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Made Krisna Adi Jaya
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krisnaadijaya598@gmail.com
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jpsa@unud.ac.id
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Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770
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INDONESIA
Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2020.v02.i01
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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THE POTENTIAL OF FRANGIPANI FLOWER EXTRACT (Plumeria alba L.) AS AN ANTIBACTERIAL Hana Yuniestica Sinaga; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p05

Abstract

Background: Bacteria develop naturally in the human body to aid in protecting the individual. Antibiotic resistance is quickly increasing and is becoming a global health concern. In this situation, the risk of synthetic antibiotic resistance against bacterial infections makes it critical to find alternative medications that are safe, easy to obtain, and better than synthetic antibiotic alternatives. The frangipani plant is one of the medicinal plants used in traditional medicine as an antibacterial. The frangipani plant possesses antibacterial properties comparable to broad-spectrum medicines against uro-gastro pathogens. Objective: The purpose of this study was to determine the activity of the frangipani flower as an antibacterial. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify frangipani flowers with antibacterial activity. Results: Results showed that frangipani flowers have antibacterial activity against gram-positive and gram-negative bacteria because frangipani flowers contain various antibacterial chemical components, such as terpenoids, saponins, phenols, flavonoids, tannins, and essential oils. Conclusion: Frangipani flowers have the potential to an antibacterial against gram-positive and gram-negative bacteria. Keywords: Frangipani flower, Antibacterial, Bacteria
FORMULATION EFFERVESCENT TABLETS ETHANOL EXTRACT OF PAPAYA LEAVES (Carica papaya L.) AS TOPICAL ANTISEPTIC WITH CITRIC ACID-TARTARIC ACID VARIATIONS Tri Isa Partama; Ni Kadek Ari Kristiani; Anak Agung Istri Manik Priastari; Gusti Ngurah Jemmy Anton Prasetia
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p01

Abstract

Background: Antiseptic products that are widely found in the market contain chloroxylenol which can cause irritation and allergic reactions when used frequently. In addition, antiseptic products in liquid form are considered less practical and economical. The alternative used to overcome these problems is to utilize natural ingredients that are made in solid dosage forms in the form of effervescent tablets. One alternative plant that has the potential as an antiseptic is papaya leaves. Objective: To determine the effect of variations in citric acid and tartaric acid as a source of acid in the formulation of effervescent tablets and to find out what formula is the effervescent tablet of papaya leaf ethanol extract has the best physical properties to meet the physical qualification requirements of the tablet. Methods: Extraction was carried out by the maceration method with 96% ethanol as solvent. The method used for the manufacture of effervescent tablets is wet granulation. Therefore, in this study, observations were made on the effect of variations in citric acid and tartaric acid (1:3; 1:1 and 3:1) on the physical quality and antibacterial activity of effervescent tablets. Result: The tablet formulations F1 with variation citric acid-tartaric acid (1:3) showed physical characteristics that met the tablet quality requirements. Based on the antibacterial activity test of Escherichia coli on effervescent tablets, papaya leaf ethanol extract (Carica papaya L.) for formulation I showed an inhibitory power of 7,5±1,29 mm. The inhibitory power is more effective than the positive control, namely antiseptic products on the market with an inhibition zone of 6,5 ± 0,05 mm. Conclusion: Based on the variation of citric acid and tartaric acid used, it did not affect the physical properties of effervescent tablets of papaya leaf ethanol extract (Carica papaya L.) including uniformity of weight, but influenced hardness, friability, and dissolving time of effervescent tablets of papaya leaf ethanol extract (Carica papaya L.). Keywords: Papaya leaf (Carica papaya L.), effervescent tablet, citric acid, tartaric acid, antiseptic
ANTI-INFLAMMATORY ACTIVITIES OF PEPEROMIA PELLUCIDA [L.] KUNTH.: A REVIEW I Gusti Agung Ayu Kartika; Ni Ketut Sinarsih; Ni Made Dwi Mara Widyani Nayaka
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p06

Abstract

Background: Inflammation is a natural body response, but when it reaches the systemic chronic inflammation stage, it can cause more dangerous complications. Many natural ingredients have been developed as anti-inflammatory agents. One of them is sirih bumi (Peperomia pellucida [L.] Kunth). Objective: This study aims to summarize and examine the research results related to the anti-inflammatory activity of the sirih bumi. Methods: Research articles were collected from various online databases such as Google Scholar, Google, Medline, Pubmed, and Science Direct. Inclusion and exclusion criteria were applied to obtain original research articles relevant to the desired topic, published in the last ten years, the full text was accessible, and the research methods and results were well explained and valid. Results: In total, only six articles are eligible to be discussed. The research was conducted in Indonesia, Nigeria, and Malaysia. In vitro and in vivo methods with various models and parameters were used to test the anti-inflammatory activity. All parts of the plant are proven to have anti-inflammatory effects that can be presented in extracts or herbal teas. The activity of sirih bumi is determined by the dose or concentration of administration, processing process, and harvest time. The combination with other samples must be reconsidered to maintain the desired anti-inflammatory effect. Conclusion: Anti-inflammatory activity of sirih bumi has been proven through various studies. The development of the sirih bumi product is expected to help handle inflammation and other diseases related to inflammation. Keywords : peperomia pellucida, inflammation, extract, tea
ANTI-INFLAMMATORY ACTIVITY OF PEGAGAN LEAVES (Centella asiatica (L.) Urban) EXTRACT CREAM Siti Mardiyah
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p02

Abstract

Background: Pegagan leaves (Centella asiatica (L.) Urban) is an herbal plant family of Apiaceae containing the active ingredients of the triterpenoid group glycosides (asiaticoside, Asiatic acid, madekasat acid, madikassosida) centelloside, flavonoids, and Asiatic acids. Inflammation is a complex reaction in tissues that involves a response to blood vessels and leukocytes. Objective: The purpose of this study was to find out the anti-inflammatory activity that occurs in the legs of mice in the form of preparation of pegagan extract cream (Centella asiatica (L.) Urban). Methods: Pegagan extract is done by the maceration method that uses ethanol 70%. Test animals used to squeak white males as much as 10 heads with a body weight of 20-30 grams. Animals test were divided into 5 treatment groups, namely the pegagan extract group with a dose of 2 g/kg BB; 4 g/kg BB; 6 g/kg BB, positive control (Betason cream 0.1%), and negative control (pegagan extract 2 g/kg BB). 1 hour before treatment of squeaky soles is inducted with a 1% carrageenan solution subplantarically. Results: Measurement of edema volume on the soles of the feet of mice is observed every 1 hour for 6 hours. The results showed that pegagan extract cream with a dose of 6 g / kg BB showed the maximum percentage of inhibition edema that is at the 6 hours with a result of 80,2%. The results of the data analysis of the percentage of inhibition of Centella asiatica extract from the treatment group Negative Control-Formula II and Negative Control-Formula III showed significant differences (p<0.05). Conclusion: Pegagan leaves extract has an anti-inflammatory effect on the feet of mice. Keywords: Anti-inflammatory, Pegagan leaves, Centella asiatica (L.) Urban
JPSA TABLE OF CONTENT (VOLUME 4, ISSUE 1, JUNE 2022) Made Krisna Adi Jaya Editor
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

THE EFFECTIVENESS TEST OF INFUSION CELERY ROOT (Apium graveolens L.) AS A DIURETIC IN WISTAR MALE WHITE RATS (Rattus Norvegicus) Ida Ayu Dhea Rahnia; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol 4 No 1 (2022): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p03

Abstract

Background: Hypertension is defined by persistently elevated arterial blood pressure. The increase in systolic blood pressure is generally>140mmHg or diastolic blood pressure> 90mmHg. The prevalence of hypertension increases with lifestyle changes. Objective: To determine the diuretic effect of celery (Apium graveolens L.) on male wistar rats (Rattus norvegicus). Methods: This research uses a literature study method, the type of the research is descriptive qualitative with literature research (library research) systematic. Results: Based on research data, there were 5 groups of mice that received different treatments. Among the five treatment groups, 0.5 % CMC suspension (KP-) showed the least mean cumulative urine volume, and furosemide suspension (KP+) showed a large mean cumulative urine volume when compared to negative controls. Conclusion: Celery root infusion can increase urine volume because it contains flavonoids that play a role in increasing urine volume (diuresis). Keywords: Diuretic, Celery (Apium graveolens L.), Furosemide, Hypertension, Wistar rats
JPSA TABLE OF CONTENT VOL 4, NO 2, DECEMBER 2022 JPSA Editor
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This Section consists: 1. JPSA Cover 2. Editorial Board 3. Table of contents for the JPSA Volume 4, Issue 2, December 2022.
THE EFFECT OF EDUCATIONAL LEAFLET USING BLOOD ADDED TABLETS ON THE KNOWLEDGE LEVEL OF PREGNANT MOTHER PATIENTS WITH ANEMIA AT PUSKESMAS 1 JEMBRANA I Gusti Ayu Diah Candra Dewi; Ida Ayu Manik Partha Sutema; I Gede Suasnawa
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p03

Abstract

Background: Anemia in pregnancy is a condition where the hemoglobin (Hb) level is less than 11gr/dl in women who are pregnant. Providing education through leaflets to pregnant women is expected to help prevent anemia during pregnancy. Objective: The purpose of this study was to determine the effect of providing education on the use of blood supplement knowledge on the level of knowledge of pregnant women with anemia at Puskesmas I Jembrana in 2022. Methods: The research design used in this study was a quantitative study with a pre-experimental design approach of Groups Pretest-Posttest. The sampling technique used was total sampling with 67 pregnant women with anemia. Results: The results of this study revealed that there was an effect of leaflet education on the use of blood-added tablets on the knowledge level of pregnant women with anemia at Puskesmas 1 Jembrana with a p-value of 0.000 < (0.05) and a mean difference in the pretest and posttest values ??of 5.43. Conclusion: There is a significant effect between the level of knowledge about the use of blood steadfast tablets and the incidence of anemia in pregnant women. It is hoped that the public, especially pregnant women, will pay more attention to their condition and always consult health workers regarding the use of blood-added tablets. Keywords: Anemia; Leaflet; Knowledge
PERCEPTION OF HYPERTENSION PATIENTS ON THE USE OF HERBAL DRUGS IN COMPLEMENTARY THERAPY OF HYPERTENSION IN DENPASAR CITY Califia Ersa Vinata; Ni Putu Aryati Suryaningsih; Made Karma Maha Wirajaya
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p04

Abstract

Backgrounds: Hypertension or Silent killer is a condition when the systolic pressure is measured 140 mmHg or the diastolic pressure is measured 90 mmHg. The prevalence of hypertension in Denpasar City is still quite high, with an estimated 177,627 hypertension sufferers in Denpasar City in 2019. One alternative treatment that can be an option to lower blood pressure is herbal therapy. Herbal therapy is complementary therapy using medicinal plants. Objective: The purpose of this research is to identify the characteristics of respondents, the perception of hypertension sufferers on the use of herbal medicines in the complementary therapy of hypertension and the types of herbs used in complementary therapy of hypertension. The type of research used is descriptive research with using a quantitative approach. Methods: Sampling technique is purposive sampling. The research sample is hypertensive patients who use conventional and complementary herbal combination therapy, age >17-65 years, using a research instrument in the form of a questionnaire. Data analysis is carried out using SPSS software. Results: The majority of hypertension sufferers are in the age range of 46-65 years (elderly) as many as 71 people (71%), female as many as 57 people (57%). Respondents who have a positive perception of 55% and who have a negative perception of 45%. The types of herbs used are cucumber, melon, watermelon, celery leaves, bay leaves, moringa leaves, meniran leaves, garlic and Ginger. Conclusion: The majority of hypertensive patients perceptions of drug use herbs in the complementary therapy of hypertension has a positive value. That means, respondents believe that herbs have benefits and can help reduce treatment costs. The most widely used types of herbs are: cucumber (40%) and celery leaves (30%). Keywords: Hypertension; Perception; Complementary Therapy
ANTIBIOTICS USAGE OVERVIEW IN ORTHOPEDIC SURGERY PATIENTS AT A HOSPITAL IN BALI Putu Ary Pudak Wangi; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol 4 No 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p05

Abstract

Backgrounds: Antibiotic resistance can be prevented by controlling the use of antibiotics wisely. Based on WHO recommendations, controlling the use of antibiotics is done by grouping antibiotics with the AWaRe category. Objective: This work aims to present an overview of the use of antibiotics in orthopaedic surgery patients as an effort to monitor the use of antibiotics in a hospital in Bali. Methods: Based on the patient's medical record data, the antibiotics used for orthopaedic surgery were calculated and grouped with the AWaRe classification. Result: Results showed that the most prescribed antibiotic was ceftriaxone (84.74%). There were no antibiotics in the reserve category, but the highest percentage was 94.92% in the watch category, and the access category was 5.08%. Conclusion: There is still non-selective use of antibiotics in this hospital, so in the future, it is necessary to evaluate qualitatively and quantitatively to ensure rational use as well as efforts to prevent the occurrence of antibiotic resistance. Keywords: Antibiotics; Resistance; AwaRe; Hospital; Bali

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