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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Skrining Aktivitas Antibakteri Ekstrak Etanol 70% Sepuluh Daun Tanaman Terhadap Klebsiella Pneumoniae Qolbi, Nurul; Yuliani, Ratna
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i1.6169

Abstract

Klebsiella pneumoniae causes several diseases such as chronic obstructive lung disease and community pneumonia. The antibiotics used for treating the infectious diseases cause several side effects. Therefore, alternative medicines which have minimal side effects are needed. This research aimed to investigate antibacterial activity of ten ethanolic extract of leaves against K. pneumoniae, identify compounds and active compounds in extract which has the highest antibacterial activity. Compounds in leaves were extracted using 70% ethanol with maceration method. The disk diffusion method was used for screening antibacterial activity against K. pneumoniae. The identification of group of compounds in extract with the largest inhibitory zone diameter was done using Thin Layer Chromatography (TLC) and bioautographic test was performed to determine the active compounds. The results of antibacterial activity screening tests showed that all extracts have antibacterial activity except bamboo leaf extract. Breadfruit extract (Artocarpus altilis) has the highest antibacterial activity with diameter of inhibition zone of 18,33 ± 5,57 mm. Breadfruit extract contains tannin, polyphenol, alkaloid, terpenoid, saponin, and the active antibacterial compounds were terpenoid and saponin.
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Apotek Kabupaten Rembang Utami, Sally Astya; Cholisoh, Zakky
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.5990

Abstract

Government regulations regulate pharmaceutical care standards at pharmacies to ensure the quality of pharmaceutical care to patient. The impact of not implementing a good pharmaceutical service activity is that medication errors can occur in the pharmaceutical service process. The study aimed to determine if there is any correlation between customer satisfaction and the application of the standards of pharmaceutical care in Rembang. This is a cross sectional survey research with purposive sampling technique. Data was obtained by distributing questionnaires filled by community pharmacists and patients attending community pharmacies. The study was conducted at 4 (four) community pharmacies in Rembang. Data were analyzed using Pearson correlation. Questionnaires were filled by 4 pharmacists’ measuring aspects of facilities, infrastructure and services. The level of satisfaction of 94 community pharmacies’ patients were measured in 5 dimensions i.e. reliability, assurance, tangibles, empathy and responsiveness. The quality of pharmaceutical care scoring and patients’ satisfaction showed no relationship p (95%; 2 tailed) = 0.503.
Analisis Rasionalitas Penggunaan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap RSJD Atma Husada Mahakam Samarinda Tahun 2016 Saputri, Rika Paramitha; Sulistyawati, Elina Endang; Untari, Meta Kartika
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i1.6180

Abstract

Schizophrenia is a chronic heterogeneous syndrome characterized by irregular mindset, delusion, hallucination, improper behavioral changes, and psychosocial dysfunction. The purpose of this research was to know the pattern of antipsychotic use and rationality of antipsychotic use in schizophrenia patient at Inpatient Installation of Atma Husada Mahakam Psychiatric Hospital Samarinda  in 2016 based on right indication, right drug selection, right patient, and right dose. The study was use descriptive non-experimental method with retrospective data collection from medical record of patients with purposive sampling technique. The samples used was 94 patients who received antipsychotic with age range 17-55 years and had a complete medical history. The data obtained were analyzed according to Guideline Texas Medication Algorithm Project Procedural Manual of Schizophrenia Treatment Algorithms. Based on the results obtained data of single antipsychotic the most widely used was haloperidol as 39 prescriptions (53.42%). The use of the most commonly prescribed combination of two antipsychotic was combination of clozapine-haloperidol as 19 prescriptions (38,00%), while combination of three prescribed antipsychotic was combination of chlorpromazine-risperidone-clozapine and haloperidol-risperidone-clozapine each as 1 prescription (50,00%). The rationale of antipsychotic use obtained percentage of right indication was 100%, right drug selection 95,20%, right patient 100%, and right dose 100%.
Reduksi Kadar Besi Dalam Air Sumur di Lingkungan Universitas Muhammadiyah Surakarta dengan Filter Pawarti, Hesti; Citradewi, Lia Intan; Fadhilla, Aulia Tassya; Suhendi, Andi
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6527

Abstract

Iron was silvery white, clay, and can be formed.  it was usually obtained as hematite in nature. Iron was a chemical element that could be found in almost all places on the face of the earth, in all parts of the geological layer, and all bodies of water. In surface water, Fe was rarely found more than 1 mg / L, but in the water, Fe content could be much higher. When it accumulated in the body, iron could cause health problems, such as skin irritation, respiratory problems, and cause cancer in a long time. This study aims to determine the reduction of iron content in well water at the Universitas Muhammadiyah Surakarta (UMS) using the Spectrophotometry method with phenanthroline reagents. The samples were taken as many as five points in three different regions, namely Tanuragan (near the river), Menco and Nilasari (dense settlements), and Gonilan (near the rice fields) showed positive results containing iron with the highest levels in the sample without filtering at 9,478 ppm. These levels decreased after filtration using four filters, namely filters made of carbon, cotton, foam, carbon three layers in each sample. The iron content reduction was best to use cotton filters with 100% reduction in percent.
Formulasi dan Karakterisasi Sediaan Nanoemulgel Serbuk Lidah Buaya (Aloe Vera L.) Imanto, Teguh; Prasetiawan, Roseh; Wikantyasning, Erindyah Retno
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8114

Abstract

Aloe vera L. contains antiseptic saponins and anthraquinone complexes as antibacterial. This research was conducted to formulate aloe vera powder into nanoemulgel, characterize and test its physical properties, and to know the effect of gelling agent concentration (carbopol and chitosan) on nanoemulgel. Emulsion type used is oil in water (O / W) with surfactant tween 80 and co-surfactant propylene glycol. Nanoemulsion is characterized by percent of transmittance with UV-Vis spectrophotometer, also potential droplet and zeta size distribution with Particle Size Analyzer. Hydrogels consist of 4 combination formulas of carbopol 0.5%; 1%; 1.5%; 2% and 0.3% chitosan. The formula is tested for physical properties including organoleptic, pH, spreadability, adhesion, viscosity and stability with freeze thaw method. The results showed that the nanoemulsion droplet size was 65.05nm ± 13.49 with zeta potential of -0.1mV and the percent of transmittance above 98%. The result of physical properties of the four formulas shows that the different gelling agent concentration gives different physical properties of viscosity and spreadability. Overall, formula 3 has the best physical properties and physical stability compared to formula 1, 2 and 4.
Karakterisasi Fisik dan Aktivitas Antioksidan Masker Wajah Gel Pell Off Yang Mengandung Sari Buah Naga (Hylocerus polyrhizus) Setiawati, Ririn; Sukmawati, Anita
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7245

Abstract

Damaged skin due to free radicals from ultraviolet radiation can be prevented using antioxidants. Red dragon fruit (Hylocereus polyrhizus) containing antioxidants can be made into a peel off gel face mask using gelatin as a gelling agent to be applied easily to the skin. The purpose of this study is to determine the effect of various gelatin concentrations on the physical properties and antioxidant activity of peel off gels containing red dragon fruit juice. The peel off gels face mask were made using various gelatin concentration i.e 7.5% w/w (F1); 10% w/w (F2); and 12.5% w/w and containing 10% w/w red dragon fruit. The peel off gels then evaluated for physical properties and antioxidant activity using DPPH. The result showed that the increasing of the gelatin concentration would increase the drying time and adhesive ability of the peel off gels. The escalation of gelatin concentration from 7.5% w/w (F1) to 10% w/w (F2) did not affect the spreading ability of the peel off gel. However, the spreading ability of the peel off gel decreased with the increasing concentration of gelatin from 10% w/w (F2) to 12.5% w/w (F3). The antioxidant test of peel off gel had an average percentage of inhibition of 9.101% (F1); 12.469% (F2); and 15.109% (F3). Based on the results of physical properties and antioxidant activity showed that formula 2 was recomended.
Evaluasi Penggunaan Antibiotik pada Pasien Infeksi Saluran Kemih di Instalasi Rawat Inap RSUP X di Klaten Tahun 2017 Nawakasari, Nawang; Nugraheni, Ambar Yunita
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8113

Abstract

Urinary tract infections are infections are characterized by the presence of bacteria that grow and multiply in the urinary tract in excess of the normal amount. Based on the Indonesian Health Profile, urinary tract infections (UTI) are the 10 most common causes of death. Improper use of antibiotics can cause no therapeutic effect and resistance. This study aims to evaluate the accuracy of antibiotic use in patients with urinary tract infections in central hospital Klaten in 2017 covers the right indication, right patient, right medication, and right dosage. Research with non-experimental methods of data retrieval retrospectively and analyzed descriptively. The inclusion criteria in this study were adult patients 18-64 years old, inpatients suffering from urinary tract infections including cystitis and pyelonephritis, receiving antibiotics and complete medical record data. The results showed that patients with urinary tract infections in RSUP in Klaten 2017 had 72 patients with 76 antibiotic prescriptions. Based on the number of patients, the evaluation results showed the right indication is 100% and the right patients is 100%, while the exact evaluation results of the right drug is 96.05% and the right doses is 27,63%.
Pengaruh Perbedaan Metode Ekstraksi Metabolit Sekunder Streptomyces sp. GMR22 terhadap Toksisitas pada Sel BHK-21 Mentari, Diani; Naima, Mirtani; Wulansari, Riska; Widada, Jaka; Nuringtyas, Tri Rini; Wibawa, Tri; Wijayanti, Nastiti
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8032

Abstract

Streptomyces sp. GMR22 is local isolate from Wanagama 1 Forest in Yogyakarta. They have the potential to be developed to produce active compounds because have PKS and NRPS genes.The active compounds from isolation are strongly influenced by various factors, one of them is extraction techniques. Effect difference of extraction technique will be affected by the quality of secondary metabolites produced.The purpose of this study was to compare the cytotoxicity effects of secondary metabolites of Streptomyces sp. GMR22 which have extracted with different stages from previous studies. The extraction technique was carried out by multilevel separatory funnel extraction methods, which was first extracted using non-polar solvent (n-hexane) and then extracted using semi-polar solvent (ethyl acetate). This research is important because in previous studies (separatory funnel only extracted using ethyl acetate) with the use of the lowest concentration in the dengue virus antiviral test (further test) caused 100% of deaths in BHK-21 cells.This study indicate that multilevel extraction result in lower CC50 value than previous studies. There are 49.160 µl/ml (n-hexane extract) and 284.56 µl/ml (ethyl acetate extract) while water extract is 464,38 µl/ml. FTIR compound analysis show that the three extracts produced have different spectrum patterns, especially in the n-hexane and ethyl acetate extract. Value of CC50 is not too high, it is expected that the secondary metabolites contained in the extracts can be used for further analysis such as antiviral testing because it is safe for normal host cells such as BHK-21 cells
Uji Aktivitas Antijamur Gel Serbuk Lidah Buaya (Aloe vera L.) Berbasis Carbopol 934 Terhadap Candida albicans dan Trichophyton mentagrophytes Afifah, Hani; Nurwaini, Setyo
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7658

Abstract

Fungal infections that occur in the skin and nails were caused by fungi such as Candida albicans and Trichophyton mentagrophytes. Aloe vera contains saponins and acemannan that were effective as an antifungal. This study aims to determine the effect of carbopol concentration variation on aloe vera gel to antifungal activity of Candida albicans and Trichophyton mentagrophytes.Aloe vera powder was obtained from freeze drying aloe vera juice which had been frozen. Aloe vera powder was formulated in gel form using carbopol base with concentration 0.5; 1.0; 1.5; and 2.0 %w/w. The aloe vera gel was tested for its physical properties and then tested the antifungal activity using the diffusion method of wells.The result of evaluation of physical properties showed the high concentration of carbopol then pH, viscosity, adhesiveness increased, and spreading capacity decreased. The results of antifungal activity test showed that aloe vera powder had activity on Candida albicans and Trichophyton mentagrophytes with inhibition zone of 15 ± 3 mm and 13 ± 0,5 mm. Aloe vera gel test results with variation of carbopol concentration 0.5; 1.0; 1.5; and 2.0 %w/w did not affect the antifungal activity of Candida albicans and Trichophyton mentagrophytes.
Aktivitas Sitotoksik Ekstrak Etanol, Fraksi Etanol, Etil-Asetat, dan Heksana Kulit Jeruk Purut (Citrus hystrix DC.) terhadap Sel Kanker Payudara T47D Nabilla, Isya Isma; Indrayudha, Peni
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8173

Abstract

Kaffir lime peels (Citrus hystric DC.) have been reported that it has activity on HeLa cell. The purpose of this study was to determine the cytotoxic activity of ethanol extract, ethanolic, ethyl acetate, and hexane fraction of kaffir lime peels to T47D breast cancer cells and to identify the compounds of kaffir lime peels (Citus hystrix DC.). Extraction was done by maceration using 96% ethanol. The results of thick extracts were fractionated by the liquid-liquid partition method using solvent with different polarity, namely hexane, ethyl acetate, and ethanol. Cytotoxic activity tests were carried out using the MTT assay. Identification of compounds were carried out by Thin Layer Chromatography (TLC) method with silica gel GF 254 as a stationary phase. The mobile phase used was hexane:ethylacetate (6:4) for ethanol extract, ethyl acetate and hexane fractions, and hexane:ethylacetate (4:6) for ethanol fractions. IC50 ethanol extract, ethyl acetate and hexane fractions obtained were 268.49, 286.82, and 136.27 mg/mL respectively. Ethanol extract, ethyl acetate, and hexane fractions contain alkaloid, flavonoid, terpenoid and phenolic compounds, while the ethanol fraction contains only flavonoid compound. Cytotoxic results of ethanol extract, ethanol, ethyl acetate, and hexane fraction of kaffir lime peels did not active against T47D breast cancer cells.

Page 7 of 35 | Total Record : 345

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