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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

Arjuna Subject : -

Articles 706 Documents

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Drug-related problems and clinical risk factors relationship in hepatic cirrhosis patients Amelia Lorensia; Widyati .; Aziz Hubeis; Hary Bagijo
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diffusion processes in hepatic cirrhosis is characterized with fibrosis and structural changed. Patients with cirrhosis are at risk to get problems because of the effects of the drugs used have drug-related problems (DRPs), due to changes in heart function that affects many aspects of drug pharmacokinetics. Therefore, treatment of patient with hepatic cirrhosis should consider the drug and dose adjustment so that subsequent problems could be avoided. The research method was prospective and descriptive, with a purposive sampling technique. Patients’s treatment were monitoring and analyzed. Significance of 0000 means that p (0000) <0.05, then the Pearson correlation test results are H1a, ie there was a relationship between the numberof DRPs events by the total number of clinical risk factors of DRPs in patientswith cirrhosis. Therefore from this relationship could be expected to know the possible risk of DRPs in patients. The increasing number of clinical risk factors DRPs in patients with cirrhosis, indicate thatthe patient should receive a more stringent monitoring of the provision of therapy because the risk of experiencing DRPs more.Key words: cirrhosis, drug related problems (DRPs), clinical risk factors of DRPs

Improvement of artemisinin content through mutation of in vitro shoot cultures of Artemisia cinamedicinal plant Aryanti .
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Improvement of plant traits through mutation induction of herbal medicine of shoots Artemisia cina in vitro have conducted by gamma rays. About 200 of A.cina shoots in vitro were cultured in Murashige & Skoog(MS) medium without phyto-hormone were irradiated by the dose of 10 Gy at Gamma Chamber in PATIR – BATAN. Irradiated shoot cultures were then multiplication and selected. The selected mutant lines have acclimatized and cultivated at distance of 0.5 x 1 m at Bogor region. 21 of mutant lines have been obtained from 630 A.cina mutant lines from field cultivation. The morphological observation i.e., leaves area, plants high and percentage of flower emerge have conducted when the plants were cultivated in the field. The artemisinin content of mutant lines and original plant have conducted by using HPLC. The result shown that the mutant lines had higher leaves area than original plant and some of mutant lines were shorter than original plant. The percentage of emerge flowers were reached 50.17% to be A31.1 mutant line. The improvement of plant traits by gamma rays was showed by increasing of artemisinin in A.cina mutant lines. The highest artemisinin content to be A32a2, A32c1 and A36.2 were found 21.03 mg/g, 19.99 and 15.79 mg/g respectively compared to the original plant only 0.40 mg/g. The improvement of artemisinin content of mutant line A32a2, A32c1 and A36.2 were 52.25; 48.97 and 38.48% respectively.Key word :mutation, shoots in vitro, artemisinin, Artemisia cina

Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.

Development of cassava starch-avicel PH 101 for coprocess diluent of direct compression tablet Yudi Wicaksono; Nailis Syifa'
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Cassava starch is tablet excipient with poor of both flowability and compressibility which can not be used as diluent of direct tablet compression. The purpose of this research was to develop co-process of cassava starch-Avicel PH 101 for diluent of direct compression tablet. To achieve this goal, the thing that has been done are : (1) isolation of cassava starch (2) co-processing of cassava starch-Avicel PH 101 (3) testing of mechanic-physic properties of co-process of cassava starch-Avicel PH 101 (4) evaluation of co-process of cassava starch-Avicel PH 101 as diluent of direct compression tablet. The results indicated that ratio cassava starch-Avicel PH 101 (60:40) provided co-process with the best of mechanical-physical and compression properties. The best of mechanical-physical properties were flowability about 6,70±0,28 g/dt and tapping index about 12,57±1,18.%. The best compression properties of cassava starch-Avicel PH 101 co-process were crushing strength about 4,97±0,23 kp and friability about 0,52±0,03.% with disintegration time and tablet uniformity fulfill with requirement of pharmacopoeia.Key words: cassava starch, Avicel PH 101, co-process, direct compression tablet

Effect of curcumin and 4-n-propil curcumin on glutation s-transferase activity in rat liver Kusumawati, Fitriyah; Martono, Sudibyo; ., Supardjan
Indonesian Journal of Pharmacy Vol 15 No 2, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Curcumin, a plant phenol in rhizome Curcuma longa L. has been reported to be a potent inhibitor of glutathione S-transferase (GST) in rat liver with in vitro with substrate 1,2-dikloro-4-nitrobenzen (DCNB). By using DCNB, a specific substrate for GST mu, This work was aimed to know whether curcumin derivatives: 4-n-propyl curcumin can also inhibit GST activity in vitro.Glutathione activity can be measured by conjugating GSH and DCNB catalized with GST. The product can be measured spectrofotometrically. Curcumin and its derivatives decreased GST activities with IC50 values 6,86 μM for curcumin and 8,41 μM for 4-n-propyl curcumin. This means that 4-n-propyl curcumin has a weaker inhibition potency than curcumin.Curcumin (consentration 10μM) inhibited GST activity by mixed with the Ki dan Ki’ values 2,77 μM dan 7,33 μM, whereas 4-n-propyl curcumin (consentration 10μM) inhibited GST activity by competitive with the Ki values 6,28 μM.Key words : Curcumin, 4-n-propyl curcumin, glutathione S-transferase, 1,2-dikloro-4-nitrobenzen.

CYTOTOXICITY ASSAY OF ACTIVE COMPOUNDS OF Gynura procumbens (Lour) Merr TO SEVERAL CELL LINE Rina Handayani; Sugiyanto .; Nina Salamah
Indonesian Journal of Pharmacy Vol 12 No 3, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp140-151

The leaves of Dewa (Gynura procumbens (Lour) Merr), is utilized in traditional medicine as anticancer, had been reported to contain flavonoid derivatives and supposed to have cytotoxic properties. Hence, these particular substances might be useful to be developed as anticancer in the future. Research on ethanol extract of Gynura procumbens (Lour) Merr leaves as anticarcinogen has been carried out, using toxicity assay model to vero, myeloma and lymphocyte cells. This research applied varied concentrations and adriamycin as a positive control. Observation to the cell growth inhibition was carried out for 4 days. The result showed that the dominant substance (the third spot of paper chromatogram) inhibit the growth of vero and myelome cells but lymphocyte cell. The LC50 of this substance to myelome, vero and lymphocyte cells were < 82.8 g/ml, 103.86 g /ml and > 2650 g/ml, respectively, whereas the LC50 of adriamycin to the cell lines were < 0.015 g /ml. Therefore, substances obtained from Gynura procumbens (Lour) Merr leaves might be developed against cancer.Key word: Gynura procumbens (Lour) Merr, mieloma

Effect of gambir extract Uncaria gambierRoxb. on fetal of pregnant mice induced by alcohol A, Almahdy
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

AnomalyÂ inÂ theÂ fetusÂ ofÂ miceÂ mayÂ inducedÂ byÂ theÂ presentÂ ofÂ oxidative stress on the dam during gestation. Alcohol is a potential substance that able to generate the oxidative stress. Antioxidant theoretically should reduce the above process.Â GambirÂ extractÂ isÂ aÂ notoriousÂ nonÂ toxicÂ herbalÂ whichÂ richÂ of antioxidants.Â ThisÂ studyÂ aimsÂ toÂ seeÂ whetherÂ theÂ oxidativeÂ stressÂ in pregnant miceÂ inducedÂ byÂ alcoholÂ couldÂ beÂ suppressedÂ withÂ gambirÂ extracts.Â The results showed that administration of gambir extract to thepregnant dam of mice after been induced by alcohol during gestation, reduced the presence of a thrombus on the pup.Key words: Gambir extract, ethanol, teratogen, mice

The influence of Pasak Bumi (Eurycoma longifolia Jack.) root infusa to male white mouse libido Diana Itjin; Luciana Kuswibawati
Indonesian Journal of Pharmacy Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Pasak Bumi ( Eurycoma Longifolia Jack.) is one of forest plant which have been used as aphrodisiac for many generation by the people in hinterland Kalimantan. The study was aimed to gain information of influence of pasak bumi root infusa to male white mouse libido.The research was pure experimental applying completely randomized design. Sixteen male white mice was divided into 2 groups which first group (negative control) was treated with aquadest by oral and the second group treated with pasak bumi roots infusa which its dosage 100 mg / 100 g body weight of male white mice by oral once a day for 21 days..Data of introduction, climbing, and coitus analysed with one way ANOVA and General Linear Measure model with 95% confidence level. The result indicated that usage period of pasak bumi root infusa (Eurycoma Longifolia Jack.) improving male white mice Iibido, which was showed by the increament amount of introduction and climbing of male white mice to female white mice.Key words: Eurycoma longifolia roots, libido, introduction, climbing, coitus

CONSUMEN MOTIVATION TO WARD INFORMATION SERVICE AND DRUG CONSULTATION OF PHARMACEUTICAL STORE IN YOGYAKARTA CITY Ika Puspita Sari
Indonesian Journal of Pharmacy Vol 12 No 2, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Consumer perception and motivation study to drug information services has been performed in Jogjakarta. The result have shown that consumer motivation based on drive not the respon variable. For people it is important to get information services from drug store but its drug information is not enough for safety drug use, and it is difficult for them to acces drug information services in drug store.Key words : consumer perception, consumer motivation, drive, drug information services

SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES Gupta, Rajul; Fuloria, Neeraj Kumar; Fuloria, Shivkanya
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Various substituted acetophenones (1-5) on treatment with iodine and thiourea yielded 2-amino-4-(substituted-phenyl)-thiazole (1a-5a), which on further treatment with various substituted aldehydes to get N-(substitutedbenzylidene)-4-(substitutedphenyl) thiazol-2-amine (1b-5b). All the synthesized compounds were characterized by their respective FTIR, 1H NMR and mass data. Synthesized compounds (1b-5b) were subjected to investigation for their antibacterial and antifungal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Asperigillus flavus and Asperigillus fumigatus by disk diffusion method. Compound 5b was found to be most effective with largest zone of inhibition.Key words: thiazole, acetophenones, antibacterial, antifungal, substituted aldehydes.

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