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Tingkat Penggunaan dan Kesadaran Masyarakat dalam Konsumsi Obat Tradisional Di Wilayah Kerja Puskesmas Gombong Kiromah, Naelaz Zukhruf Wakhidatul; Widiastuti, Tri Cahyani; Krisdiyanti, Yayu; Kurniawan, Yusuf
Jurnal Ilmiah Kesehatan Keperawatan VOL 15, NO 1 (2019): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM STIKES MUHAMMADIYAH GOMBONG

Bangsa Indonesia telah lama memanfaatkan tanaman sebagai sarana pengobatan. Obat tradisional merupakan suatu pengobatan yang memanfaatkan tanaman dimana tela digunakan dari secara turun menurun.Penggunaan obat tradisional secara umum dinilai lebih aman dibandingkan dengan obat modern. Akan tetapi hal tersebut tentu saja harus disertai dengan cara penggunaan obat tradisional yang tepat untuk menjamin manfaat dan keamanannya.Â Tujuan dari penelitian ini adalah untuk mengetahui tingkat penggunaan dan kesadaran dalam konsumsi obat tradisional khusunya di wilayah kerja Puskesmas Gombong 2 yang terdiri dari 9 desa. Penelitian ini merupakan penelitian non eksperimental dan bersifat deskriptif yang menggunakan angket (kuisioner). Responden yang berpartisipasi dalam penelitian ini sejumlah 242 orang. Karakteristik responden yang mengikuti penelitian ini adalah mayoritas perempuanÂ (59,50%), berpendidikan terakhir SD (33,47%), pekerjaan sebagai ibu rumah tangga (33,06%). Masyarakat di wilayah kerja Puskesmas Gombong 2 yang memilih pengobatan dengan obat tradisional (42,97%), dasar pemilihan penggunaan obat tradisional bersumber dari teman, saudara dan tetangga sebesar 42,31%, dan semua responden merasakan manfaat serta khasiat dari obat tradisional. Dalam penelitian ini juga menunjukkan bahwa mayoritas masyarakat telah mengetahui keamanan obat tradisional (67,36%) akan tetapi sumber informasi didapatkan dari teman, saudara dan tetangga. Sehingga diperlukan kegiatan penyuluhan tentang manfaat dan keamanan serta penggunaan obat tradisional yang baik dan tepat.

FORMULASI DAN EVALUASI SEDIAAN TABLET NANOPARTIKEL EKSTRAK DAUN SALAM (SYZYGIUM POLYANTHUM) DENGAN VARIASI KONSENTRASI NA ALGINAT DAN AVICEL PH 102 Setiawan, Agung; Kiromah, Naelaz Zukhruf Wakhidatul; Widiastuti, Tri Cahyani
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.

Aktivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus altilis) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli Fiana, Fuan Maharani; Kiromah, Naelaz Zukhruf Wakhidatul; Purwanti, Ery
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10108

Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10%, 15% and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mm. The activity of ethanol extract of the breadfruit leaves against the Staphylococcus aureus and Escherichia coli bacteria is included in the weak category.

IDENTIFIKASI ETNOBOTANI TANAMAN OBAT YANG DIMANFAATKAN OLEH MASYARAKAT KECAMATAN SEMPOR KABUPATEN KEBUMEN Widiastuti, Tri Cahyani; Kiromah, Naelaz Zukhruf Wakhidatul; Ledianasari, L
Jurnal Ilmiah Kesehatan Keperawatan Vol 13, No 2 (2017): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM STIKES MUHAMMADIYAH GOMBONG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jikk.v13i2.216

Indonesian is a tropical country that has been known as a producer of various agricultural commodities, including medicinal plants. Traditional medicine is a hereditary heritage of the ancestors who are deeply rooted in the culture of the nation, therefore both in the herb and in its use as a traditional medicine is still based on experiences passed down from generation to generation both orally and in writing. Health services in Indonesia have grown, but people's interest in utilizing traditional medicine remains high. This study aims to reveal the knowledge of the community about the types of plants that are utilized for the fulfillment of daily living needs. This research was conducted around Sempor District Kebumen District. This study uses survey method designed to obtain a description of the various types of medicinal plants used by the community. Determination of informants by using snowball sampling. The results of the survey and the interviews were made of the categories of plant utilization. From the results of the research, it is found that the people around Sempor still have a good knowledge about the diversity of plants and their utilization in everyday life. Based on the survey results, there were 200 species of plants utilized by the community, grouped into categories: foodstuff (90 species), herbal medicine and traditional medicine (44 species), building materials (29 species), fuelwood (13 species) , animal feed ingredients (11 species), craft materials and tools (8 types), fiber materials and rope (3 types), and toxic materials (2 types)

PENGARUH PEMBERIAN EKSTRAK AKAR PASAK BUMI (EURYCOMA LONGIFORA JACK) TERSTANDAR TERHADAP GAMBARAN HISTOPATOLOGIK TESTIS TIKUS WISTAR Miyarso, Condro Suro; Widiastuti, Tri Cahyani; Kiromah, Naelaz Zukhruf Wakhidatul
Jurnal Ilmiah Kesehatan Keperawatan Vol 13, No 3 (2017): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM STIKES MUHAMMADIYAH GOMBONG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jikk.v13i3.230

The root of pasak bumi (Eurycoma longifolia, Jack) is one of plant from Indonesia known as aphrodisiac. The study about its standardized extract as aphrodisiac was show increasing libido, testosterone level, FSH and LH on male rats. This study was conducted to evaluate testosterone level and histopathological changes of the testes of male rats of standardized extract of pasak bumi root. There are 50 old male rats which ages 3-4 months old divided to five groups. Group I as negative control was administered aquadestilata. Group II as positive control was administered testosterone (AndriolÂ®). Group III, IV and V ware given standardized extract of pasak bumi root at the dose 50, 100 and 200 mg/kg body weight Respectively. The extract was given orally twice a day for six days and forty nine days and then the testes was taken out on 7th and 50th day. The histopathological of the testes was evaluated using quantitative parameter by the presence of testes weight, number and diameter of Leydig cells. Testosterone level was taken on 7th and 50th day used ELISA method. The results were analyzed using parametric test, one way ANOVA (P<0,05), post hoc Dunnet (2-sided) (P < 0,05). The result of this study shows that the standardized extract of pasak bumi root was not effect on histopathological changes of the testes but it could increased the level of testosterone m at the dose 100 and 200 mg/kg body weight.Â Â Key word : Eurycoma longifolia, Jack, aphrodisiac, histopathological testes testosteron

Uji Aktivitas Antibakteri Ekstrak Metanol dan Akuades Daun Ganitri (Elaeocarpus ganitrus Roxb.) Terhadap Bakteri Streptococcus mutans Naelaz Zukhruf Wakhidatul Kiromah; Wahyu Rahmatulloh
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3237

Streptococcus mutans is responsible for cause the dental caries. The purpose of this research was to test antibacterial activity of Ganitrus leaves. The bacterial activity of methanol and aquadest by disc difusion method with 10; 20; 30; 40; 50 and 100%. The extracts showed that methanol extract had activity with category susceptible at concentration of 50% and 100% against Streptococcus mutans with inhibition zone 16,70 and 17,68 mm respectively. Aquadest extract showed activity with category intermediet of 30% and 100% with inhibition zone 11,04 and 11,39 mm. There is a significant difference in the inhibition zone diameter at each treatment.

Aktivitas Antioksidan Ekstrak Etanol Daun Ganitri (Elaeocarpus Ganitrus Roxb.) dengan Metode DPPH (2,2 Difenil-1-Pikrilhidazil) Naelaz Zukhruf Wakhidatul Kiromah; Sadam Husein; Titi Pudji Rahayu
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.12161

Free radicals are one of the cause of various diseases. The use of synthetic antioxidant compounds could prevent the effect of the free radicals, however may cause adverse effects on the human body such as impaired liver, lung, intestinal and poisoning. Therefore antioxidant from natural resources needs to be developed. The purpose of this research was to determine the antioxidant activity and IC50 value of the ethanol extract of ganitri (Elaeocarpus ganitrus Roxbs.) leaves. Ganitri leaf ethanol extract activity test was carried out using DPPH method with vitamin C as a standard. Antioxidant activity was determined as a decreas in the absorbance of DPPH at 517 nm wavelength after an addition of the extract with the concentrations of 20, 40, 80, and 100 ppm. The antioxidant acitivity measurement of the ganitri leaf extract showed that the linier regression equation obtained was y = 0.3669x + 29.546, r = 0.4573 while the IC50 value was 54,12 ppm. Based on the result, it is concluded that the ethanol extract of ganitri (Elaeocarpus ganitrus Roxb.) leaf showed was categorized as strong antioxidant.

Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102 Agung Setiawan; Naelaz Zukhruf Wakhidatul Kiromah; Tri Cahyani Widiastuti
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.

Aktivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus altilis) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli Fuan Maharani Fiana; Naelaz Zukhruf Wakhidatul Kiromah; Ery Purwanti
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10108

Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10%, 15% and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mm. The activity of ethanol extract of the breadfruit leaves against the Staphylococcus aureus and Escherichia coli bacteria is included in the weak category.

Uji Aktivitas Antioksidan Menggunakan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Terhadap Ekstrak Etanol Kulit Buah Durian (Durio zibethinnus L.) dari Desa Alasmalang Kabupaten Banyumas Eko Prasetyo; Naelaz Zukhruf Wakhidatul Kiromah; Titi Pudji Rahayu
Jurnal Pharmascience Vol 8, No 1 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i1.9200

Kulit durian merupakan bagian tanaman yang pernah diteliti sebelumnya dan mempunyai aktivitas farmakologi sebagai antioksidan. Kulit durian mengandung metabolit sekunder yaitu flavonoid, tanin dan alkaloid. Kulit durian diekstrak menggunakan pelarut etanol 70% dengan metode sokletasi. Pengujian aktivitas antioksidan menggunakan metode pengukuran penangkapan radikal bebas oleh 1,1-difenil-2-pikrilhidrazil (DPPH). Vitamin C digunakan sebagai kontrol positif dengan nilai IC50 5,63 ppm dan ekstrak etanol sebesar 204,33 ppm. Penelitian ini menunjukkan bahwa ekstrak etanol kulit durian tidak memiliki aktivitas antioksidan menggunakan metode DPPH. Kata Kunci: Durian, Sokletasi, DPPH (2,2-difenil-1-pikrilhidrazil), antioksidan, IC50 Durian fruit peels (Durion zibethinus Murr.) have been studied previously and reported to have phramacological activity that has the potential to be antioxidant. The durian fruits peels, contained secondary metabolite, namely flavonoids, tannin and alkaloid. Durian fruit peels (Durion zibethinus Murr.) were extracted with ethanol 70% with soxletation method. The antioxidant activity of extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Vitamin C was used as standard with IC50 5,63 ppm and the ethanol eztracts showed IC50 204,33 ppm. This study provided that Durian fruit peels (Durion zibethinus Murr.) cannot inhibit free radical usimg the DPPH method.

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