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Sport and Fitness Journal
Published by Universitas Udayana
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Core Subject : Social,
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Articles 286 Documents
The IMMUNOMODULATORY  EFFECT OF ENDURANCE EXERCISE (EE) AND RESISTANCE EXERCISE (RE) THROUGH THE KYNURENINE PATHWAY IN HEALTHY AND CANCER SUBJECT Sienny Muliaty Sumali; Marta Wangsadinata Wong; Ireene Hillary Artauli Sinurat; Indira Vidiari Juhanna; I Putu Adiartha Griadhi
Sport and Fitness Journal Vol 11 No 2 (2023): Volume 11, No.2, May 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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ABSTRACT Introduction: Kynurenine pathway is a process that breaks down tryptophan, an amino acid found in many foods. One of the products of this pathway is kynurenine, which has been shown to affect the immune system.Acute and resistance exercise can alter the kynurenine pathway and enhance immune function by modifying immune cell mediators. Methods: This systematic review analyzed the effects of acute and resistance exercise on the kynurenine pathway and immune system. The study collected information through a computerized publication database search using specific text words and MeSH-Terms, limited to original articles published in English between 2016-2021. Results: From 10 clinical trials were summarized Exercise influences the kynurenine pathway and immune system, according to three studies acute and chronic endurance training in healthy patients resulted in higher kyn clearance and lower kyn levels. And two studies through a reduction in kyn levels and a downregulation of the kynurenine tryptophan ratio, cancer patients can modify their immune systems. Meanwhile one study had no effect on kyn levels in depressed patients who had undergone both short-term and long-term endurance and strength training. One study had increased their levels of kyn and their kyn:trp ratio. One study examined the short-term impacts of resistance and endurance training found that both types of exercise increased the expression of increase in CD3+ lymphocytes after both EE and RE and an increase in PD-1+ CD8+ T-cells after EE. Proportions of T-cell populations changed only after EE but without explicitly examining metabolites of the kynurenine pathway. Conclusion: By changing immune cell mediators, endurance exercise (EE) and resistance exercise (RE) can affect the kynurenine pathway and improve immunological function. Exercise therapies can result in cancer patients having lower levels of kynurenine and higher levels of tryptophan and kynurenic acid, both of which are linked to enhanced immune function and decreased inflammation. According to this research, exercise can be a non-pharmacological intervention to improve immune function and possibly prevent chronic illnesses linked to inflammation and immunological dysfunction. Keywords : physical activity, Exercise,aging, immunosenescence, innate immune system, adaptive immune system
CARDIOMYOCYTE CELLULAR REGULATION ON EXERCISE Indira Vidiari
Sport and Fitness Journal Vol 11 No 2 (2023): Volume 11, No.2, May 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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ABSTRACT 85% of deaths from cardiovascular disease are caused by CHD. More than 75% of deaths from cardiovascular disease occur in low- and middle-income countries. Myocardial injury caused by ischemia-reperfusion (IR) is a serious clinical problem. Reperfusion injury can cause damage or death to the myocardium and coronary vessel endothelium. Therefore it is necessary to develop a strategy in the field of cardiac regeneration, both for the prevention and curative of cardiovascular disease. Cellular reprogramming occurs in cardiomyocytes in response to physical exercise. Cardiomyocytes keep up with increased demand, reflecting that there is optimal energy potential and reserve capacity. It is often referred to as the ''athlete's heart''. Cardiac remodeling in response to chronic exercise to match the increased workload is by increasing heart size, in the absence of cardiomyocyte proliferation. This physiological growth is accompanied by an increase in energy production capacity, especially in mitochondria. Normal hypertrophic growth is characterized by normal contractile function at rest. This is in contrast to the pathological growth produced by prolonged hypertension or ischemic heart disease, in which contractile function and metabolic energy production are decreased. At the cellular and molecular level, it is clear that the activation of signaling pathways and the resulting transcriptional response different between physiological and pathological cardiac growth.
THE EFFECT OF RESISTANCE TRAINING ON TRABECULAR BONE SCORE Lia Arista Wijaya; Clarin Hayes; Indira Juhanna; Adiartha Griadhi
Sport and Fitness Journal Vol 11 No 2 (2023): Volume 11, No.2, May 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Osteoporosis is one of the many signs of aging. Physical activities has been known as the best non-pharmacology treatment for osteoporosis as resistance training can stimulate and maintain bone gain. Bone mineral density (BMD) is usually used as the parameter to evaluate bone quality since BMD is used for osteoporosis diagnosis. But, trabecular bone score (TBS) is a far more superior parameter in evaluating bone quality. Regrettably, there is a scarcity of research on this topic, as the majority of studies utilize BMD as the parameter for assessing bone quality. This literature review aims to provide data about the effect of resistance training on TBS for better early prediction and prevention of morbidity and mortality caused by osteoporosis-related fractures. The study searches for articles published in the last 10 years in English or French discussing resistance training and TBS. Five studies are included, which consist of 3 experimental studies and 2 case-control studies. The results suggest that resistance training can stimulate and maintain bone gain, which is superior to non-weight-bearing exercise. TBS has been found to be a more accurate predictor of fracture risk compared to BMD alone. Overall, the literature review suggests that resistance training may improve TBS and prevent osteoporosis-related fractures. Based on Frost's mechanostat theory, bone mechanical properties can be significantly enhanced through high strain generated during physical activity. Nevertheless, the bone's adaptive response to resistance exercise is typically specific to the trained site, which means that only the region exercised will exhibit greater bone mineral density.
EFFECT OF VITAMIN E ON CREATINE KINASE POST-EXERCISE IN ADULT Monica Caroline Molenaar; Nila Wahyuni
Sport and Fitness Journal Vol 11 No 3 (2023): Volume 11, No. 3, September 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Introduction: Exercise is well-known for its benefits to strengthen muscle and improves whole-body energy metabolism. Increased creatine kinase (CK) level in blood is an indicator of skeletal muscle damage induced by strenuous physical exercise. It is known that vitamin E plays a key role as strong antioxidant which can be considered as the solution to attenuate exercise-induced muscle tissue damage by reducing creatine kinase (CK) concentration. Method: The literature search was performed using several databases: Research Gate, PubMed, and Google Scholar. The following search terms were used: “exercise”, “vitamin e”, “creatine kinase”, “exercise-induced muscle damage” and “muscle soreness”. Results: There were 7 articles obtained and analyzed in this literature review which showed various results regarding the effect of vitamin E on creatine kinase (CK) level post-exercise especially in adult. Discussion: There were still inconsistence results of vitamin E which can decrease serum creatinine kinase after exercise. Some studies showed that 250 mg of vitamin E administration 1 hour before exercise were effective in reducing creatine kinase (CK) after moderate exercise. In contrary, another study revealed that there was no beneficial effect on creatine levels after administration of 235 mg vitamin E combined with 1000 mg of vitamin C 2 hours prior to exercise in runners over 30 years of age.
THE HIGH INTENSITY INTERVAL TRAINING (HIIT) CORRELATES WITH TELOMERE LENGTH Sherla Wijoyo; Debby Chesilya Wijaya; Lisye Marrilyn Lukas; I Putu Gede Adiatmika
Sport and Fitness Journal Vol 11 No 3 (2023): Volume 11, No. 3, September 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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There are many types of training for exercise in this current era where personalized workout is very popular nowadays. One of the popular workout regimens is the high intensity interval training where it only took half a time than a normal workout time, which may encourage people to exercise more. Recent studies had shown that exercise influence biological aging process, one of the markers is telomere length. One of the characteristics of cellular aging is telomere shortening, where the telomeres shorten as people age. There are many factors that may hasten or slow down this process, which is oxidative stress, lifestyle, chronic inflammation, stress, chronic diseases, and exercises. The primary goal of this literature review is to analyze and investigate the correlation between high intensity interval training (HIIT) and telomere length. The approach taken for this review is from multiple journals using many searches engine like Google Scholar, PubMed, Science Direct and Mendeley Search. The results for each article were reviewed and compared to determine the correlation between high intensity interval training with telomere length. The conclusion of this study showed that people who exercise with high intensity interval training have a considerable lengthening of telomeres.
The Effect of Aerobic Exercise on TNF-Alpha in older adults Donabella Fortuna Santosa; Nila Wahyuni
Sport and Fitness Journal Vol 12 No 1 (2024): Volume 12, No. 1, January 2024
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Inflamation and muscle mass and function is the problem the aging process. This literature review evaluate the aerobic exercise efficacy on TNF-? in older adults. This literature review will investigate the effect of aerobic exercise determined by TNF-? level analysis in the older adult patient. Google Scholar, ResearchGate, and Mendeley were used as the search engine. The keywords were aerobic exercise, TNF-? & older adults to analyze seven articles. A significant effect on inflammatory marker proofed by TNF-? improvement. The change TNF-? level was various, but another clinical progress such as cardiovascular, endocrine, and other research parameter. Aerobic exercise can be an alternative way to maintain inflammatory process in older adult patients.
RELATIONSHIP BETWEEN EXERCISE AND ANDROGENIC ALOPECIA Frida Angelina; Clorinda Chandra; Indira Vidiari Juhanna; I Putu Adiartha Griadhi
Sport and Fitness Journal Vol 11 No 3 (2023): Volume 11, No. 3, September 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Androgenic alopecia is a common cause of thinning hair whose prevalence increases with age and aging. The incidence of alopecia is also related to genetic and non-genetic factors, including exercise, although research is still limited. Therefore, this literature review was organized to examine the relationship between androgenic alopecia and exercise in more detail. An article search was conducted in five electronic journal databases (Google Scholar, PubMed, ScienceDirect, MEDLINE, and EMBASE) to find scientific articles on the relationship between exercise and androgenic alopecia published within the last ten years (2013-2023), without language restrictions, with criteria inclusion as follows: 1) respondents with androgenic alopecia; 2) an explanation of the relationship between exercise and androgenic alopecia; and 3) description of the effect of intensity, frequency, and form of exercise on the incidence of androgenic alopecia. In total, there were two cross-sectional studies used in this literature review. This study found that an increase in the frequency of low-intensity exercise in the group with or without a family history of androgenic alopecia increased the proportion. However, progressivity can be reduced, and symptom improvement can occur in the group that does any exercise lasting more than 60 minutes with a frequency of 5-7 times per week, so this exercise method can be recommended. Thus, this literature review has answered that there is a relationship between exercise and the incidence of androgenic alopecia, which can increase or decrease the progression and symptoms depending on the type, intensity, duration, and frequency of exercise. Keywords: aging; androgenic alopecia; exercise; progressivity
The Effect of Resistance Exercise to Prevent and Manage Sarcopenia Dicky Hartono; Angela Christine; Anggraini Eny; Adiatmika Gede I Putu
Sport and Fitness Journal Vol 11 No 3 (2023): Volume 11, No. 3, September 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Sarcopenia is a loss of muscle mass and function because of the aging process. The goal of this literature review was to evaluate an resistance training efficacy on pre-sarcopenic body composition and strength in elderly. This literature review will investigate the effect of resistance training determined by body mass analysis in the sarcopenia patient. Google Scholar, ResearchGate, and Mendeley were used as the search engine. The keywords were strength training, resistance exercise & sarcopenia. The effect of resistance exercise on sarcopenia prevention were analyzed from 28.300 articles. Significant effect on sarcopenia proofed by body composition improvement. The depletion of lean body and total fat mass was analyzed by a mean of gram unit. An easy-to-use functional resistance exercise was effective to maintain functional strength and to gain muscle mass in pre-sarcopenia elderly patients.
EFFECT OF YOGA TRAINING ON SUPEROXIDE DISMUTASE IN ADULT Devi Paramita Yasa; Nila Wahyuni
Sport and Fitness Journal Vol 12 No 1 (2024): Volume 12, No. 1, January 2024
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Due to its capacity to enhance both physical and emotional well-being as well as to treat a number of medical illnesses like diabetes, cardiovascular disease, and chronic pain, yoga has become increasingly popular on a global scale. Yoga's ability to increase the body's antioxidant levels, especially those of superoxide dismutase (SOD), which may have anti-aging benefits, is one potential benefit. Although the precise mechanisms are still unclear, regular yoga practice has been found to raise SOD levels. Possible processes include hormesis-induced antioxidant defense mechanism stimulation and deep breathing-induced relaxation promotion and enhanced oxygenation. This review of the literature identifies gaps and restrictions in the research while providing an overview of the current studies on the impact of yoga on antioxidant levels. The ideal sort and length of yoga practice for maximum antioxidant benefits are still being determined, as are the mechanisms of action. Overall, practicing yoga may have the ability to increase antioxidant status and enhance general health and wellbeing. Keywords: yoga training; antioxidant
THE POTENTIAL EFFECT OF L-CARNITINE AND EXERCISE ON MUSCLE STRENGTH IN AGING: A LITERATURE REVIEW Kusuma Sri Whisnu Puteri; Kristina Puspadewi; Indira Vidiari Juhanna; I Putu Adiartha Griadhi
Sport and Fitness Journal Vol 11 No 3 (2023): Volume 11, No. 3, September 2023
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

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Aging is an inevitable process, and it can affect various aspects of the human body, including the musculoskeletal system. L-carnitine (LC) has the potential to be used in conjunction with exercise to mitigate the loss of muscle strength associated with aging. This review aims to investigate the impact of LC and exercise on muscle strength in the context of aging. We conducted a comprehensive literature search using various online databases such as PubMed, EMBASE, CENTRAL, and Google Scholar. Our search involved keywords such as "L-carnitine," "exercise," "muscle strength," and "aging" to identify relevant literature. A total of 8 studies were included in this review and 7 of them were conducted in elderly. We present a narrative review to examine the role of exercise and L-carnitine in relation to muscle strength during the aging process. The combination of LC and exercise holds promise as a potential intervention. Both LC and exercise have shown benefits in mitigating the loss of muscle mass, strength, and function. However, when used together, they may yield even better results, particularly because LC can help improve functions that are typically impaired by aging. The decline in muscle mass, function, and subsequently strength associated with aging can significantly impact one's quality of life. LC and exercise both have impact to improve muscle strength in aging but further studies have to be made to assess precisely how the combination of both may benefit for the elderly. Keywords: aging; exercise; L-carnitine; muscle strength