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Berkala Kedokteran

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Published by Universitas Lambung Mangkurat

ISSN : 14120550 EISSN : 25485660 DOI : http://dx.doi.org/10.20527

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 478 Documents

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DISTRIBUSI POLA DIET PASIEN KANKER KOLOREKTAL DI RSUD ULIN BANJARMASIN PERIODE AGUSTUS OKTOBER 2015 Emma Rahmadania; Agung Ary Wibowo; Lena Rosida
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Colorectal cancer is a malignancy of epithelial cells of the colon or rectum. Factors associated with an increased risk of this type of cancer include eating habits. The purpose of this study was to determine distribution the dietary patterns in colorectal cancer patients at hospitals Ulin Banjarmasin period from August to October 2015 by a review of fat dietary, protein dietary, fiber dietary by age and gender. This research is a descriptive observasional with cross sectional approach. Data was collected using a food frequency questionnaire and interviews. Sampling was conducted with consecutive sampling technique to obtain the sample amounted to 30 patients in accordance with the inclusion criteria. Obtained the age group of patients when first diagnosed with colorectal cancer is highest in the age group 41-60 years (50%) as many as 15 people. Sex ratio of colorectal cancer patients in hospitals Ulin Banjarmasin the period August-October 2015 that men of 15 people (50%) and women of 15 people (50%). Of the 30 respondents, there are 28 (93.4%) patients with colorectal cancer who rarely consume fat, there are 25 (83.4%) patients with colorectal cancer who rarely consume protein, and there were 25 (88.7%) patients with colorectal cancer are rare consuming fiber. Distribution of pattern dietary (fat, protein, fiber)by age and sex obtained the same result that most are in the rare category. Keywords: colorectal cancer, fat, protein, fiber. Abstrak: Kanker kolorektal adalah suatu keganasan dari sel epitel kolon atau rektum. Faktor yang berkaitan dengan peningkatan risiko kanker jenis ini antara lain kebiasaan makan. Tujuan penelitian ini adalah untuk mengetahui distribusi pola diet pasien kanker kolorektal di RSUD Ulin Banjarmasin periode Agustus-Oktober 2015 dengan tinjauan terhadap diet lemak, diet protein, diet serat berdasarkan usia dan jenis kelamin. Penelitian ini merupakan penelitian yang bersifat deskriptif observasioal dengan pendekatan cross sectional. Data dikumpulkan dengan menggunakan lembar kuesioner food frequency dan wawancara. Pengambilan sampel dilakukan dengan teknik consecutive sampling sehingga didapatkan sampel berjumlah 30 pasien yang sesuai dengan kriteria inklusi. Didapatkan kelompok usia pasien saat pertama kali terdiagnosis kanker kolorektal terbanyak adalah pada kelompok usia 41-60 tahun (50%) yaitu sebanyak 15 orang. Rasio perbandingan jenis kelamin pasien kanker kolorektal di RSUD Ulin Banjarmasin periode Agustus-Oktober 2015 yaitu laki-laki sebanyak 15 orang (50%) dan perempuan sebanyak 15 orang (50%). Dari 30 responden, terdapat 28 (93,4%) pasien kanker kolorektal yang jarang mengkonsumsi lemak, terdapat 25 (83,4%) pasien kanker kolorektal yang jarang mengkonsumsi protein, dan terdapat 25 (88,7%) pasien kanker kolorektal yang jarang mengkonsumsi serat. Distribusi pola diet (lemak, protein, serat) berdasarkan usia dan jenis kelamin didapatkan hasil yang sama yaitu paling banyak berada pada kategori jarang. Kata-kata kunci: kanker kolorektal, lemak, protein, serat

AKTIVITAS LARVASIDA EKSTRAK ETANOL DAUN BINJAI (Mangifera caesia) TERHADAP LARVA Aedes aegypti Isfarani Nadila; Istiana Istiana; Erida Wydiamala
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Binjai leaf is known to have effective secondary metabolites as larvacide. The aim of this study was to recognize larvacidal effectivity of Binjai leaf ethanol extract toward Aedes aegypti larva. This was experimental study with posttest only control group design by using 7 treatment and 4 replication. Treatment was available from preliminary test which were 1000, 5000, 10.000, 15.000 and 20.000 (mg/L), negative xontrol (water) and positive control (themephos 100 mg/L). Probit test resulted in LC50 value=5493.390 mg/L and LC90 value=14988.861mg/L Kruskal-Wallis test resulted in p=0,000 which meaned there was an effect of binjai leaf ethanol extract toward Aedes aegypti larva. Meanwhile, Mann-Whitney test resulted in p=0,371 which meaned there was no significant difference between concentration of 20.000 mg/L and temephos 100 mg/L. In conclusion, binjai leaf (Mangifera caesia) ethanol extract have larvacidal activity as effective as temephos toward Aedes aegypti larva. Keywords: Larvacide, Binjai leaves, Aedes aegypti Abstrak: Daun binjai diketahui memiliki kandungan metabolit sekunder yang berpotensi sebagai larvasida. Tujuan penelitian ini adalah untuk mengetahui efektivitas larvasida ekstrak etanol daun binjai terhadap larva Aedes aegypti. Penelitian ini menggunakan jenis eksperimental dengan metode posttest only contol grup design menggunakan tujuh kelompok perlakuan dan 4 replikasi. Tujuh kelompok perlakuan tersebut adalah 5 serial konsentrasi yang diperoleh dari uji pendahuluan: 1000, 5000, 10.000, 15.000 dan 20.000 (mg/L), kontrol negatif (air) dan kontrol positif (temephos 100 mg/L). Hasil uji probit didapatkan nilai LC50 dan LC90 sebesar 5493.390 dan 14988.861 (mg/L). Uji kruskal-Wallis didapatkan nilai p=0,000, terdapat pengaruh ekstrak etanol daun binjai terhadap larva Aedes aegypti. Hasil uji Mann-whitney didapakan nilai p=0,371, tidak terdapat perbedaan signifikan antara konsentrasi 20.000 mg/L dengan kontrol positif. Kesimpulan dari penelitian ini ekstrak etanol daun binjai memiliki aktivitas larvasida dan efektivitas setara dengan temephos 100 mg/L terhadap larva Aedes aegypti. Kata-kata kunci : Larvasida, daun binjai, Aedes aegypti

GAMBARAN FAKTOR RISIKO PASIEN KANKER KOLOREKTAL DI RSUD ULIN BANJARMASIN PERIODE APRIL-SEPTEMBER 2014 Dhia Raihana Rahdi; Agung Ary Wibowo; Lena Rosida
Berkala Kedokteran Vol 11, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

The incidences of colorectal cancer in a developing country such as Indonesia are thought to increase, related to some risk factors that increase the likelihood of colorectal cancer to develop. We have done a study aimed to describe the incidence of colorectal cancer based on risk factor in patients of RSUD Ulin Banjarmasin from April-September 2014. This is a descriptive study using primary data obtained through the use of questionnaire. A total of 39 samples were chosen using non randomized accidental sampling technique. The age group with the most incidence of colorectal cancer was the productive age group (15-64 years old) with as many as 79,49% of all samples. Colorectal cancer patients with a bad diet pattern were as many as 82,05% of all samples. Most of the colorectal cancer patients were diagnosed with colorectal tumor or polyp (69,72%). A total of 30 patients (76,92%) were never diagnosed with ulcerative colitis. As many as 76,93% patients were without any familial history of cancer. The lifestyles of 61,54% colorectal cancer patients were bad lifestyle. Based on the result it can be concluded that diet pattern, age, tumor history, and lifestyle had a significant distribution on the incidences of colorectal cancer. Keywords: colorectal cancer, colorectal polyp, ulcerative colitis.

Klebsiella pneumoniae IDENTIFICATION OF PRODUCING EXTENDED SPECTRUM BETA LACTAMASE (ESBL) AND RESISTANCE PATTERN OF ANTIBIOTICS IN ULIN GENERAL HOSPITAL BANJARMASIN Ayudiah Puspita Mayasari
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Klebsiella pneumoniae(K. pneumoniae) can synthesize beta lactamase enzymes that have the ability to open lactam beta rings and cause resistance to antibiotics such as amoxicillin, third generation cephalosporins namely cefotaxim, ceftazidim, ceftriaxone and monobactam groups such as aztreonam. Extended spectrum beta lactamase (ESBL) is a plasmid enzyme that mediates the occurrence of hydrolysis and inactivation of beta lactam antibiotics. Infections caused by ESBL-producing bacteria become a serious problem for hospitals worldwide. ESBL isolate susceptibility tests against antibiotics are required to provide a sensitivity pattern that can be used as a reference in more rational antibiotic selection. This study was conducted to describe the prevalence of ESBL group K. pneumoniae and antibiotic resistance pattern at Ulin General Hospital Banjarmasin. The method of this research used secondary data material in the form of reporting document of antibiotic sensitivity test result that isolation and identification using VITEK 2, and then be analyzed using Microsoft Excel. The culture examination toward 50 patients in the Dahlia ward, Ulin General Hospital Banjarmasin was taken from January until May 2017, with the results arefrom 24 data Staphylococius aureus (S.aureus) isolate, more than half of it are ESBL group (54.16%). The results of sensitivity test of K.Pneumoniae of ESBLpositive to antibiotic group were found to be antibiotics that still have> 90% sensitive were meropenem (100%), amikacin (100%), tigecycline (92,85%), ertapenem (92,86%). The antibiotics with resistance> 50% was found in ampicillin antibiotics (100%), ceftriaxone (78.5%), ceftazidime (64.28%), cefepime (57.14%) and aztreonam (71.4%). As for ESBL negative results obtained sensitive> 90% for all antibiotics except ampicillin, ampicillin / sulbactam, and nitrofurantoin. Meropenem (100%), amikacin (100%), tigecycline (92.85%), ertapenem (92.86%) are antibiotic choices that are still sensitive to ESBL infection Keywords: antibiotic resistance, ESBL pattern, Vitek 2

HUBUNGAN KETUBAN PECAH DINI DENGAN KEJADIAN SEKSIO SESARIA DI RSUD ULIN BANJARMASIN PERIODE JUNI-JULI 2014 Herla Maulita Surdhawati; Renny Aditya; Farida Heriyani
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.193

Premature Rupture of Membranes (PROM) is a membranes rupture during before delivery takes. PROM cause a direct contact between the world outside and inside uterus. PROM cause some problems for both mother and fetus, because it should be managed by cesarean section. The purpose of this study is to determine the relationship between PROM with cesarean section in RSUD Ulin Banjarmasin on June to July 2014. This is an observasional analytic study with cross sectional approach. The sample was selectedusingaccidental samplingwith a sample size160,the resultswere analyzedusingchi-square test with confidence interval 95%.The results showed 29 mothers with PROM, then found 15(51.724%)managed by cesarean sectionand(48.275%) samples of vaginal birth. Whilethe131women witha diagnosisinstead ofPROM, 34(25.954%) samples managed bycesareansectionand97(74.046%) samples ofvaginalbirth. Chi-square test showed the value of p=0,006 and odds ratio of 3,056. The conclusion of this research is there are relationship between PROM with cesarean section in RSUN Ulin Banjarmasin on June to July 2014. Keywords: premature rupture of membranes, cesarean section, vaginal birth

The Potential of Candida Biofilm Protein as Bioreceptor for Candidiasis Immunoassay Masfufatun Masfufatun; Loo Haryanto; Harsono Harsono
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Candidiasis or infection that is caused by Candida has become a new list of the therapeutical problems recently. The difficulties in diagnosing are the main cause of the unsatisfactory results from common therapies and diagnosis methods. This has urged researchers to find alternative ways in candidiasis diagnosis such as serology-based detection using antigen or antibody development. The aim of this study was to evaluate the potential of protein derived from Candida albicans biofilm as bioreceptor on candidiasis immunoassay through Dot Blot method. The research method used descriptive method with the following stages: (1) preparation of Candida albicans biofilm (2) extraction of Candida albicans protein through enzymatic and mechanical methods, (3) determination of protein molecular weight with SDS-PAGE (4) production of polyclonal anti- candida and (5) analysis of protein extract as bioreeceptor on dot blot. Profile of biofilm proteins on SDS-PAGE analysis were shown on molecular weight 27,42; 29,89; 38,10; 44,90; 48,75; 52,92; 55,14; 59,86; 70,56; 87,36; 102,54;115,05; 130,14;143,14;181,53 kD. There were differences in the intensity of dots in the control group (44070) and treatment groups (63170.5). It is noticeable that biofilm protein extract of C. albicans can be used for induction of anti-Candida polyclonal antibody production as the potential candidate of bioreceptor in candidiasis immunoassay. Keywords: SDS-PAGE, polyclonal antibody, immunoassay, dot blot, biofilm

Perbandingan Tekanan Nadi Berdasarkan Indeks Massa Tubuh Pada Mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat Niarsari Anugrahing Putri; Asnawati Asnawati; Alfi Yasmina
Berkala Kedokteran Vol 9, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i1.913

ABSTRACT: Obesity is a global problem occurring worldwide, both in developed and developing countries, including Indonesia. Obesity and overweight may affect the pulse pressure through the increased level of leptin, which mainly secreted by adipose tissue. The research was aimed to determine the difference in pulse pressure based on body mass index (BMI) in students of Faculty of Medicine, Lambung Mangkurat University (FM LMU). This research applied analytic observational method with cross sectional approach, with 60 male students of FM LMU as subjects. Data were obtained based on the measurement of pulse pressure and BMI. Result showed that as many as 66.8% of the students of FM LMU had normal BMI and 19.2% had BMI of overweight and obesity. The average pulse pressure of students with normal BMI was 33 mmHg and students with overweight and obesity was 42 mmHg. Data analysis using the Mann-Whitney test with confidence level of 95% gave the value of p = 0.000. It was concluded that there was a significant difference in pulse pressure based on BMI in students of FM LMU. Keywords: pulse pressure, body mass index ABSTRAK: Obesitas merupakan masalah global yang melanda masyarakat dunia, baik di negara maju maupun negara berkembang, termasuk Indonesia. Obesitas dan overweight dapat mempengaruhi tekanan nadi melalui peningkatan kadar leptin yang terutama disekresi oleh jaringan adiposa. Penelitian ini dilakukan dengan tujuan untuk mengetahui perbedaan tekanan nadi berdasarkan indeks massa tubuh (IMT) pada mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat (FK Unlam). Penelitian ini menggunakan metode observasional dengan pendekatan cross sectional dengan subyek penelitian mahasiswa FK Unlam sebanyak 60 orang. Data diperoleh berdasarkan pengukuran tekanan nadi dan IMT. Hasil penelitian menunjukkan bahwa sebanyak 66,8% mahasiswa di FK Unlam memiliki IMT normal dan 19,2% memiliki IMT overweight dan obesitas. Rerata tekanan nadi pada mahasiswa dengan IMT normal adalah sebesar 33 mmHg dan pada mahasiswa dengan IMT overweight dan obesitas sebesar 42 mmHg. Analisis data menggunakan uji Mann-Whitney dengan tingkat kepercayaan 95% memberikan nilai p = 0,000. Dapat diambil kesimpulan bahwa terdapat perbedaan tekanan nadi yang bermakna berdasarkan IMT pada mahasiswa FK Unlam. Kata-kata kunci : tekanan nadi, indeks massa tubuh

Free Radical, Oxidative Stress and Its Roles on Inflammatory Response Putu Oky Ari Tania
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Chronic inflammation contributes to the occurrence of various metabolic diseases and even cancer. Chronic inflammation results from excessive response of free radicals. Free radicals are triggered by various agents and oxidation processes in the body as Reactive Oxygen Stress (ROS). The high level of free radicals (oxidants), without adequate intake of antioxidants will lead to oxidative stress conditions. Oxidative stress triggers persistent of inflammation. The formation of ROS is difficult to avoid because it can be generated from cellular metabolic processes. Therefore, we should intake adequate of antioxidants and avoid the various agents induces ROS in everyday life. Keywords : ROS, Stress Oxidative, Inflammation

Uji Sensitivitas Isolat Bakteri Pasien Urolithiasis di Ruang Perawatan Bedah Rsud Ulin Banjarmasin terhadap Antibiotik Terpilih Strata Pertiwi; Eka Yudha Rahman; Lia Yulia Budiarti
Berkala Kedokteran Vol 10, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.929

ABSTRACT: Urinary tract infection (UTI) is defined as the presence of microorganisms in urine which is marked with significants bacteriuria. Urinary tract infection is very common condition that occurs in both women and men in all ages. Urinary tract stone (Urolithiasis) can lead to the development of bacteriuria. Bacterial resistance to antibiotics has long recovery from UTI. The aim of this research was to find out bacterial sensitivity urinary tract infection in patients urolithiasis to selected antibiotic in Surgical Treatment Ulin General Hospital Banjarmasin period Juni-Agustus 2013. The selected antibiotics were ceftriaxone, levofloxaxin and gentamicin. The research was a descriptional research. The subject of this research is all patients urolithiasis with complication urinary tract infection in Surgical Treatment Ulin General Hospital Banjarmasin period Juni-Agustus 2013. The sampling technique in this research was consecutive method. The sensitivity test to antibiotic test in the research used Kirby-Bauer method and analyzed according to CLSI 2011 standard. Based of the research can be concluded that bacteria that sensitive to selected antibiotics in succession is levofloxaxin 61,54%, seftriaxone 15,38% and gentamicin 15,38%. Percentage of bacteria that resisten to antibiotic seftriaxone 23,8%. Keywords: bacteriuria, gentamicin, urinary tract infection (UTI), in vitro, levofloxaxin, seftriaxone, urolithiasis ABSTRAK: Infeksi saluran kemih (ISK) didefinisikan sebagai adanya mikroorganisme dalam urin yang ditandai dengan bakteriuria bermakna. Infeksi saluran kemih merupakan kondisi yang sangat umum terjadi baik pada wanita maupun pria pada semua usia. Batu saluran kemih (urolithiasis) dapat menyebabkan perkembangan bakteriuria. Resistensi bakteri terhadap antibiotik menyebabkan lamanya penyembuhan dari ISK. Penelitian ini bertujuan untuk mengetahui sensitivitas bakteri penyebab ISK pada pasien urolithiasis terhadap antibiotik terpilih di Bagian Perawatan Bedah RSUD Ulin Banjarmasin periode Juni-Agustus 2013. Antibiotik terpilih yaitu seftriakson, levofloksasin dan gentamisin. Penelitian ini merupakan penelitian deskriptif murni sensitivitas isolat bakteri Escheriachia coli, pseudomonas sp., dan proteus sp. dari pasien urolithiasis dengan ISK terhadap antibiotik uji terpilih. Subjek penelitian ini adalah seluruh pasien urolithiasis dengan komplikasi infeksi saluran kemih di ruang perawatan bedah RSUD Ulin Banjarmasin periode Juni-Agustus 2013. Teknik pengambilan sampel pada penelitian ini adalah consecutive method. Uji sensitivitas antibiotik pada penelitian ini menggunakan metode Kirby-Bauer dan dianalisa sesuai dengan standar CLSI 2011. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bakteri yang sensitif terhadap antibiotik terpilih secara berturut-turut adalah levofloksasin 61,54%, seftriakson 15,38%, dan gentamisin 15,38%. Persentase bakteri yang resisten terhadap antibiotik seftriakson 23,8%. Kata-kata kunci: bakteriuria, infeksi saluran kemih (ISK), in vitro, levofloksasin, gentamisin, seftriakson, urolithiasis

Relationship between Family Mobility and the Incidence of Dengue Hemorrhagic Fever at Sleman Regency, Yogyakarta, Indonesia Tri Wulandari Kesetyaningsih; Dimas Pradana Putra; Farizki Muhammad Muhammad
Berkala Kedokteran Vol 15, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Dengue hemorrhagic fever is a public health problem in the world. Transmission of dengue through Aedes mosquito, so that the incidence is locally limited to the distance of flying. A role of mobility towards dengue spreading have not been consistent. This study aims to provide information about the role of family members’ mobility in dengue incidence by using observational study with case control design. Case group are families whose members have suffered from dengue in 2014-2016 and control groups are their neighbors. There were 114 people for case and 116 for control group which is divided into two locations namely Sleman and gamping. Data on DHF patients and their addresses were obtained from Health Office, and mobility obtained through questionnaires then analyzed using chi square to determine the role of mobility in DHF incidence. The results show that there is no significance relationship between family mobility and the incidence of DHF. In Gamping, P high - low is 0.307 and P moderate - low is 0.523. In Sleman, P high - low is 0.685 and P moderate - low is 0.438. It was concluded that the mobility of family members was not a risk factor for dengue infection. Keywords: family mobility, DHF incidence, risk factor

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Eko Suhartono

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esuhartono@ulm.ac.id

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+6281251126368

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jbk@ulm.ac.id

Editorial Address
Jalan Veteran No.128 Banjarmasin

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Kota banjarmasin,

Kalimantan selatan

INDONESIA