklooksigenase-2 isoenzyme, so thats with inhibiting the changing of arachidonic acid to prostaglandin can be decreased. Ibuprofen belongs to BCS class II, because it has high permeability and low solubility. The goals of this research are to determine the pKa of ibuprofen and to know the influence of the complexe formation of ibuprofen with β-cyclodextrin on ibuprofen solubility. Determinnation of the pKa value of ibuprofen has been conducted by measuring absorbance at wavelength 266 nm. The optimization of complexes formation has been worked using factorial design method. Then, the complex of ibuprofen and β-cyclodextrin evaluated using infrared spectrophotometry, and optimized with using software design expert version: 7.1.3. The result of this research showeds that the pKa value of ibuprofen wasis 4, 37 ± 0,07 and 5, 24 ± 0,07. The complexes ibuprofen with β--siklodekstrin was evaluated using infrared spectrophotometry there was no peak at 1721 that indicated that there was no functional group of –C=O. Based on simplex lattice design calculation, the best complexes consisted of ibuprofen and β-cyclodextrin in ratio 120 and 180. The solubility data showed that complexes of ibuprofen with β-cyclodextrin was 2,30 ± 0,12 times at pH 1,30 ± 0,16 times; 1,74 ± 0,06 times , and 0,99 time ± 0,02 at pH 7,2; respectively at pH of 2,39; 6,39; and 7,2. Based on factorial design data, it was known that the combination of ibuprofen (100 mg) and β-cyclodextrin (200 mg) has an optimum solubility in codition pH 2,39; 6,39 and temperature 30°C. In codition, pH of 3,2 this mixture has an optimum solubility at temperature 45°C. Keywords:solubility,β-cyclodextrin, ibuprofen, pKa.

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