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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 38 Documents
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Search results for , issue "Vol 12, No 2 (2023)" : 38 Documents clear
The Therapeutic Potential of Cola nitida in Health and Disease: A Review Sanusi, Kamaldeen Olalekan; Usman, Umar Zayyanu; Usman, Dawoud; Adeshina, Kehinde Ahmad; Uthman, Yaaqub Abiodun; Jimoh, Lukman; Imam-Fulani, Aminat Omolola
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.637-643

Abstract

Cola nitida, also known as Kola nut, is a tropical plant native to West Africa and has a rich history of traditional medicinal use. In this narrative review, we aim to provide an overview of the protective effects of Cola nitida in various health and disease states. Cola nitida has been traditionally used for its medicinal properties, and its bioactive compounds include caffeine, alkaloids, tannins, flavonoids, and phenolics. These compounds contribute to its potential therapeutic effects. Here, we examine the potential benefits of Cola nitida in several areas of health, discussing its role in cognitive function, cardiovascular health, immune system function, gastrointestinal health, and metabolic and endocrine health. Relevant original articles available from PubMed, African Journals Online (AJOL), SCOPUS, and Google Scholar were retrieved using the keywords “cola” AND “nitida” without date restriction until July 17, 2023. Evidence suggests that Cola nitida may have positive effects on health, with indications of adverse effects only from its chronic usage. However, more research is needed to establish its efficacy and safety. Cola nitida holds promise as a natural remedy for various health conditions. Understanding the benefits and limitations of Cola nitida will contribute to its effective utilization in health and disease management.
Prevalence of Enterobacteriaceae Producing Extended Spectrum Beta-Lactamase (ESBL) in Broiler Meat (Gallus domesticus) Sold in Regional Markets of West Surabaya Risnanda, Kadek Rio; Masfufatun, Masfufatun; Listyawati, Agusniar Furkani; Kuntaman, Kuntaman; Sudibya, Akhmad
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.607-610

Abstract

Broiler meat is a foodstuff that is easily damaged by bacterial growth. Several pathogenic bacteria from the Enterobacteriaceae family have also been found as contaminants in chicken meat. While Extended Spectrum Beta-Lactamases (ESBL) are enzymes that have the ability to hydrolyze antibiotics of the penicillin class, first, second, and third generation cephalosporins as well as the monobactam group. Based on this phenomenon, the researchers wanted to examine the prevalence of the ESBL-producing Enterobacteriaceae family in broiler chicken (Gallus domesticus) meat sold in the West Surabaya market. This research is a descriptive observational type using a cross-sectional approach. The population in this study was broiler chicken meat taken from broiler traders in several markets in West Surabaya which had met the inclusion and exclusion criteria with a large sample of 50 samples. Then the data were analyzed using the chi-square test. The results of the analysis showed that 13 samples produced ESBL. The prevalence of Enterobacteriaceae bacteria producing ESBL in broiler chicken (Gallus domesticus) meat in several markets in West Surabaya is 26% of the 50 samples used. The results of the chi-square test showed that there was no significant difference between locations where ESBL was found.
In vivo Alpha-amylase and Alpha-glucosidase Inhibitory Potentials of Panicum maximum Jacq. (Guinea grass) Leaf Extract on Wister Rats Enin, Godwin Ndarake; Okokon, Jude Efiom; David, Enobong Mfon; Emmanuel, Saviour Elisha; Ekanem, Esther Michael; Antia, Bassey Sunday
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.681-685

Abstract

Panicum maximum Jacq. (Guinea grass) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for its effect on alpha amylase and alpha glucosidase enzymes in vivo. The crude ethanol extracts (150, 300 and 450 mg/kg) of P. maximum were investigated using starch, sucrose, glucose and maltose as substrates and acarbose as reference drug. The leaf extract caused significant (p<0.05) reduction in blood glucose levels of the treated rats with the four substrates used. The findings show that the leaf extract of Panicum maximum has the potentials to inhibit alpha amylase and alpha glucosidase in rats.
Potency of Biocoagulant from Cationic Modified Starch of Balbis Banana Blossom Waste for Palm Oil Wastewater Treatment: Literature Study Fadhallah, Esa Ghanim; Hidayat, Alif Fikri Nur; Saffanah, Arfika Julya; Iswahyudi, Bella Amanda; Wasalamah, Diah Shihatin; Putri, Eka Cahyani; Ningtias, Nadila; Ummi, Yana Hijriyatin
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.645-649

Abstract

Lampung is one of the provinces producing Indonesia's second-largest banana crop. Operational activities at the Palm Oil Mill produce a by-product of Palm Oil Mill Effluent (POME), which can potentially be the most enormous environmental pollution. Communities often use chemicals to treat liquid waste, which causes health problems, cannot be decomposed, and can damage the environment. Therefore, treating liquid waste using organic materials that are more environmentally friendly, safe for health and easily degraded is necessary. By modifying cationic starch, natural polymers found in banana blossom waste may be utilized for producing natural biocoagulant that are more effective. This paper aims to review the potential of cationic-modified balbis banana blossom waste starch as a natural biocoagulant for processing palm oil waste. Starch was first modified into cationic starch by etherification method with the help of HMMAHC cationic reagents. The mechanism of cationic starch as a biocoagulant is the exchange of starch cation ions and waste anions to form bridges between colloidal particles and then form flocs that can precipitate. The implementation technique of this idea is by collaborating with several parties to ensure the successful use of banana hump starch as a biocoagulant material, providing support and facilities for the industry and promoting the use of biocoagulant, conducting literature studies related to the use of banana hump starch as a natural biocoagulant, testing the effectiveness of biocoagulant, implemented in the palm oil processing industry.
Effect of Citrullus lanatus Seeds Extract on Haematological Parameters After Administration with Medroxyprogesterone Acetate on Female Wistar Rats Nnumolu, Michael Chuks; Godspower, Onyeso
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.611-617

Abstract

This study was carried out to investigate the effect of Citrullus lanatus seeds extract on the haematological parameters after administration with medroxyprogesterone acetate on female Wistar rats. Twenty-five rats weighing 170-230 g were divided into five groups containing five rats each. Group I served as control and received only rat chow and water; Group II received rat chow, water and a high dose of MPA only; Group III received rat chow, water, a high dose of MPA and a high dose of extract; group IV received rat chow, water, high dose of MPA and a low dose of extract, and group V received rat chow, water and high dose of extract only. The administration lasted for twenty-eight days after two weeks of acclimatisation. On the twenty-ninth day, the animals were anaesthetised using chloroform, sacrificed and their blood samples obtained via cardiac puncture for haematology analysis. The results showed that the level of haematological parameters significantly increased (p<0.05) in the rats that received a high dose of MPA and a high dose of Citrullus lanatus seed extract compared to the control group. This suggests that MPA affects bone marrow, which produces blood cells, significantly decreasing platelet count, white blood cell count, red blood cell count, haemoglobin count, packed cell volume, mean corpuscular volume, and mean corpuscular haemoglobin concentration. This study also shows that an aqueous extract of Citrullus lanatus seed is potent in increasing the level of haematological parameters when co-administered with MPA.
Antimicrobial and Antioxidant Activities of Sesquiterpenes-Rich Essential Oil of Trichilia monadelpha (Thonn) J.J. De Wilde of Root Bark Odeja, Oluwakayode Olubunmi; Onocha, Patricia A.; Oloyede, Ganiyat Kehinde; Ayoyerokun, Damola; Ibok, Michael Gabriel; Okpala, Ejike Onwudiegwu
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.687-692

Abstract

Trichilia monadelpha (Thonn) J.J. De Wilde (Meliaceae) is used in traditional medicine for the treatment of ulcers, cough and inflammatory disorders such as arthritis. In this present study, the essential oil of T. monadelpha root bark was obtained by hydrodistillation using an all-glass Clevenger apparatus. The identification and characterisation were done using Gas Chromatography-Mass Spectrometry. We also, aimed to evaluate the antimicrobial activity of the essential oil against ten micro-organisms using the Agar diffusion method and the free radical scavenging capacity was determined using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) methods. Twenty (20) different compounds made up the hydrodistilled essential oil, which made up 99.0% of the entire oil content.  Sesquiterpene compounds made up about 73.3% of the essential oil from the root bark of T. monadelpha, which was described as sesquiterpenes-rich. Sesquiterpenes' most abundant constituents include (E)-Longipinene (18%), 10s,11s-Himachala-3-(12),4-diene (15.26%), Aromadendrene (11.12%), Alloaromadendrene oxide-(1) (8.82%), and β-Caryophyllene (5.92%). The essential oil inhibited growth against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aerugunosa, Candida albicans, Aspergillus niger, Klebsiella Pneumonia and Salmonella typhi at concentrations of 200 mg/mL to 50 mg/mL with an inhibitory zone of 20 – 10 mm while the antioxidant analysis of the essential oil revealed low scavenging activity which reveals that the synthetic antioxidants were more effective with an Ascorbic acid; IC50 value of 1.47 mgmL-1, Butyl hydroxyanisole; 1.88 mgmL-1, α-Tocopherol; 4.83 mgmL-1 followed by the essential oil with an IC50 value of 9.95 mgmL-1. T. monadelpha root bark essential oil contains notable chemical compounds that are responsible for its antioxidant and antimicrobial activities.
Identification and Toxicity Profiling of Column Fractions of Ethanol Leaf Extract of Ziziphus mauritiana Owolarafe, Tajudeen Alowonle; Kailani, Salawu
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.651-662

Abstract

Different plants may contain varying amounts of phytochemicals and also different degrees of toxicity. This study aimed to evaluate the phytochemicals present in the most active column fraction of ethanol leaf extract of the Ziziphus mauritiana plant and their toxic effects using brine shrimp lethality assay and animal model. Crude ethanol extract was obtained by maceration while fraction was achieved using a column chromatography experiment. Toxicity was evaluated with brine shrimp lethality assay and albino rat’s models while characterization was achieved with liquid chromatography-mass spectrophotometry. Ziziphus mauritiana leaves revealed 42 fractions pooled into seven fractions. Fraction three (3) was the most toxic with the brine shrimp lethality assay of (31.48ug/ml) and its toxicological evaluation revealed an adverse effect on the hematological parameter, biochemical indices, and histo-architecture of the liver and kidney of the experimental model studied. LCMS analysis of the most toxic fraction revealed the presence of Antirrhinoside, Lucidumol A, Apigenin 7-glucuronide-4'-(6''-malonylglucoside), Dioscoreside C, Camellioside D, and others which have been reported for various pharmacological effects including adverse effects, The mode of toxicity may be synergistic, individual, or antagonistic which may explain the moderate toxicity observed in animal model. Administration of these fractions may lead to toxicity despite their potential.
Investigating the Insecticidal Properties of Alangium salviifolium Root Extracts on Culex quinquefasciatus Mosquitoe Yagoo, Alex; Milton, M.C. John; Vilvest, Jelin
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.619-624

Abstract

This study evaluated the effectiveness of successive hexane, chloroform, and methanol extracts of Alangium salviifolium roots in combating mosquito-borne diseases caused by Culex quinquefasciatus mosquitoe in India. The hexane extract showed the highest efficacy with LC50 values of 105.0 ppm (larvicidal activity), 108.0 ppm (pupicidal activity), and 65.6 ppm (ovicidal activity). The chloroform extract had LC50 values of 156.8 ppm (larvicidal), 376.0 ppm (pupicidal), and 20.0 ppm (ovicidal), while the methanol extract had LC50 values of 235.7 ppm (larvicidal), 441.8 ppm (pupicidal), and 30.4 ppm (ovicidal). The hexane extract of A. salviifolium roots shows potential as a mosquito control agent, specifically against Cx. quinquefasciatus mosquitoes. Further studies are needed to assess the safety and effectiveness of this extract. This research highlights the potential of plant extracts as alternative mosquito control agents for mitigating mosquito-borne diseases in India.

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