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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
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Articles 19 Documents
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Search results for , issue "Vol. 9 No. 2 (2023): July" : 19 Documents clear
BIOINFORMATICS STUDY OF 7,8-DIHYDROXYFLAVONE AS A NEUROPROTECTIVE AGENT IN ISCHEMIC STROKE VIA TRKB REGULATION AND GLUTAMINASE INHIBITION Rislan Faiz Muhammad; Basya Adnani; Safira Dita Arviana; Aldita Husna Violita; Husnul Khotimah; Shahdevi Nandar Kurniawan; Mokhamad Fahmi Rizki Syaban; Yuyun Yueniwati Prabowowati Wadjib; Masruroh Rahayu
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.12

Abstract

Background: Stroke, particularly ischemic stroke, is one of the leading causes of death worldwide. Ischemic stroke causes a failure of oxidative phosphorylation and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, all of which result in cell death. Neuroprotective agents are given to prevent the infarct area from expanding. Objective: This study aims to predict an in silico interaction by 7,8-dihydroxyflavone as neuprotective agent through TrkB signaling and inhibiting Glutaminase activity. Methods: In silico simulation with 7,8-dihydroxyflavone (DHF) as neuroprotective agent using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol software. This study analyzes the pharmacokinetics, pharmacodynamics, and protein-ligand interactions between 7,8-DHF as a ligand with TrkB (4AT5) and Glutaminase (5JYO) as protein target, compared to their native ligand. Results: 7,8 DHF binds to 4AT5 and 5JYO with lower bond energy (-9.4 Kcal/mol and -6.3 Kcal/mol, respectively) than the native ligand (-5 Kcal/mol and -5.9 Kcal/mol, respectively). It means that 7,8-DHF may increase protective mechanism. Conclusion: These findings tend to increase downstream signaling pathways, leading to increased TrkB expression, which induces protective mechanisms, and decreased glutamate expression, which reduces glutamate toxicity.
PSYCHOLOGICAL TREATMENT VARIANT WITH EYE MOVEMENT DESENSITIZATION AND REPROCESSING: A CASE REPORT Alejandro Checa
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.16

Abstract

Background: EMDR (eye movement desensitization and reprocessing) is a structured psychotherapy method that facilitates the treatment of various psychopathologies and problems related to both traumatic events and more common but emotionally stressful experiences.1 Due to the confinement due to the COVID-19 (Coronavirus Disease 2019) pandemic, people have developed a mixture of anticipatory anxiety, stress, tiredness, misunderstanding and fear, a psychological and emotional mixture that does not fit into any of the existing boxes in the classification of mental disorders.2 Eye Movement Desensitization and Reprocessing (EMDR) has abundant evidence of efficacy in trauma spectrum disorders. Its efficacy in anxious and depressive disorders in children and adolescents has been scarcely studied.3 Objective: To evaluate the efficacy of an alternative EMDR protocol. Methods: It is about a 13-year-old female adolescent who seeks care after having made her second suicide attempt after 9 months of failed psychological and psychiatric therapy, the standard EMDR protocol is executed in a first unsuccessful session and a variant of the EMDR protocol that occurred incidentally achieving the therapeutic goal. Results: This is an adolescent with a history of failed mental health treatment, the standard intervention protocol with EMDR was executed without success, however; In a second attempt, the patient spontaneously proceeds with desensitization from positive experiences without ever directly addressing the traumatic event. In this case, the reprocessing of the events occurred through positive experiences for the patient instead of what is indicated in the standard protocol where the trauma is reprocessed through the negative event. Conclusion: Psychological treatment using EMDR was effective despite its atypical execution, therefore variations to the original protocol can be applied.
MULTIPLE SCHMORL’S NODES ON YOUNG ADULT WITH MYOFASCIAL PAIN SYNDROME: A CASE REPORT I Gusti Agung Ayu Andra Yusari; Putu Gede Sudira; Ida Ayu Sri Wijayanti
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.17

Abstract

Background: Schmorl’s node (SN) is described as intraosseous disc herniations which penetrate into the spinal canal, which is caused by the weakening of the cartilaginous endplate and subchondral bone. SN is usually detected on imaging which appears small, focal, and rounded with varying degrees of adjacent reactive sclerosis. Case Report: We present a rare case of symptomatic SN in 25-year-old male patient with complaints of discomfort and muscle strain in the back. These complaints were exacerbated by physical exercise. Severe tenderness was found at several levels of the thoracic vertebrae during palpation, where the trigger points were found in the lower trapezius muscle. Computerized tomography (CT) scan of the vertebra showed multiple bony lesions, noted as Schmorl’s nodes, at the inferior endplates of the T6-T11, and superior endplate of the T11 vertebra, in accordance to the location of severe pain during palpation. Conclusion: SN is associated with disc degeneration due to osteonecrosis process which leads to ischemia in the vertebral body. Microtrauma from excessive physical exercise could also contribute to the herniation through the weak points of the vertebral endplates. Knowledge and awareness of SN as one of the causes for acute or chronic back pain is essential for deciding early examination and diagnosis. Therefore, appropriate management could be delivered.
CLINICAL SIGNIFICANCE OF INTRAOPERATIVE NEUROPHYSIOLOGICAL MONITORING DURING SCOLIOSIS SURGERY: A LITERATURE REVIEW Sylvia Tanumihardja; Dedeh Supantini; Julia Windi Gunadi; Ardo Sanjaya; Katherine Marcella
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.14

Abstract

Mechanical damage to nerve fibers during scoliosis correction can result in severe neurological disorders. It has been demonstrated that intraoperative neurophysiological monitoring during spinal surgery reduces the risk of motor deficits or paraplegia. Despite significant advances in the technique and application of IONM (intraoperative neurophysiological monitoring), data reporting the impact of implementing intraoperative neurophysiological monitoring on scoliosis surgery intervention remains very limited. Therefore, this review aims to investigate the correlation between the application of IONM and the risk of neurologic deficits in scoliosis patients undergoing surgery. The database sourced from PubMed (Jan 2010 to Jan 2022) was used to identify all studies evaluating the effectiveness and impact of intraoperative neurophysiological monitoring during scoliosis surgery and reducing the risk of postoperative complications. This systematic review included five studies. Multimodal IONM, with its high sensitivity and specificity, provides an objective benchmark that surgeons can implement to review surgical strategies to reduce the risk of permanent neurologic deficits. Multimodal IONM can be considered the gold standard of IONM in scoliosis surgery to prevent neurological damage and provide a more satisfactory result of surgical intervention.
PANCOAST TUMOR PRESENTING WITH HORNER SYNDROME: A CASE REPORT Raden Andi Ario Tedjo; Hillary Hillary; Vivienne Tjung; Stefanus Erdana Putra; Muhammad Hafizhan
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.18

Abstract

Case Report: A 50-year-old man was referred to Dr. Moewardi General Hospital with history of right chest pain that radiate to the right back and hand for 2 months. His complaint did not improve with medication and physical therapy. On physical examination we observed multiple nodules on the right axilla, scapula, and colli region. Neurological examination revealed right sided partial ptosis, anisocoria, ipsilateral weakness, and ipsilateral allodynia, and anhidrosis T1 dermatome. CT-scan showed a right lung mass in the superior lobe of the apical segment. The diagnosis of Horner syndrome is then established caused by multiple lymphadenopathies. His symptoms then relieved after lymphadenectomy. Conclusion: Horner syndrome, characterized by ipsilateral pupillary anisocoria, ptosis and anhidrosis, is one of the complications of Pancoast tumor invasion to the sympathetic nervous system in the C8, T1, and T2 nerve territory.
CLINICAL CHARACTERISTICS OF LACUNAR ISCHEMIC STROKE PATIENTS Anindyta Murfia Khairunnisa; Lisda Amalia; Eppy Buchori Aristiady; Harry Galuh Nugraha; Asep Nugraha Hermawan
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.9

Abstract

Background: Stroke is the leading causes of death and disability in the world. Ischemic stroke covered 85% of stroke types. Based on the subtypes of ischemic stroke, lacunar ischemic stroke encompassed 20% of them. Knowing the characteristics help physicians to diagnose patients clinically and offer management to treat risk factors. Objective: This study aimed to know the characteristics of lacunar ischemic stroke based on patients risk factors, ischemic location on CT-scan, clinical syndrome, and NIHSS score. Methods: Using retrospective analytical study with cross sectional approach, medical record data from 2019-2022 were collected from RSUP DR. Hasan Sadikin Bandung. Results: From 60 patients, 35% (21) are 55-64 years old. Both sexes are equally distributed. 50 patients (83.3%) have multiple risk factors. Out of 60 patients, 57 (95%) have hypertension, 8 (13.3%) have diabetes mellitus, 44 (73.3%) have dyslipidemia, 6 (10%) have hyperuricemia, and 14 (23.3%) smoke. On admission, out of 60 patients, 34 (56.7%) have mild stroke, 23 (38.3%) have moderate stroke, 2 (3.3%) have moderate to severe stroke, and 1 (1.7%) has severe stroke. 44 (73.3%) out of 60 patients have pure motor hemiparesis. 41 (68.3%) out of 60 patients have basal ganglia ischemic. Conclusion: Lacunar ischemic stroke patients were equally distributed in sex with peak incidence occur between 55-64 years old. Most patients have multiple risk factors, basal ganglia lesion, pure motor hemiparesis, and history of hypertension, dyslipidemia, and smoking. On admission, most patients have mild stroke, followed by moderate stroke.
THE POTENTIAL OF STEM CELL THERAPY AS A MANAGEMENT OF CHRONIC PAIN: A SYSTEMATIC REVIEW Putu Yogi Pramana; Agung Bagus Sista Satyarsa; Ida Ayu Sri Wijayanti; Anak Agung Raka Sudewi
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.15

Abstract

Background: Stem cells has previously been used with promising results as a therapeutic modality for neurodegenerative diseases and pain but has recently been introduced as a treatment for chronic pain. Objective: This study aims to review the available literature on the role of stem cell therapy as a treatment for chronic pain. Methods: A review of clinical reports using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) method published in Pubmed, EMBASE (Excerpta Medica Database), and ScienceDirect were used from 2013 to 2023, and The search tool was used to locate and enroll patients for ongoing, presently active clinical studies. The search terms used included “chronic pain,” “therapy,” “prosedure” “neuropathic,” “discogenic,” “modality,” “musculoskeletal” and “stem cell.” The research was then carried out to assess the quality of the study using the Critical Appraisal Skills Program questionnaire. Results: There were around 186 studies related to the keyword, and only about 11 studies that met the inclusion criteria included in this article were obtained. Based on the results of the study, it was found that the role of stem cell therapy in the form of MSC and ADS, which was used, had a significant effect as a chronic pain therapy in patients. A decrease in the quality of pain was obtained based on VAS (Visual Analog Scale), ODI (Oswestry Disability Index), and NRS (Numeric Rating Scale) assessments as well as an increase in patient function. Conclusion: Although current research suggesting the use of mscs as a novel therapy method for disc, neuropathic, and musculoskeletal pain, further studies are required to demonstrate the efficacy as well as security of this modality
THE DEPICTION OF GENERAL PHYSICIAN’S KNOWLEDGE LEVEL OF PARKINSON’S DISEASE IN INDONESIA Neila Raisa; Adeliza Firzarosany Insanitaqwa; Masruroh Rahayu
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.10

Abstract

Background: Parkinson's disease still requires special attention considering that this condition is a progressive disease that leads to a decrease in the quality of life and life expectancy of the patient. Objective: This study aims to determine the level of understanding of general practitioners regarding Parkinson's disease and other movement disorders. Methods: We conducted a one group pretest posttest design study on 124 general practitioners who attended the World Parkinson Day Seminar. . The research instrument was a questionnaire with 20 questions, filled in by the participants independently.  Knowledge level categories are good (76-100), sufficient (56-75), and poor (<55). Results: The result of the study showed that 18% [22 respondents] had a good level of understanding, 58% [72 respondents] had sufficient knowledge, and 24% [30 respondents] had poor knowledge in terms of the pretest score. There was an increase in the average score (from 65.93 to 78.9) of the respondents after attending the seminar (p<0.05). Conclusion: This study identified that there was a significantly increased level of knowledge of Parkinson's disease symptoms after the seminar for general practitioners in Indonesia.
THE IMPORTANT OF NEUROPHYSIOLOGY EXAMINATION IN DIAGNOSING SEGMENTAL ZOSTER PARESIS: CASE REPORT Eric Hartono Tedyanto; Ni Made Dwita Pratiwi; I Komang Arimbawa; I Putu Eka Widyadharma
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.19

Abstract

Background: Segmental zoster paresis (SZP) is a very uncommon complication characterized by localized weakening of the upper or lower limbs. Case report: A 69-year-old man came with complaints of weakness in the right leg two months ago. He had weakness in his right leg after two days of having herpes on his right leg. There was paresthesia and hypesthesia on neurological examination according to the L1-L3 dermatome. Neurophysiology examination revealed a neuropathy in the right femoral nerve. Discussion: Varicella-zoster virus, being a neurotrophic virus, primarily invades and incubates in the dorsal root or cerebral ganglion nerve cells. Etiological investigations in SZP patients have revealed that the anterior root is the most prevalent location of inflammation and degeneration. Conclusion: SZP is a rare complication following VZV infection that can lead to misdiagnosis and overtreatment in clinical practice. The neurophysiological examination is very important in diagnosing segmental zoster paresis.

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