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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 297 Documents
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PNEUMONIA IN ICU HOSPITALIZED NEUROLOGIC PATIENTS: THE RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND PROCALCITONIN LEVELS WITH THE RESULTS OF BLOOD AND SPUTUM CULTURES Indah, Carolin Tiara Lestari; Widyantara, I Wayan; Putra, Ida Bagus Kusuma; Tini, Kumara
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.7

Abstract

Background: Pneumonia is often experienced by neurology patients, especially in the intensive care unit (ICU). Culture and antibiotic sensitivity tests as the gold standard of pneumonia require a long time, then other examinations are needed, namely C-reactive protein markers (CRP), and procalcitonin (PCT). Objective: To determine the relationship between CRP and PCT levels with the results of blood and sputum cultures in ICU hospitalized neurologic patients Prof I.G.N.G. Ngoerah General Hospital, Denpasar, Bali. Methods: A cross-sectional study that includes all neurology patients with pneumonia in the ICU of Prof I.G.N.G. Ngoerah General Hospital in 2018-2022. The required examination data are demographic data, CRP and procalcitonin levels, and blood and sputum culture results. Data analysis using SPSS Version 24 qualitatively. Results: We identified 121 ICU hospitalized neurologic patients with pneumonia involving 59 blood and 85 sputum culture-positive and 15 isolated pathogens. The leading pathogens were Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeuroginosa, Escherichia coli, Staphylococcus aureus,  Candida albican, Streptococcus suis, and Staphylococcus haemolyticus, and other pathogens which were isolated in 31 (19,7%), 25 (15.9%), 20 (12.7%), 11 (7%), 10 (6.4%), 4 (2.5%), 3 (1.9%), and 1 (0.6%) cases, respectively, however Klebsiella pneumoniae has the highest number of resistance cases, especially ESBL. There was a significant relationship between high CRP (>97.9) and blood culture (OR 6.42, p <0.03). Conclusion: CRP can be considered as a fast and appropriate examination to establish an early diagnosis of pneumonia in patients.
A SIX-MONTH STUDY OF CLINICAL SYMPTOMS, IMAGING AND OUTCOMES OF PATIENTS DIAGNOSED WITH CEREBRAL VENOUS SINUS THROMBOSIS (CVST) Ardalani, Ghasem Fatahzadeh; Pourfarzi, Farhad; Haddad, Amir
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.2

Abstract

Background: One of the unusual cause of headache and stroke is CVST with very diverse clinical manifestation. Onset of focal headache, headache with seizures, papilledema, or focal defect are some of important clinical features. Consideration of risk factors, especially the use of hormonal drugs, recent pregnancy, coagulation disorders, as well as recent infections and systemic inflammation, can lead to clinical suspicion of CVST. For early and accurate detection we can use modern MR imaging. Objective: To evaluate the clinical symptoms and imaging findings of patients with a diagnosis of CVST during 6-months follow-up. Methods: This cross-sectional study was used on 56 patients with CVST. Clinical, preclinical, and imaging records of inpatients and also information like age, sex, and underlying diseases were collected at a checklist.  After 6 months from the start of treatment, the identified patients were followed up through a telephone interview, and if there were any positive symptoms, they were visited on an outpatient basis in the neurology clinic of Alavi Hospital in Ardabil, and the necessary information was extracted. Collected data were analyzed by statistical methods in SPSS version 21. Results: Of all patients, 47 (84%) were women. The most common symptom was headache with 87.5% and then nausea and vomiting, sensory and visual symptoms with 57.1%, 51.8% and 44.6%, respectively. Conclusion: The results of this study showed that, the clinical symptoms of patients are very various and misleading, but the most common clinical symptoms were headache, nausea and vomiting. Women were involved more than men. The results of the study disclosed that CVST had wide range of clinical manifestations and non-specific symptoms at the beginning. For that reason, in especially high risk groups for thrombosis, the diagnosis of CVST should be kept in mind.
HYPERDENSE BASILAR ARTERY SIGN IN ISCHEMIC STROKE PATIENT WITH COVID-19: A CASE REPORT Asrini, Neoniza Eralusi; Umam, David Noor
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.19

Abstract

Background: Coronavirus disease 2019 (COVID-19) can cause coagulopathy, leading to thromboembolism disease such as ischemic stroke. Ischemic stroke due to basilar artery occlusion (BAO) is rare condition, which is hard to diagnose and has high mortality especially if accompanied by COVID-19. Objective: To evaluate the presence of infarction in the basilar area in COVID-19 patients and prevent complications that arise due to misdiagnosis Methods: 41 year old male patient came to the emergency unit with left-side weakness, slurred speech, vertigo, and nausea 7 hours before admission. He also had mild fever, cough, and fatigue a week before admission. Patient had full consciousness, blood pressure 180/100, left hemiparesis (motoric 3/5), dysarthria, dysphagia. His National Institutes of Health Stroke Scale (NIHSS) score was 7. Results: From laboratory examination, neutrophil lymphocyte ratio (NLR) was increased to 3.60, he tested positive for SARS-CoV-2 rapid antigen and Polymerase Chain Reaction (PCR) with cycle threshold (CT) value 28.66, and D-dimer was increased to 4000 ng/mL. Bronchovascular markings increased on chest X-ray and hyperdense bacillary artery sign found on head CT-scan suggesting vertebrobasilar infarct.  Acute stroke ischemic due to large vessel occlusion in COVID-19 found more often in young men with mild symptoms or asymptomatic COVID-19. Prodromal symptoms and stroke onset in BAO can be atypical and variable. Hyperdense bacillary artery sign on head CT scan was a specific sign and can support the diagnosis of BAO. Concussion: Patient’s condition got better progressively and was allowed to discharge from hospital after 6 days. BAO patients with younger age, lower NIHSS scores, early diagnosis, and prompt treatment had better prognosis.
CASE STUDY OF A TARLOV CYST IN A SYRIAN PATIENT Salman, Hala; Kharma , Leen; Khammash, Farah; Murad, Musab; Alquobaili, Faizeh
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.15

Abstract

Tarlov cyst is a rare disease that affects the nervous system, which is a vesicle filled with spinal cord fluid, the cyst surrounding the nerve are fluid-filled sacs that greatly affect the nerve root and are detected by magnetic resonance in some cases the bag expands and put pressure on the affected nerve root. Several treatment methods have been used, including pharmacological and non-pharmacological methods such as cortisone injections and surgery. As a result of the multiplicity of information about Tarlov’s cyst disease, a questionnaire was conducted for the project to prove the views of its being a rare disease and to find out the extent of awareness in society in differentiating between symptoms associated with Tarlov’s cyst and other neurological diseases, we found that 86.4% of people who contributed in our questionnaire were not able to identify the disease, so we found its important to study the Tarlov cyst case that was diagnosed in 2019  which belongs to a  20-year-old girl. X-ray and MRI were used to diagnose Tarlov's Cyst after one year of the first visit to the doctor. After treating the cyst with muscle relaxants and cortisone for one year the pain persisted and surgery was carried out in 2021.  Late diagnosis is common and the degree of knowledge of the disease is low even among medical practitioners. Therefore, we concluded that awareness must be spread through increased research and scientific seminars to introduce it, especially with regard to the medical branches.
EVALUATION OF BRAIN LESIONS BY MAGNETIC RESONANCE SPECTROSCOPY IN TERTIARY HOSPITALS OF FAISALABAD Khokhar, Abdul Maajid; Ali, Rimsha; Habib, Wazooha
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.3

Abstract

Background: One of the most fascinating and intricate organs in the human body is the brain. Infectious and neoplastic lesions in brain tissues can be identified by Magnetic Resonance Imaging (MRI). Objective: This study sought to determine which Magnetic Resonance Imaging (MRI) sequence is more usually used for differentiating brain lesions and which metabolites are examined by Magnetic Resonance Spectroscopy in Tertiary hospitals of Faisalabad. This study also aimed to check the efficacy and cost-effectiveness of MRI in the detection of various brain lesions. Methods: A cross-sectional study was conducted in the Radiology Department of different tertiary hospitals in Faisalabad. The data was collected from 25 patients (aged between 25 to 70 years) via a convenient sampling technique. Data was collected by performa and analyzed by SPSS V 20. Results: Out of 25 patients; 20 were male and 5 were female. 15 patients were diagnosed with a tumor, 5 with tuberculosis infectious lesions, 3 with empyema, and 2 with a heterogenous picture of metabolites. According to the results of MRS, different metabolites are used by different hospitals for the evaluation of various brain lesions. Brain infectious and neoplastic lesions can be distinguished quite effectively using MRS, although some infectious lesions can be difficult to distinguish. Conclusion: MRI is a non-invasive technique to identify brain tumors and infectious lesions. The main metabolites in H1MRS are Choline, Creatine, and N-Acetyl Aspartate. A high Cho/Cr ratio indicates brain tumors while a low NAA/Cr ratio indicates infectious lesions. When MRS indicates a tumor, not only a brain 99mTc scan should be performed, but if necessary surgical removal of brain lesions should be preferred.
A GLOBAL SCIENTOMETRIC ANALYSIS OF HERPES ENCEPHALITIS RESEARCH IN THE LAST 50 YEARS Yildirim, İrem; Alkan, Sevil
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.12

Abstract

Background: Herpes encephalitis is the most common of all encephalitis worldwide and has the highest mortality rate. The aim of this study is to review articles on this topic in order to provide a guide for future herpes encephalitis studies to assess current publishing trends and hotspots on herpes encephalitis research globally. Objective: People have been affected by the herpes virus for many years, but advances in supportive care and antiviral drugs have only recently made it possible for doctors to treat the most severe types of infections. To the authors' knowledge, however, no bibliometric analysis has been done to rate Herpes encephalitis research. In order to enhance research in this area, this study used a bibliometric analysis to assess current publishing trends and hotspots on herpes encephalitis research globally. Methods: The Web of Science database was searched for pertinent publications between January 1970 and December 2021. The research points, comprising publishing countries, affiliations, first authors, cited authors, cited references, and their clustering, as well as keyword co-occurence, were analyzed using VosViewer to identify  research trends and hotspots. Results: The results of this study's search methodology revealed that between 1970 and 2021, 2138 documents. Only articles (n=1223) were included the study.  89.37% of the articles were written in English. The first article published in 1970 and  most of the articles published in the years 1982, 1988, 2007, 2016, and 2017. The United States of America (USA) (29.109%), England (9.076%), France (7.441%), Japan (7.359%) and Germany (7.032) were the other top ranked countries. The most citation numbers were recorded in the year 2021. Conclusion: This bibliometric analysis outlined the general overview for Herpes encephalitis research and offered insightful guidance for continuing investigations.
A RARE CAUSE OF ENCEPHALOPATHY IN CHILDREN: PRES SYNDROME Tosun, Demet; Akçay, Nihal; Oğur, Mustafa; Şevketoplu, Esra
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.16

Abstract

Background: Major clinical symptoms of posterior reversible encephalopathy syndrome include headache, mental status changes, visual disturbances, seizures, especially in the posterior cerebral region, and radiographic findings of vasogenic edema, especially in the posterior cerebellar region. Case Report: We present our 6-year-old patient with chronic renal failure. admitted to our pediatric emergency department with an acute hypertensive crisis. Generalized tonic-clonic seizures and mental status changes were accompanied in the follow-up of the patient whose GCS was 11; With symptomatic treatment, regression in both clinical complaints and imaging findings of our patient is consistent with Posterior reversible encephalopathy syndrome (PRES). Conclusion: It is imperative to consider PRES syndrome as a differential diagnosis when pediatric patients exhibit symptoms of acute encephalopathy. It is crucial to emphasize the critical nature of early diagnosis and treatment, as well as the potential for complete recovery without sequelae.
WEB OF SCIENCE BASED BIBLIOMETRIC ANALYSIS STUDY: TUBERCULOSIS MENINGITIS FROM 1970 TILL TO PRESENT Alkan, Sevil; Celik, Mehmet; Gürbüz, Esra
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.4

Abstract

Background: Tuberculous meningitis (TBM) is the most dangerous and incapacitating type of tuberculous and has a high mortality rate. Objective: We aimed to reveal the general perspective of tuberculous meningitis, with bibliometric analysis. Methods: This study included only articles as a document type, searched in the Web of Science database, indexed in ‘‘Science Citation Index Expanded’’ and ‘‘Emerging Sources Citation Index’’ from 1970 to the present. Results: A total of 2370 publications were reached and 1516 articles were included in the study. 87.401% of them were published in Science Citation Index Expanded and 12.599% in  the Emerging Sources Citation Index. The articles were mostly published in English (92.084%) language. Most of the articles (6.266%) were published in 2021. 107 countries contributed to the tuberculous meningitis literature. India, the USA, and South Africa were the countries with the highest number of articles published. Most articles were published in “The International Journal of Tuberculosis and Lung Disease’’ journal. The countries that financially supported tuberculous meningitis studies the most were the USA and the United Kingdom (UK). Conclusion: TB continues to be an important public health problem globally, especially in low-middle-income countries. In this study, it was observed that there has been a significant increase in publications related to TBM in recent years. It was seen that the USA and UK were the countries that provided the most publications and financial support to the studies, although they were not, particularly the countries where TBM was watched most frequently.
PSEUDOBULBAR AFFECT AND COGNITIVE DECLINE POST SEVERE TRAUMATIC BRAIN INJURY: A CASE REPORT Yusari, I Gusti Agung Ayu Andra; Laksmidewi, Anak Agung Ayu Putri
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.15

Abstract

Introduction: Pseudobulbar affect is described as episodes of laughing or crying that occur suddenly and uncontrollably without appropriate stimulation. Pseudobulbar affect is often preceded by various neurological disorders, one of which is a history of severe head injury. Case Report: Female, 21 years old, experienced sudden frequent laughing for no apparent reason and could not be controlled. This has been happening after she suffered a severe head injury, which was a subarachnoid hemorrhage, about two years ago. She was diagnosed with pseudobulbar affect according to Cummings criteria and confirmed by Center for Neurologic Study – Lability Scale (CNS-LS) questionnaire with a score of 19. The patient also complained of forgetting things, therefore a cognitive function was examined with Indonesian Version of the Montreal Cognitive Assessment (MoCA-Ina) with a score of 14 which indicated moderate cognitive impairment. Discussion: Pseudobulbar affect post traumatic brain injury is suspected to be caused by decreased inhibition of sensory cortex transmission to the motor cortex and limbic system leading to disturbances in the cerebellum and decreased threshold for emotional expression. Pseudobulbar affect may coexist with impaired cognitive function due to the intersection of the anatomical structure of cognitive function with pathways that regulate emotion. Conclusion: Pseudobulbar affect with cognitive impairment creates a burden and interferes the patient’s quality of life. It is necessary for health workers to be able to identify the clinical manifestations of pseudobulbar affect as a complication after traumatic brain injury, therefore optimal management for the patients can be achieved.
PROFILE OF CHARACTERISTIC, RISK FACTOR, AND CLINICAL SEVERITY OF ISCHEMIC STROKE PATIENTS Perdana, Philips Carel; Ardhi, Mohammad Saiful; Susanto, Hermawan
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.8

Abstract

Background: Ischemic strokes account for 87% of all strokes, making them the second leading cause of disability and one of the leading causes of mortality worldwide. Using the National Institutes of Health Stroke Scale (NIHSS), the clinical severity of an ischemic stroke can be assessed. Objective: The objective of this study is to ascertain the clinical severity, risk factors, and characteristics of patients with ischemic stroke at the neurology department of RSUD Dr. Soetomo Surabaya. Methods: The participants in this descriptive observational study comprise individuals who sought medical attention at the neurology department of RSUD Dr. Soetomo between January 2019 and December 2020 due to an ischemic stroke. The observed profile comprises the following factors: age, gender, obesity, smoking status, alcohol consumption, physical inactivity, family history of vascular disease, form of infarction, dyslipidemia, hypertension, cholesterol, and diabetes. Results: In the medical record data collection of 89 ischemic stroke patients, 36 patients were excluded when they first entered the hospital. So a total of 53 ischemic stroke patients were collected. 29 (54.72%) patients are male. The age range is dominated by 48 - 62 years from 29 (54.72%) patients. 44 (83.02%) patients are Javanese. 18 (33.96%) patients had a history of smoking, 1 (1.89%) patient consumed alcohol, and 1 (1.89%) patients were inactive physically. 13 (24.53%) patients have a family history of vascular disease, 45 (84.91%) patients have hypertension, 26 (49.06%) patients have dyslipidemia, and 19 (35.85%) patients have diabetes. 34 (64.15%) patients had moderate strokes, 15 (28.30%) patients had mild strokes, 2 (3.77%) patients had moderate-severe strokes, and 2 (3.77%) patients had severe strokes according to the results of the NIHSS assessment on the first admission. Conclusion: Ischemic stroke patients were mostly in the age range of 48 – 62 years. Comorbidities such as hypertension, dyslipidemia, hypertriglyceridemia, and diabetes are present in the majority of patients. The NIHSS scoring identified moderate stroke patients as having the most frequent outcomes, followed by patients with mild stroke.

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