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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 22 Documents
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Search results for , issue "Vol 17, No 1 (2020)" : 22 Documents clear
AKTIVITAS SITOTOKSIK EKSTRAK HEKSAN, EKSTRAK ETIL ASETAT, EKSTRAK ETANOL BUAH MENGKUDU (MORINDA CITRIFOLIA L ) TERHADAP SEL T47D Maryati, Maryati; Anas, Ahmad Novian Nur; Khairudin, Muhammad Nur
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10761

Abstract

Noni fruit (Morinda citrifolia L) is one of the natural ingredients commonly used as traditional medicine to overcome various diseases, such as cancer. Noni fruit contains anthraquinone and coumarin which have anticancer effects. This study aims to determine the cytotoxic effects of n-hexane, ethyl acetate and ethanol extract of noni fruit and to determine the presence of anthraquinone and coumarin in the extract. Extraction was carried out by maceration method using n-hexane, followed by ethyl acetate and ethanol. The cytotoxic activity on T47D cells was carried out by the MTT method. The presence of anthraquinone and coumarin was identified using thin layer chromatography (TLC). Results showed that n-hexane extract had moderate cytotoxic effect on T47D cells with IC50 value of 582.13 ± 61.64 µg/mL, while the ethanol and ethyl acetate extract did not have cytotoxic effect on T47D cells. TLC results indicated that n-hexane extract of noni fruit contains anthraquinone and coumarin.
Front Matters Vol.17 No.1 Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.11492

Abstract

Penggunaan Obat Off-Label dan Unlicensed pada Bayi dan Neonatus di Bangsal Anak Zakky Cholisoh; Siti Alfiatur Rohmah
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10828

Abstract

The prescription of medications outside the listed marketing authorizations (MA) is considered off-label. This practice is still frequently occurs in clinical practice. One of the reasons is because the lack of clinical trials and research in babies and neonates. This study was conducted to evaluate the off-label and unlicensed medications, their level of use and further describe the level of evidence of the commonly prescribed off-label and unlicensed medication in this population. Medications prescription and administration to hospitalised babies and neonates were recorded. Medication record data in a year were collected. Medication- licensing status of all drugs administered was determined according to marketing authorization information from monograph. The data then were categorised as off-label and unlicensed if the indication, dosage regimens, age category, and route of administration were not listed in the market authorization of the products. Furthermore the administrations of the most commonly used off-label medications were reviewed based on published journal articles to determine their level of evidence. Total medications administered during a year were 2,576 which were obtained from 139 patients. Of all, 15.25% (339) and 2.69% (69) medications administered were categorised as off-label and unlicensed respectively. Off-label of dosage regimens and route of administration were not identified, but 1.63% (42) medications were used for indications that were not listed in the (MA), and 13,63% (351) were prescribed out of age category of the listed marketing authorization. Off-label drug that often prescribed are salbutamol which had no evidence to support its use; valproic acid which had high level of evidence against its use on baby and neonates; and ondancetron which had high level of evidence to be used outside its marketing authorization.
Efek Pemberian Ekstrak Etanol Buah Adas (Foenicullum vulgare Mill.) terhadap Kadar Hormon Prolaktin Tikus Putih Betina Post Partum Ahwan Abdul; Fridah Wahyu Safitri; Rantika Purbowati
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9245

Abstract

Fennel plants are plants that have various traditional properties, such as facilitating breast milk or lactagogum. The aim of this research was to give ethanol extract of fennel fruit to increase the level of the hormone prolactin in lactating mice, so that the milk produced was increased. Subjects consisted of 12 postpartum female rats, divided into 1 control group (1% CMC Na) and 3 treatment groups (doses of 100, 500 and 1000 mg / Kg BW). Fennel fruit extract was given orally for each group for 14 days, after the treatment of blood samples were taken and centrifuged, the serum was read by Elisa Reader. The data obtained were analyzed using the Kolmogorov-Smirnov test, one-way ANAVA and Tukey's Multiple Comparison (post hoc test). Fennel fruit extract given from a dose of 100; 500 and 1000 mg / kg BW can significantly increase levels of the hormone prolactin (p 0.05) in nursing mice, respectively by 42.11; 44.26 and 43.83 ng / mL compared to controls (32.64 ng/mL).
Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102 Agung Setiawan; Naelaz Zukhruf Wakhidatul Kiromah; Tri Cahyani Widiastuti
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

Abstract

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.
Potensi Ekstrak Etanol dan Fraksi-Fraksinya Dari Tiga Varietas Jahe Sebagai Agen Antibakteri Terhadap Staphylococcus aureus Dewi Dianasari; Endah Puspitasari; Indah Yulia Ningsih; Bawon Triatmoko; Fauzia Ken Nasititi
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ‘emprit ginger (Zingiber officinale var. Amarum), ‘ gajah’ ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 μg (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Uji Aktivitas Antioksidan Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L) dari Daerah Sleman dengan Metode DPPH Disa Andriani; Lusia Murtisiwi
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9321

Abstract

Telang flower (Clitoria ternatea L.) contains phenolic compounds which can act as antioxidants by donating hydrogen so as to stabilize the lack of electrons in free radicals. This study aims to determine the antioxidant potential of telang flower ethanol extract by looking at the IC50 value. Telang flowers were extracted by maceration method using 70% ethanol solvent. The potential for antioxidants was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a comparison of vitamin C which had been shown to have the potential of free radicals which were very potent. The results showed the IC50 value of telang flower ethanol extract was 41.36 ± 1.191 μg / mL, based on that value the telang flower extract from the Sleman area was in the very potent category so that it could be developed as a source of antioxidants from natural ingredients.
Evaluasi Penggunaan Antibiotik pada Balita Penderita Pneumonia Rawat Inap di RSUD “Y” di Kota “X” Tahun 2016 Panji 'Utsman; Hidayah Karuniawati
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.5991

Abstract

Pneumonia was pulmonary lung disease called parenchyma caused by microorganism, Pneumonia can be cured byantibiotic to prevent the resistantof bacteria and to improve the effective of the treatment, the right antibiotic must be determining. This research purpose is to determine the accuracy of using antibiotic in toddler patients suffering pneumonia who hospitalized in RSUD “Y” “X” City, in 2016. This is nonexperimental research. Data collected retrospectively and was analized descriptively. Samplestaken by purposive sampling method which searched the medical report of toddler patient suffer pneumonia hospitalized in RSUD “Y”X City, in 2016 which met the inclusion criteria. Reseach accuracy was analized used “Pedoman Pelayanan Medis Ikatan Dokter Anak Indonesia year 2009” and “British National Formularium for Children 2011-2012”, Such as indication accuracy, precision medicine accuracy, patient accuracy and drug dose accuracy. The result of the research was found that in 49 toddler patient suffering pneumonia, the kind of antibiotic used was cefotaxime (89,80%), Ampicillin (4,08%), combination of cefotaxime + gentamicin (4,08%) and ampicillin + gentamicin (2,04%). Evaluation of accuracy of the use antibiotic 100% right in indication, precision medicine by 93,87%,100% patient accuracy, and 10,20% drug dose accuracy.
Uji Aktivitas Antiinflamasi Infusa Daun Afrika (Vernonia amygdalina) pada Tikus Putih yang Diinduksi Karagenan Lusi Agus Setiani; Moerfiah Moerfiah; Yulianita Yulianita
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9322

Abstract

Inflammation is one of the immune system's main responses to infection and irritation. One of the medicinal plants that can be used as anti-inflammatory is African leaves because there have flavonoid compounds. Flavonoid compounds have anti-inflammatory effects that can regulate arachidonic acid metabolism by inhibiting cyclooxygenase (COX) and lipooxygenase activity.This study aims to determine the effectiveness and determine the effective dose of African leaf infusion as anti-inflammatory in sparague dawley strain  induced carrageenan male white rats. The method used is measurement of udema with subplantar 1% carrageenan induction.Test animals used were 20 male rats divided into 5 groups. Each group consisted of 4 rats. Group I as a negative control was given CMC-Na solution, the second group as a positive control was given diclofenac sodium with 1.26 mg/200 gBB body weight, group III, IV and V were given African leaf infusion with three dose ratings namely 100, 150, 200 mg/kgBB bodyweight. The results showed that the infusion of African leaves had Antiinflammatory Activity with dose 200 mg/kg body weight as the most effective dose against inhibition of inflammation.           
Ethanolic Extract of Papaya Leaves (Carica papaya) and its Fractions have no Potential Cytotoxicity on T47D Cells Ratna Yuliani; Faisal Syahdeni
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10760

Abstract

Breast cancer is one type of cancer that causes high mortality rate in women. Plants produce secondary metabolites with a wide range of activity, one of which is as an anticancer. This research was conducted to investigate the cytotoxic effect of ethanolic extract of papaya leaves (Carica papaya) and its fractions on T47D cell line. Extraction of the natural compounds from papaya leaves was carried out by soaking the leaf powder in 96% ethanol followed by filtration and solvent evaporation. Liquid partition was done to obtain hexane, ethyl acetate, and water fractions. The cytotoxicity of the extract and the fractions was tested using MTT assay. Identification of chemical compounds in the ethyl acetate fraction was conducted using a thin layer chromatography method that used silica gel GF 254 as the stationary phase and acetone and hexane (4:6) as the mobile phase. The MTT assay result shows that the extract does not inhibit the growth of T47D cells. The viability of T47D cells can be reduced by the hexane, ethyl acetate, and water fractions with IC50 values of 2,231.30, 557.33, and 2,112.81 g/mL, respectively. The ethyl acetate fraction contains flavonoids, alkaloids, phenolics, and terpenoids. The ethanolic extract of papaya leaves and the fractions has no potential cytotoxicity on T47D cells due to high IC50 values.

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