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THE EFFECT OF Trichuris muris EGG ON THE GOBLET CELLS IN INTESTINE OF MICE (MUS MUCULUS) Lulu Hasna Ulfadila; Ahmad Husairi; Istiana Istiana
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (608.443 KB) | DOI: 10.20527/jbk.v13i2.4078

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Abstract: Goblet cells are the immune response in the intestinal epithelium to produce mucus as a defense digestive tract mucosa caused by Trichuris muris infestation. The study purpose was to analyze the effect Trichuris muris towards goblet cells number in mice’s intestine. This research was a true experimental with the posttest control group design. The subjects were 30 male mice types BALB / c which 2 months old with an average weight 20-30 gram. Samples were taken by simple random sampling. Mice divided into a control group, low-dose group (40 worm eggs) and high-dose groups (200 worm eggs) observed for 30 days and then counted the goblet cells number in each preparation. The data analysis was tested by shapiro wilk test and one-way ANOVA and continued by post hoc test. The results demostrated the average value of the goblet cells number in the control group, low-dose and high dose increased by higher dose worm eggs and had the value (p =< 0.05). This described there were Trichuris muris’s eggs inflluence towards the goblet cells number in mice (Mus musculus). Keywords: Trichuris muris,  mice (Mus musculus), goblet cells in intestinum
Hubungan Aktivitas Pendonor dengan Kejadian Malaria Berdasarkan Hapusan Darah Pendonor di PT. Pama Kecamatan Kintap Barra Gerry Prakoso; Nelly Al Audhah; Istiana Istiana
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.963

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ABSTRACT: Malaria is most disease caused by plasmodium in the bloodstreams. Plasmodium be carried in the bloodstreams from Anopheles mosquito bites. Transmission of malaria depending on the level of immunity. Malaria symptoms are high fever, anemia, and enlargement of the spleen. The incident of malaria determined by exposed of malaria as a carrier of disease. The aim of this research was to figure out the relationship activity donors with the incident of malaria at endemic areas and counting of the incident of malaria on donors by smear of blood transfusion. It was a descriptive analytic study with cross-sectional approach. All subjects were 46 persons at August 2013. The data were analyzed by chi-square test statistics with 95 % confidence interval. The result showed infected with malaria 4,34%, Most activity there daytime were 87%, indoor activities were 58,7%, long-time activity >6 hours 58,7%. Based on the uji fisher statistic analysis, it could be concluded that there is no relationship between kind of activity (p=0,165) and time of activity (p=0,246) about the incident of malaria based blood smear at PT. PAMA Kecamatan Kintap Key words: activity, incident of malaria, donors. ABSTRAK: Malaria adalah penyakit yang sebagian besar penyebabnya adalah Plasmodium yang berada di dalam aliran darah. Plasmodium dibawa ke aliran darah dari gigitan nyamuk Anopheles. Penularan malaria tergantung dari tingkat imunitas. Malaria ditandai dengan demam tinggi, anemia, dan pembesaran limpa. Terjadinya penyakit malaria ditentukan oleh seberapa besar kemungkinan kontak dengan nyamuk sebagai vektor pembawa penyakit. Penelitian ini bertujuan untuk mengetahui hubungan Aktivitas pendonor dengan kejadian Malaria di daerah endemis malaria dan menghitung angka kejadian malaria berdasarkan hapusan darah pendonor. Penelitian ini bersifat observasional analitik dengan pendekatan cross-sectional. Subyek penelitian sebanyak 46 orang pada periode Agustus 2013. Analisis data menggunakan uji statistik Chi-squere dengan tingkat kepercayaan 95 %. Hasil penelitian menunjukkan angka kejadian malaria sebanyak 4,34%. Aktivitas terbanyak terdapat pada siang hari 87%, aktivitas di luar ruangan 58,7%, lama aktivitas >6 jam 58,7%. Berdasarkan analisis statistik uji fischer dapat disimpulkan bahwa tidak ada hubungan bermakna untuk jenis aktivitas (p= 0,165) dan waktu aktivitas (p= 0,246) terhadap kejadian malaria berdasarkan hapusan darah pendonor di PT. PAMA Kecamatan Kintap. Kata-kata kunci: aktivitas, kejadian malaria, pendonor
NILAI DIAGNOSTIK SKOR KLINIS DIBANDINGKAN DENGAN BIOPSI PATOLOGI ANATOMI DALAM MENDIAGNOSIS PASIEN KARSINOMA NASOFARING Dini Desviana Rahmayanti; Ika Kustiyah Oktaviyanti; Istiana Istiana
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.739 KB) | DOI: 10.20527/jbk.v11i1.188

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Nasopharyngeal malignancy is the most commonly found among head and neck malignancies. Generally, nasopharyngeal cancer, has a good prognosis if it is detected as soon as possible. It is very important to diagnose it earlier because survival rate can be longer if therapy is given early. This study aims to determine the diagnostic value of clinical scores compared with histopathology biopsy to diagnose nasopharyngeal carcinoma in patients of RSUD Ulin Banjarmasin in the period 2012-2014. Subjects of this study were patients of RSUD Ulin Banjarmasin Hospital which is suspected nasopharyngeal carcinoma, who have examined the clinical symptoms by history and physical examination, had been registered in the medical record, and had been examined with histopathology biopsy. Data of clinical examination and histopathology biopsy from each sampel were collected for clinical symptom scores were analyzed according to get sensitivity value, specifity value, positif predictive value, and negative predictive value.Total subject of this research was 30. In this study, a minimum clinical score to lead to a nasopharyngeal malignancy that if found clinical score of 4, with a sensitivity, specifity, positive predictive value , and negative predictive value of 75%, 83.33%, 94.74%, 45.45% respectively. Clinical characteristics have high sensitivity and specifity to diagnose nasopharyngeal carcinoma. Keywords: diagnostic value, clinical scores, nasopharyngeal carcinoma
Perbandingan Efektifitas Rapid Diagnostic Test (Rdt) Dengan Pemeriksaan Mikroskop Pada Penderita Malaria Klinis : Di Kecamatan Jaro M. Aulia Rakhman; Istiana Istiana; Nelly Al Audhah
Berkala Kedokteran Vol 9, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.631 KB) | DOI: 10.20527/jbk.v9i1.916

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ABSTRACT: Malaria is a disease caused by genus Plasmodium. Enforcement of the diagnosis malaria is microscopic examination of thick blood droplets and thin blood droplets and examination of Rapid Diagnostic Test (RDT). Gold standard for the diagnosis of malaria is microscopic examination. Rapid Diagnosis Test (RDT) is one alternative diagnostic tool in detecting Plasmodium quickly and doesn’t require special skill. The purpose of this study was to discover the effectiveness of Rapid Diagnostic Test (RDT) compared with microscopic examination in patient with clinical malaria in Jaro Sub-district. This study was a descriptive analytic study using the data of the result of malaria examination means of microscope examination and RDT on January – June 2012, with cross sectional approach. RDT examination result showed 98% sensitivity value, 100% specificity value, 100% positive predictive value and 98% negative predictive value compared with microscopic examination. Statistical test using Mc.Nemar test with 95% level of confidence interval p=0,125 (p>0,05). This show was no difference in the effectiveness of RDT examination and microscopic examination of patients with clinical malaria in Jaro Sub-district.Keywords: effectiveness, Rapid Diagnostic Test (RDT), microscopic examinationABSTRAK: Malaria adalah penyakit yang disebabkan oleh genus Plasmodium. Penegakkan diagnosis malaria adalah dengan pemeriksaan mikroskopis berupa tetesan darah tebal dan tetesan darah tipis serta pemeriksaan Rapid Diagnostik Test (RDT).  Gold standard untuk diagnosis malaria adalah dengan pemeriksaan mikroskopis. Rapid Diagnosis Test (RDT) merupakan salah satu alat diagnostik alternatif dalam mendeteksi Plasmodium secara cepat dan tidak memerlukan keterampilan khusus. Tujuan penelitian ini untuk mengetahui efektifitas Rapid Diagnostic Test (RDT) dibandingkan dengan pemeriksaan mikroskop pada penderita malaria klinis di Kecamatan Jaro. Penelitian ini merupakan penelitian deskriptif analitik menggunakan data hasil pemeriksaan malaria melalui pemeriksaan mikroskop dan RDT selama bulan Januari – Juni 2012 dengan pendekatan cross sectional. Hasil penelitian menunjukkan pemeriksaan RDT memiliki nilai sensitivitas 98%, spesifisitas 100%, nilai duga positif 100% dan nilai duga negatif 98% dibandingkan dengan pemeriksaan mikroskopis. Analisis uji statistik menggunakan uji Mc.Nemar dengan tingkat kepercayaan 95% didapatkan nilai p=0,125 (p>0,05)S. Hal ini menunjukkan tidak terdapat perbedaan efektifitas  pemeriksaan RDT dan mikroskopik pada penderita malaria klinis di Kecamatan Jaro.. Kata-kata kunci: efektifitas, Rapid Diagnostic Test (RDT), pemeriksaan  mikoskopisABSTRACT: Malaria is a disease caused by genus Plasmodium. Enforcement of the diagnosis malaria is microscopic examination of thick blood droplets and thin blood droplets and examination of Rapid Diagnostic Test (RDT). Gold standard for the diagnosis of malaria is microscopic examination. Rapid Diagnosis Test (RDT) is one alternative diagnostic tool in detecting Plasmodium quickly and doesn’t require special skill. The purpose of this study was to discover the effectiveness of Rapid Diagnostic Test (RDT) compared with microscopic examination in patient with clinical malaria in Jaro Sub-district. This study was a descriptive analytic stud
HUBUNGAN REAKSI LIMFOSIT DENGAN DERAJAT KEGANASAN KANKER SERVIKS DI RSUD ULIN BANJARMASIN PERIODE JANUARI-DESEMBER 2013 Ahmad Marzuki Rifki Hanafi; Ika Kustiyah Oktaviyanti; Istiana Istiana
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.027 KB) | DOI: 10.20527/jbk.v11i1.184

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Cervix cancer is a malignancy in women at most 3rd in the world, which occurs in the cervix uteri. Etiologic factor of cervix cancer is infection with human papilloma virus (HPV). Lymphocyte very important role in eradicating cancer cells. However, cervix cancer mortality rates remain high, especially in poor differentiated grade. This may be related to the level of mixed lymphocyte reaction and depending on the status of the tumor grade. This study aimed to determine the correlation between lymphocyte reaction with tumor grade in patients with cervix cancer in RSUD Ulin Banjarmasin period from January to December 2013. The study design was observational analytic study with cross-sectional approach. The data were taken in the form of primary data in the form of checks degrees lymphocytes with a microscope. The population is all women who underwent histopathological examination in RSUD Ulin period from January to December 2013. The sample was taken by purposive sampling as many as 56 people who had met the inclusion criteria. The results showed that the incidence of cervix cancer well-differentiated at most that 25 cases (44%) and lymphocyte reaction that many are mild lymphocyte reaction as much as 33 cases (59%). Somers'd test analysis in the study obtained value (aprox sig. = 0.761). These results indicate that there is no significant correlation between lymphocyte reaction with tumor grade cervix cancer in RSUD Ulin period from January to December 2013. Keywords: cervix cancer, tumor grade, lymphocyte reaction
HEMODYNAMIC STABILITY AND RECOVERY TIME OF PROPOFOL AND SEVOFLURANE IN ULIN GENERAL HOSPITAL BANJARMASIN Rina Lesiana; Kenanga Marwan Sikumbang; Istiana Istiana; Oky Susianto; Erida Wydiamala
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.28 KB) | DOI: 10.20527/jbk.v13i2.4070

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Abstract: The main interest in general anesthesia is safety and the well being of the patient especially the stability of hemodynamic during induction until extubation. The most common causes of prolonging awakening are residual effects of drugs either anesthetics, sedatives, and analgesics. This study aimed to compare hemodynamic stability and recovery time between propofol and sevoflurane at Ulin General Hospital Banjarmasin. This was an observational analytic study conducted in July until November 2016 on 31 patients. The result showed that mean systolic blood pressure, diastolic blood pressure and heart rate for 90 minutes maintenance were no significant difference in group-A (propofol) compare with group-B (sevoflurane), post hoc Bonferroni test showing p>0.05. Mean recovery time to consciousness was faster in group-A (10,46 minutes) than group-B (15,59 minutes), there was no significant difference in two group. In conclusion, there was no significant difference in hemodynamic stability and recovery time between propofol and sevoflurane. Keywords: hemodynamic stability, recovery time, propofol, sevoflurane.
Hubungan Riwayat Malaria Sebelumnya dengan Kejadian Malaria Berdasarkan Hapusan Darah Pendonor di PT Pama Kecamatan Kintap Wahyu Aditia Husada Putera; Nelly Al Audhah; Istiana Istiana
Berkala Kedokteran Vol 10, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.930

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ABSTRACT: Malaria is a disease that is caused by the Plasmodium genus and still become a problem around the world due to high mortality and morbidity. Several types of Plasmodium sp can be transmitted through blood transfusion. The aim of this study was to determine the relationship between history of previous malaria exposure with the event of malaria through donor’s blood smear at PT Pama Kintap subdistrict, Tanah Laut district. It was a survey of analytic-deskriptive study that performed on blood donors by using a questionnaire to see a history of previous malaria, and a smear of blood transfusion donors to see the Plasmodium sp in the blood transfusion. Sample of the research used total sampling method and gained 46 samples. The result was 4 (8.7%) had a previous history of malaria, and 2 (4.3%) was found some Plasmodium sp from their transfusion blood smear. Statistical analyisis used Fischer test, showed p value = 0.006 (p <0.05) which means there is a significant relation between a history of previous malaria exposure with the event of malaria through donor’s blood smear at malaria’s endemic region. Keywords: history of malaria, incident of malaria, blood donor ABSTRAK: Malaria adalah penyakit yang disebabkan oleh Plasmodium dan masih menjadi masalah di seluruh dunia karena angka morbiditas dan mortalitas yang tinggi. Beberapa jenis Plasmodium sp dapat ditularkan melalui transfusi darah. Penelitian ini bertujuan untuk mengetahui hubungan riwayat penyakit malaria sebelumnya dengan kejadian malaria berdasarkan hapusan darah pendonor di PT Pama kecamatan Kintap di kabupaten Tanah Laut. Penelitian ini bersifat survey analitic-descriptive yang dilakukan pada pendonor darah dengan menggunakan kuesioner untuk melihat riwayat malaria sebelumnya, dan hapusan darah transfusi pendonor untuk melihat adanya Plasmodium sp. Sampel penelitian menggunakan teknik total sampel dan mendapatkan 46 pendonor. Hasil penelitian menunjukkan bahwa 4 orang (8,7%) memiliki riwayat malaria sebelumnya, dan 2 orang (4,3%) ditemukan plasmodium dalam hapusan darah transfusinya. Analisis statistik menggunakan uji Fischer mendapatkan p value = 0,006 ( p < 0,05) yang menunjukkan ada hubungan yang bermakna antara riwayat malaria sebelumnya dengan kejadian malaria melalui hapusan darah transfusi pendonor. Kata-kata kunci: riwayat malaria, kejadian malaria, donor darah
HUBUNGAN POLA ASUHAN IBU DENGAN KEJADIAN CACINGAN PADA MURID SDN KUIN SELATAN 5 BANJARMASIN Herry Syawali Rabidhamadi; Istiana Istiana; Noor Muthmainah
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.757 KB) | DOI: 10.20527/jbk.v13i1.3443

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Abstract: Worm infestation is an infection caused by worm parasites. The infection can be affected by mother care for sanitation and health which are methods to overcome worm transmission. This research aimed to discover the correlation between mother care and worm infestation incident on SDN Kuin Selatan 5 Banjarmasin students in 2016. This was analytic observational research with cross sectional design. There were 95 samples of 1st to 6th grade students chosen by using purposive sampling method. The data was collected by stool examination and questionnaire with chi-square test to analyze it. The result portrayed that there were 6,3% positive worm infected children. Based on analysis test, there is no correlation between mother care and worm infestation incident (p=0,667). Keywords: worm infestation, mother care, SDN Kuin Selatan 5 Abstrak: Infeksi cacingan adalah penyakit infeksi yang disebabkan oleh parasit berupa cacing. Infeksi cacingan dapat dipengaruhi oleh pola asuhan ibu tentang kebersihan dan kesehatan yang merupakan salah satu cara menanggulangi penularan cacingan. Tujuan penelitian adalah untuk mengetahui hubungan antara pola asuhan ibu dengan kejadian cacingan pada murid SDN Kuin Selatan 5 Banjarmasin tahun 2016. Jenis penelitian yang digunakan adalah penelitian observasional analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 95 anak dari kelas 1-6, dengan teknik pengambilan sampel secara purposive sampling. Pengumpulan data dilakukan dengan pemeriksaan feses dan pengisian kuesioner, sedangkan analisis data menggunakan uji chi square. Hasil penelitian menunjukkan terdapat 6,3% anak positif terinfeksi cacing. Berdasarkan analisis statistik tidak terdapat hubungan pola asuhan ibu terhadap kejadian cacingan (p=0,667). Kata-kata kunci: cacingan, pola asuhan ibu, SDN Kuin Selatan 5
TINGKAT KEPADATAN JENTIK NYAMUK Aedes aegypti PADA TEMPAT PENAMPUNGAN AIR CONTROLLABLE SITES DAN DISPOSABLE SITES DI SEKOLAH DASAR KECAMATAN BANJARBARU UTARA Linawati Alim; Farida Heriyani; Istiana Istiana
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.548 KB) | DOI: 10.20527/jbk.v13i1.3434

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Abstract : District Northern Banjarbaru is a region with high Dengue Haemorrhagic Fever (DHF) incident in South Borneo province. The density of Aedes aegypti larvae become one of the causes. This research aimed to understand the density level of Aedes aegypti larvae in water reservoirs of 23 elementary schools in District Northern Banjarbaru. The research was conducted in September-October 2016 by using observational descriptive design study . The examinated sites were 517 water reservoirs with 505 controllable sites and 12 disposable sites. The most larvae populated reservoirs were bath tub and water dispenser. Container index (CI) levels found were 32% on all water reservoirs, 32% on controllable sites and 8% on disposable sites. Based on the CI indicator, it can be concluded that the density level of Aedes aegypti larvae at District Northern Banjarbaru elementary schools water reservoirs is high. Keywords:  Density level, Aedes aegypti, water reservoirs, elementary school Abstrak : Kecamatan Banjarbaru Utara adalah salah satu daerah dengan kejadian Demam Berdarah Dengue (DBD) yang tinggi di Provinsi Kalimantan Selatan. Kepadatan jentik nyamuk Aedes aegypti menjadi salah satu penyebab tingginya kejadian DBD tersebut. Penelitian ini bertujuan untuk mengetahui tingkat kepadatan jentik nyamuk Aedes aegypti pada tempat penampungan air (TPA) di 23 sekolah dasar (SD) Kecamatan Banjarbaru Utara. Penelitian dilakukan pada bulan September-Oktober 2016 dengan menggunakan rancangan penelitian observasional. TPA yang diperiksa berjumlah 517 TPA dengan 505 controllable sites dan 12 disposable sites. TPA yang paling banyak ditemukan jentik adalah bak mandi dan dispenser. Nilai container index (CI) yang didapatkan pada seluruh TPA sebesar 32%, pada controllable sites sebesar 32%, dan pada disposable sites sebesar 8%. Berdasarkan indikator CI yang digunakan berarti tingkat kepadatan jentik nyamuk Aedes aegypti pada TPA di SD Kecamatan Banjarbaru Utara tergolong tinggi. Kata-kata kunci : kepadatan jentik, Aedes aegypti, tempat penampungan air, sekolah dasar
UJI EFEKTIVITAS BEBERAPA LARVASIDA TERHADAP LARVA NYAMUK Aedes aegypti DARI BANJARMASIN BARAT Istiana Istiana
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.645 KB) | DOI: 10.20527/jbk.v11i1.185

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Dengue Haemorrhagic Fever (DHF) is a dangerous infectious disease caused by the dengue virus and is transmitted through the bite of the mosquito Aedes aegypti. DHF control depends on controlling mosquitoes and larvae. Currently larvicidal control still uses temefos, although some studies have reported the presence of resistance. Larvicides that WHO recommended as a substitute temefos is permethrin. In addition there are some new larvicides derived from the class of insect growth regulator (IGR) which contain active pyriproksifen and active ingredients methopren. This study aims to determine the effectiveness of larvicides and effective concentration to kill 50% of larvae of Aedes aegypti from the sub Banjarmasin West. This study is an experimental study design with Posttest-Only Control Group Design with permethrin dose group was 0.0015 g / l; 0.0018 g / l; 0.002 g / l; 0.0022 g / l; 0.0025 g / l; and 0.0030 g / l, for pryriproksifen use dose groups of 0.5 ppm, 0.1 ppm, 0.05 ppm, 0.01 ppm, 0.008 ppm, 0.005 ppm, and methopren with dosis0 group g / l, 0, 0063 g / l, 0.0025 g / l, 0.005 g / l, 0.01 g / l, and 0.1 g / l. Each treatment group was exposed to larvae of Aedes aegypti larvae and change shape as well as the deaths were followed for 10 days. The results showed that the effective dose of permethrin kills 50% of larvae (Lethal Concentration / LC50) 24 hours ranged from 24 hour LC50 0.01439 - 0.01829 mg / l, with an average of 0.01671 mg / l and 24-hour LC99 ranged from 0.02856 - 0.03852 mg / l with an average of 0.03196 mg / l. This study showed that the larvae of Aedes aegypti in the district of West Banjarmasin are resistant to permethrin. As for pyriproksifen larvicides effectively killed larvae by 70% after seven days of exposure, and for larvicidal with active methopren killed 50% of larvae on the eighth day. This study shows that larviciding of IGR group can be an alternative in the area that has been declared resistant to abate as in the sub-district of West Banjarmasin. Keywords: effectiveness, permethrin, pyriproksifen, methopren, Aedes aegypti