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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 706 Documents
 31   32   33   34   35 
COMPRESSIONAL CHARACTERISTICS OF Piper Guineense FRUIT Bakre Lateef Gbenga; Ayodele Damilola
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.139 KB) | DOI: 10.14499/indonesianjpharm0iss0pp186-192

Abstract

The dried fruit of Piper guineense is widely used for its antibacterial and antifungal properties. The objective of this present study was to examine the compressibility of dried powdered fruits of Piper guineense with a view to determining the suitability of its formulation into tablet dosage form. The compressional properties was studied in comparison with that of microcrystalline cellulose, dicalcium phosphate dihydrate and corn starch BP using density measurements and the Heckel and Kawakita equations for the analysis of the compression data at dwell times 5, 15 and 30s. The Heckel plots showed that the P. guineense powder is a Type A material and the degree of onset of plastic deformation increases as the dwell time is increased. Piper guineense exhibited the fastest onset of plastic deformation at 30s dwell time and the overall amount of plastic deformation was higher for Piper guineense than cornstarch and dicalcium phosphate dihydrate at all dwell times. The overall amount of plastic deformation for Piper guineense was highest at 15s dwell time. Results suggest that it should be of significant benefit to use a dwell time of 15s for the compression of Piper guineense powder.Key words: Piper guineense, cornstarch, microcrystalline cellulose, dwell time, compressional characteristics
The pattern of acute respiratory infections treatment in children of 0 – 59 month’s old in Puskesmas I Purwareja, Banjarnegara year of 2004 Wahyono, Djoko; Hapsari, Indri; Budi Astuti, Ika Wahyu
Indonesian Journal of Pharmacy Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.403 KB) | DOI: 10.14499/indonesianjpharm0iss0pp20-24

Abstract

The purpose of this research was to describe the pattern of acute of respiratory tract infections in children of 0-59 month’s old in Puskesmas I Purwareja Klampok, Banjarnegara. The data was taken by retrospective method from medical record. The data collected was analysed by nonanalytic descriptive statistic method, and then compared them to standard of therapy provided by Indonesian Health Departement. The result showed that all of 120 patients were pneumonia acute respiratory tract infections, which were 55.8% boys and 44.2% girls. The antimicrobials used were Cotrimoxazol (86.7%) and amoxicillin (13.3%). The major product used in that puskesmas was syrup (91.7%), and tablet that delivered in the form of powder was 8.3%. The treatment using these antimicrobial at Puskesmas I Purwareja, Klampok, Banjarnegara was in accordance to standard of therapy provided by Indonesian Health Departement. Key words: pneumonia acute respiratory tract infection, 0-59 months old children, antimicrobial, puskesmas I Purwareja Klampok Banjarnegara
Synthesis and cytotoxicity test of LR-2 on breast cancer cell line T47D Ritmaleni Ritmaleni; Dina Anitasari; Sinta Susanti; Sismindari .
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.952 KB) | DOI: 10.14499/indonesianjpharm0iss0pp21-32

Abstract

LR-2  is  a  compound  analog  of  monastrol,  an  anticancer  agent,  which  has been succesfully synthesised through the application of Biginelli reaction and one of  LR  compound  series  that  synthesised  in  Faculty  of  Farmacy,  Universitas Gadjah  Mada.  This  reserach  was  aimed  to  synthesized the  LR-2  compound  and to investigate the cytotoxicity of LR-2 on breast cancer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaldehyde, 2-indanone and thiourea were reacted together for 6hours in acid catalyst. The cytotoxicity  test  was  carried  by  using  breast  cancer  cell  line  the  MTT  assay method and the LC50 was ditermined by using the probit analysis with Miller and Tainter  method.  The  product  was  isolated  by  using  preparative  TLC  in  54  % yield. The structure was elucidated by spectroscopymethods (UV-Vis, H-NMR, IR and GC-MS).The LC50 is 159 µM.Keywords : LR-2, benzaldehyde, 2-indanone, thiourea, T47D 
THE OPTIMISED CONDITIONS OF INDUCTION OF RECOMBINANT RIP rMJC15310 ACTIVITY ISOLATED FROM Mirabilis jalapa L. LEAVES Astuti, Puji; ., Sudjadi; ., Sismindari
INDONESIAN JOURNAL OF PHARMACY Vol 23 No 2, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (836.5 KB) | DOI: 10.14499/indonesianjpharm0iss0pp93-98

Abstract

Ribosome Inactivating Proteins (RIPs) are compounds isolated from plants with ability to inhibit protein synthesis. The inhibition of protein synthesis is due to inactivation of ribosomal RNA through a site-specific  deadenylation  mediated  by  RNA  N-glycosidase. Reportedly, RIPs mainly possess wide range of bioactivity including antiviral  activity  against  plant  infections.  Other  activities  of  RIP were  as  abortifacien,  antivirus  and  anticancer.  This  study  was aimed  to  isolate  and  characterize  the  optimum  conditions  for inducing  the  expression  of  recombinant  RIPs  isolated  from  the leaves  of  Mirabilis  Jalapa  L.  We  have  been  successfully  isolated several  RIPs  and  engineered  these  proteins  to  be  expressed  in  E. coli. These recombinant proteins were obtained by screening cDNA library  originated  from  the  mRNA  of  Mirabilis  jalapa  L  leaves,  and inserted  into  pUC19  carrying  lacZ  gene.  The  presence  of recombinant  plasmid  was  tested  by  using  α-complementation assay. Many RIPs have been isolated from plants and these proteins express  enzymatic  activity  by  cutting  supercoiled  double  stranded DNA. One RIP namely rMJC15310 was obtained from this study and the  proteins  having  ~  8kb  in  size,  cut  the  supercoiled  DNA  into linear  form  at  the  concentration  as  low  as  5  µg.  The  ability  to  cut supercoiled  DNA  increased  on  inducing  its  expression  with  0.4% IPTG.Key words:   Ribosome  Inactivating  Proteins  (RIP),  IPTG,  Mirabilis  jalapa L., recombinant protein 
FORMULATION AND EVALUATION OF DEXTROMETHORPHAN HYDROBROMIDE CONTROLLED RELEASE HOLLOW MICROSPHERES USING NATURAL POLYMER C, Sai Sathavahana
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (779.78 KB) | DOI: 10.14499/indonesianjpharm25iss3pp181

Abstract

The objective of this study was to formulate and evaluate gastric floating dosage forms of hollow microspheres for controlled delivery of dextromethorphan hydrobromide (DBM). Hollow microspheres were prepared by emulsion polymerization method using natural polymer gelatin as release retardant and coating agent. Hollow microspheres were characterized by FT-IR, DSC, SEM, and micromeritic properties. FT-IR and DSC studies showed no chemical interaction between the drug and polymers. Hollow microspheres were evaluated for percentage yield, encapsulation efficiency and in vitro release studies. The obtained angle of repose, % Carr’s index, Hausner ratio, and tapped density values were within the limits indicating good flow properties. The surface morphology revealed that microspheres were spherical with minute pores and invert dents on the surface. Among all the formulations, F-3 of hollow microspheres showed highest drug release of 79.69±0.12% at the end of 12h which was considered as the best formulation. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero order to evaluate the release kinetics and mechanism of the drug release. The release kinetics indicated that drug release followed non-fickian diffusion mechanism. Results of the stability studies showed that there were no significant changes in the drug content and physical appearance. 
Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet Irawan, Eka Deddy; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.204 KB) | DOI: 10.14499/indonesianjpharm0iss0pp231-238

Abstract

Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).Key words : mucoadhesive, factorial design, DE480 , chitosan, CMC Na, Mg stearat, contour plot
Effect of Indonesian medicinal plants essential oils on Streptococcus mutansbiofilm Triana Hertiani; Sylvia Utami Tanjung Pratiwi; Irami Duma Kencana Irianto; Dian Adityaningrum; Budi Pranoto
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.812 KB) | DOI: 10.14499/indonesianjpharm0iss0pp174-181

Abstract

Essential  oil’s  component  such  as  menthol  and  eucalyptol  were  already used as dental plaque inhibitors. In searching of potential dental plaque inhibitor from natural products, a study to explore the potency of essential oils extracted from  several  Indonesian  medicinal  plants  against  planktonic  growth  and  biofilm adherence  of  S.  mutans was  performed.  A  total  of  14  essential  oils  from  some selected Indonesian medicinal plants were extractedby steam-hydro distillation. Antibacterial assay was performed against S. mutansby micro dilution technique on  nutrient  broth  media.  Biofilm  formation  inhibition  assay  was  conducted  on  a flexible  U-bottom  96-wells  PVC  micro  plate  by  using BHI  enriched  with  sucrose 2%  at  36.6  °C  for  18-24  h.  After  staining  with  1%  crystal  violet,  the  optical density  was  read  at  595  nm.  A  mouthwash  commercial  product  containing essential  oil  component  was  used  as  a  positive  control.  Result  showed  that  the essential oils of  C. sintoc exhibited the highest biofilm formation inhibition (IC50 =  0.005%),  and  Z.  officinale showed  the  highest  biofilm  degradation  with  EC50 value  of  0.013%.  Both  were  active  against  bacterial planktonic  growth  but  C. sintocshowed lower MIC90 value (0.6%) in comparison to Z. officinale(0.06%). Meantime,  C.  citratus was  showed  promising  antibacterial  and  antibiofilmactivities with MIC90 value of 0.06%, MBC 0.6%, IC50 0.008% and EC50 0.026%. It is concluded that the essential oils of C. citratus, Z. officinaleand C. sintocare potential to be developed as dental plaque inhibitors.Key words: essential oils, antibacterial, biofilm, Streptococcus mutans
PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE. Sri Hartati Yuliani; Achmad Fudholi; Suwijiyo Pramono; Marchaban .
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.975 KB) | DOI: 10.14499/indonesianjpharm23iss4pp203-208

Abstract

Binahong  (Anredera  cordifolia (Ten)  Steenis)  has  been used  as  wound  healing  in  traditional  Indonesian  medicine.  The developing of the dosage forms using the formulation technology approach  has  been  done.  The  aim  of  this  study  was  to  examine the  physical  properties  of  the  wound  healing  gel  of  ethanolic extract of binahong during storage. The factorial design method 3 factors  and  2  levels  was  employed  to  achieve  this  study.  The three  factors  used  in this  study  were Carbopol, CMC-Na  and Caalginate  with  low  and  high  level  for  each  factor.  The  physical properties  of  the  wound  healing  gel  of  ethanolic  extract  of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion  study.   The  result  showed  that  CMC-Na  and  Caalginate  increased  the  alteration  of  physical  properties  of  wound healing  gel  of  ethanolic  extract  of  binahong  during  storage.  The carbopol  maintained  the  physical  properties  of  the  gel  during storage.Key words: bioadhesion, binahong, viscosity, wound healing gel.
ANALYSIS OF COST AND OUTCOME THERAPY OF BLOOD TRANSFUSION ON ANEMIA TREATMENT FOR INPATIENT WITH CHRONIC RENAL FAILURE Satibi, Satibi
Indonesian Journal of Pharmacy Vol 25 No 1, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.189 KB) | DOI: 10.14499/indonesianjpharm25iss1pp51

Abstract

Chronic Renal Failure (CRF) is a slow progressive loss of kidney function over a period of several years. One of its complications that determines the patient’s quality of life is anemia. Blood transfusion can be used to treat anemia in patient with CRF. The purpose of this study are to measure the average costs per patient, assess the therapy outcomes, and determine the factors that influence the cost of blood transfusion in anemia treatment for patients with CRF in A, B, and C hospitals. This study was a descriptive non-experimental research. Cost analysis was based on the perspective of the hospital. Data were obtained retrospectively from medical records and payment details of inpatient with CRF who experienced anemia in A (tertiery hospital in Yogyakarta province), B (tertiary hospital in Central Java province), and C (private hospital in the province of Yogyakarta) hospitals. Data was analysed by calculating the average costs per patient, while therapy outcome was measured by calculating the percentages of patients who achieved the target of hemoglobin level. Furthermore, the factors that influenced the amount of the total cost were analysed using Oneway ANOVA and Independent T-Test for data with normal distribution and the Kruskal-Wallis and Mann-Whitney for data with non-normal distribution. The results showed that the average costs per patient for anemia treatment in patient with CRF who had blood transfusion therapy were Rp 8,873,243.39±4,417,825.83 in A hospital, Rp 5,249,464.97±4,283,655.41 in B hospital; and Rp 7,961,088.00±6,105,501.80 in C hospital. Most of the patients in A, B, and C hospitals had achieved the target of hemoglobin level (>7g/dL) with the percentages of 95.56%, 68.57% and 87.50% respectively. The factors that mainly influenced the cost of anemia treatment in CRF are length of hospitalization for A hospital, age, gender, payment models, and length of hospitalization for B hospital, whereas age and length of hospitalization for C hospital. Key words: cost analysis, outcome therapy, blood transfusion, anemia, chronic renal failur
Isolation and identification of eurycomanone from akar pasak bumi (Eurycoma longifolia, Jack) and its antiangiogenic activity Sugiyanto .; Nina Salamah; Mae Sri Hartati; Farida Hayati; Pinus Jumariyatno
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.242 KB) | DOI: 10.14499/indonesianjpharm0iss0pp118-126

Abstract

Pasak bumi is one of the Indonesian original plants having anti cancer activity. One compound of akar pasak bumi, i.e eurycomanone was proven to have cytotoxic effect on cancer cell culture by apoptosis induction on HeLa cells. Therefore, this study was aimed to isolate and identify euycomanone from akar pasak bumi and to look at the anti angiogenic activity of the compounds on corio alantois membrane (CAM) of chicken embryo induced by bFGF.The akar pasak bumi was ground and was macerated with methanol. The macerate was fractioned by mean of VLC. Six fractions was obtained. The second fraction exhibited two spots on a TLC system, one spot was cochromatographed with eurycomanone as the reference standart and another spot exhibited blue fluorecence at 254 nm. This second fraction, then, was chromatographed on a preparative scale TLC to separate isolate A. Anti angiogenic test was performed for Isolate A at concentration series of 5, 10, 15, 20, 40 μg/mL respectively. Egg embrio (8-9 days) were divided into 8 groups. The first group was implanted paper disc only, the second group were given bFGF on Tris HCl buffer and the third group were given bFGF (on Tris HCl buffer) + 0,8 % DMSO. The fourth to eighth group were induced by 10 ng bFGF and the test preparation at the respective concentration. After incubation at 39 °C for 3 days, each egg was opened, the content of each was aspired and discarded, the CAM sticked to its shell was examined macroscopically and microscopically for the formation of new blood vessels.Based on spectral data of UV, IR, 1H NMR, 13C NMR and MS of isolate A and comparison with the spectral data of the standart, the isolate A was eurycomanone. Eurycomanone inhibited angiogenesis at concentration of 10 μg/mL.Key words: antiangiogenic, angiogenesis, E.longifolia, eurycomanone,CAM.

Page 33 of 71 | Total Record : 706

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