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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 706 Documents
 39   40   41   42   43 
LABELING OF MIBI (METOXY ISOBUTYL ISONITRYL) WITH TECHNETIUM-99m AS A PERFUSION MYOCARDIAC IMAGING RADIOPHARMACEUTICAL Nurlaila Z.
Indonesian Journal of Pharmacy Vol 14 No 2, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.417 KB) | DOI: 10.14499/indonesianjpharm0iss0pp306-311

Abstract

Coronary artery disease is one the major causes of death in Indonesia. For early diagnosis of the disease, it is deemed necessary to visualize the myocardium blood flow perfusion. 99mTc-MIBI labeled compound is one of the agent that could be used for such purpose. The labeling of MIBI with technetium-99m under some variations of several parameters has been carried out. The labeling efficiency was determined by counting the radiochemical purity using ITLC-SG 60 thin layer chromatography using two kinds of solvents, i.e. methanol and 0.9% NaCl solutions. The optimum labeling condition was achieved at the pH = 5.5 – 6.0, 1 mg of [Cu(MIBI)4BF4, 0.060 mg SnCl2.2H2O and 10 minutes incubation time in a boiling water bath, gave ± 99% of labeling efficiency. Under the formulation stated above, MIBI dry kit produces could give the radiochemical purity of more than 95%.Key words : metoxy isobutyl isonitril (MIBI), technetium-99m, labeling, myocardiac perfusion imaging.
Optimization formula gastroretentive tablet of ranitidine HCl with floating system Sulaiman, T.N. Saifullah; Fudholi, Achmad; Nugroho, A. Kharis
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.929 KB) | DOI: 10.14499/indonesianjpharm0iss0pp106-114

Abstract

Ranitidine  HCl  is  an  H-2  receptor  antagonists  for  the  treatment  of  peptic gastric  secretion  with  a  small  bioavailability,  so  that  should  be  developed  in  a sustained  release  dosage  form  are  retained  in  the  stomach.  Ranitidine  HCl floating  tablet  was  formulation  by  effervescent  system.  Simplex  lattice  design was  applied  to  optimize  the  formula  of  ranitidine  HCl  floating  tablet  by varying levels of Methocel K15M 100-185 mg, sodium bicarbonate 15-100 mg, and  citric  acid0-85 mg.  The  Optimum  formula  determined  by  superimposed contour  plot  from  various  parameters:  flowability  of  granules,  physical properties of tablet and drug release using Design-Expert®program. Based on superimposed  contour  plot obtained  optimum  formula  for  the  area  in  the  range of Methocel K15M 100-145 mg, sodium bicarbonate 20-80 mg and citric acid 25-80 mg.Key words: Ranitidine HCl, Gastroretentive, Simplex lattice design 
Phenolic content and antibacterial properties of various extracts of gambir (Uncaria gambir Roxb) Rindit Pambayun; Murdijati Gardjito; Slamet Sudarmadji; Kapti Rahayu Kuswanto
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.053 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-146

Abstract

Extraction of gambir product with various solvents gave vary in amount of yields, phenolic contents, and its antibacterial properties. Extraction was performed by maseration and Soxhlet methods with some solvents; chloroform, ethyl acetate, ethanol, water, and their combination. The results showed that the highest yield of extract obtained from the solvent combination of ethanol and water (1:1 v/v) both at the maseration and Soxhlet metods, i.e. 84.77 and 87.69 %, respectivelly. Soxhlet method gave the yield of extract higher than that of maseration method. The highest phenolic content was found at the extracts using ethyl acetate both in maseration and soxlet methods, i.e. 88,30 and 90,85 %, respectivelly. Antobacterial properties on the Gram-positive bacteria such as Streptococcus mutans, Staphylococcus aureus, and Bacillus subtilis, indicated that the extracts extracted by using ethyl acetate gave highest inhibitory properties. On the other hand, the extracts did not inhibit Gram-negative bacteria. Extraction was continued by using solvent combination of ethanol and water at the various proportion and at the three levels of temperature, 4, 30, and 60 °C. The results showed that solvent combination of ethanol and water (1:2), gave the highest yield of extracts but lower in phenolic contents and aantibacterial properties.Key words: antibacterial, phenolic content, extract of Uncaria gambir Roxb
Biosynthesis of a biopolymer poly(3-hydroxybutyrate) from a mixture of palm oil and 2-butanol as carbon sources Djamaan, Akmal
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.566 KB) | DOI: 10.14499/indonesianjpharm0iss0pp315-322

Abstract

Polyhydroxybutyrate  [P(3HB)]  are  synthesized  as  carbon  and  energy reserve materials by many types of microorganisms under certain environmental condition. These biosynthetic polyesters have much received attention as they can  be  considered  to  be  a  source  for  developing  novel  biodegradable  plastic materials for pharmaceutical, medical and biodegradable packages industries. In this case,  Erwiniasp. USMI-20, a locally soil isolated microorganism has been found  to accumulate  P(3HB)  in its  cells  during  growth  on  mineral-media  with  a mixture of palm oil and 2-butanol as carbon source. Fermentation process was conducted  through  a  feedbatch  cultivation  under  aerobic  condition  at  pH  7.0, incubation temperature 30 oC, and agitation rate of 200 rpm for 48 hours. The characterization of the  polymer production  was based  on  cell growth  (biomass) and  polymer  content  detected  by  a  gas  chromatography  methode.  Result showed  that  from  a  mixture  of palm  oil:2-butanol  (4.62g/L+0.89g/L) produced P(3HB) of 50.86 %w/w with biomass of 5.82g/L; a mixture of palm oil:2-butanol (4.62g/L+1.65g/L) produced  P(3HB)  of 57,77%  w/w  with  biomas  of 6.01g/L,  a mixture  of  palm  oil:2-butanol  (4.62g/L+2.48g/L)  produced  P(3HB)  of  55.85%w/w with  biomass  of  6.57g/L,   a  mixture  of palm  oil:2-butanol (4.62g/L+3.29 g/L) produced P(3HB) of 56.37% w/w with biomass of 6.67g/L and a mixture of palm  oil:2-butanol  (4.62g/L+4.12g/L)  produced  P(3HB)  of  47.70%  w/w  with biomass of 6.33g/LKey words:biopolymer, poly(3-hydroxybutyrate), palm oil, and n-butanol.
TOXICITY TEST OF MAKUTADEWA (Phaleria macrocarpa (Scheff.)Boerl.) BARK AGAINST Artemia salina Leach AND THIN LAYER CHROMATOGRAPHY PROFILE OF THE ACTIVE FRACTION Triana Hertiani; Silvia Utami Tanjung Pratiwi
Indonesian Journal of Pharmacy Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.013 KB) | DOI: 10.14499/indonesianjpharm0iss0pp65-70

Abstract

Makutadewa (Phaleria macrocarpa (Scheff) Boerl.) is one of the herbal medicines used against cancer, however, the scientific basis of the activity still void. Daphne mezereum, the same family (Thymelaeaceae) to makutadewa has been proved to contain cytotoxic substances in its bark. Therefore, the aims of this research were to investigate the toxic effect of makutadewa bark against Artemia salina Leach. as the primary step to identify an anticancer activity and find out substances responsible to this activity. The material powder was extracted using Soxhlet apparatus with chloroform, followed by methanol and finally by distilled water. The toxicity of chloroform, methanolic and aqueous extracts were assayed against A.salina Leach. The chloroform extract (most active) with the LC50 of 29.6  0.14 g/ml was fractionated by vacuum liquid chromatography using wash benzene 100 % (a); wash benzene-ethyl acetate =20:1 (b); 15:1 (c); 10:1 (d); 5:1 (e); 2:1 (f) and chloroform-methanol 1:1 (g) as mobile phases. The active fractions against A.salina were E {combination of (e) and (f)} with LC50 of 106,9 g/ml and F (g) with the LC50 of 131,53 g/ml, hence less toxic than the original extract. The thin layer chromatogram profiles showed that E and F fractions contained terpenoid and alkaloid substances.Key words: toxicity test, (Phaleria macrocarpa (Scheff)Boerl.), bark
Antiurolitihatic potency of Ketimun juice (Cucumis sativus L.) on white male rats using Kalkuli method Sumi WIjaya; Farida L Darsono
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.525 KB) | DOI: 10.14499/indonesianjpharm0iss0pp173-176

Abstract

The aim of this research was to know the antiurolitihatic activities of Ketimun juice (Cucumis sativus L.) on white male rats which have been induced with hydroxyproline 30 % with a dose of 2,5 g/Kg BW. The 20% Ketimun juice (1.5 ml/100 g BW) and distilled water 1.5 ml/100 g BW were given the test animals orally. The parameter tests were characteristics of the kidney : the colour, shape, size and ratio of kidney weight /200 g BW and 24 hour urine on the first and the third days which included pH, 24 hour urine volumes and the calcium content in the urine. The data were analyzed using one sampel t-test. There were significant differences (p
The effect of extract Kaempferia galanga rhizomes on the elimination kinetics of quinidine in rabbits Hayati, Farida; Hakim, Lukman
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.269 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-181

Abstract

The research was aimed to observe the effect of the juice of Kaempferia galanga rhizomes on quinidine elimination kinetics in rabbits. The study on interaction of extract Kaempferia galanga rhizomes to quinidine elimination kinetic was conductedly employing a cross randomized design using male rabbits which were divided into 3 groups (6 rabbits for each group). The groups were given a single oral quinidine 30 mg/kg BW as a control group and were conferred single oral extract “kencur” 4.8 mi/kg BW each dose for 4 days prior to the treatment with quinidine. Serial blood samples(0,2 ml) were withdrawn at various interval time via the ear marginal for spectrofluorometric analysis of unchanged quinidine in blood. The concentration of quinidine was determined using a standard curve and the concentration to time data was used to determine quinidine elimination kinetics i.e. Clt and MRT. The results indicated that extract “Kencur” was found to decrease quinidine clearance 17,19% and 7,07% (P>0,05) and increase quinidine MRT198,89% and 71,70% (p>0,05).Key words : Kaempferia galanga rhizomes, quinidine, elimination
DESIGN AND OPTIMIZATION OF SOLID LIPID NANOPARTICLES (SLNs) OF ZOLMITRIPTAN FOR THE MANAGEMENT OF MIGRAINE Garud, Akanksha; Singh, Deepti; Garud, Navneet
Indonesian Journal of Pharmacy Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (695.517 KB) | DOI: 10.14499/indonesianjpharm0iss0pp245-252

Abstract

Solid lipid nanoparticles (SLNs) of zolmitriptan were produced by solvent emulsification-diffusion technique. Soya lecithin and poloxamer 188 were used as surfactants and stabilizers of the particles. The formulations were optimized for independent variables (amount of stearic acid, amount of lecithin and homogenization time) in order to achieve desired particle size with maximum percent entrapment efficiency (% EE). Prepared SLNs were characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM) and zeta potential measurements. To achieve our goal, eight formulations (F1–F8) of SLNs were prepared by solvent injection technique and optimized by 23 full-factorial design. The responses of the design were analyzed using Minitab 15. On the basis of software analysis, formulation F8 was selected as optimized formulation and was evaluated for the independent parameters. Optimized formulation showed particle size of 340nm, percent entrapment efficiency (EE) of 81.36 and 79.11% of in-vitro drug release after 24h. The release kinetics of the optimized formulation best fitted the Higuchi model.Key words: solid lipid nanoparticles, zolmitriptan, solvent emulsificationdiffusion technique, in-vitro release.
Antimalarial activity of ethyl acetate extract of Garcinia dulcis kurz stem bark Gunawan Pamudji Widodo; Mamik Ponco Rahayu
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.562 KB) | DOI: 10.14499/indonesianjpharm0iss0pp225-229

Abstract

In-vivo antimalarial activity of ethyl acetate extract of Garcinia dulcis Kurz stem  bark  have  been  evaluated  against  Plasmodium  berghei  induced  mice. Antimalarial  test  was  conducted  by  paracitemia  investigation  and  leucocyte counting  of  paracite  induced  mice  blood,  after  oral  administration  of  Garcinia dulcis  stem  bark  extract  dose  of  25  mg,  50  mg,  as  well  as  75  mg/kg  bw.  The highest  antiplasmodial  activity  and  decresing  of  leucocyte  amount  was  showedby  extract  of  dose  of  50  mg/kg  bw.  The  compounds  identified  in  ethyl  acetate extract  of  Garcinia  dulcis  stem  bark  were  flavonoid,  saponin  and  tannin.  The compounds that have antimalarial activity weren’t yet known.Keywords: antimalarial, Garcinia dulcis Kurz, stem bark, paracitemia
IDENTIFICATION OF SAFETY ALERT BY MONITORING ANALYTICAL PARAMETERS AND HIGH-RISK DRUGS Vilaplana, Vicente Escudero-; Antúnez, María Gómez-; García, Esther Durán-; Míguez, Antonio Muiño-; Sáez, María Sanjurjo-
INDONESIAN JOURNAL OF PHARMACY Vol 23 No 2, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (662.163 KB) | DOI: 10.14499/indonesianjpharm0iss0pp130-134

Abstract

Early detection of  adverse  drug  reactions  (ADR) increases patient  safety.  Our  objective  was  to  identify  ADR  by  monitoring laboratory  parameters  and  high-risk  drugs.  We  carried  out  a two-month  prospective  observational  study  in  a  Internal Medicine  Department,  with  daily  recording  of  drugs  prescribed and  the  following  parameters:  Na,  K,  Ca,  serum  creatinine, glomerular  filtration  rate  (GFR),  INR,  glucose,  haemoglobin, platelets,  ALT,  AST,  bilirubin,  GGT,  alkaline  phosphatase,  TSH, T4,  and  blood  digoxin.  High-risk  drugs  were  closely  monitored. 52  patients  included,  of  whom  46.2%  experienced  an  ADR.  We observed  an  association  with  drugs  in  25.5%,  as  follows: reduction  in  GFR,  26.9%  (associated  with  loop  diuretics [41.7%],  angiotensin-converting  enzyme  [ACE]  inhibitors [33.3%],  angiotensin  II  receptor  blockers  [ARB]  [16.6%],  andanti-diabetic  drugs  [8.3%]);  hypokalemia,  22.3%  (associated with  loop  diuretics  [50.0%],  potassium-free  fluid  [37.5%],  and salbutamol  [12.5%]);  hyperkalemia,  14.4%  (associated  with ACE  inhibitors  [60.0%]  and  ARB  [40.0%]);  INR  out  of  range, 10.8%  (associated  with  drug  interactions  [66.7%]); hyperglycemia,  8.1%  (associated  with  corticosteroids  [66.7%] and  anti-diabetic  drugs  [33.3%]);  and  other  conditions,  18.8%. We  conclued  that  patient  safety  could  be  improved  by implementing  warnings  in  electronic  prescriptions  in  cases  of  a decrease  in  GFR  or  modification  of  potassium  levels  in  patients who are prescribed loop diuretics, ACE inhibitors, or ARBs.Key words:   Adverse drug reaction,  clinical decision support,  high-risk drug, safety 

Page 41 of 71 | Total Record : 706

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