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Made Krisna Adi Jaya
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Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2020.v02.i01
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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THE CORRELATION OF PHARMACEUTICAL SERVICES TO THE LEVEL OF SATISFACTION WITH COVID-19 VACCINATION PARTICIPANTS IN RS TINGKAT II UDAYANA Iwan saka nugraha; Wahyuni W Udi
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p01

Abstract

Background: The obligation to vaccinate against Covid-19 in an effort to prevent national COVID transmission is contained in Presidential Regulation No.99 of 2020. Healthy, safe and quality COVID-19 vaccination services can be realized with pharmaceutical services. Objective: This research aims to study the correlation of pharmaceutical services to the level of satisfaction after the covid-19 vaccination at RS Tingkat II Udayana. Methods: The research design was a Cross-Sectional study which used an analytical survey. The population in the study was all participants of the COVID-19 vaccine in June at RS Tingkat II Udayana, which consisted of 500 participants. The sample in this study was obtained by using the total sampling method. Data collection in this study used primary data. Data analysis is carried out univariately and bivariate. Results: The results of the study found that vaccination participants were satisfied with pharmaceutical services, as shown from the comparison of services received and patient expectations. There is a relationship between pharmaceutical services, variables of guarantee, empathy, and physical evidence to the satisfaction of COVID vaccination participants at RS Tingkat II Udayana. Conclusions: variables of guarantee, empathy, and physical evidence have a significant correlation with the satisfaction of vaccination participants. Keywords: Pharmaceutical Services; Satisfaction; Vaccination
THE EFFECT OF ONLINE-BASED EDUCATION ON TREATMENT ATTITUDES AND MEDICATION ADHERENCE OF TUBERCULOSIS PATIENTS AT THE DENPASAR CITY HEALTH CENTER Ni Made Andrinia Ratih Sri Indarswari; Ida Ayu Manik Partha Sutema; I Made Bakta
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p06

Abstract

Background: Tuberculosis is an infectious disease with a high prevalence rate in Denpasar City. Medication adherence affects increased tuberculosis cases in Denpasar City. Medication adherence in tuberculosis patients is associated with a low attitude toward treatment, so it is necessary to make efforts to improve treatment attitudes and medication adherence of tuberculosis patients by providing health education. Online-based education with Google Meet can be a solution in delivering health education with virtual face-to-face features, so education delivery becomes more effective. Objective: This study aims to determine the effect of online-based education on treatment attitudes and medication adherence of tuberculosis patients at the Denpasar City Health Center. Methods: The pre-experiment study used one group pretest-posttest design that was conducted from February until April 2022 at several public health centers in Denpasar City. The total samples of 30 tuberculosis patients accorded the inclusion criteria were taken by purposive sampling. A questionnaire was used to measure treatment attitudes, where online-based education is given a week after the pre-test and the post-test is given 2 weeks after online-based education. Pill-count method was used to measure medication adherence. Wilcoxon analysis was used to analyze research data. Results: Wilcoxon's analysis showed a significant increase in treatment attitudes and medication adherence of tuberculosis patients before and after online-based education with google meet (p<0.05). Conclusion: Online-based education with google meet provides an increase in treatment attitudes and medication adherence of tuberculosis patients at the Denpasar City Health Center. Keywords : Online-based Education; Treatment Attitudes; Medication Adherence; Tuberculosis
FIGURE OF POTENTIAL MEDICATION ERROR IN MEDICINE PRESCRIPTION FOR OUTPATIENT SERVICES OF "X" HOSPITAL IN BALI Dewa Gede Wahyu Nuryatama; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p02

Abstract

Background: Medication errors (ME) in health services; in this case, hospitals are supposed to have zero accidents. Evaluation of the potential ME, such as doctor's prescription writing, must still be carried out in an effort to maintain service quality, especially in maintaining patient safety or preventing medication errors. Objective: This research aimed to see the figure of potential medication errors that occur in the prescribing process, in this case, is related to the completeness of the prescription seen from the administration and pharmaceutical approach, as well as the legibility of the prescriptions originating from outpatient services at one of the hospitals in Bali. Methods: This research was observational with a qualitative descriptive approach. Data collection was carried out retrospectively through medication prescriptions for patients received by pharmaceutical installations for outpatient services at hospitals from July until October 2022, totaling 110 prescriptions. Results: Results showed that 1.8% of prescriptions still did not write down the patient's name, then 9.1% of prescriptions had not written down the patient's age, 21.8% of prescriptions had not written down the patient's gender, and as many as 93.6% of prescriptions did not include the patient's weight, 2.7 % of prescriptions did not include the name of the doctor, 75.5% of the prescriptions did not include the doctor's SIP number, 1.8% of the prescriptions still did not write down the rules for using the drug, 10.9% of the prescriptions did not write down the strength of the drug dosage and 19.1% of the prescriptions did not provide information about dosage form to be administered to the patient. This study also shows 8.9% of the prescriptions are Illegible prescription. Conclusion: The results of the research found that administratively and pharmaceutically incomplete prescriptions and also Illegible prescription writing were still found. So the results of this study show how important it is to always evaluate the potential of medication errors, especially at the prescribing and transcribing phases, to improve patient safety. Keywords: Medication error; Prescription; Hospital; Retrospective
A REVIEW OF ANTIBACTERIAL POTENTIAL OF BANANG-BANANG PLANT (Xylocarpus granatum J.Koenig) EXTRACT Galuh Bela Pertiwi; I Gusti Agung Ayu Kusuma Wardani; Ni Made Dwi Mara Widyani Nayaka
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p03

Abstract

Background: Xylocarpus granatum has been used traditionally by coastal communities to treat various diseases. It is known that this plant contains secondary metabolites with various pharmacological activities, including as an antibacterial. Objective: This review article aims to provide information regarding the potential antibacterial activity of banang-banang plants and to summarize the content of compounds that have antibacterial properties and their mechanism of action. Methods: The preparation of this article is through literature studies from various international journals and national journals obtained online by taking into account predetermined inclusion and exclusion criteria. Then it was selected and studied further to obtain data related to the antibacterial activity of banang-banang plants and the content of secondary metabolites that have potential as antibacterials. Results: The banang-banang plant, especially the leaves, roots, fruit, seeds, fruit flesh, fruit peels, stems and bark with its secondary metabolites can inhibit several bacterial species such as Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Vibrio alginolyticus, Staphylococcus aureus, Shigella boydii , Proteus spp., Streptococcus pyogenes, Ralstonia solanacaerum, Propionibacterium acnes, Agrobacterium tumefaciens, Aspergillus paraciticus, Bacillus subtilis, Candida albicans, Pseudomonas fluorescence, Micrococcus luteus, Saccharomyces ceresiviae, Salmonella typhi, Vibrio alginoliticus and Aeromonas hydrophilla. The secondary metabolites of this plant that have potential as antibacterial are tannins, saponins, steroids, phenols, triterpenoids, flavonoids, alkaloids, terpenoids and glycosides which have their respective mechanisms of action as antibacterial agents. Conclusion: Secondary metabolites contained in each part of the Xylocarpus granatum plant are thought to have a role in its antibacterial activity.Keywords: Antibacterial, Mechanism of action, Secondary metabolite, Xylocarpus granatum J.Koenig.
JPSA TABLE OF CONTENT (VOL 5, NO 1, JUNE 2023) JPSA Editor
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

DRUG MANAGEMENT EVALUATION THROUGH EXPIRED DRUG PROFILE ANALYSIS AT “X” HOSPITAL IN BALI Kadek Lia Andini; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p04

Abstract

Background: One of the most important hospital management in the provision of health services as a whole is drug management. Remember the important position of drugs for hospitals; their management must be carried out effectively and efficiently because if they do not, they can have a negative impact on hospitals, both medically, socially and economically. Drug management is crucial in the drug management cycle to determine drug stocks that suit the needs of health services with guaranteed quality and can be obtained when needed. One of drug management is by controlling expired drugs. Medicines that have passed their expiry date can be dangerous because they reduce the stability of the drug and can cause toxic effects. Objective: This study aims to describe drug management in terms of expired drug profiles and determine the factors that influence the number of expired drugs in "X" Hospital. Methods: Research in the form of observational research with a descriptive approach. The samples used are all expired drugs in the warehouse and have not been destroyed. Factors affecting the number of expired drugs were observed by interview. Results: The results of the study show that the percentage of expired drugs in the period 2019 to 2022 is obtained from the loss value and inventory management value of 0.11%, respectively; 0.18%; 0.14%; and 0.93%. Expired drugs were also classified based on the ABC analysis, with the highest number in group C with 137 items; in the VEN analysis, the essential medicines group with the highest number of 122 items; and in the ABC-VEN combination analysis, the EC group occupied the highest rank. The existence of expired drugs is caused by several factors, including the influence of information systems, human resources and methods of recording drugs that are still manual. Conclusion: The management of expired drugs in the pharmaceutical installation of "X" Hospital is quite good because the percentage is still under control because it is less than 2%.Keywords: Drug management; Evaluation; Expired drugs
COST ANALYSIS OF PATIENTS WITH SQUAMOUS CELL CERVICAL CANCER STAGE IIB-IIIB WITH PACLITAXEL CISPLATIN CHEMOTHERAPY FROM THE SOCIETAL PERSPECTIVE Ni Kd Rintan Listiani Ekayanti; Rini Noviyani; Sagung Chandra Yowani; Ketut Ariawati; I Nyoman G. Budiana
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p05

Abstract

Background: The high prevalence of cervical cancer patients and the variety of necessary expenses needed causing financial hardship to both the patient and hospital. Furthermore, the disparity between the INA-CBGs rates and the costs of treatment incurred by hospitals and the limited information regarding the costs of cervical cancer undergoing cisplatin paclitaxel chemotherapy as viewed from a societal perspective were the reasons to conduct this research. Objective: The aim of this study was to determine the cost of squamous cell cervical cancer patients at stage IIB-IIB who received cisplatin paclitaxel chemotherapy from a social perspective. So in this study the difference in costs is used to calculate costs from a hospital perspective. Methods: This research was an observational study with a prospective incidence approach and consecutive sampling as the sampling method. This research was conducted from January to June 2017 at Sanglah General Hospital, Denpasar. Cost data from a societal perspective for six chemotherapy series were obtained from the Claim Guarantee Installation, Fund Mobility Section, interviews and filling in the logbook by patients and then calculated using the micro-costing method. Results: The results of this study obtained five patients who met the inclusion criteria. From the perspective of BPJS Kesehatan, the average cost of cervical cancer with paclitaxel cisplatin chemotherapy was IDR 24.703.470,00. From a hospital perspective, the average cost of cervical cancer with paclitaxel cisplatin chemotherapy was IDR 6.619.204,00., and from the perspective of patients and their families, the average burden of costs for cervical cancer with paclitaxel cisplatin chemotherapy was IDR 9.149.300,00. Conclusion: Cost analysis on five squamous cell cervical cancer patients with stage IIB-IIIB with six series of paclitaxel cisplatin chemotherapy viewed from the perspective of BPJS Kesehatan, hospital was IDR 24,703,470.00, IDR 6,619,204.00, and IDR 9,149,300.00, respectively. Keywords: Cervical Cancer; Chemotherapy; Cost Analysis; Paclitaxel Cisplatin; Societal Perspective
EVALUATION OF THE ACCURACY OF USING TOPICAL ANTIBIOTICS IN SELF-MEDICATION FOR ACNE VULGARIS AT THE DENPASAR REGIONAL PHARMACY Ida Ayu Manik Partha Sutema; Alma Lystia Savitri Mahayasa; I Made Bakta
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p01

Abstract

Background: One of the skin problems that are often experienced by teenagers today is acne. Acne vulgaris or acne is a chronic inflammatory disease of pilosebaceous follicles which is characterized by the formation of papules, pustules, or nodules. Purpose: This study aims to provide an accurate description of the use of topical antibiotics in acne vulgaris patients and to find out which drugs are often used as self-medication for acne vulgaris. Methods: This research is included in a descriptive research design. Data collection was done by direct observation and recorded on the checklist sheet for Acne Vulgaris patients who did self-medication at the pharmacy. Results: Judging from the evaluation of the accuracy of the use of topical antibiotics in AV patients at the Denpasar Regional Pharmacy, the results obtained were 53 patients, or 92.98% of patients included in the right indication group, 57 patients, or 100%, included in the right dose group, 54 patients or 94.74% included in the right group for the duration of administration, 57 patients or 100% were included in the appropriate time interval group for administration and 100% of patients were included in the side effect alert group. The accuracy of giving antibiotics, which is included in the category of inappropriate indications by 5.71% of respondents, and inappropriate duration of administration by 5.08% of respondents. The drugs used for AV therapy are Topical Retinoids, Mediklin Gel, Mediklin TR, and Erymed. The drug most often given by pharmacists is topical antibiotics, namely Mediklin TR from the Semisynthetic Lincosamide group, as much as 38.57%. Conclusion: There is still suitability for prescribing topical antibiotics in acne vulgaris seen from its severity.Keywords: Acne; Evaluation; Topical antibiotics
PRODUCTION OF HUPERZINE A BY FUNGAL ENDOPHYTES ASSOCIATED WITH HUPERZIACEAE PLANTS Ni Putu Ariantari; Ni Wayan Prasanthi Swarna Putri
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p06

Abstract

Background: Endophytic fungi are known as a producer of a myriad of bioactive natural products, including those originally produced by the host plants. Huperzine A (Hup A), a lycopodium alkaloid, which was reported as an active acetylcholinesterase inhibitor (AChEI) agent used for the treatment of Alzheimer’s disease, was originally isolated from medicinal Chinese herbs Huperzia serrata. Moreover, various species of endophytic fungi associated with H. serrata and other species within Huperziaceae plants were found capable of producing Hup A, suggesting these microorganisms as promising sources of Hup A. Objective: This review aimed to summarize the evidence of Hup A produced by various endophytic fungi as part of efforts to assess alternative producer of Hup A. Methods: Scientific articles on endophytic fungi producing Hup A published from 2000 until 2022 were screened through scientific databases. Results: Thirty-two endophytic fungal strains belonging to fifteen fungal genera were documented as capable of producing Hup A. These fungal endophytes were isolated from Huperziaceae plants, H. serrata, Phlegmariurus phlegmaria and Phlegmariurus taxifolius. Conclusion: We summarize herein the capability of endophytic fungal strains associated with Huperziaceae plants to produce Hup A, an active AChEI agent, which could be considered as an alternative producer of Hup A on a larger scale.Keywords: Acetylcholinesterase inhibitor (AChEI); Alzheimer’s disease; Fungal endophytes; Huperziaceae; Huperzine A (Hup A).
THE RELATIONSHIP BETWEEN KNOWLEDGE AND COMMUNITY BEHAVIOR IN UTILIZATION OF TELEPHARMACY SERVICES IN THE TABANAN CITY Ni Putu Aryati Suryaningsih; Ni Wayan Mita Arisia; I Ketut Tunas
Journal Pharmaceutical Science and Application Vol 5 No 1 (2023): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2023.v05.i01.p02

Abstract

Background: Telepharmacy appears to be a technology that represents a unique and innovative way to deliver quality pharmaceutical services to rural and regional areas in particular. Providing appropriate pharmaceutical services to patients and conducting consultations with other health workers have an important role in reducing the use of inappropriate and less effective drugs. The development of telepharmaceutical services can be influenced by the knowledge and practice of the community. Objective: to determine the relationship between knowledge and community practice on the use of telepharmaceutical services in Tabanan City. Methods: This research is an observational study using a cross-sectional design. The sample in this study amounted to 100 people who met the inclusion and exclusion criteria. The sample was taken from the population using a purposive random sampling technique. The research instrument used in this study was a questionnaire (questionnaire), collecting data formally for the subject to answer questions in writing. Data were analyzed using computer software, namely the Chi-square test. Results: The respondents who have sufficient knowledge, as many as 55 people have sufficient behavior, and as many as 42 people, while those who have good behavior, 13 people and respondents who have good knowledge, 45 people have sufficient behavior, as many as 23 people and behavior well as many as 22 people (p-value <0.05). There is a relationship between knowledge and practice regarding the use of telepharmaceuticals in the community of Tabanan City. Conclusion: there is a relationship between knowledge and practice regarding the use of telepharmaceuticals in the community of Tabanan City. Keywords: Knowledge; Practice; Telepharmaceutic

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