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Indonesian Journal of Cancer

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Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)

ISSN : 19783744 EISSN : 23556811 DOI : -

Core Subject : Health,

Health Professions

The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.

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Articles 448 Documents

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Profil Jantung Pasien Akut Limfoblastik Leukemia Anak yang Mendapatkan Terapi Anthracycline WAÃ¢Â€Â™U, DAVID VICTORY; MULATSIH, SRI; MURNI, INDAH KARTIKA
Indonesian Journal of Cancer Vol 11, No 1 (2017): Jan-Mar
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.452 KB)

ABSTRACTAcute lymphoblastic leukemia (ALL) is the most common malignancy in children under fifteen years of age. Advanced cancer therapy with anthracycline has increased survival rate but also chronic health problem and the most iscardiovascular. This study aims to describe cardiac events of ALL patients who received anthracyline during chemotherapy. We conducted a cross sectional study of childhood ALL who were hospitalized at DR Sardjito hospital between April and June 2016. Electrocardiography (ECG) and echocardiography were performed. Results of this study shows childhood ALL who received anthracycline may suffer from cardiotoxicity. Cardiac events can be found in all stage of chemotherapy.ABSTRAKLeukemia limfoblastik akut (LLA) adalah keganasan yang paling banyak dialami anak di bawah usia 15 tahun. Kemajuan pengobatan kanker dengan anthracycline telah meningkatkan angka kesintasan penderita LLA dan masalah kesehatan kronik, terutama penyakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui kelainan jantung pada pasien LLA yang mendapatkan kemoterapi anthracyline. Penelitian dilakukan secara potong lintang dengan subjek anak penderita LLA yang dirawat di rumah sakit Dr. Sardjito antara AprilâJuni 2016. Pasien menjalani pemeriksaan elektrokardiografi (EKG) dan echocardiography. Penelitian ini menyimpulkan bahwa anak penderita ALL yang mendapatkan anthracycline dapat mengalami kardiotoksisitas. Kelainan jantung dapat ditemukan pada semua tahap kemoterapi.

Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Rejeki, Marliana Sri; Arozal, Wawaimuli; Setiabudy, Rianto; Atmakusuma, Djumhana
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40 mg/m2 cisplatin-based chemotherapy. The levels of urinary KIM-1, NGAL and serum level of BUN and creatinine were measured before and after receiving cisplatin. Statistical analyses were ANOVA, Pearson, Spearman, Kolmogorov-Smirnov test and SPSS version 22.0.Result: There was a significant difference of delta BUN level (p=0.0001) and delta urinary NGAL level (p = 0.025) before and after treatment in all three groups; while delta KIM-1 level showed no significant difference in all three groups (p=0.275). Cisplatin may cause accumulated nephrotoxicity, which has dose-dependent manner.Conclusion: Measuring urinary NGAL level can detect an early stage of kidney dysfunction; however, it still cannot replace the role of BUN. Measurement of urinary KIM-1 level cannot detect kidney dysfunction.

Expression of γ-H2AX Using Immunofluorescence Assay as an Adaptive Response of PBMC in Radiation Workers at Dharmais Cancer Hospital Musthafa, Arifin; Djuita, Fielda; Kurnia, Iin
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Exposure ionizing of radiation in radiation workers has the potential to cause DNA damage in the form of double strand break as the beginning of genomic instability. DNA damage can be observed with γ-H2AX as the biomarker of DNA double strand breaks (DSBs). The formation of γ-H2AX in the nucleus can occur after radiation exposure of 1 mGy. This study aims to determine the radiation effects in radiation work environments as a study of adaptive responses of peripheral blood mononuclear cell (PBMCs) after radiation by observing γ-H2AX foci expression.. Methods: Blood samples from nine radiation workers and nine non-radiation workers were irradiated with doses 0 Gy, 1 Gy, 1.5 Gy, and 2 Gy. Detection of γ-H2AX foci was done by immunofluorescence assay. The mean of γ-H2AX foci was counted in 50 PBMCs per sample. The comparison mean of γ-H2AX foci was analyzed using tindependent test. Result: Based on the result study, there were no significant differences in the number of γ-H2AX foci without treatment (p = 0.807). The results of study showed that the formation of 2-3 foci per cell after exposure of 2 Gy increases along with the increasing irradiation doses. Conclusion: The mean of index of γ-H2AX foci in PBMCs within normal limits between non-radiation workers and radiation workers and level of risk DSBs damage is relatively similar after exposure at doses 1 Gy, 1.5 Gy, and 2 Gy.

The Role of Family Meeting In Dealing With Rejection Towards Hospital Discharge of Terminally Ill Cancer Patients Witjaksono, Maria; Yatiningsih, Dwi; Widaretno, Hesti; Asdiniah, Rani; Ame, Ame
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Rejection towards discharge planning of terminally ill patients and the role of family meetings to overcome such issue has not been evaluated. The aims of this study were to identify who and the reasons of rejection, to evaluate the effectiveness of family meetings, and to assess the important aspects in preparing homecare.Methods: This is an interventional study using queasy-experimental design. Samples of the study were family members of terminally ill patients who refused patient discharge from 1st of May to 31st of October 2016. Paired-Sample T-test was applied to analyze the result. Result: Rejections of discharge planning was mostly by the families. The most reason of rejection was lack of knowledge and skills in taking care of the terminally ill patients (40%). Family meetings solved the problem of rejection. The total score of 10 aspects needed in taking care of terminally ill patients was significantly increased (p=0.000). Conclusion: Family meetings effectively changed the attitude towards hospital discharged

Prevalence of Liver Cancer in Isfahan Province, Iran Ghamari, Zahra Tolou; Tadayon, Farhad; Mazdak, Hamid
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Liver cancer remains to grow worldwide. We aimed to describe the period prevalence (PP) and incidence rates (Irs) for liver cancer in Isfahan Province that is located in the center of Iran and ranked as the third province in terms of population.Methods: Information related to the Surveillance, Epidemiology, and End Results; (SEER) was collected from the Isfahan Cancer Registry. Period prevalence (PP) was calculated per 100,000 people. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by topography code (C22).Result: Among all registered liver cancer patients, 57% of the 920 cases were male. The mean age of the patients was 65.9 ± 16.8 years. Reported age in 13% of the patients was less than 50 years and as high as 84% were in between 50 to 90 years. With a total PP of 18.5 per 100,000 people, this value was 24.4% higher in males when compared to females (16.8 vs. 20.9). In the previous years, incidences were 3.9 (2011-2012), 5.3 (2012-2013), 4.9 (2013-2014) and 4.2 (2014-2015) per 100,000 people. There were 89% reported deaths among the total population.Conclusion: The PP for liver cancer in male population was approximately 24.4% higher than females. There was a 7.7% increase in the Irs over the study period. Further study toward estimation of the proportion of the causes of liver cancer and deaths due to infection of hepatitis B and C virus, exposure to aflatoxin, alcohol drinking and smoking seem to be advantageous. Therefore, the plan of healthcare system should focus on greater effort toward strategic evidence-based pharmacotherapy in Isfahan province/Iran.

An Indonesian Pregnant Woman with Lung Cancer and Liver Metastasis : A Case Report Jayalie, Vito Filbert; Priantono, Dimas; Amin, Zulkifli
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Lung cancer in pregnancy is a rare disease compared to other types of cancer. However, special issue should be applied in order to maximize benefit for mother without harming the fetus.Methods: We present a case of 37-year-old, five months pregnant woman who came to the hospital with chief complain of shortness of breath. Later on, she was found to have a stage IV Non-Small Cell Lung Cancer (NSCLC) with adenocarcinoma subtype.Result: This may be the first lung cancer in pregnancy reported in Indonesia. Being a developing country, several challenges emerged before diagnosing patient of having lung cancer.Conclusion: Careful considerations along with multidisciplinary approach are necessary to provide the best care for the patient.

Faktor yang Berhubungan dengan Terinfiltrasinya Areola dan Papilla pada Karsinoma Payudara Operabel HERIADY, YUSUF; ACHMAD, DIMYATI
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

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Mastectomy is one of the most frequent surgery performed for operable breast cancer and included resection of the nipple-areola complex (NAC). The risk of local recurrence behind the nipple areolar complex (NAC) is the main limitating of the nipple-sparing mastectomy (NSM) procedure. The aim of this study is to investigate the incidence and to determine associated risk factors with cancer infiltration to nipple-areola complex (NAC) in operable breast cancer patients. This is an observational analytic, cross sectional study using retrospective medical record of patients with mastectomy, at Soedarso Hospital Pontianak from 2006 to 2013. Results: In a period of 7 year, we included 310 patients, the mean age is 47,3 years (24-78 years). The NAC involvements 30,6%. In bivariate analysis showed that age, tumor size, tumor stage, lymh node status, lymvovascular invasion and tumor distance are associated with NAC involvement. In the multivariate analysis showed that only lymh node status (p = 0,001; prevalence odds ratio [POR], 1.52; 95% confidence interval [CI], 1.18?1.95), tumor distance (p<0.001; POR, 0.47; CI, 0.36?0.61) and tumor size (p = 0.012; POR, 2.05; CI, 1.17?3.60) are the only variables that remain significant predictors of NAC involvement. In the logistic regression analysis showed that high risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4. Conclusions: NAC involvement is 30,6%. Predictor factors of NAC involvement are lymh node status, tumor distance and tumor size. High risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4.

Comparison of Nuclear Matrix Protein-22 and Urine Cytology in Diagnosing Bladder Cancer Soedarso, Mohamad Adi; Wahyuni, YinYin; Tjahjati, Maria Immaculata
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Urine cytology (UC) is a classic marker used to detect bladder malignancy through urine examination microscopically at the presence of malignant transitional cells that are released. UC is also used to evaluate recurrence after past treatment. A new method that is simpler, faster and easier is by measuring protein in urine produced by malignant cells, namely nuclear matrix protein-22 (NMP-22). The aim of this study was to compare the diagnostic value of NMP-22 and UC to histopathological biopsy in diagnosing bladder carcinoma and to evaluate whether the NMP-22 test could be used for bladder carcinoma screening and recurrence monitoring.Methods: Diagnostic tests on 24 suspected bladder malignancies were performed by taking urine samples for NMP22 examination and UC. Sensitivity, specificity, positive predictive value and negative NMP-22 and UC on histopathological biopsy were analyzed.Results: Positive results were obtained in 21 (87.5%) and negative in 3 (12.5%) NMP22 examinations. The sensitivity, specificity, positive and negative predictive values of NMP-22 on histopathological biopsy were 95%; 67%, 95%, 67%. Sensitivity, specificity,positive predictive value and negative UC on histopathological biopsy were 38.1%; 100%, 100%, 18.8%.Conclusions: NMP-22 sensitivity is higher than UC in diagnosing bladder carcinoma. NMP-22 can be used for bladder carcinoma screening and for recurrence monitoring

Pengaruh Autoclave terhadap Properti Fisik dan Histopatologi Tulang: Sebuah Penelitian Dasar Rekonstruksi WIRATNAYA, I GEDE EKA; KAMAL, ACHMAD FAUZI; PATTIATA, RINO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

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Background: Autoclave autograft is a promising alternative procedure in surgical treatment of bone tumors. A minimum effective autoclaving time of 15 minutes at 134C to devitalise tumour cells. This study aims to know the effect of autoclave to physical properties and histopathology of bone.Methods: We performed experimental study in 28 femoral bone of goat (Capra Aergagus circus) at age 1?2 year old. We divide into two groups with simple random sampling to be 14 autoclave and 14 control group. Autoclaving was performed to the bone at 134C for 15 minute. We examined physical properties each 7 autoclave group to axial and bending force compared with physical properties of the control group. We also examined histopatology of the bone both groups. Independent t-test statistical analysis to evaluate the difference of axial and bending force between autoclave and control group.Results: There were significant difference between autoclave and control group in axial force (p = 0.000) and bending force (p = 0.03). Physical properties of autoclave bone decreased 58.58 % in axial force and 20.33% bending force to control group. Histopathology examination revealed that all osteocytes were death in autoclave group but without matrix changes.Conclusion: Autoclave at 134C for 15 minute caused physical properties of bone decrease and statistically significant difference. It also made all osteocytes died but without matrix disturbance.

Physical Wellbeing in Cervical and Breast Cancer Survivors: A Cross-sectional Study in Surabaya, Indonesia Purnama Sari, Ni Putu Wulan
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cervical and breast cancer are the two top leading cases of female cancer worldwide. Both cases share some similar clinical manifestations as specific symptoms of cancer. Physical wellbeing often decreased as frequent symptoms appear. This study aimed to compare and analyze the physical wellbeing among cervical cancer and breast cancer survivors (CCS and BCS).Methods: This cross-sectional study involved 47 CCS and 58 BCS in the district of Rangkah, Gading, and Pacarkeling, Surabaya, Indonesia. Instrument of Quality of Life – Cancer Survivors (QOL-CS) was used for data collection. Independent sample T test and Mann-Whitney U test were used in data analysis (α< .05). Results: More severe fatigue, appetite changes, pain, sleep disturbance, constipation, nausea-vomiting, and menstrual changes were found in CCS. More poor perceived health status and optimal physical wellbeing were found in BCS. Overall, most sufficient physical wellbeing was found in both groups. There were significant differences of fatigue, pain, sleep disturbance, appetite changes, constipation, health status (p<.001 for each), nausea-vomiting (p= .004), and menstrual changes (p= .001) were found between groups. Overall, physical wellbeing was significantly different between groups (p< .001). Sleep disturbance (84.7% of influence) and appetite changes (75.7% of influence) were the best predictors for determining physical wellbeing in CCS and BCS respectively.Conclusion: More severe cancer symptoms were found in CCS, but more poor perceived health status was found in BCS. There was a significant difference of physical wellbeing found between CCS and BCS.

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