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All Journal e-Journal Pustaka Kesehatan Jurnal Riset Kimia Pharmacon Warta Pengabdian JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Cendekia : Jurnal Pengabdian Masyarakat Journal of Tropical Ethnobiology Jurnal PkM (Pengabdian kepada Masyarakat)
Indah Yulia Ningsih
University Of Jember
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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POTENSI EKSTRAK ETANOL DAN FRAKSI-FRAKSINYA DARI TIGA VARIETAS JAHE SEBAGAI AGEN ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Dianasari, Dewi; Puspitasari, Endah; Ningsih, Indah Yulia; Triatmoko, Bawon; Nasititi, Fauzia Ken
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ?emprit ginger (Zingiber officinale var. Amarum), ? gajah? ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 ?g (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Gambaran Histopatologi Organ Jantung Tikus Putih Jantan Galur Wistar (Rattus norvegicus) dalam Uji Toksisitas Akut Kombinasi Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lmk.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Novia Hilma; Nuri Nuri; Endah Puspitasari; Indah Yulia Ningsih
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7574

Abstract

Jati belanda leaves (Guazuma ulmifolia Lmk.) and Roselle petals (Hibiscus sabdariffa L.) have been known for their activity as antihyperlipidemia with different mechanisms. Combination of these plants was expected to has a synergy effect in reducing cholesterol. However, the toxicity of jati belanda leaves and roselle petals extract combination must be investigated for knowing its safety. Based on the acute toxicity test, the LD50 value of jati belanda leaves and roselle petals extract combination was >5,000 mg/kg bw. It was classified as category 5 or unclassified. This research aimed to study about its effect in cardiac by cardiac histopathology examinations of the rats. The result showed that there was no cardiac histopathology changes of the rats at doses 5,000 mg/kg bw. Keywords: jati belanda leaves, roselle petals, acute toxicity, cardiac histopathology
Pengaruh Pemberian Kombinasi Ekstrak Etanol Daun Sidaguri (Sida rhombifolia L.) dan Rimpang Jahe Merah (Zingiber officinale Rosc.) pada Mencit Jantan Hiperurisemia Kinanthi Putri Rizki; Siti Muslichah; Indah Yulia Ningsih
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7566

Abstract

This study aimed to determine the effect of the combination of sidaguri leaves and red ginger rhizome extracts in uric acid levels of hyperuricemic male mice. Thirty-six mice were divided into nine groups including normal group, the positive control (+), negative control (-), extracts of four treatment groups with a variety of combinations and two groups of single extract. Hyperuricemia induction was performed by administering mixture melinjo 10% of the standard feed mice for 7 days dan potassium oxonate 250 mg/kg BB intraperitoneally at 2 hours before blood sampling. The results showed that the combination dose of sidaguri leaves of 50 mg/kg BB and red ginger rhizome 400 mg/kg BB had higher antihyperuricemia activity than other combinations in lowering uric acid levels of mice. Compounds may have antihyperuricemic activity were flavonoids, alkaloids, saponins, tannins, and terpenoids. Keywords: sidaguri leaves, red ginger rhizome, antihyperuricemic activity, uric acid
Potensi Ekstrak Etanol dan Fraksi-Fraksinya Dari Tiga Varietas Jahe Sebagai Agen Antibakteri Terhadap Staphylococcus aureus Dewi Dianasari; Endah Puspitasari; Indah Yulia Ningsih; Bawon Triatmoko; Fauzia Ken Nasititi
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ‘emprit ginger (Zingiber officinale var. Amarum), ‘ gajah’ ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 μg (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Pengembangan Produk Penyedap Rasa dan Tepung Jamur Tiram di Desa Penambangan dan Kelurahan Dabasah Kabupaten Bondowoso Indah Yulia Ningsih; Ika Barokah Suryaningsih; Ema Rachmawati
Warta Pengabdian Vol 12 No 3 (2018): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v12i3.8632

Abstract

Jamur tiram merupakan salah satu hasil pertanian yang diminati masyarakat. Banyaknya petani jamur tiram menyebabkan sulitnya harga komoditas ini bertahan bila seringkali terjadi panen raya secara bersamaan. Di Kabupaten Bondowoso, tepatnya di Desa Pertambangan dan Kelurahan Dabasah telah dilakukan budidaya oleh kelompok petani. Namun, para petani jamur tiram tersebut tidak memiliki pengetahuan, dan keterampilan untuk menghasilkan produk olahan jamur tiram yang tahan lama dan memiliki nilai jual yang tinggi. Oleh karena itu, pada kegiatan pengabdian ini dilakukan penyuluhan dan pelatihan mengenai pembuatan dan pengemasan produk olahan jamur tiram dalam bentuk penyedap rasa dan tepung jamur tiram. Adanya diversifikasi produk berperan dalam meningkatkan nilai tambah komoditas jamur tiram, sehingga dapat meningkatkan pendapatan para petani. Kata Kunci: Jamur Tiram, Penyedap Rasa, Tepung Jamur, Pengembangan Produk
Studi Etnofarmasi Suku Osing Kecamatan Kabat, Singojuruh dan Rogojampi Auralia Putri Pratama; Debi Listiayana; Dedi Irawanto; Jacinda Na’ilahafitra; Rismatul Khoiroh; Yuniatin Hasanah; Indah Yulia Ningsih; Evi Umayah Ulfa
Journal of Tropical Ethnobiology 2021: Prosiding Seminar Nasional PMEI V 2020
Publisher : The Ethnobiological Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Medicinal plants have been widely used for public health maintenance. Ethnic traditional medicine traditions can be used as a reference for the discovery of new medicines from natural ingredients. The Osing tribe that inhabits several areas in Banyuwangi Regency, including in Kabat District, Singojuruh District and Rogojampi District, has traditional medicine passed down by their ancestors and has not been well documented. The purpose of this ethnopharmaceutical study is to document the knowledge of traditional medicine of the Osing tribe and identify plant species used for medicine. Traditional medicine knowledge was carried out by semi-structural interviews using open-ended questions with 24 informants. Data were analyzed with the value of Used Value (UV) and Informant Consensus Factor (ICF). The results of the study recorded 30 types of plants, nine types of animals and four types of minerals used by the Osing tribe for treatment. Plants that have UV values above 0.5 are Curcuma longa (1,208), Stenosemia aurita (Sw) C. presl (0.625), and Moringa oleifera (0.625). The parts of the plant that were widely used were leaves (36.39%), rhizomes (20.65%) and fruit (18.68%). The highest ICF value in this study was conjunctivitis (0.8) with the medicinal plant used, namely Stenosemia aurita Sw C. Presl. This study shows that medicinal plants play a very important role in maintaining the health of the Osing people.
Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia) Nuri Nuri; Endah Puspitasari; Mochammad Amrun Hidayat; Indah Yulia Ningsih; Bawon Triatmoko; Dewi Dianasari
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (917.154 KB) | DOI: 10.25077/jsfk.7.2.143-150.2020

Abstract

The leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G. ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL).
Kapasitas Antioksidan Ekstrak Buah Salak (Salacca zalacca (Gaertn.) Voss) Varian Gula Pasir Menggunakan Metode Penangkapan Radikal DPPH Endah Puspitasari; Indah Yulia Ningsih
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 01 Juli 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRAK Penelitian ini bertujuan untuk mengevaluasi kemampuan antioksidan dari ekstrak air buah salak Salacca zalacca (Gaertn.) Voss varian gula pasir melalui aktivitas penangkapan radikal bebas 1,1-difenil-2-pikrilhidrazil (DPPH). Harga Inhibition Concentration (IC50) dari ekstrak buah salak yang menunjukkan kemampuan suatu bahan dalam menghambat 50% dari total 100% radikal DPPH sebesar 40,89±6,35 μg/mL. Sedangkan kontrol positif kuersetin memiliki harga IC50 sebesar 8,79±0,90 μg/mL. Berdasarkan harga IC50, dapat disimpulkan bahwa ekstrak buah salak varian gula pasir menunjukkan aktivitas antioksidan yang sangat kuat. Skrining fitokimia membuktikan adanya kandungan golongan senyawa polifenol yang diduga bertanggung jawab atas aktivitas antioksidannya yang tinggi. Golongan senyawa ini dapat melindungi dari radikal bebas sebagai penginduksi kerusakan biomolekul. Kata kunci: Salacca zalacca (Gaertn.) Voss, gula pasir, antioksidan, DPPH, polifenol. ABSTRACT The aim of this study was to evaluate antioxidant capacity of gula pasir variant of snake fruit (Salacca zalacca (Gaertn.) Voss) water extract using free radical scavenging activity of the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). The inhibition concentration (IC50) sufficient to elicit 50% of a maximum effect estimated in 100% was 40.89±6.35 μg/mL for the DPPH radical scavenging activity. While the positive control, quercetin, had IC50 value of 8.79±0.90 μg/mL. Based on the IC50 value, we concluded that gula pasir variant of snake fruit extract exhibited a very strong antioxidant activity. The phytochemical screening revealed the presence of polyphenol which could be responsible for the high antioxidant activity. This compound may provide protection against free radicals induced damage to biomolecules. Key words: Salacca zalacca (Gaertn.) Voss, gula pasir, antioxidant, DPPH, polyphenol
Studi Etnofarmasi Penggunaan Tumbuhan Obat Oleh Suku Tengger di Kabupaten Lumajang dan Malang, Jawa Timur Indah Yulia Ningsih
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 01 Juli 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRAK Suku Tengger merupakan salah satu suku di Indonesia yang masih berpegang teguh pada adat istiadat dan budayanya, termasuk pengetahuan lokalnya mengenai pengobatan menggunakan tumbuhan obat. Masyarakat Tengger tinggal di Kabupaten Probolinggo, Pasuruan, Lumajang, dan Malang, Jawa Timur. Di antara keempat kabupaten tersebut, suku Tengger di Lumajang dan Malang memperoleh pengaruh luar yang lebih besar karena adanya integrasi Islam dan lokasinya yang jauh dari pusat ritual budaya Tengger. Saat ini, generasi muda suku Tengger cenderung untuk memilih pengobatan konvensional karena kerjanya yang cepat dan praktis. Untuk menghindari hilangnya budaya ini, maka perlu dicari informasi lebih lanjut mengenai pengobatan tradisional suku Tengger. Salah satu metode yang digunakan untuk mengeksplorasi pengetahuan lokal akan tumbuhan obat adalah etnofarmasi. Kata kunci: etnofarmasi, suku Tengger, tumbuhan obat. ABSTRACT Tengger is one of tribes in Indonesia which still conserves its tradition and culture, including local knowledge about medicinal plants remedy. Their people live in Probolinggo, Pasuruan, Lumajang, and Malang dictrict, East Java. Among the four districts, Tengger tribe in Lumajang and Malang get more influenced than the others because of Islam integration and their far location from the center of Tengger cultural rituals. Currently, young generation of Tengger tribe tend to choose conventional medicine because of their fast action and practicality. To avoid the extinction of this culture, it is need to find more information about their traditional remedy. One of methods used to explore local knowledge of medicinal plants is ethnopharmacy. Key words: ethnopharmacy, Tengger tribe, medicinal plants.
PENGARUH ELISITOR BIOTIK DAN ABIOTIK PADA PRODUKSI FLAVONOID MELALUI KULTUR JARINGAN TANAMAN Indah Yulia Ningsih
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 11 No. 02 Desember 2014
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.829

Abstract

ABSTRAK Kultur jaringan tanaman merupakan alternatif produksi metabolit sekunder bioaktif, seperti flavonoid, yang efisien dan sangat menguntungkan. Flavonoid termasuk golongan senyawa fenolik alami pada buah, sayur, biji, kulit batang, akar, batang, dan bunga yang memiliki berbagai aktivitas biologis. Dengan menerapkan kultur jaringan tanaman, maka dapat dilakukan peningkatan produktivitas metabolit sekunder melalui perubahan ekspresi jalur metabolisme. Salah satu caranya adalah dengan menggunakan elisitor, baik elisitor biotik maupun abiotik. Elisitor bekerja dengan cara memicu pembentukan metabolit sekunder melalui pengaktifan jalur sekunder dalam merespon stres biotik dan abiotik. Hingga saat ini masih terus dilakukan berbagai penelitian untuk mengetahui jenis dan mekanisme kerja elisitor yang efektif dalam peningkatan produksi flavonoid. Kata kunci: kultur jaringan tanaman, flavonoid, elisitor biotik, elisitor abiotik. ABSTRACT Plant tissue culture appears to be a good alternative for production of bioactive secondary metabolites, such as flavonoids. These metabolites are naturally phenolic compounds in fruits, vegetables, seeds, bark, roots, stems, and flowers with various biological activities. Application of this method can increase secondary metabolites productivity through changes in expression of metabolic pathways, mainly by biotic and abiotic elicitors utilization. Elicitors influence secondary metabolites production through secondary pathway activation as a major response to biotic and abiotic stresses. Many studies have been being performed to find elicitors with an outstanding influence on the accumulation of flavonoids and its mechanisms. Key words: plant tissue culture, flavonoids, biotic elicitors, abiotic elicitors.
Co-Authors Annisa Ragdha Eka Nuryuanda Auralia Putri Pratama Bambang Kuswandi Bawon Triatmoko Debi Listiayana Dedi Irawanto Dewi Dianasari Dianasari, Dewi Ema Desia Prajitiasari Ema Rachmawati Endah Puspitasari Endah Puspitasari Evi Umayah Ulfa Fauzia Ken Nasititi Ika Barokah Suryaningsih Jacinda Na’ilahafitra Kinanthi Putri Rizki Lisa Kusuma Wardhani Mochammad Amrun Hidayat Nasititi, Fauzia Ken Novia Hilma Noviani Tri Wahyuning Nuri Nuri Nuri Nuri Rismatul Khoiroh Siti Muslichah Yuniatin Hasanah