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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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IN VITRO ANTIPLASMODIAL ACTIVITY OF COUMARIN 8-HYDROXYISOCAPNOLACTONE-2',3'-DIOL ISOLATED FROM Micromelum minutum (G. Forst.) Wight & Arn Ratna Asmah Susidarti
Indonesian Journal of Pharmacy Vol 25 No 1, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Malaria remains a health problem in tropical and subtropical countries. The spread of antimalarial resistant parasites has prompted the research to find more effective new antimalarials. One strategy to discover new antimalarial drugs is through the exploration of medicinal plants traditionally used to treat malaria. Micromelum minutum is one of medicinal plants has been used to treat malaria and other infectious diseases in Malaysia. The coumarin 8-hydroxyisocapnolactone-2¢,3¢-diol has been isolated from this plant and showed to have strong cytotoxic activities. This study aimed to evaluate the in vitro antiplasmodial activity of 8-hydroxyisocapnolactone-2¢,3¢-diol against chloroquine-resistant (FCR-3) and chloroquine-sensitive (D-10) Plasmodium falciparum. Culture of P. falciparum was continuously grown using a candle jar. Antiplasmodial assay was conducted by microradioactive method. The antiplasmodial activity was expressed by the IC50 indicating the concentration of the compound yielding 50% inhibition of the parasit growth. The results showed that 8-hydroxyisocapnolactone-2¢,3¢-diol has in vitro antiplasmodial activity against FCR-3 and D-10 with the IC50 values of 6.39 µg/mL (16.99 μM) and 24.23 μg/mL (64.45 μM), respectively.Key words: 8-hydroxyisocapnolactone-2’,3’-diol, M. minutum, anti-plasmodial activity, P. falciparum, FCR-3, D-10

Antibacterial activity and GC-MS analysis of the Citrus amblycarpa (Hassk) Ochse essential oil Mulyani, Sri; ., Susilowati; Hutabarat, Maniur
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A research about anti-bacterial activity and components of essential oil from leaves and peels of Citrus amblycarpa have been done.The components of essential oil had been identified by using GC-MS and anti-bacterial activity against S. aureus ATCC 25923 and E. coli ATCC 25922 had been determined with liquid dilution method. The component of essential oil from leaves that can be identified are Î²-pinene, linalool, citronellal, citronellol and geraniol, while from peels are Î²-pinena, cymene, limonene and citronellal.Oil from the leaves has stronger anti-bacterial activity against S. aureus than from peels. On the other hand oil from peels is stronger anti-bacterial activity against E coli.Key words : Citrus amblycarpa, essential oil, anti-bacterial activity.

Fractionation and activity assay of the root extract of Piper sarmentosum Roxb. ex Hunter against Candida albicans Hartiwi Diastuti; Sadijah Achmad; Enny Ratnaningsih
Indonesian Journal of Pharmacy Vol 15 No 2, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Piper sarmentosum Roxb. ex Hunter (“sirih duduk”) has long been used as a traditional medicine against fungoid diseases, especially at vagina and foot-sole. The investigation of the bioactive compounds of P. sarmentosum roots has not infections been carried yet. This research was then aimed to fractinate and to examine the antifungus activity of the extract of P. sarmentosum roots.The extraction was performed by using organic solvents such as methanol, ethyl acetate, chloroform, benzene, and n-hexane. The bioactivity tests were performed against C. albicans. The active extracts were then fractionated by coloumn chromatography.The result showed that the ethyl acetate fraction of methanol extract of P. sarmentosum roots have an antifungus activity against C. albicans. Phytochemical study showed that the active fractions of the methanol extracts of P. sarmentosum roots contained alkaloid.Key words : Piper sarmentosum, activity test, Candida albicans.

Sinergisitas efek sitotoksik kombinasi arekolin dan doxorubicin pada sel kanker serviks HeLa Astrid Ayu Maruti; Rahmi Khamsita; Suven .; Dyaningtyas Dewi Putri; Edy Meiyanto
Indonesian Journal of Pharmacy Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Arecoline, the main alcaloid of Areca cathecuL has been proven to posses cytotoxic activity against various cancer cell lines. The research conducted to examine the cytotoxic activity of arecoline alone and its combination with doxorubicin against HeLa cervical cancer cell line. Single treatment of arecoline in various concentration on HeLa cancer cell were done followed by the combinational treatment with doxorubicin. The cell viability as the parameter of cytotoxicity was measured using MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide) assay. The apoptotic effect was examined by double staining assay using etidium bromide – acridin orange. Arecoline did not show potent cytotoxicity effect against HeLa since the value of IC50 is 462µM. The combinational treatment of arecoline and doxorubicin showed synergicity with the optimum CI value is 0,48 given by the treatment of 30mM arecoline combined with 125 nM doxorubicin. The result of this study shows that arecoline has potential to be proposed as co-chemotherapeutic agent for cervical cancer. However, further study on its molecular mechanism needs to be conducted.Key words: arecoline, synergicity, doxorubicin, MTT assay, HeLa cell line

POLYMORPHISM OF CYTOCHROME P450 2A6 (CYP2A6*1 AND CYP2A6*4) AMONG JAVANESE INDONESIAN SMOKER AND NON SMOKER Christine Patramurti; Sugiyanto .; Arief Nurrochmad; Sudibyo Martono
Indonesian Journal of Pharmacy Vol 26 No 1, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Cytochrome P450 2A6 (CYP2A6) is the principal enzyme involved in the metabolic activation of tobacco-specific nitrosamines to their ultimate carcinogenic forms and metabolism of nicotine. The present study was developed to investigate the genetic polymorphism of CYP2A6 in Javanese Indonesian subjects carrying the CYP2A6*1 allele and the CYP2A6*4. The whole gene deletion of CYP2A6 (CYP2A6*4) may inhibit smokers from giving up smoking, but appears to function as a protective factor against to some cancer. However, the investigation of these allele, a major functional polymorphisms common in Asian populations, have not been reported among Javanese Indonesian population. A single polymerase chain reaction-restriction fragment length polymorphism was used to resolve the genotypes into CYP2A6*1 (wild type) and CYP2A6*4 (CYP2A6del). The sample studied consisted of 100 healthy subject that consist of 50 non smokers and 50 smoker from Javanese Indonesian population. The allele frequencies of *1 (wild type) and *4, were 47.5 and 52.5%, respectively. When the two allel were considered simultaneously, among the non-smokers, 45% were genotyped for CYP2A6*1/*4 and 5% were genotyped for CYP2A6*4/*4; on the other hand all of the smoker were genotyped for CYP2A6*1/*4 and there was no homozygote of wild type. Based on the data collected, it could be concluded that the polymorphism of CYP2A6 were detected in among Javanese population sample study and the allele frequencies of CYP2A6*4 were high.Key word: Polymorphism, CYP2A6*1, CYP2A6*4, Javanese Indonesian

Optimization of sorbitol, glycerol, and propyleneglycol mixture in sunscreen gel of ethanolic extract of Curcuma mangga Yuliani, Sri Hartati Hartati
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research about optimization of sorbytol, glycerol, and propyleneglycol mixtureÂ inÂ sunscreenÂ gelÂ ofÂ ethanolicÂ extractÂ ofÂ CurcumaÂ mangga hasÂ been done.Â TheÂ aimsÂ ofÂ thisÂ researchÂ wasÂ toÂ discoverÂ the optimumÂ mixtureÂ of sorbytol,Â glycerolÂ andÂ propyleneglycolÂ thatÂ gaveÂ goodÂ physycalÂ characteristicÂ of theÂ gel.Â First, made the ethanolic extract of Curcuma mangga as active ingredient.Â The SPF value of the ethanolic extract of Curcuma mangga was measured.Â SimplexÂ latticeÂ designÂ wasÂ employedÂ toÂ createÂ theÂ optimum compositionÂ ofÂ sorbitol,Â glycerolÂ andÂ propyleneglycolÂ inÂ theÂ sunscreenÂ gel. Physical characteristic of the gel including spreadability, viscosity and the alteration of the gel viscosity was measured. The result showed that there were optimum composition between sorbytol, glycerol and propyleneglycol which gave goodÂ physicalÂ characteristicsÂ basedÂ onÂ theÂ shadingÂ areaÂ atÂ theÂ counterplot superimposed.Keywords: sorbitol, glycerol, propyleneglycol, Curcuma mangga, sunscreen gel

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE Dixit, Yuwaraj Dilipsingh; Suruse, Pravin Babarao; Shivhare, Umesh Dhaniram
Indonesian Journal of Pharmacy Vol 24 No 1, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperidone maleate. It is an antiemetic synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Mucoadhesive Domperidone maleate tablet formulation was prepared by direct compression method. The formulation F3 containing (Carbopol 940 + sodium alginate) was found to be best among all the formulation batches because of its consistent release rate for 7 h and extent of drug release was 94.44%. Graphical treatment of the formulation F3 to Higuchi’s equation showed that the drug release was diffusion mediated. In-vitro permeability study for formulation F3 for 7 h had shown 76.69% drug release. FTIR studies showed no evidence on interaction between drug and polymers. Key words: Domperidone maleate, Mucoadhesive tablet, antiemetic

Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship ., Pudjono; Susilowati, Sri Sutji; ., Rehana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

This research aim was to find out the new compounds model of paminophenol derivates which have analgesic anti-inflammatory activity based on structure and biologic activity relationship analysis by computation methods. Seventeen compounds of p-aminophenol derivates were used in this research, and six compounds known its analgesic-antiinflammatory activity were used for determine QSAR equation model. This research’s result was a QSAR equation that can be using for synthesis the higher activity new compound of paminophenol. Key words : p-aminophenol compounds, analgesic anti-inflammatory activity, structure and activity relationship, QSAR equation, computation methods

Optimization of synthesis of 4-dimetilamino benzalaseton by speed and duration variation of stirring using sodium hydroxide as catalyst ., Sardjiman; Utami, Dwi; ., Dachlan; Intani, Dei; Susanty, Rinnny F.
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Aldol condensation is followed by dehydration used 4-dimetilamino benzaldehida and aseton will produce 4-dimetilamino benzalaseton. A factor which influences the rendement of 4-dimetilamino benzalaseton producing is stirring. Due to of that, should be researched about the speedy influencing of stirring in synthesis of 4-dimetilamino benzalaseton used NaOH as catalyst for production of yield produced.The variation of stirring speed that used in the research are 500 rpm; 700 rpm; 900 rpm. Synthesis process taken place for 5 hours 10 minute. The synthesis compound was isolated and counted its yield. The purification was done by recrystalization using etanol absolute : aquadest and counted its recovery. The identification of synthesis compound was conducted by Infrared Spectrometer and NMR Spectrometer.The result showed that the average from the variation of stirring speed 500 rpm; 700 rpm; 900 rpm in gradually are 78,61 %; 85,0 %; 86,1 %. The ANAVA statistic analyzing that the confidence level of 95 % showed in which many variation of stirring speed hasn't given influence for production of yield was produced. The highest yield has found in stirring speed 700 rpm. From the result of melting point data was found that synthesis was produced in stirring speed 500 rpm possessed melting point 129,4OC Â 131,6OC, 700 rpm possesses melting point 131,63OC -133,13OC, 900 rpm possesses melting point 128,67OC-131,23OC while from result of TLC, The retention factor is 0.2 in average. The identification of synthesis compound was conducted by using Infrared Spectrometer and NMR after were compared with starting material showed that the synthesis product was 4-dimetilamino benzalasetonKey words : Benzalaseton, 4-dimetilamino benzalaseto.

IN–VITRO PHARMACEUTICAL EVALUATION OF TWO BRANDS OF DISPERSIBLE ACETYL SALICYLIC ACID TABLETS AVAILABLE IN OMAN Khan, Shah Alam; Al Shabibi, Maryam Nasser; Nazmi, Abdul Salam
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Acetyl salicylic acid (ASA), a non-steroidal anti-inflammatory drug (NSAID) is widely used for its analgesic, antipyretic, antiinflammatory and anti-thrombotic action. The aim of the present study was to investigate the pharmaceutical equivalence of two brands of dispersible ASA tablets marketed in Oman. Two different brands of dispersible ASA tablets (300mg) were purchased from the retail pharmacy outlets and their pharmaceutical quality were assessed by using in-vitro tests as per the British Pharmacopoeia (BP) and unofficial standards as recommended by the manufacturers. The assessment of tablets included the evaluation of uniformity of weight and diameter, friability, crushing strength, disintegration and chemical assay by volumetric titration and colorimetric methods to determine the content of active pharmaceutical ingredient (API). Both brands of the ASA tablets passed the BP standards for uniformity of weight and diameter, disintegration, friability and crushing strength. However one of the two brands did not comply with the standard assay of content of active ingredient. Thus based on these results it can be concluded that these two brands of ASA are not pharmaceutically equivalent.Key words: ASA tablets, pharmaceutical equivalence, disintegration, volumetric method.

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