cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
pharmacon@ums.ac.id
Editorial Address
Jl. A. Yani 1 Pabelan Kartasura Surakarta 57162 INDONESIA
Location
Kota surakarta,
Jawa tengah
INDONESIA
Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Arjuna Subject : -
Articles 17 Documents
 1   2 
Search results for , issue "Vol 21, Special Issue 1, 2024" : 17 Documents clear
Antibiotic Evaluation of Hospitalized Pneumonia Patients Using Gyssen or DDD 100 Bed Days or DDD 1000 Patient Days: Review Syam, Ricky Aditya; Karuniawati, Hidayah
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23589

Abstract

Pneumonia remains one of the significant infectious diseases in society, especially in developing countries such as Indonesia, with its prevalence continuing to increase year after year. Pneumonia caused by bacteria requires antibiotic treatment, increasing antibiotic use and presenting a risk of antibiotic resistance. Therefore, this study evaluated the use of antibiotics in hospitalized pneumonia patients, with qualitative and quantitative approaches using the Gyssen and ATC / DDD methods. The articles taken as research samples involve a publication period from 2013 to 2023. The data included include the Gyssen parameter, DDD/100, and DDD/1000 patient days. The synthesis showed that ceftriaxone and meropenem antibiotics were the top choices, with values of 1547.735 DDD/100 bed days and 3011.2 DDD/1000 patient days, respectively. Ceftriaxone was documented in 21 journals, while in 8 of 37 journals, meropenem considered antibiotic use in hospitalized pneumonia patients. Evaluation of the quality of antibiotic use showed the highest level in category (0) at 93.7%, followed by (IVa) at 67.6%. Meanwhile, analysis of bacterial resistance to antibiotics showed that Klebsiella pneumonia was the most resistant bacteria, especially to antibiotics carbapenems, ertapenem, doripenem, cephalosporin generation 3, extended-spectrum cephalosporin, and piperacillin/tazobactam, with significant values 0.05%. These findings provide deep insight into patterns of antibiotic use in hospitalized pneumonia patients while identifying potential areas for improving the quality of antibiotic use and treating bacterial resistance. Thus, this study contributes to efforts to optimize pneumonia management and reduce the impact of antibiotic resistance in the community.
Study of Liquid Self-nanoemulsifying Drug Delivery System (L-SNEDDS) that Use Oleic Acid as the Oil Phase: Literature Review Lestari, Ratih Guswinda; Sukmawati, Anita
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23468

Abstract

Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a nanoemulsion system that can be used to increase the bioavailability of drugs that are hardly soluble in water and have low bioavailability. Oleic acid, a saturated fatty acid that is found in many vegetable oils, is an oil that is often used for the oil phase in SNEDDS. Therefore, this review article aims to review, study, analyze and explore the optimum formula of SNEDDS that use oleic acid as the oil phase. The articles were searched via Google Schoolar, Science Direct, and Pubmed. The total number of articles is 464 articles. The total number articles that include exclusion criteria is 453 articles. The total article that use is 11 articles. SNEDDS, which uses oleic acid as the oil phase, produces droplet sizes of 19.75-190.03 nm with a polydispersity index of 0.278-0.532. Zeta potential value, only 2 articles have a zeta potential value above +/-30, that is mefenamic acid SNEDDS and furosemide SNEDDS. Overall, SNEDDS which uses oleic acid as the oil phase has a better dissolution and bioavailability profile compared to the commercial product or the pure drug. If solubility and bioavailability increase, it can increase the pharmacological activity of the drugs
A Systematic Review: Ethnomedicinal Uses And Pharmacological Activity Of Male Papaya Flower (Carica papaya L.) Purwaningsih, Purwaningsih; Indrayudha, Peni
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23474

Abstract

An extensively utilized plant in traditional medicine is the papaya plant (Carica papaya L.). Papaya plants are useful in almost all parts, one part of (Carica papaya  L.) that has potential is the papaya flowers. Papaya flowers are often used as a vegetable, but papaya flowers also have health benefits. The purpose of this review is to present thorough and current information on the ethnomedical usage and pharmacological activity of male papaya flowers. The search method was carried out using relevant keywords of the following databases: Google Scholar, ScienDirect, and NCBI. The results of the article search after going through the article selection process based on the database resulted in 25 relevant articles. Male papaya flowers contain many bioactive compounds known pharmacological activities, including antioxidant, anticancer, antibacterial, antidiabetic, analgesic, wound healing, antihyperlipidemic, bioinsecticide, tyrosinase inhibition and sun protection activity. This pharmacological activity may be caused by the large number of bioactive compounds contained in male papaya flowers.
Evaluation of The Quality of Pharmaceutical Care and Identification of Human Resources and Infrastructure in The Pharmacy Installation of Hospital in Sukoharjo in 2023 Pinasthika, Shinta; Nugraheni, Ambar Yunita
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23463

Abstract

The fulfillment of pharmaceutical Minimum Service Standards (MSS) an important role in improving the quality of pharmaceutical services and public health. This study aims to evaluate the quality of pharmaceutical care following the pharmaceutical minimum service standards as well as the identification of human resources (HR) and infrastructure facilities at the Hospital Pharmacy Installation in Sukoharjo. This type of research is descriptive non-experimental. Samples in the study included prescriptions and patients. Samples in the study included prescriptions and patients. MSS data on indicators of dispensing time for drug services, indicators of prescription suitability with the formulary and patient satisfaction analyzed based on Menkes RI Number 30 of 2022. Data on HR and infrastructure were analyzed based on Menkes RI Number 56 of 2014 and Menkes RI Number 72 of 2016. The results showed the indicator dispensing time does not meet the standard because dispensing time ≤ 60 minutes is 45.66% (less than standard of 80%). The results on the indicator of the suitability of prescriptions with the formulary are 89.5% (≥80%), and the patient satisfaction indicator is 91.25% (76.61%) so it has met the standard. The results of HR identification based on the classification of the number of pharmaceutical personnel have met the standard. However, classification based on pharmacist workload and identification of facilities and infrastructure does not meet the standard.
Application Of Factorial Design To Optimize Lubricant Concentration And Granule Mixing Time In The Formulation Of Sour Star Fruit (Averrhoa bilimbi L) Ethanolic Extract Tablet Setiyadi, Gunawan; Putri, Yola Veranita
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23590

Abstract

The use of lubricant in tablet compaction can reduce both intergranular and granule to die-wall friction that in turen improve granule flow properties and reduce adhesion of granule mass to the die wall. However, the concentration and method of adding lubricants into granule mass has also been known to influence the physical properties of tablets, such as hardness, friability, disintegration time and dissolution. This study aimed to apply 2-factor-2-level-factorial (22) design to determine the effect of lubricant concentration in granule mass (factor A) and the granule mixing time (factor B) on the physical properties of granules and tablets of starfruit leaves (Averrhoa bilimbi L.) ethanolic extract and to obtain the optimum setting of both factors that results in responses that satisfy most of the predefined criteria. The factorial design was set as follows: (l) = 2.5%, 5 minutes, a = 5%, 5 minutes, b = 2.5%, 15 minutes, and ab = 5%, 15 minutes. The lubricant used was a mixture of magnesium stearate and talc in a ratio of 1:9. Experimental design and optimization were carried out using Design Expert 13.0 software with granule flowability, angle of repose, and compressibility, as well as tablet weight uniformity (%RSD), hardness, friability, and disintegration time as responses. Optimum results were obtained with 2.5% lubricant and 5 minutes factor combination. The verification test to the optimum parameters showed that the granule flowability, angle of repose, tablet hardness and tablet friability are within the prediction interval range (PI 95%).
Formulation and Characterization of Gels of Telang Flower Extract (Clitoria Ternatea L) with Variations of Carbopol Concentration and Antioxidant Activity Test Using DPPH Methods Nurwaini, Setyo; Fatimah, Mutiara Nurul
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23469

Abstract

Telang flower (Clitoria ternatea L) has antioxidant activity. Formulation in gel form provides convenience in the use of telang flower extract. This study aims to determine the effect of carbopol as a gelling agent on the physical properties of the gel and to determine the antioxidant activity of telang flower extract gel. Telang flower extract was obtained by maceration method. The gel was formulated with 3 variations of carbopol concentration, namely 0.5%, 1% and 2%. Characterization of Clitoria ternatea L. gel includes: organoleptic, homogeneity, pH, viscosity, spreadability and stickiness. Antioxidant activity test of telang flower (Clitoria ternatea L) using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The gel formulation of telang flower extract (Clitoria ternatea L.) from 3 formulas met the requirements. Gel with 2% carbopol concentration was the gel with the best characteristics: pH 5.82; viscosity 2,666 cP; spreadability 4.33 cm; stickiness 2.2 s. The Antioxidant activity test of telang flower extract gel showed strong category with an IC50 value of 97.72 ppm. Carbopol has an influence on the physical properties of telang flower extract (Clitoria ternatea L) gel and strong antioxidant activity of bay flower extract gel.
Relationship Between Knowledge and Behaviour of Self-Medication in Cough Towards One Community in East Java Netta, Shella Naradewi; Hajma, lilla Prapdhani Agni
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23465

Abstract

Coughing is often considered a minor illness, but in reality it disrupts daily activities. In dealing with coughs, treatment can be done independently or known as self-medication. In Indonesia, the practice of self-medication tends to increase. However, improvement in self-medication practices is often not aligned with adequate knowledge. This research aims to determine the profile of self-medication in society, the level of self-medication knowledge, the level of self-medication behaviour, and analyze the relationship between knowledge and behaviour. Questionnaires that have been tested for validity and reliability on 30 respondents are used as instruments. The data collection method was carried out cross-sectionally using a purposive sampling technique in September-November 2023. Respondents in this study were community in one of the regions in East Java with the inclusion criteria. The total respondents in this study were 363 respondents. Univariate analysis was carried out on self-medication profile, level of knowledge, and level of behaviour. The relationship between level of knowledge and behaviour was analyzed using the Spearman Rank method. In this study, the average community knowledge score was 76.86% with a good level of knowledge (54.3%). In the behavioral variable, the average value is 77.39% with the good behaviour level category (59%). There is a relationship between the level of knowledge and cough self-medication behaviour in the community as evidenced by a sig. (2-tailed) 0.000. A positive correlation coefficient of 0.49 was obtained thus indicating that the strength of the relationship between knowledge level and behavior is moderate.
Purification of Curcumin Derivate (1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on) Using Chromatotron Harimurti, Sabtanti; Fadhilah, Alfan; Widada, Hari; Damarwati, Vella Lailli
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23593

Abstract

Curcumin derivate with IUPAC name 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on is also known as Gamavuton-0 (GVT-0) reported has an activity as anti-inflammation and anti-cancer. GVT-0 can be synthesized using vanillin and acetone as starting material by aldol condensation. Purification process of GVT-0 after synthesis usually was done using maceration. This method resulting un-pure GVT-0, therefore, another separation technique of Chromatotron was chosen. This research aims to investigate the effectiveness of Chromatotron towards the purity of GVT-0. The study was started by GVT-0 synthesis. The synthesis was using 4.4 mole of vanillin and 1 mole acetone as the raw material. Microwave irradiation was used as the energy source. Isolation of GVT-0 using hot water maceration. Further, the purification of GVT-0 was conducted using Chomatotron. First step of purification using Chomatotron was preparing best ratio between hexane and chloroform as solvent to remove vanillin. Further, the best combination of solvent was used to separate all the vanillin remaining in the bulk of GVT-0. Last step after all vanillin was removed, the GVT-0 remining in the silica was elucidated using chloroform. The purity was evaluated using Melting-point analysis and Thin Layer Chromatography (TLC) with four different mobile phases. Based on the data of melting point and TLC, a pure GVT-0 was obtained. The Chomatotron may be recommended for purification of GVT-0, however this method consumes a lot of organic solvent that may need to be improved in the future with more environmentally process
Formulation And Evaluation Of Telang Flower (Clitoria Ternatea L.) Extract Gel Preparation With Tragacanth As Gelling Agent And Antioxidant Activity Test Nurwaini, Setyo; Amanda, Alifah Tasya
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23470

Abstract

Telang flower has antioxidant activity as a scavenger of free radicals. Formulation in gel form can facilitate its use as a cosmetic preparation. This study aims to determine the characteristics of telang flower extract gel at different concentrations of tragacanth as a gelling agent and its antioxidant activity.Gel formula of telang flower extract with different concentration levels of tragacanth, namely 3%, 4%, and 5%. Gel evaluation includes organoleptic test, homogeneity, pH, spreadability, stickiness, and viscosity. The best formula will be tested for antioxidant activity.Based on the gel characteristics of telang flower extract, F3 has good physical properties, namely pH value of 7.28 ± 0.06, viscosity of 2133.3 ± 23.09 cP, spreadability of 6.05 ± 0.13 cm, and stickiness of 1.17 ± 0.07 seconds. The telang flower extract exhibited an IC50 value of 71.125 ppm, classifying it as strong antixodant. The IC50 value of telang flower extract gel was 92.867 ppm
Optimization of Ethanol Extract Preparation Gel Formula from the Combination of Lime Peel and Neem Leaves : Optimum Physical Properties and Antibacterial Activity Rahmana, Andrea Yovva; Nurwaini, Setyo
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23586

Abstract

Lime peel (Citrus aurantifolia) and neem leaf (Azadirachta indica) have antibacterial properties, especially against Staphylococcus aureus. These two ingredients can be used to treat various skin problems caused by Staphylococcus aureus. This study aimed to determine the optimal ratio of 96% ethanol extract of lime peel and neem leaves to produce a gel formula with optimum physical properties and antibacterial activity. Physical properties tested were pH test, adhesion test, spreadability test, and viscosity test. Antibacterial activity was measured by inhibition zone diameter when tested by the well method. There were 8 gel formula with the various ratio of components of lime peel and neem leaves extracts, FI (8:2), FII (6.5:3.5), FIII (5:5), FIV (3.5:6.5), FV (2:8). The optimization method used was Simplex Lattice Design using the Design Expert 11 application (Trial). The optimum formula obtained from the Design Expert was verified and analyzed using the SPSS one-sample t-test with a 95% confidence level. The optimum formula of lime peel and neem leaves obtained were 8.00%:2.00% with a desirability value of 0.471. The one sample t-test showed that the results were not significantly different between the predicted and verified values.

Page 1 of 2 | Total Record : 17

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 21, Special Issue 1, 2024 Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021 Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2012) Vol 13, No 2 (2012) Vol 13, No 1 (2012) Vol 13, No 1 (2012) Vol 12, No 2 (2011) Vol 12, No 2 (2011) Vol 12, No 1 (2011) Vol 12, No 1 (2011) Vol 11, No 2 (2010) Vol 11, No 2 (2010) Vol 11, No 1 (2010) Vol 11, No 1 (2010) Edisi Khusus: RAKERDA, SEMINAR, PID IAI More Issue