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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Validation of Analytical Method LC MS/MS for Determination Isoniazid in Rats Serum Suhendi, Andi; Rohman, Abdul; Wahyono, Djoko; Nurrochmad, Arief; Manggo, Tasya Faradillah
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23293

Abstract

Determination of isoniazid concentration for therapeutic drug monitoring must produce valid values, so validation of the analytical method of LC-MS/MS needs to be carried out. This research aims to obtain valid method of LCMS/MS in order to determination isoniazid in rats serum. Sample preparation was carried out using the liquid-liquid extraction method using acetonitrile and methanol (2:1). The chromatography system was developed with a C18 column (ACQUITY UPLC® HSS T3 1.8 µm, 2.1 × 100 mm), the mobile phase was 70% acetonitrile with 0.1% formic acid (A), water with 0.1% formic acid (B), as well as methanol (C) with a flow rate of 0.3 mL/min, with gradient elution, detection in ESI+ mode with multiple reaction monitoring (MRM) at the transition 138 m/z → 121 m/z. The research results showed that the method was accurate with a % recovery of 96 - 113% and an RSD of 2.4 ± 0.9%. The precision value was obtained with an average RSD of 3.7 ± 2.4% for intra-day and 4.1 ± 2.3% for inter-day. Linearity showed good results with a correlation coefficient of 0.9956 in tests with 5 different concentrations. The LOQ and LOD values obtained from the linear regression equation were 0.1987 µg/mL and 0.0656 µg/mL respectively. The results showed that the LC-M/MS method was valid for determining isoniazid levels in rat serum
The Antihyperglycemic Effects of Glibenclamide and Matoa Leaves Extract (Pometia pinnata J.R. Forst & G. Forst) On Alloxan-Induced Rat Niam, Muhammad Labib Qotrun; Ziah, Nur Khalida; Fadhilah, Arini
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23665

Abstract

Glibenclamide (GLI) orally treatment for diabetes mellitus has adverse effects, such as hypoglycemia and weight gain. A synergistic effect achieved through the combination of natural constituents provides an alternative method for reducing adverse effects. The aim of this study was to investigate the contribution of 50% ethanol leaves extract (EEDM) to the administration of GLI in alloxan induced rats. A total of 20 rats were divided into 4 groups, namely normal control (NC), negative control, GLI 5 mg/KgBW group, and the combination of GLI 5 mg/KgBW and EEDM 100 mg/KgBW. Fasting blood sugar data (FBG), body weight, urine chemistry for 15 days of treatment measured. The results show that the ability of the GLI-EEDM combination to lower FBG is more effective and can withstand the hypoglycemic effects of GLI, in addition to improving the secretion of glucose in the urine.
Acute Toxicity Test Oral Effervecent Tablet Ethanol Extract of Ramania Leaves (Bouea macrophylla Griffith.) from South Kalimantan Aryzki, Saftia; Budi, Setia; Yanti, Yanti
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23472

Abstract

Ramania (Bouea macrophylla Griffith.) is a herbal plant that has antioxidant properties and inhibits free radicals. This research aims to evaluate the safety of effervescent tablets of the ethanol extract of ramania leaves with acute toxicity test. The experimental animals used in this research were female Wistar white rats. The acute toxicity test was carried out orally using the fixed dose method in 4 groups of animals with dose groups of 50 (I), 300 (II), 2000 (III) and 5000 mg/kgBW (IV) respectively. Observations were made on the LD50, clinical condition, body weight and pathological condition of the test animals. The results of this study were that there were no animal deaths in all groups of test animals during observation. In clinical conditions, the 4 groups experienced discoloration and hair loss, while in groups III and IV the animals were inactive (weak). Based on the body weight of the test animals from the 4 observation groups, the sig value 0.05 means there is no significant change in the weight of the test group, on day 7 the values are 0.921 and 0.314, meaning there is no significant change in the weight of the test group. However, in the weight group 14 day with a value of 0.031, it means there is a significant difference to the weight of the test group. It can be concluded that the effervescent tablets of the ethanol extract of ramania leaves have an LD50 5000 mg/kg BW with a classification of non-toxic to animals.
Nutritional Status and Quality of Life of Hemodialysis Patients in a Hospital in Yogyakarta Siswandi, Siswandi; Suhendra, Gugun; Wulandari, D; Simanjuntak, LB; Dania, Haafizah; Irham, Lalu Muhammad; Faridah, Imaniar; Adnan, Adnan; Perwitasari, Dyah Aryani
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23313

Abstract

Kidney failure is a disease with a moderate prevalence in Indonesia but causes the second highest cost burden in Indonesia. One of the treatments for chronic kidney failure is hemodialysis. The problem with hemodialysis patients is a high incidence of malnutrition, which can affect the patient's quality of life. Therefore, this study will examine the relationship between nutritional status and quality of life in chronic kidney failure patients undergoing hemodialysis. This research is a cross-sectional study by collecting medical record data and filling out questionnaires. Selection of research subjects with inclusion criteria aged ≥18 years, routinely undergoing hemodialysis, willing to participate in the study and complete medical record data. The patient's nutritional status was seen from the Body Mass Index (BMI), and the patient's quality of life was assessed by the Indonesian version of the Kidney Disease Quality of Life Short-Form (KDQoL-SFTM) questionnaire. The average age of the hemodialysis patients in this study was 53.70 years, the average body weight was 57.24 kg and the average height was 10.82 cm. Patients with lean BMI were 20.5%, normal 56.4%, overweight 23.1%, and obesity 2.6%. The domain of employment status is related to nutritional status (p-value 0.005). Nutritional status is related to the quality of life of hemodialysis patients in the occupational status domain.
Economic Losses of Unused Medicines Among Households in Grobogan Regency Sulistyaningrum, Indriyati Hadi; Santoso, Arifin; Fathnin, Fildza Huwaina; Nugrahaini, Atmarulin Dewi; Arfianto, Erki; Maulidina, Herlisa
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.19743

Abstract

All medicines that are stored and no longer used will be returned to pharmacies, health professionals, thrown away at medicine collection points or through household waste which can be considered as medicine waste. Medical waste from unused or expired medicines is thought to have financial consequences. This research is a descriptive quantitative observational study using a cross sectional study method. Sampling was carried out using the Snowball Sampling method. The sample obtained consisted of 271 household respondents from 19 sub-districts in Grobogan Regency. Data collection was carried out using a questionnaire indirectly via Google Form using descriptive analysis. The results of the research were that the largest number of drugs not used and stored based on therapeutic class was the analgesic group, namely Rp. 610,249 (37%). The total estimated value of unused drugs from 13 therapeutic classes is IDR. 2,609,388 with an average per household of IDR 9,629. The conclusion of the research is that the value of unused medicine can illustrate that the amount of wasted costs to households is IDR 9,629.

Page 35 of 35 | Total Record : 345

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