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INDONESIA
MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 297 Documents
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CASE REPORT OF ADULT-ONSET CHARCOT MARIE TOOTH TYPE X Suherlim, Richard; Laksmidewi, Anak Agung Ayu Putri; NKA, Sudiarini
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.14

Abstract

Charcot-Marie-Tooth (CMT) or Hereditary Motor and Sensory Neuropathy (HMSN) is the most common hereditary peripheral nerve disease with progressive chronic weakness, muscle atrophy, and sensory disturbances. There are several types and subtypes of CMT with their respective clinical manifestations. In this article, we reported a patient with of CMT type X. A 43-year-old male patient was referred to a neurology clinic with weakness in both limbs for 2 years, accompanied by tingling and sensory disturbance in both hands and feet. There are several of his family members who had similar complaints. Lumbosacral magnetic resonance imaging (MRI) examination revealed mild nucleus pulposus herniation. Electroneuromyography (ENMG) examination revealed demyelinating sensory motor polyneuropathy. Histopathological examination of nerve biopsy showed demyelination of the sural nerve. It is hard to make a diagnosis of CMT, because it requires high suspicion from clinicians once encounter a suspected case and also need to supported by sophisticated equipment such as electrophysiological examinations, nerve biopsy examinations, and genetic examinations. It is vital for clinicians for being able to diagnose CMT correctly and provide treatment as soon as possible in order to maintain the patients’ quality of life.
INDIRECT CEREBRAL REVASCULARIZATION ON OPTHALMIC ARTERY BY USING A DRUG-ELUTING BALLON FOR SUSPECTED MOYAMOYA DISEASE Alwahdy, Ahmad Sulaiman; Usman, Fritz Sumantri
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.15

Abstract

Moyamoya disease (MMD) is a rare idiopathic progressive vaso-occlusive disease causing multiple occlusion of cerebral vessels lead to ischemic stroke. Asian population is the most common race to be affected. We present a male patient 33-years old with suspected MMD with right hemiparesis and neurocognitive changes. On digital substraction angiography (DSA) there was appearance of ‘puff of smoke’ on his right hemisphere, stenosis middle cerebral arteries M1 bilaterally, stenosis of right opthalmic artery (OA), stenosis of left anterior cerebral artery (ACA) and aplasia of right ACA. Ballon angioplasty was performed on right OA that supply the contralateral symptomatic stenosis area (left A1) indirectly through anterior ethmoidal artery and anterior falcine artery (OA-ACA collateral). While no guidelines for the management of MMD, cerebral revascularization by using drug-eluting ballon (DEB) in right opthalmica artery is potentially effective treatment  that could allow the brain to have good blood supply (gives good collateral to both ACA), reduces burden of the fragile moya-moya vessels to be ruptured followed by  improvement of clinical results. Patient’s selection by understanding the stage, its progressivity and collateral formation are crucial before decision is made.
DECREMENTAL RESPONSE ON PROLONGED EXERCISE TEST IN A PATIENT WITH THYROTOXIC PERIODIC PARALYSIS Ostwal, Piyush; Alshaheen, Maher
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.13

Abstract

Paralysis of acute onset often presents a diagnostic challenge for the assessing physician because of a large number of differential diagnosis and overlap of clinical features among them. Thyrotoxic periodic paralysis is an uncommon cause of acute weakness. In addition to serological tests, electromyography findings during prolonged exercise test are very helpful in confirming the diagnosis. Only a few case reports of thyrotoxic periodic paralysis have been published from Middle East and none of them have described this specific electrophysiological data. A man in his 20s presented to us with acute onset weakness in both legs which was evaluated further and found to have hypokalemia. The work up for the etiology revealed thyrotoxic status and a final diagnosis of thyrotoxic periodic paralysis was established. The prolonged exercise test performed in this patient showed typical progressive decremental respsonse with nadir at 40 minutes after the exercise.
NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY Dewi, Nadia Artha; Arfan, Muhammad; Rahmasari, Herisa; Putri, Mutiara Kristiani; Rosandi, Rulli; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.12

Abstract

Diabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pathogenesis of diabetic retinopathy. In fact, neuroretinal changes in diabetes can take place even before vasculopathy can be clinically detected.  This condition is marked by accelerated loss of neurons due to apoptosis, particularly in the inner retinal layer. The characteristic of neurodegeneration can be detected through retinal imaging and electrodiagnostics. This review is very crucial, because identifying the pathophysiology of diabetic neurodegeneration better, we may be able to provide interventions using the appropriate therapy. We may also be able to utilize these diagnostic tools  for early detections of diabetic retinopathy, thus preventing blindness due to diabetes.
SALTWATER FISH CONSUMPTION AND THE RISK OF STROKE IN COASTAL POPULATION Haq, Abiyyu Didar; Harahap, Herpan Syafii; Wahyudi, Safat; Susilawati, Ni Nyoman Ayu
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.13

Abstract

Indonesia, consisting of tens of thousands of islands, has a rather long coastline with relatively high percentage of it is population that lives in the coastal area. High consumption of saltwater fish in the coastal population is an inevitability. Several studies have observed a relation between saltwater fish consumption and the risk of stroke with contradicting results, protective effect on one side and harmful on the other. The protective effect is mainly mediated by the poly-unsaturated fatty acid (PUFA) content of the saltwater fish while the harmful effect is mediated by the sodium content. PUFA exerts its protective effect through it is antioxidant effect on the endothelial wall, anti-inflammatory effect and the activation of anti-apoptotic pathways in the state of ischemic stroke while sodium increases the risk of hypertension which is the main predisposing factor for stroke and induces anatomical remodeling of the endothelial wall as well as functional abnormalities. Several public health interventions have been carried out to mitigate the harmful effect of the sodium content of saltwater fish yet there hasn’t been a specific intervention for coastal population.
EFFICACY OF NON-PHARMACOLOGICAL APPROACHES TO IMPROVE SLEEP QUALITY INDICES IN POST-STROKE INSOMNIA PATIENTS Hidayat, Shaffana; Veronica, Fifi; Amalia, Lisda; Goenawan, Hanna
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.14

Abstract

Background: Post-stroke insomnia (PSI) is a highly prevalent complication of stroke. Clinical manifestations of PSI include non-refreshing, non-restorative sleep quality and short sleep duration, leading to stroke recovery impediment, cognitive, emotional, and daytime dysfunction, and poor quality of life in stroke patients. PSI can be treated with medications, but studies have reported various adverse effects of hypnotic drugs in PSI. Objective: This study explores non-pharmacological treatments for their efficacy to improve sleep quality in PSI patients. Methods: An electronic search in Medline, Google Scholar, Elsevier, Directory of Open Access Journals (DOAJ), and Semantic Scholar was performed to identify studies examining the efficacy of non-pharmacological approaches to PSI. Results: A total of ten studies examining the efficacy of non-pharmacological approaches to PSI were reviewed. The characteristics of PSI patients in these studies comprised the older population typically at several months after suffering commonly from ischemic type stroke. The evaluated treatments are EEG biofeedback, acupuncture, cognitive-behavioral therapy (CBT), light therapy, and repeated transcranial magnetic stimulation (rTMS). All treatments successfully improved sleep quality, insomnia symptoms, and quality of life in stroke patients as assessed by various measurements including PSQI and actigraphy. Only mild adverse events were reported following acupuncture, such as local hematoma and hand numbness. Conclusion: Non-pharmacological approaches can be considered efficacious in improving sleep quality index, insomnia symptoms, and quality of life of PSI patients. Furthermore, they do not cause severe or long-lasting adverse effects, thus deemed safe for stroke patients.
THE CORRELATION BETWEEN ADENOID, TONSIL SIZE, AND BODY MASS INDEX WITH OBSTRUCTIVE SLEEP APNEA SEVERITY IN PEDIATRIC PATIENTS Murdiyo, Mohammad Dwijo; Christianty, Finna; Leonard, Aditya
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.11

Abstract

Background: Sleep disturbance in pediatrics produce daytime sleepiness and decrease productivity. Obstructive sleep apnea (OSA) was the most common cause of daytime sleepiness in children. Adenoid and tonsil hypertrophy was a major determinant of OSAS in pediatrics, in addition to other disorders such as craniofacial anomalies and obesity. Understanding the correlation between adenoid, tonsil size and body mass index (BMI) can be useful in managing optimal treatment strategies. Objective: To examine the correlation between adenoid, tonsil size, and BMI with OSA severity in pediatric patient with OSAS. Methods: The medical records of the Department of Otorhinolaryngology Head and Neck Surgery were utilised for this retrospective cross-sectional study spanning from January 1, 2016 to December 31, 2018. This research comprised a cohort of nineteen patients in total. The medical record was queried for the patient's age, sex, adenoid, and tonsil dimensions. The results of a pre-operative polysomnography to assess the severity of OSA were obtained as part of a routine examination and documented in the patient's medical records. Results: The correlation between variables showed in crosstabulation and Scatter Plot. A p-value below 0.05 indicated that the correlation coefficient of -0474 between adenoid size and OSA severity was statistically significant. The correlation between tonsil size and the severity of obstructive sleep apnea (OSA) was not statistically significant (R2 < 0.3, p < 0.05). Similarly, the correlation between BMI and OSA severity showed no significancy with p-value > 0.05, respectively. Conclusion: Adenoid size measured with Cohen and Konak ratio show significant correlation with OSA severity. While tonsil size and BMI showed no significancy in OSA severity.
HIV-RELATED CEREBRAL TOXOPLASMOSIS TREATED WITH ANTIMALARIA MEDICINES: A CASE REPORT Bintang, Andi Kurnia; Atiah, Ummu; Billi, Billi
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.18

Abstract

Background: Cerebral toxoplasmosis is a central nervous system disease caused by infection of intracellular parasite (Toxoplasma gondii) which happened due to activation of dormant form inside brain tissue in immunodeficient patients, especially in people living with HIV/AIDS (Human Immunodeficiency Virus/ Acquired Immunodeficiency Syndrome) or PLWHA. Case Presentation: A 36-year-old man with subacute headache, fever, changing personal behaviour and confusion that persisted for one month. He also had white spot in mouth, history of significant weight loss, meningeal signs, and motoric disturbance. His non contrast head CT scan shown presumptive cerebral toxoplasmosis appearance. We treated the patient with combined antimalaria drugs consists of Pyrimethamine-Sulfadoxin. Conclusion: Early diagnosis by available and rationale empiric treatment, then repeated cranial study is recommended which can dramatically reduce the high mortality and morbidity associated with this disease.
SPINAL INTRADURAL EXTRAMEDULLARY TUMORS AND SIMILAR PATHOLOGIES: A SINGLE CENTER STUDY Altınel, Faruk; Pekcan, Yonca Özvardar; Sivrikoz, Oya Nermin
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.01

Abstract

Background: We wanted to analyze the neurological symptoms and prognosis of five spinal IDEM (intradural extramedullary) tumors cases diagnosed, and to emphasize that a spinal cord tumor can be found incidentally in evoluation of the proximal regions of the vertebral column in patients who were mistakenly operated for lumbar disc herniation on lumbar MRI, but whosesymptoms did not resolve. Objective: To emphasize the need for examinations such as MRI along the vertebral columna in patients with different spinal pathologies and whose symptoms and clinical signs do not improve. Methods: Patients with spinal IDEM tumors treated with surgical excision and followed for more than 2 years were retrospectively analyzed. Issessed pain with the visual analo scale (VAS), and neurological function with the Nurrick grade.Preoperative complaint time,location of tumor in sagital and axial sections in MRI and pathological diagnosis were investigated. Results: The pathological diagnosis in our study was meningioma in two cases,dural arteriovenous fistula in one case,teratoma in one case ,and myxopapilary epandimoma in one case.İn one case,disc herniation surgery was performed in another hospital due to misdiagnosis, but because the patient’s complaints were resistant. In examination, an IDEM tumor at T11 level was detected, and he was operated. In all cases the VAS score (mean) was reduced from 7.8 to 0.4 as well as the Nurrick grade (mean) was from 2.0 to 0.6. In the dAVF case, spasticity in the lower extremities, bladder and bowel disfunction continued. Conclusion: In cases with severe neurological deficits, MRI scanning of the proximal parts of the vertebral column will help in the differential diagnosis of the lesion occupying the intraspinal space.
DIFFUSION WEIGHTED IMAGING IN WILSON’S DISEASE Kalekar , Tushar; Jaipuria, Radhika; Hadi, Ayesha; Kuber, Rajesh; Karanjule, Pooja
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.1

Abstract

Background: Wilson’s disease is a disorder affecting metabolism of Copper resulting in its accumulation in various organs and thereby various manifestations. Neurologic involvement in Wilson’s disease is well diagnosed using Magnetic Resonance Imaging (MRI). Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) sequences aid to the diagnosis of Wilson’s disease. Objective: To assess the role of Diffusion-Weighted Imaging (DWI) in Wilson's disease and investigate its application in the clinical course of the disease and to study its demographic distribution. Methods: A prospective observational study on 25 patients diagnosed to have Wilson's disease with or without any neurological manifestations was done performing MRI of brain with Diffusion-weighted imaging (DWI). A follow-up of the patients was performed at end of 6 months eliciting their clinical history. Results: In 25 patients studied, 24% patients showed diffusion restriction, corresponded with a poor prognosis as compared to the other 76% with Wilson's disease. Follow-up study after 6 months on these patients revealed that even after having good adherence with de-coppering therapy, these patients showed progressive neurological deterioration. Most of the patients were between the age group 11-20 years accounting for 44% and majority of the patients were males, accounting for 72%. Conclusion: Diffusion restriction imaging can be effective in determining neurological involvement in Wilson's disease. Patients having diffusion restriction can be considered at high risk for neurological deterioration. It is prudent to obtain diffusion restriction imaging at baseline in all patients diagnosed or suspected to have Wilson's disease.

Page 20 of 30 | Total Record : 297

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