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Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 261 Documents
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PEMANFAATAN Calotropis gigantea SEBAGAI PENGOBATAN DINI BOROK GANGREN UNTUK PREVENTIF AMPUTASI PADA DIABETES MELITUS: LITERATURE REVIEW Salsabiella, Elok; Dina Anggraeni, Amaliyah
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25817

Abstract

Gangrenous ulcers due to diabetes increase the risk of amputation. Madurese herb Calotropis gigantea is empirically known to accelerate wound healing through its anti-inflammatory, antioxidant, and angiogenesis-stimulating activities, as well as helping to inhibit infection and repair tissues. To determine the effectiveness of traditional Madurese herb based on Calotropis gigantea extract as a complementary therapy in accelerating the healing of gangrenous ulcers in patients with diabetes mellitus. Using Systematic Literature Review (SLR) based on google scholar database, PubMed, and ScienceDirect for the period 2020-2025 indexed by SCImago Journal Rank (SJR) Quartile 1 - 2 articles were selected based on inclusion and exclusion criteria. Medical Subject Heading (MeSH) was used as a reference for literature search keywords with the use of the PIO (Problem, Intervention, Outcome) concept as an extraction and analysis of research articles. The results showed that Calotropis gigantea extract has anti-inflammatory, antioxidant, and angiogenesis-stimulating activities, which effectively accelerate the healing of gangrenous ulcers and reduce the risk of serious complications. The bioactive compounds in this Madurese herb support tissue regeneration and infection control. Traditional Madurese herb based on Calotropis gigantea extract has the potential to be an effective complementary therapy to support conventional treatment, reduce the risk of amputation, and improve the quality of life of patients with gangrenous ulcers due to diabetes.

Page 27 of 27 | Total Record : 261

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