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Published by Universitas Lambung Mangkurat

ISSN : 14120550 EISSN : 25485660 DOI : http://dx.doi.org/10.20527

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 478 Documents

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Ratio of Platelet-Limfosites and Leukosit Level as Indicators of Baby Feedback (APGAR Score) on Premature Rupture of Membrane Cases iIn Ulin General Hospital Yuvens Richardo Wibowo
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Premature rupture of membranes (PROM) has the potential effect to cause complications such as premature infants, neonatal sepsis, and intrauterine infection (chorioamnionitis). Some inflammatory markers have been investigated to detect PROM at their early stage and prevent the complications. Platelet lymphocyte ratio (PLR) and leukocytes are a simple, affordable inflammatory marker, and have been used to predict a variety of inflammatory conditions. This study aims to see the relationship between PLR and leukocytes with APGAR Score in the case of PROM. This study was an analytic observational study with a retrospective cross sectional design. Data from 80 samples showed PLR and leucocytes had no significant effect on APGAR value (p> 0.05). Keywords: Platelet Lymphocyte Ratio, Premature rupture of membranes, APGAR score

Perbandingan Nilai Vo2 Maks Antara Siswa Terlatih Dengan Siswa Tidak Terlatih: di SMAN 1 Martapura Nadia Harira; Asnawati Asnawati; Huldani Huldani
Berkala Kedokteran Vol 9, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

ABSTRACT: VO2 max is one of the best indicators for cardiovascular function and physical endurance. A person who has continuous exercise will have better value of VO2 max rather than a person who does not have one. The objective of this research is finding out the difference of VO2 max average value between trained students and untrained students in SMAN 1 Martapura. It is an descriptive analytic research using cross sectional approach, the population is taken from students of SMAN 1 Martapura which consist of two groups of sample, the trained students (basketball players) and untrained students with the minimal amount of samples is 30 for each group. The VO2 max is measured using multistage fitness test. The VO2 max average for trained students is 46,853 and for untrained students is 40,337. Unpaired t test result (p = 0,000) shows that there is a significant difference of VO2 max average value between the trained students and untrained students of SMAN 1 Martapura. Keywords: physical exercise dose, VO2 max, multistage fitness test ABSTRAK: VO2 maks merupakan salah satu indikator terbaik kebugaran fungsi kardiovaskular dan daya tahan tubuh seseorang. Seseorang yang rajin berolahraga akan mempunyai nilai VO2 maks yang lebih baik dibanding yang tidak berolahraga. Penelitian ini bertujuan untuk mengetahui perbedaan rerata nilai VO2 maks pada siswa yang terlatih dan tidak terlatih di SMAN 1 Martapura. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional, dengan populasi siswa SMAN 1 Martapura yang dibagi menjadi kelompok pemain siswa terlatih (pemain basket) dan tidak terlatih, sampel diambil menggunakan metode purposive sampling dengan besar sampel minimal 30 siswa untuk tiap kelompok. VO2 maks diukur menggunakan multistage fitness test. Rata-rata nilai VO2 maks untuk siswa terlatih adalah 46,853 dan untuk siswa tidak terlatih adalah 40,337. Hasil uji t tidak berpasangan (p = 0,000) menunjukkan bahwa terdapat perbedaan bermakna dalam nilai VO2 maks antara anggota siswa pemain basket dan bukan pemain basket SMAN 1 Martapura. Kata-kata kunci: dosis latihan fisik, VO2 maks, multistage fitness test

Effectiveness Test of Papaya Leaves Extract (Carica papaya L.) as Antihelmintics of Ascaridia galli Worm Farindira Vesti Rahmasari; Fikri Adhi Wibowo
Berkala Kedokteran Vol 15, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Introduction: Soil-transmitted helminth is a group of nematoda worm parasite that causes infection in human because the egg is swallowed or direct contact with the larva. More than two billion people in the world had infection for at least one spesies of the nematoda worm, especially A. lumbricoides, T. trichiura and A. duodenale. Ascaridia galli is a worm parasite that classifeid in nematoda fillum. Ascaridia worm has the same genus with Ascaris Lumbricoides that infect human. Antihelmintic is a drug that can eradicate the worm in human and animal body. There is a side effect in the antihelmintic drug like Mebendazole so another alternative like organical antihelmintic from papaya leaves (Carica papaya L.) is needed. This research is a true experiment with post test control group design. The subjects were 160 Ascaridia galli worm which were divided into 5 worms in each test group (5%, 10%, 20%, 40%, 60%, dan 80%), positive control group (Pirantel pamoat 0,5%) and negative control repeated as many as 4 replications. The treatment was given for 12 hours and observed the number of dead worm at each hour. Data were analyzed by statistical test of Kruskal Wallis Test and followed by post-hoc Mann-Whitney Test. It is also tested the probit analysis to determine lethal time (LT50 and LT90) and lethal concentration (LC50 and LC90).There was a significant difference (p <0.05) between all test concentrations except between 5% to negative control. It could be evidenced that the papaya leaves (Carica papaya L.) has an antihelmintic effect on Ascaridia gall. The results of probit analysis for LC50 and LC90 were 6,182% and 14,422% respectively. It is known that LT50 at concentrations of 25%, 10%, 20%, 40%, 60%, and 80% respectively were 11,84 hours, 10,536 hours, 9,328 hours, 6,794 hours, 5,472 hours and 2,892 hours. While the LT90 at concentrations of 25%, 10%, 20%, 40%, 60%, and 80% respectively were 13,608 hours, 12,303 hours, 11,095 hours, 8,562 hours, 7,24 hours, dan 4,66 hours.The ethanol extract of Papaya leaves Carica papaya was shown to have an antihelmentic effect on Ascaridia galli effectifically at concentrations of 10%, 20%, 40%, 60% dan 80%. The values of LC50 and LT50 at highest concentration (80%) at the end of the observations are 6,182% and 2,892 hours respectively. The values of LC50 and LT90 at the highest concentration (80%) were 14,442% dan 4,66 hours respectively. The higher concentration of ethanol extract of papaya leaves Carica papaya the greater the effectiveness in killing Ascaridia galli. Keywords: Antihelmintic – Ascaridia galli – Carica papaya L. – Lethal Concentration – Lethal Time

Perbandingan Perubahan Kepekaan Staphylococcus aureus ATCC 25923 Pada Pemaparan Amoksisilin-Asam Klavulanat Dan Eritromisin Kadar Subinhibisi In Vitro Diah Puspita Rifasanti; Lia Yulia Budiarti; Alfi Yasmina
Berkala Kedokteran Vol 9, No 2 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i2.943

ABSTRACT: Staphylococcus aureus is an organism that causes infections that can spread widely in the human body. The therapy for infection by S. aureus is amoxicillin-clavulanic acid or erythromycin, but resistance has been reported to both of them, and one of the causes was exposure to subinhibitory level of antibiotic. This study was aimed to determine whether there were any changes in the sensitivity of S. aureus ATCC 25923 caused by the exposure to subinhibitory level of amoxicillin-clavulanic acid and erythromycin and to compare the time needed to cause changes in sensitivity between the two antibiotics. It was an experimental study, using a completely randomized design, which consisted of 14 treatments based on duration of exposure, with three repetitions. Kirby Bauer disk diffusion method was used to evaluate the inhibitory effect. The result showed that there were changes in the sensitivity of S. aureus ATCC 25923 after being exposed to subinhibitory level of both antibiotics, and exposure to amoxicillin-clavulanic acid caused faster changes in sensitivity compared with exposure to erythromycin. Data analysis using the Mann-Whitney test indicated that there was a significant difference between the exposure to subinhibitory level of the two antibiotics (p = 0.025). It was concluded that there was a significant difference in changes in sensitivity of S. aureus ATCC 25923 caused by in vitro exposure to subinhibitory level of amoxicillin-clavulanic acid and erythromycin. ListenRead phoneticallyKeywords: amoxicillin-clavulanic acid, erythromycin, sensitivity, Staphylococcus aureus, subinhibitory level ABSTRAK: Staphylococcus aureus merupakan organisme penyebab infeksi yang dapat menyebar luas. Terapi untuk infeksi oleh S. aureus diantaranya adalah antibiotik amoksisilin-asam klavulanat atau eritromisin. Telah dilaporkan adanya resistensi pada kedua antibiotik tersebut dan salah satu penyebabnya adalah akibat pengaruh antibiotik kadar subinhibisi. Penelitian ini bertujuan untuk mengetahui ada tidaknya perubahan kepekaan pada S. aureus ATCC 25923 pada pemaparan amoksisilin-asam klavulanat dan eritromisin kadar subinhibisi dan membandingkan waktu yang diperlukan yang dapat menimbulkan perubahan kepekaan. Penelitian ini merupakan penelitian eksperimental, menggunakan rancangan acak lengkap, terdiri dari 14 perlakuan antibiotik berdasarkan lama pemaparan dan pengulangan sebanyak 3 kali. Metode ujinya adalah metode difusi Kirby Bauer. Hasil penelitian menunjukkan bahwa terdapat perubahan kepekaan pada S. aureus ATCC 25923 setelah dipaparkan pada antibiotik kadar subinhibisi, dan pada pemaparan antibiotik amoksisilin-asam klavulanat memerlukan waktu lebih cepat untuk menimbulkan perubahan kepekaan dibandingkan dengan pemaparan kadar subinhibisi eritromisin. Hasil uji Mann-Whitney menunjukkan terdapat perbedaan bermakna antara pemaparan amoksisilin-asam klavulanat dan eritromisin kadar subinhibisi in vitro (p = 0,025). Dapat disimpulkan bahwa terdapat perbedaan perubahan kepekaan S. aureus ATCC 25923 pada pemaparan amoksisilin-asam klavulanat dan eritromisin kadar subinhibisi in vitro. Kata kunci: amoksisilin-asam klavulanat, eritromisin, kadar subinhibisi, kepekaan, Staphylococcus aureus

Perbedaan Berat Bayi Lahir dari Ibu Preeklampsia Berat dan Tidak Preeklampsia: Tinjauan terhadap RSUD Ulin Banjarmasin Periode Juni-Agustus 2013 Yulia Margareth; Hardyan Sauqi; Meitria Syahadatina Noor
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.959

ABSTRACT: Severe preeclampsia is one of the pregnancy complication (for gestational age >20 weeks), characterized by blood pressure ≥160/110 mmHg and proteinuria >5g/24 jam. Severe preeclampsia can lead to fetus complication such as low birth weight babies. This study aimed to determine the diferences of birth weight between mother severe preeclampsia and non-preeclampsia at Banjarmasin Ulin Hospital from June to August 2013 with case-control approach. One hundred and twenty-six samples are collected with 63 samples were severe preeclampsia mother and 63 samples were non-preeclampsia mother, selected in simple random sampling. The results showed that the mean weight of babies born from severe preeclampsia mother was 2884.13 ± 524.1 grams, and mean birth weight of the mother non-preeclampsia was 3253.17 ± 390.9 grams. The results was analysed using independent T-test (α=95%) showed that p value=0,000, it can be concluded that there was a significant difference birth weight infant between mothers with severe preeclampsia and non-preeclampsia. Keywords : severe preeclampsia, birth weight infant, Banjarmasin Ulin Hospital. ABSTRAK: Preeklampsia berat merupakan salah satu komplikasi kehamilan pada usia kehamilan >20 minggu, ditandai dengan tekanan darah ≥160/110 mmHg dan proteinuria >5g/24 jam. Preeklampsia berat dapat menyebabkan komplikasi pada janin berupa bayi berat lahir rendah. Penelitian ini bertujuan untuk mengetahui perbedaan berat bayi lahir dari ibu preeklampsia berat dan tidak preeklampsia di RSUD Ulin Banjarmasin Periode Juni-Agustus 2013 dengan pendekatan case control. Total sampel sebanyak 126 orang dengan ibu preeklampsia berat 63 orang dan ibu tidak preeklampsia 63 orang, dipilih secara simple random sampling. Hasil penelitian menunjukkan bahwa rerata berat bayi lahir dari ibu preeklampsia berat sebesar 2884,13 ± 524,1 gram dan rerata berat bayi lahir dari ibu tidak preeklampsia sebesar 3253,17 ± 390,9 gram. Hasil analisis data dengan menggunakan uji T tidak berpasangan (α=95%) menunjukkan nilai p=0,000, sehingga dapat disimpulkan terdapat perbedaan bermakna antara berat bayi lahir dari ibu preeklampsia berat dan tidak preeklampsia di RSUD Ulin Banjarmasin Periode Juni-Agustus 2013. Kata kunci: preeklampsia berat, berat bayi lahir, RSUD Ulin Banjarmasin.

HUBUNGAN ANTARA MASA GESTASI DAN KEJADIAN SEPSIS NEONATORUM DI RSUD ULIN BANJARMASIN PERIODE JUNI 2014-JUNI 2015 Fitri Nur Dini; Pudji Andayani; Lena Rosida
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Neonatal sepsis is a clinical syndrome characterized by symptoms of bacteremia and systemic signs and positive blood cultures showed that during the first month of life. Prematurity and postmaturity risk of morbidity and mortality are high on the gestation age for the occurrence of neonatal sepsis. This study aims to determine the relationship between gestational age and the incidence of neonatal sepsis in Ulin Hospital Banjarmasin. The design of this study using cross sectional study with retrospective approach. The way the sampling is the purposive sampling were obtained from medical records of patients, then performed statistical analysis using chi-square test with 95%. The number of samples that fulfilled the criteria inclusion in this study as many as 246 cases. The incidence of neonatal sepsis is more common in infants born at 37-42 weeks gestation as many as 25 cases (59.52%). The data not neonatal sepsis who were born with a gestational age <37 weeks or> 42 weeks gained as many as 20 cases (9.80%) and 37-42 weeks gestation obtained as many as 184 cases (90.20%). Chi-square test showed that there is a relationship between gestational age and the incidence of neonatal sepsis in Ulin Hospital Banjarmasin (p = 0.000) with an odds ratio (OR) 6.256. It is concluded that there is a relationship of gestation age and the incidence of neonatal sepsis (p <0.05) in hospitals Ulin Banjarmasin period June 2014-June 2015 with OR 6.256. Keywords: gestational age, sepsis, neonatal Abstrak: Sepsis neonatorum merupakan suatu sindrom klinis bakteremia yang ditandai dengan gejala dan tanda sistemik serta menunjukkan kultur darah positif yang terjadi pada bulan pertama kehidupan. Prematuritas dan posmaturitas memiliki risiko kesakitan dan kematian yang tinggi pada masa gestasi untuk terjadinya sepsis neonatorum. Penelitian ini bertujuan untuk mengetahui hubungan antara masa gestasi dan kejadian sepsis neonatorum di RSUD Ulin Banjarmasin. Rancangan penelitian ini menggunakan cross sectional study dengan pendekatan retrospektif. Cara pengambilan sampel yaitu dengan purposive sampling yang diperoleh dari data rekam medis pasien, kemudian dilakukan analisis statistik menggunakan uji chi-square dengan kepercayaan 95%. Jumlah sampel yang memenuhi kriteria inklusi dalam penelitian ini sebanyak 246 kasus. Kejadian sepsis neonatorum lebih banyak dijumpai pada bayi yang lahir dengan masa gestasi 37-42 minggu yaitu sebanyak 25 kasus (59,52%). Data neonatus tidak sepsis yang lahir dengan masa gestasi <37 minggu atau >42 minggu didapatkan sebanyak 20 kasus (9,80%) dan masa gestasi 37-42 minggu didapatkan sebanyak 184 kasus (90,20%). Uji chi square menunjukkan bahwa terdapat hubungan antara masa gestasi dan kejadian sepsis neonatorum di RSUD Ulin Banjarmasin (p=0,000) dengan odds ratio (OR) 6,256. Kesimpulan penelitian ini adalah terdapat hubungan masa gestasi dan kejadian sepsis neonatorum (p<0,05) di RSUD Ulin Banjarmasin periode Juni 2014-Juni 2015 dengan OR 6,256. Kata-kata kunci: masa gestasi, sepsis, neonatus

VALIDITAS PEMERIKSAAN GARPU TALA 128 HZ SEBAGAI DETEKSI DIABETIC PERIPHERAL NEUROPATHY PADA PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. H. MOCH ANSARI SALEH BANJARMASIN I Gede Bagus; Agus Yuwono; Erida Wydiamala
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Diabetic peripheral neuropathy (DPN) is one of major complication on uncontrolled diabetes mellitus (DM) patient. Test of 128 Hz tuning fork is a simple test to detect DPN which is recommended by several international guidelines and available at a limited health facility. This research aimed to discover the validity of 128 Hz tuning fork test as diabetic peripheral neuropathy detection on type 2 diabetes mellitus patient at Dr. H. Moch. Ansari Saleh Banjarmasin hospital. This was diagnostic test research with a cross-sectional design. Data was analyzed by using diagnostic test of 2x2 table and receiving operating characteristic (ROC) curve. Subjects were 69 DM outpatient at internal medicine clinic in Dr. H. Moch. Ansari Saleh Banjarmasin hospital. The analysis results were sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve. Respectively they were 40%; 100%; 100%; 73,33%; 78,26%; and 70% (0.7) (CI 95%: 55.9%-84.1%). The test of 128 Hz tuning fork has fine validity and can be used as DPN detection on type 2 DM patient. Keywords: Validity, tuning fork 128 Hz test, diabetic peripheral neuropathy, diabetes mellitus Abstrak: Diabetic peripheral neuropathy (DPN) merupakan salah satu komplikasi tersering pada pasien diabetes melitus (DM) yang tidak terkontrol. Pemeriksaan garpu tala 128 Hz adalah salah satu pemeriksaan sederhana untuk mendeteksi DPN yang direkomendasikan oleh beberapa guideline internasional dan dapat dilakukan di fasilitas kesehatan dengan fasilitas terbatas. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan garpu tala 128 Hz sebagai prosedur deteksi neuropati perifer pada pasien diabetes melitus tipe 2 di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Penelitian ini merupakan uji diagnostik dengan pendekatan cross-sectional. Data dianalis dengan uji diagnostik tabel 2x2 dan kurva receiving operating characteristic (ROC). Subjek penelitian merupakan 69 pasien DM rawat jalan poliklinik penyakit dalam RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Hasil analisis yang didapatkan adalah sensitivitas, spesifisitas, nilai prediktif positif, nilai prediktif negatif, akurasi, dan area under curve dari pemeriksaan garpu tala 128 Hz berturut-turut adalah 40%; 100%; 100%; 74,57%; 78,26%; dan 70% (0.7) (IK 95%: 55.9%-84.1%). Pemeriksaan garpu tala 128 Hz mempunyai validitas yang cukup baik dan dapat digunakan sebagai deteksi DPN pada pasien DM tipe 2. Kata-kata kunci: Validitas, pemeriksaan garpu tala 128 Hz, diabetic peripheral neuropathy, diabetes melitus

DERAJAT INFILTRASI LIMFOSIT PADA PENDERITA KANKER KOLOREKTAL SUB-TIPE ADENOKARSINOMA Muhammad Sahal Imaduddin; Ika Kustiyah Oktaviyanti; Istiana Istiana
Berkala Kedokteran Vol 11, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Cancer is the second leading cause of death which contributes 13% of deaths from a total of 22% of deaths from non-communicable diseases in the world. One contributor to the number of cancer deaths in the world is colorectal cancer. The prognosis of colorectal cancer depend on the stage of cancer at time of diagnosis. However, the prognosis of colorectal cancer can also be determined by looking at the degree of infiltration of lymphocytes in cancer. The purpose of this research is to find out the degree of lymphocytes infiltration in patients with colorectal cancer in Laboratory of Anatomical Pathology Banjarmasin from January to December 2013. The method uses descriptive research by observing the colorectal cancer tissues were obtained from the Laboratory of Pathology Banjarmasin. From a study of 32 samples, found the degree of mild lymphocytic infiltration occurred in 12 patients (37.5%), moderate lymphocytic infiltration occurred in 12 patients (37.5%), and severe lymphocyte infiltration occurred in 8 patients (25%). From this study, found that there are differences in the degree of infiltration of lymphocytes in patients with colorectal cancer. Keywords: Colorectal Cancer, Lymphocyte Infiltration, Prognosis

EFFECT OF WARM WATER COMPRESS THERAPY ON THE INCIDENCE OF HYPEREMIA IN PHLEBITIS PATIENTS AT THE INPATIENT WARD OF BRIGJEND H. HASAN BASRI GENERAL HOSPITAL KANDANGAN Nurul Hidayah; Topan Aditya Rahman; Desilestia Dwi Salmarini
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: This study aims to determine the effect of warm water compress therapy on the incidence of hyperemia in 40 patients with phlebitis at the Inpatient Installation of H. Hasan Basry General Hospital Kandangan. Research method used quasi-experimental with two group; control and intervention. The control group was untreated phlebitis, while the intervention group was a phlebitis patient treated with warm water compresses. Data collection was collected by measuring the redness diameter before and after warm compress therapy. The result showed that the mean of intervention group diameter before treatment 49.3 mm and after treatment 40.2 mm. The mean diameter of control group before treatment 48.1 mm and after treatment 46.4 mm. The mean diameter of intervention group was decreased 9.1 mm and 1.7 mm in the control group. Statistically result test show that there was a significant difference of mean hyperemia diameter between intervention and control group (p<0.05). Statistically result test also shows that there was a significant difference of mean hyperemia between pre- and post-treatment with warm water (p<0.05). It was concluded that the warm compress therapy could decreased the incidence of hyperemia in phlebitis patients. Keywords: Hyperemia, Phlebitis, Warm Compress Therapy

PERBEDAAN WAKTU REAKSI DAN TINGKAT KELELAHAN ANTARA PEKERJA SHIFT PAGI DAN SHIFT MALAM Olivia Dewi Rianti; Fakhrurazzy Fakhrurazzy; Triawanti Triawanti
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Fatigue is a feeling of weariness or lack of energy that does not decrease when a person rests. The main reason of occupational accidents caused by humans is stress and fatigue. This study aims to analyze the differences of reaction time and fatigue stage between morning shift workers and night shift workers of coal mining department operators in PT. Kaltim Prima Coal. This research was an analytic observational research with cross sectional approach and purposive sampling technique. Data taken from 30 workers of morning shift and 30 workers of night shift who fulfill the inclusion criteria. The results showed that the average reaction time of morning shift workers was 0.81 seconds and 0.89 seconds for night shift workers. The results of questionnaire showed amount of very tired worker category, tired, and less tired on the morning shift workers for each category were 7, 21, and 2, while the night shift workers for each category were 3, 25, and 2. Results of unpaired t-test for reaction time showed no significant difference (p = 0.2) and the results of the Kolmogorov-Smirnov test for fatigue stage showed no significant difference (p = 0.952) between the morning shift workers and night shift workers of mining coal department operators in PT. Kaltim Prima Coal. Keywords: Reaction time, fatigue stage, shift workers

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