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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Pharmacon Jurnal Farmasi Sains dan Komunitas Community Empowerment Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Jurnal Medika: Medika
Hari Widada, Hari
Faculty of Pharmacy, Universitas Gajdah Mada. Yogyakarta, Indonesia.
Arts Humanities Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Analisis Kandungan Vitamin E pada Buah Borassus flabellifer Linn. Menggunakan High Performance Liquid Chromatography (HPLC) Widada, Hari
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 3 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i3.2478

Abstract

Vitamin E hanya disintesis di dalam tanaman dan sumber terbanyak adalah tanaman yang menghasilkan minyak, termasuk buah siwalan (Borassus flabellifer Linn.). Siwalan merupakan salah satu tanaman jenis palma yang dapat tumbuh baik di ekosistem pantai dan telah diketahui mempunyai banyak manfaat. Penelitian ini bertujuan untuk menetapkan kandungan vitamin E dalam buah siwalan. Ekstraksi vitamin E dalam buah siwalan dilakukan dengan ekstraksi kering dan ekstraksi basah untuk membandingkan perolehan kadar vitamin E-nya. Ekstrak dianalisis dengan sistem HPLC fase normal dengan sistem kolom: C18, fase gerak: etil asetat/ asam asetat/ heksana = 1/1/198, kecepatan alir 2 mL/ menit, detektor UV-Vis 295 nm dengan volume injeksi 20,25L. Validasi metode analisis untuk menentukan parameter uji kesesuaian sistem, linearitas, limit of quantification, akurasi, presisi dan recovery. Hasil ekstraksi buah siwalan diperoleh rendemen ekstrak basah sebesar 0.152% dan rendemen ekstrak kering sebesar 5.77%. Parameter validasi metode analisis berturut-turut meliputi uji kesesuaian sistem 1.34%, linearitas r2 0.995, limit of quantification 2.14 ng/ mL, akurasi % difference 6.33%, presisi intra-day 4.39%, inter-day 3.88% dan recovery 3.49%. Hasil proses validasi memenuhi kriteria menurut FDA (2001). Hasil analisis kandungan vitamin E diperoleh kadar rata-rata ekstrak kering sebesar 3.19% ± 0.12% dan ekstrak basah sebesar 4.76% ± 0.17%.Vitamin E is only synthesized in plants and is the largest source of oil-producing crops, including fruit palm (Borassus flabellifer Linn.). Siwalan is one type of palm plants that grow well in coastal ecosys­tems and have been known to have many benefits. This study aims to establish the amount of vitamin E in the palm fruit. The extraction of vitamin E in the palm fruit is done by extraction of dry and wet extrac­tion to compare the acquisition of vitamin E was. Extracts were analyzed by normal-phase HPLC system with a system of columns: C18, mobile phase: ethyl acetate / acetic acid / hexane = 1/1/198, flow rate of 2 mL / min, UV-Vis detector at 295 nm injection volume of 20 uL. Validation of analytical methods to determine the parameters of the system suitability test, linearity, limit of quantification, accuracy, preci­sion and recovery. Results obtained by extraction of palm fruit extract yield amounted to 0152% wet and dry extract yield of 5.77%. Parameter validation of analytical methods respectively include system suit­ability test 1:34%, 0995 r2 linearity, limit of quantification 2:14 ng / mL, 6:33 Difference%% accuracy, precision intra-day 4:39%, 3.88% inter-day and 3:49% recovery. Results of the validation process meets the criteria according to the FDA (2001). Results of the analysis of the content of vitamin E obtained an average level of dry extract of 3:19% ± a 0.12% and amounted to 4.76% wet extract ± 0:17%.
SAGO STARCH AND SODIUM ALGINATE AS NATURAL CROSSLINKING FOR CAPSULE ALTERNATIVES Harimurti, Sabtanti; Mulyanti, Amelia Nur'afni; Kusnindyasita, Anisa; Widada, Hari; Febriansah, Rifki; Suwanda, Totok; Muhtadi, Muhtadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8856

Abstract

Capsule shells are generally made from gelatin. The gelatin that is spread in the world is commonly derived from pigs. This animal is forbidden to be consumed by Muslims. This issue is due to the halal aspect. Sago starch and sodium alginate are halal materials that are capable of gelatinizing. This property made it able to be molded as a capsule. This research aims to determine the formula of sago and sodium alginate as a capsule and the evaluation. Three formulas were made with the ratio of sago and sodium alginate 100%: 0% (formula 1), 50%: 50% (formula 2), and 0%: 100% (formula 3). The capsule was manually molded using a food-grade stainless steel capsule mold. The size of the capsule, weight uniformity, swelling, and disintegration time were determined for a physical evaluation. SLD was used to determine the best formula, and the validation was done using One-sample T-test. The evaluations of the capsule shell were found ranged as follows: the size specifications were 21-22 mm, the body diameter was 6.1-7.2 mm, the cap diameter was 13.6-13.8 mm, weight uniformity was 0.10-0.26 gram, the swelling test was 433-1583%, and the disintegration time was 10.20-14.43 minutes. The best formula based on the SLD of the experiment was formula 3, which are two parameters that met the requirements, i.e., swelling and disintegration time. The sago and sodium alginate were crosslinked, and the capsule was made. However, the performance dislike of gelatin capsules. Continued research shall be done to find the optimum formula and its characteristics for alternative material on halal capsules.
Emergency medicine management training for scouts of Kwarda DIY: Improving disaster response capacity Ghozali, Muhammad Thesa; Widada, Hari; Anggraini, Laelia Dwi; Styawan, Anita Agustina; Septiyanna, Rosemaladewi; Nisa, Lia Fakila; Faatin, Salsa
Community Empowerment Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12834

Abstract

Indonesia’s high disaster vulnerability necessitates highly competent emergency medical response volunteers. This training program aimed to enhance the emergency medicine management skills of Disaster Response Scouts in the Yogyakarta Special Region (DIY). Thirty participants from five sub-districts (Gunungkidul, Sleman, Kulonprogo, Bantul, and Yogyakarta City) attended the training held May 19, 2024, at the DIY Regional Scout Hall. The training integrated mini-lectures, small group discussions, and hands-on practice for a holistic approach to theory and practical skills. Pre-test and post-tests, along with simulation observations, evaluated the training's effectiveness. Results showed a significant increase in average scores from 50.83 (pre-test) to 86.25 (post-test, p < 0.0001, Wilcoxon Test), with 66.7% of participants achieving “very good” status post-training (compared to 13.3% pre-training). This training enhanced not only participant knowledge and skills but also fostered collaboration among DIY Regional Scouts, health institutions, and academia.
Pelatihan Simple Emergency Management untuk Peningkatan Kapasitas Kader LLHPB ‘Aisyiyah Gamping Ghozali, Muhammad Thesa; Damarwati, Vella Lailli; Orbayinah, Salmah; Widada, Hari; Kurniawan, Nanang; Dini, Riyanti Raf’al; Abidin, Ghaida Rahmani Putri
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/48wsk951

Abstract

The purpose of this community service is to improve the capacity of LLHPB PCA ‘Aisyiyah Gamping cadres in managing emergency drug management through Simple Emergency Management training, as well as building an independent and sustainable community emergency response system. This community service activity uses the Asset-Based Community Development (ABCD) approach which emphasizes strengthening the internal potential of the community, such as LLHPB cadres, local pharmacists, and networks with the Drug Assistance Team (TBO) Sedative of the Pharmacy Study Program, Muhammadiyah University of Yogyakarta and BPBD. The implementation stages include asset identification (discover), formulation of a shared vision (dream), action planning (design), to implementation and sustainability (destiny) through participatory and contextual Simple Emergency Management training. As a result, a Drug Alert Team was formed and there was a significant increase in the understanding and skills of the cadres, demonstrating the effectiveness of the ABCD approach in building community independence in dealing with emergency situations. The results of the activity showed an increase in community capacity in managing emergency drugs. The Simple Emergency Management training succeeded in improving participants' understanding based on the results of the pre-test and post-test. Local cadres play an active role as facilitators, and the training process is designed in a participatory manner according to the community's potential. This program not only improves technical knowledge, but also strengthens the independence and sense of community ownership in dealing with emergency situations.
Isolation and Protein Profile of Chicken, Pork and Processed Products Nugget with Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) Method Orbayinah, Salmah; Widada, Hari; Anindita, Nosa Septiana; Mohdar, Adhe Filiyahtri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007099

Abstract

Chicken nuggets are known as a nutritious processed meat food ingredient and are widely available in supermarkets and are very popular with consumers. Nugget is made by mixing it with various other additives, so that it raises a bit of concern about the ingredients used in terms of halal. The purpose of this study was to determine and analyze the protein profile of chicken, pork, nugget references, and nugget commercials. The method used in this study is an experimental laboratory analysis of variables using SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis). The data were obtained from observing the description of protein bands, calculations were carried out using linear regression, and descriptive analysis was carried out. The results of this study showed 4 protein bands in pork that were not found in chicken meat with a molecular weight of 62.95 kDa, 41.86 kDa, 31.28 kDa and 17.46 kDa. Based on the protein fraction, the protein referred to as BM 31.28 kDa is Tropomyosin and BM 17.46 kDa is Troponin C. Nugget reference shows similarities to the protein bands found in pork, whereas nugget commercially did not show specific similarity. 
Synthesis and Characterization of Ethanolic Extract of Red Betel Leaf as an Antiseptic Gel Harimurti, Sabtanti; Hidayaturahmah, Rizky; Arsito, Puguh Novi; Febriansah, Rifki; Widada, Hari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006555

Abstract

Hand hygiene is one way to maintain health. There are several ways to clean hands, namely by washing hands and applying a hand sanitizer. The use of hand sanitizer is increasing due to its practical nature. Utilizing natural materials for preparing hand sanitizer widely available around us will be beneficial, one of which is red betel leaf which some people of Indonesia empirically use for antiseptic. This study aims to develop antiseptic gel preparations with ethanolic extracts from red betel leaves. The extraction was done using maceration with 70% ethanol solvent. The formula for choosing a carbomer as a gelling agent with the red betel leaf extract concentration was 0%, 2.5%, 5%, 10%, and 15%. The assessments of the gel were physical and antiseptic evaluations. The physical evaluations included an organoleptic, pH, viscosity, adhesion, and dispersion tests. The antiseptic activity was determined by a replica method. The physical evaluation results of red betel gel revealed that the higher the red betel leaf extract levels are, the darker the green color will be, and the lower the pH and viscosity will be. Furthermore, the antiseptic activity showed that red betel extract gel effectively reduced the number of bacterial colonies. 
Purification of Curcumin Derivate (1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on) Using Chromatotron Harimurti, Sabtanti; Fadhilah, Alfan; Widada, Hari; Damarwati, Vella Lailli
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23593

Abstract

Curcumin derivate with IUPAC name 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on is also known as Gamavuton-0 (GVT-0) reported has an activity as anti-inflammation and anti-cancer. GVT-0 can be synthesized using vanillin and acetone as starting material by aldol condensation. Purification process of GVT-0 after synthesis usually was done using maceration. This method resulting un-pure GVT-0, therefore, another separation technique of Chromatotron was chosen. This research aims to investigate the effectiveness of Chromatotron towards the purity of GVT-0. The study was started by GVT-0 synthesis. The synthesis was using 4.4 mole of vanillin and 1 mole acetone as the raw material. Microwave irradiation was used as the energy source. Isolation of GVT-0 using hot water maceration. Further, the purification of GVT-0 was conducted using Chomatotron. First step of purification using Chomatotron was preparing best ratio between hexane and chloroform as solvent to remove vanillin. Further, the best combination of solvent was used to separate all the vanillin remaining in the bulk of GVT-0. Last step after all vanillin was removed, the GVT-0 remining in the silica was elucidated using chloroform. The purity was evaluated using Melting-point analysis and Thin Layer Chromatography (TLC) with four different mobile phases. Based on the data of melting point and TLC, a pure GVT-0 was obtained. The Chomatotron may be recommended for purification of GVT-0, however this method consumes a lot of organic solvent that may need to be improved in the future with more environmentally process
Bromelain-Extracted of Virgin Coconut Oil: Physical and Chemical Stability in Different Temperature During the Storage Harimurti, Sabtanti; Sukamdi, Dyani Primasari; Widada, Hari; Sari, Hasna Fadia; Amid, Azura
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6857

Abstract

The bromelain-enzymatic reaction is applied in virgin coconut oil (VCO) production. Hydrolysis of the emulator by bromelain enzyme in coconut milk during fermentation maximized further the separation of oil and water. In the higher demand for VCO in many industries, the VCO stability during transportation and storage must be evaluated.  The research aims to evaluate the physical and chemical stability of the effect of temperature in the storage. VCO's physical and chemical stability was evaluated under two different temperature and storage periods: an elevated temperature of 50°C for 10 days and room temperature (27-30°C) for 50 days. The storage was conducted in a clear glass bottle. The evaluation was based on physical and chemical stability tests before and after storage, including organoleptic, pH changes, density, viscosity, acid number, peroxide number, and saponification number. Based on the data, the quality of the VCO after storing at 50°C for 10 days and 27-30°C for 50 days was found to be changed for pH, specific gravity, viscosity, acid number, peroxide number, saponification number, while for the appearance was found to be no changes. The VCO was very sensitive to environmental effects. Therefore, it is necessary to find the best storage chamber and temperature for stabilizing the VCO.
Co-Authors Abidin, Ghaida Rahmani Putri Agustina Styawan, Anita Amid, Azura Arsito, Puguh Novi Dini, Riyanti Raf’al Faatin, Salsa Fadhilah, Alfan Faray, Kartini Hidayaturahmah, Rizky Kurniawan, M. Fariez Kusnindyasita, Anisa Laelia Dwi Anggraini, Laelia Mohdar, Adhe Filiyahtri Muhammad Thesa Ghozali Muhtadi Muhtadi Mulyanti, Amelia Nur'afni Nanang Kurniawan Nisa, Lia Fakila Nosa Septiana Anindita Rifki Febriansah Sabtanti Harimurti, Sabtanti Salmah Orbayinah Sari, Hasna Fadia Septiyanna, Rosemaladewi Totok Suwanda Vella Lailli Damarwati