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Made Krisna Adi Jaya
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Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2020.v02.i01
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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CHARACTERIZATION OF ANTIBACTERIAL BIOACTIVE COMPOUNDS FROM KUSAMBI LEAF EXTRACT (Schleichera oleosa (L) Oken) Sanan, Antonius Oenunu; Murti, Yosi Bayu; Hertiani, Triana
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p03

Abstract

Background: The kusambi plant is traditionally used by people to treat various diseases. This plant is thought to contain various secondary metabolites with various pharmacological activities, including antibacterial. Objectives: This study aims to determine the antibacterial activity of various extracts using n-hexane, ethyl acetate, and 96% methanol as solvents against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 bacteria and identify what groups of compounds are contained in the kusambi leaf extract. Method: Kusambi leaves were extracted with Soxhlet using n-hexane, ethyl acetate, and 96% methanol (1:4 w/v). Activity testing uses the agar diffusion method, and compound class testing uses the TLC (thin layer chromatography) method and spray reagents. Results: The research showed the highest yield was 22% for methanol extract, 12% for N-hexane extract, and 20% for ethyl acetate extract. Methanol extract activity test Kusambi leaves show moderate intensity inhibitory activity against bacteria S.aureus bacteria, while bacteria E.coli did not show inhibitory activity. The most significant inhibition zone diameter in the ethyl acetate extract was 9.22 mm with a concentration of 10?g/mL, the methanol extract had an inhibition zone diameter of 8.82 mm with a concentration of 10 ?g/mL, and the leaf N-hexane extract had no inhibition zone. The identification results of the compound groups were flavonoids, alkaloids, phenols, steroids, and triterpenoids, as proven by the TLC method and spray reagents. Conclusion: Kusambi leaf extract using ethyl acetate solvent has inhibitory activity against bacteria S.aureus and contains flavonoids, phenols, steroids, alkaloids, and triterpenoids. Keywords: Kusambi plant; antibacterial; secondary metabolite compounds.
IMPLEMENTATION OF IMAGE ANALYSIS FROM THIN LAYER CHROMATOGRAM OF PURPLE SWEET POTATO LEAF EXTRACT IN CHEMICAL FINGERPRINTING Mirayanti, Ni Putu Dinda; Yustiantara, Putu Sanna; Wirasuta, I Made Agus Gelgel
Journal Pharmaceutical Science and Application Vol 5 No 2 (2023): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i02.p01

Abstract

Background: Purple sweet potato (Ipomoea batatas L.) is a crop that contains rich amounts of anthocyanins and flavonoids. For maintaining its quality in preparations, fingerprint analysis using Thin Layer Chromatography (TLC) is commonly used. Objective: In this study, image analysis was implemented on the chromatogram to develop fingerprint profiles of the leaves of various types of purple sweet potatoes. Methods: Fingerprint analysis and acquisition of data were carried out by combining modern TLC equipment with software for image analysis. The in-situ fingerprint analysis using WinCats was compared with the image analysis results obtained in this study. The chemometric technique, cluster analysis, was performed to measure their difference in terms of sample classification. Cluster analysis was carried out to confirm that the clusters formed from image analysis were the same as those from WinCats. Results: The results obtained were two dendrograms, both showing the formation of two clusters but with a different order of samples. This study concluded that the data obtained from image analysis using ImageJ software resulted in clustering with a similarity of 38.15%, while the data obtained from WinCats software resulted in classification with a similarity of 28.31%. Both methods had issues in determining the fingerprint profiles, as evidenced by the low level of similarity. Conclusion: These results indicate that image analysis has the potential to be implemented for fingerprint profile development. However, further analysis is needed to align the Rf values and confirm the compounds in the peaks.
OPTIMIZATION OF GUMITIR FLOWER EXTRACT (TAGETES ERECTA L.) SUNSCREEN CREAM : SIMPLEX LATTICE DESIGN METHOD Putra, I Gusti Ngurah Agung Windra Wartana; Septiari, I Gusti Ayu Agung
Journal Pharmaceutical Science and Application Vol 5 No 2 (2023): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i02.p06

Abstract

Background: Sunscreen cream is used to protect the skin from the bad effects of sunlight. Making a good sunscreen cream requires paying attention to the composition of the constituent compounds to obtain a standardized cream formquality. Formula optimization is carried out in each cream formulation, including to produce of Gumitir flower extract sunscreen cream. Objective: The aim of this research is to produce an optimum formula for Gumitir flower extract sunscreen cream. Methods: The method used in this research is the Simplex Lattice Design optimization method to find the optimum base between stearate acid cream base and triethanolamine. Results: Optimization results show that variations in stearic acid and triethanolamine cream bases influence the physical properties of viscosity and adhesiveness of sunscreen cream preparations, with stearic acid as the dominant factor influencing viscosity. Conclusion: The conclusion obtained from this research is that the optimum formula for Gumitir flower extract sunscreen cream was obtained with a base composition of 13.5% stearic acid and 2.5% triethanolamine. Keywords: Optimization; Gumitir; Extract; Sunscreen

Page 7 of 7 | Total Record : 63

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